Safdar, Adeel, Yardley, Nicholas J., Snow, Rodney, Melov, Simon, Tarnopolsky, Mark A.
Creatine monohydrate (CrM) supplementation has been shown to increase fat-free mass and muscle power output possibly via cell swelling. Little is known about the cellular response to CrM. We...
Mahoney, Douglas J., Carey, Kate, Fu, Ming-Hua, Snow, Rodney, Cameron-Smith, David, Parise, Gianni, ...
Studies examining gene expression with RT-PCR typically normalize their mRNA data to a constitutively expressed housekeeping gene. The validity of a particular housekeeping gene must be determined...
Mahoney, Douglas J., Carey, Kate, Fu, Ming-Hua, Snow, Rodney, Cameron-Smith, David, Parise, Gianni, ...
Studies examining gene expression with RT-PCR typically normalize their mRNA data to a constitutively expressed housekeeping gene. The validity of a particular housekeeping gene must be determined...
Ridell, Michael C., Partington, Sara L., Stupka, Nicole, Armstrong, David, Rennie, Courtney, Tarnopolsky, Mark A.
Compared to males, females oxidize proportionately more fat and less carbohydrate during endurance exercise performed in the fasted state. This study was designed to test the hypothesis that there...
Cellular adaption to repeated eccentric exercise-induced muscle damage (2001)
Stupka, Nicole, Tarnopolsky, Mark A., Yardley, Nick, Phillips, Stuart M.
Eccentrically biased exercise results in skeletal muscle damage and stimulates adaptations in muscle, whereby indexes of damage are attenuated when the exercise is repeated. We...
The overall purpose of this thesis was to examine N metabolism and the dietary protein (PRO) requirements of resistance athletes. The first investigation was a randomized, cross-over study designed...
Resistance Exercise Reverses Aging in Human Skeletal Muscle
Melov, Simon, Tarnopolsky, Mark A., Beckman, Kenneth, Felkey, Krysta, Hubbard, Alan
Human aging is associated with skeletal muscle atrophy and functional impairment (sarcopenia). Multiple lines of evidence suggest that mitochondrial dysfunction is a major contributor to sarcopenia....
Gibala, Martin J, Little, Jonathan P, Van Essen, Martin, Wilkin, Geoffrey P, Burgomaster, Kirsten A, Safdar, Adeel, ...
Brief, intense exercise training may induce metabolic and performance adaptations comparable to traditional endurance training. However, no study has directly compared these diverse training...
Adams, Melanie M, Ditor, David S, Tarnopolsky, Mark A, Phillips, Stuart M, McCartney, Neil, Hicks, Audrey L
Tarnopolsky, Mark A, Parise, Gianni, Gibala, Martin J, Graham, Terry E, Rush, James W E
Myoadenylate deaminase (AMPD) deficiency is present in 1–2 % of the population. In theory, this deficiency may alter exercise energy metabolism by impairing the purine nucleotide cycle (PNC) and...
Contraction-induced muscle damage in humans following calcium channel blocker administration
Beaton, Louise J, Tarnopolsky, Mark A, Phillips, Stuart M
Following contraction-induced damage of skeletal muscle there is a loss of calcium homeostasis. Attenuating the damage-induced rise in myocellular calcium concentration may reduce proteolytic...
Thesis (Ph.D.)--McMaster University (Canada), 1991.
The mitochondrial theory of aging in human skeletal muscle : effects of resistance exercise /
Parise, Gianni., Tarnopolsky, Mark A.
Introduction. The mitochondrial theory of aging proposes that a vicious cycle of events including an age-related increase in mitochondrial (mt) reactive oxygen species (ROS) cause damage to mtDNA,...
Safdar, Adeel, Abadi, Arkan, Akhtar, Mahmood, Hettinga, Bart P., Tarnopolsky, Mark A.
MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNA species involved in post-transcriptional gene regulation. In vitro studies have identified a small number of skeletal...
McKay, Bryon R., De Lisio, Michael, Johnston, Adam P. W., O'Reilly, Ciara E., Phillips, Stuart M., Tarnopolsky, Mark A., ...
Sex Differences in Global mRNA Content of Human Skeletal Muscle
Maher, Amy C., Fu, Minghua H., Isfort, Robert J., Varbanov, Alex R., Qu, Xiaoyan A., Tarnopolsky, Mark A.
Women oxidize more fat as compared to men during endurance exercise and several groups have shown that the mRNA content of selected genes related to fat oxidation are higher in women (e.g. hormone...
Wilkinson, Sarah B, Phillips, Stuart M, Atherton, Philip J, Patel, Rekha, Yarasheski, Kevin E, Tarnopolsky, Mark A, ...
Resistance (RE) and endurance (EE) exercise stimulate mixed skeletal muscle protein synthesis. The phenotypes induced by RE (myofibrillar protein accretion) and EE (mitochondrial expansion) training...
McKay, Bryon R, O'Reilly, Ciara E, Phillips, Stuart M, Tarnopolsky, Mark A, Parise, Gianni
Muscle regeneration following injury is dependent on the ability of muscle satellite cells to activate, proliferate and fuse with damaged fibres. This process is controlled by the myogenic regulatory...