Horizontal versus familial transmission of Helicobacter pylori (2008)
Schwarz, Sandra, Morelli, Giovanna, Manica, Andrea, Balloux, Francois, Owen, Robert J., Graham, David Y., ...
Transmission of Helicobacter pylori is thought to occur mainly during childhood, and predominantly within families. However, due to the difficulty of obtaining H. pylori isolates from large...
Horizontal versus familial transmission of Helicobacter pylori (2008)
Schwarz, Sandra, Morelli, Giovanna, Manica, Andrea, Balloux, Francois, Owen, Robert J., Graham, David Y., ...
Transmission of Helicobacter pylori is thought to occur mainly during childhood, and predominantly within families. However, due to the difficulty of obtaining H. pylori isolates from large...
Horizontal versus Familial Transmission of Helicobacter pylori (2008)
Schwarz, Sandra, Morelli, Giovanna, Kusecek, Barica, Manica, Andrea, Balloux, Francois, Owen, Robert J., ...
Transmission of Helicobacter pylori is thought to occur mainly during childhood, and predominantly within families. However, due to the difficulty of obtaining H. pylori isolates from large...
Nübel, Ulrich, Roumagnac, Philippe, Feldkamp, Mirjam, Song, Jae-Hoon, Ko, Kwan Soo, Huang, Yhu-Chering, ...
Holt, Kathryn E., Parkhill, Julian, Mazzoni, Camila J., Roumagnac, Philippe, Weill, Francois-Xavier X., Goodhead, Ian, ...
Ceftriaxone-resistant Salmonella enterica serotype Newport, France (2008)
Egorova, Svetlana, Timinouni, Mohammed, Demartin, Marie, Granier, Sophie A., Whichard, Jean M., Sangal, Vartul, ...
The multidrug-resistant (MDR) Salmonella enterica serotype Newport strain that produces CMY-2 β-lactamase(Newport MDR-AmpC) was the source of sporadic cases and outbreaks in humans in France during...
The rise and spread of a new pathogen: Seroresistant Moraxella catarrhalis (2007)
Wirth, Thierry, Morelli, Giovanna, Kusecek, Barica, Van Belkum, Alex, Van Der Schee, Cindy, Meyer, Axel, ...
The nosocomial human pathogen Moraxella catarrhalis is one the most important agents of human respiratory tract infections. This species is composed of two distinct lineages, one of only moderate...
Julia Leimkugel, Abraham Hodgson, Abudulai Adams Forgor, Valentin Pflüger, Jean-Pierre Dangy, Tom Smith, ...
Julia Leimkugel, Abraham Hodgson, Abudulai Adams Forgor, Valentin Pflüger, Jean-Pierre Dangy, Tom Smith, ...
BackgroundThe Kassena-Nankana District of northern Ghana lies in the African “meningitis belt” where epidemics of meningococcal meningitis have been reoccurring every eight to 12 years for the...
Stephen D. Bentley, George S. Vernikos, Carol Churcher, Claire Arrowsmith, Tracey Chillingworth, ...
The bacterium Neisseria meningitidis is commonly found harmlessly colonising the mucosal surfaces of the human nasopharynx. Occasionally strains can invade host tissues causing septicaemia and...
An African origin for the intimate association between humans and Helicobacter pylori (2007)
Linz, Bodo, Balloux, Francois, Moodley, Yoshan, Manica, Andrea, Liu, Hua, Roumagnac, Philippe, ...
Infection of the stomach by Helicobacter pylori is ubiquitous among humans. However, although H. pylori strains from different geographic areas are associated with clear phylogeographic...
An African origin for the intimate association between humans and Helicobacter pylori (2007)
Linz, Bodo, Balloux, Francois, Moodley, Yoshan, Manica, Andrea, Liu, Hua, Roumagnac, Philippe, ...
Infection of the stomach by Helicobacter pylori is ubiquitous among humans. However, although H. pylori strains from different geographic areas are associated with clear phylogeographic...
Andrzejewska, Joanna, Lee, Sae Kyun, Olbermann, Patrick, Lotzing, Nina, Katzowitsch, Elena, Linz, Bodo, ...
Leimkugel, Julia, Hodgson, Abraham, Forgor, Abudulai Adams, Pflüger, Valentin, Dangy, Jean-Pierre, Smith, Tom, ...
Background The Kassena-Nankana District of northern Ghana lies in the African “meningitis belt” where epidemics of meningococcal meningitis have been reoccurring every eight to 12 years for the...
An African origin for the intimate association between humans and Helicobacter pylori (2007)
Linz, Bodo, Balloux, François, Moodley, Yoshan, Manica, Andrea, Liu, Hua, Roumagnac, Philippe, ...
Bentley, Stephen D., Vernikos, George S., Snyder, Lori A. S., Churcher, Carol, Arrowsmith, Claire, Chillingworth, Tracey, ...
The bacterium Neisseria meningitidis is commonly found harmlessly colonising the mucosal surfaces of the human nasopharynx. Occasionally strains can invade host tissues causing septicaemia and...
The rise and spread of a new pathogen: seroresistant Moraxella catarrhalis. (2007)
Wirth, Thierry, Morelli, Giovanna, Kusecek, Barica, Van Belkum, Alex, Van Der Schee, Cindy, Meyer, Axel, ...
The rise and spread of a new pathogen: Seroresistant Moraxella catarrhalis (2007)
Wirth, Thierry, Morelli, Giovanna, Kusecek, Barica, Van Belkum, Alex, Van Der Schee, Cindy, Meyer, Axel, ...
The nosocomial human pathogen Moraxella catarrhalis is one the most important agents of human respiratory tract infections. This species is composed of two distinct lineages, one of only moderate...
Didelot, Xavier, Achtman, Mark, Parkhill, Julian, Thomson, Nicholas R., Falush, Daniel
All Salmonella can cause disease but severe systemic infections are primarily caused by a few lineages. Paratyphi A and Typhi are the deadliest human restricted serovars, responsible for ∼600,000...
Stephen D. Bentley, George Vernikos, Carol Churcher, Claire Arrowsmith, Tracey Chillingworth, ...
The bacterium, Neisseria meningitidis, is commonly found harmlessly colonising the mucosal surfaces of the human nasopharynx. Occasionally strains can invade host tissues causing septicaemia and...
Mark Eppinger, Claudia Baar, Bodo Linz, Günter Raddatz, Christa Lanz, Heike Keller, ...
Helicobacter pylori infection of humans is so old that its population genetic structure reflects that of ancient human migrations. A closely related species, Helicobacter acinonychis, is specific for...
Mark Eppinger, Claudia Baar, Bodo Linz, Günter Raddatz, Christa Lanz, Heike Keller, ...
Helicobacter pylori infection of humans is so old that the population genetic structure of H. pylori reflects ancient human migrations. A closely related species, Helicobacter acinonychis, is...
Eppinger, Mark, Baar, Claudia, Linz, Bodo, Raddatz, Günter, Lanz, Christa, Keller, Heike, ...
Helicobacter pylori infection of humans is so old that its population genetic structure reflects that of ancient human migrations. A closely related species, Helicobacter acinonychis, is specific for...
Mismatch induced speciation in Salmonella: model and data (2006)
Falush, Daniel, Torpdahl, Mia, Didelot, Xavier, Conrad, Donald F., Wilson, Daniel J., Achtman, Mark
Evolutionary history of Salmonella Typhi (2006)
Roumagnac, Philippe, Weill, François-Xavier, Dolecek, Christiane, Baker, Stephen, Brisse, Sylvain, Chinh, Nguyen Tran, ...
Andrzejewska, Joanna, Lee, Sae Kyung, Olbermann, Patrick, Lotzing, Nina, Katzowitsch, Elena, Linz, Bodo, ...
Sex and virulence in Escherichia coli: an evolutionary perspective (2006)
Wirth, Thierry, Falush, Daniel, Lan, Ruiting, Colles, Frances, Mensa, Patience, Wieler, Lothar H., ...
Pathogenic Escherichia coli cause over 160 million cases of dysentery and one million deaths per year, whereas non-pathogenic E. coli constitute part of the normal intestinal flora of healthy mammals...
Structural variation and immune recognition of the P1.2 subtype meningococcal antigen (2006)
Tzitzilonis, Christos, Prince, Stephen. M., Collins, Richard F., Achtman, Mark, Feavers, Ian M., Maiden, Martin C. J., ...
Olbermann, Patrick, Linz, Bodo, Andrzejewska, Joanna, Lotzing, Nina, Achtman, Mark, Suerbaum, Sebastian, ...
Didelot, Xavier, Achtman, Mark, Parkhill, Julian, Thomson, Nicholas R., Falush, Daniel
All Salmonella can cause disease but severe systemic infections are primarily caused by a few lineages. Paratyphi A and Typhi are the deadliest human restricted serovars, responsible for ∼600,000...
Gain and Loss of Multiple Genes During the Evolution of Helicobacter pylori (2005)
Helga Gressmann, Bodo Linz, Rohit Ghai, Klaus-Peter Pleissner, Ralph Schlapbach, Yoshio Yamaoka, ...
Sequence diversity and gene content distinguish most isolates of Helicobacter pylori. Even greater sequence differences differentiate distinct populations of H. pylori from different continents, but...
Gain and loss of multiple genes during the evolution of Helicobacter pylori (2005)
Gressmann, Helga, Linz, Bodo, Ghai, Rohit, Pleissner, Klaus-Peter, Schlapbach, Ralph, Yamaoka, Yoshio, ...
Sequence diversity and gene content distinguish most isolates of Helicobacter pylori. Even greater sequence differences differentiate distinct populations of H. pylori from different continents, but...
Population identification of Helicobacter pylori isolates from Russia (2005)
Momynaliev, K. T., Chelysheva, V. V., Acopian, T. A., Selezneva, O. V., Linz, Bodo, Achtman, Mark, ...
Deciphering host migrations and origins by means of their microbes (2005)
Wirth, Thierry, Meyer, Axel, Achtman, Mark
Mitochondrial DNA and microsatellite sequences are powerful genetic markers for inferring the genealogy and the population genetic structure of animals but they have only limited resolution for...
Microevolution and history of the plague bacillus, Yersinia pestis (2004)
Achtman,Mark, Morelli,Giovanna, Zhu,Peixuan X., Wirth,Thierry, Diehl,Ines, Kusecek,Barica, ...
The association of historical plague pandemics with Yersinia pestis remains controversial, partly because the evolutionary history of this largely monomorphic bacterium was unknown. The...
Proteome analysis of Neisseria meningitidis serogroup A (2004)
Bernardini,Giulia, Renzone,Giovanni, Comanducci,Maurizio, Mini,Roberta, Arena,Simona, D'Ambrosio,Chiara, ...
Neisseria meningitidis is an encapsulated Gram-negative bacterium responsible for significant morbidity and mortality worldwide. Meningococci are opportunistic pathogens, carried in the nasopharynx...
Helicobacter pylori: recombination, population structure and human migrations (2004)
Suerbaum,Sebastian, Achtman,Mark
Helicobacter pylori shows extensive genetic diversity and variability due to frequent intraspecific recombination during mixed infection. In the last years, modern genetic and genomic technology as...
Wirth,Thierry, Wang,Xiaoyan, Linz,Bodo, Novick,Richard P., Lum,J. Koji, Blaser,Martin, ...
The history of mankind remains one of the most challenging fields of study. However, the emergence of anatomically modern humans has been so recent that only a few genetically informative...
Genetics of capsule O-acetylation in serogroup C, W-135 and Y meningococci (2004)
Claus,Heike, Borrow,Ray, Achtman,Mark, Morelli,Giovanna, Kantelberg,Carmen, Longworth,Emma, ...
Capsular polysaccharides of serogroup C, W-135 and Y meningococci were previously reported to be O-acetylated at the sialic acid residues. There is evidence that O-acetylation affects the...
Genetics of capsule O-acetylation in serogroup C, W-135 and Y meningococci (2004)
Claus, Heike, Borrow, Ray, Achtman, Mark, Morelli, Giovanna, Kantelberg, Carmen, Longworth, Emma, ...
Microevolution and history of the plague bacillus, Yersinia pestis (2004)
Achtman, Mark, Morelli, Giovanna, Zhu, Peixuan X., Wirth, Thierry, Diehl, Ines, Kusecek, Barica, ...
Proteome analysis of Neisseria meningitidis serogroup A (2004)
Bernardini, Giulia, Renzone, Giovanni, Comanducci, Maurizio, Mini, Roberta, Arena, Simona, D'Ambrosio, Chiara, ...
Parkhill,Julian, Sebaihia,Mohammed, Preston,Andrew, Murphy,Lee D., Thomson,Nicholas, Harris,David E., ...
Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica are closely related Gram-negative -proteobacteria that colonize the respiratory tracts of mammals. B. pertussis is a...
Traces of human migrations in Helicobacter pylori populations (2003)
Falush,Daniel, Wirth,Thierry, Linz,Bodo, Pritchard,Jonathan K., Stephens,Matthew, Kidd,Mark, ...
Helicobacter pylori, a chronic gastric pathogen of human beings, can be divided into seven populations and subpopulations with distinct geographical distributions. These modern populations derive...
Traces of human migrations in Helicobacter pylori populations (2003)
Falush, Daniel, Wirth, Thierry, Linz, Bodo, Pritchard, Jonathan K., Stephens, Matthew, Kidd, Mark, ...
Parkhill, Julian, Sebaihia, Mohammed, Preston, Andrew, Murphy, Lee D., Thomson, Nicholas, Harris, David E., ...
Clonal groupings in serogroup X Neisseria meningitis (2002)
Gagneux,Sébastien, Wirth,Thierry, Hodgson,Abraham, Ehrhard,Ingrid, Morelli,Giovanna, Kriz,Paula, ...
The genetic diversity of 134 serogroup X Neisseria meningitis isolates from Africa, Europe, and North America was analyzed by multilocus sequence typing and pulsed-field gel electrophoresis. Although...
Crystal structure of the OpcA integral membrane adhesin from Neisseria meningitidis (2002)
Prince,Stephen M., Achtman,Mark, Derrick,Jeremy P.
OpcA is an integral outer membrane protein from Neisseria meningitidis, the causative agent of meningococcal meningitis and septicemia. It mediates the adhesion of N. meningitidis to epithelial and...
Prospective study of a serogroup X Neisseria meningitidis outbreak in northern Ghana (2002)
Gagneux,Sebastien P., Hodgson,Abraham, Smith,Tom A., Wirth,Thierry, Ehrhard,Ingrid, Morelli,Giovanna, ...
After an epidemic of serogroup A meningococcal meningitis in northern Ghana, a gradual disappearance of the epidemic strain was observed in a series of five 6-month carriage surveys of 37 randomly...
Prospective study of a serogroup X Neisseria meningitidis outbreak in northern Ghana (2002)
Gagneux, Sébastien, Hodgson, Abraham, Smith, Tom A., Wirth, Thierry, Ehrhard, Ingrid, Morelli, Giovanna, ...
Clonal groupings in serogroup X Neisseria meningitis (2002)
Gagneux, Sébastien, Wirth, Thierry, Hodgson, Abraham, Ehrhard, Ingrid, Morelli, Giovanna, Kriz, Paula, ...
Falush,Daniel, Kraft,Christian, Taylor,Nancy S., Correa,Pelayo, Fox,James G., Achtman,Mark, ...
The bacterium Helicobacter pylori colonizes the gastric mucosa of half of the human population, resulting in chronic gastritis, ulcers, and cancer. We sequenced ten gene fragments from pairs of...
Falush, Daniel, Kraft, Christian, Taylor, Nancy S., Correa, Pelayo, Fox, James G., Achtman, Mark, ...
Microevolution and History of the Plague Bacillus, Yersinia pestis (1998)
Achtman, Mark, Morelli, Giovanna, Zhu, Peixuan, Wirth, Thierry, Diehl, Ines
The association of historical plague pandemics with Yersinia pestis remains controversial, partly because the evolutionary history of this largely monomorphic bacterium was unknown. The...
A genetic study of the F-factor. (1969)
Thesis (Ph. D. in Molecular Biology)--University of California, June 1969.
Maiden, Martin C. J., Bygraves, Jane A., Feil, Edward, Morelli, Giovanna, Russell, Joanne E., Urwin, Rachel, ...
Traditional and molecular typing schemes for the characterization of pathogenic microorganisms are poorly portable because they index variation that is difficult to compare among laboratories. To...
Free recombination within Helicobacter pylori
Suerbaum, Sebastian, Smith, John Maynard, Bapumia, Khairun, Morelli, Giovanna, Smith, Noel H., Kunstmann, Erdmute, ...
Sequences of three gene fragments (flaA, flaB, and vacA) from Helicobacter pylori strains isolated from patients in Germany, Canada, and South Africa were analyzed for diversity and for linkage...
Yersinia pestis, the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis
Achtman, Mark, Zurth, Kerstin, Morelli, Giovanna, Torrea, Gabriela, Guiyoule, Annie, Carniel, Elisabeth
Plague, one of the most devastating diseases of human history, is caused by Yersinia pestis. In this study, we analyzed the population genetic structure of Y. pestis and the two other pathogenic...
Zhu, Peixuan, Van Der Ende, Arie, Falush, Daniel, Brieske, Norbert, Morelli, Giovanna, Linz, Bodo, ...
The genetic variability at six polymorphic loci was examined within a global collection of 502 isolates of subgroup III, serogroup A Neisseria meningitidis. Nine “genoclouds” were identified,...
Falush, Daniel, Kraft, Christian, Taylor, Nancy S., Correa, Pelayo, Fox, James G., Achtman, Mark, ...
The bacterium Helicobacter pylori colonizes the gastric mucosa of half of the human population, resulting in chronic gastritis, ulcers, and cancer. We sequenced ten gene fragments from pairs of...
Wang, Jianfu, Jarvis, Gary A., Achtman, Mark, Rosenqvist, Einar, Michaelsen, Terje E., Aase, Audun, ...
The meningococcal PorA protein is considered a promising vaccine candidate. Although much is understood regarding the structure of PorA proteins, little is known about the structure-function...
Klee, Silke R., Nassif, Xavier, Kusecek, Barica, Merker, Petra, Beretti, Jean-Luc, Achtman, Mark, ...
The pathogenic species Neisseria meningitidis and Neisseria gonorrhoeae cause dramatically different diseases despite strong relatedness at the genetic and biochemical levels. N. meningitidis can...
Muenzner, Petra, Dehio, Christoph, Fujiwara, Taku, Achtman, Mark, Meyer, Thomas F., Gray-Owen, Scott D.
The carcinoembryonic antigen (CEA) family member CEACAM1 (previously called biliary glycoprotein or CD66a) was previously shown to function as a receptor that can mediate the binding of Opa...
Bart, Aldert, Schuurman, Ilse G. A., Achtman, Mark, Caugant, Dominique A., Dankert, Jacob, Van Der Ende, Arie
Randomly amplified polymorphic DNA (RAPD) genotyping was applied to one representative strain of each of the 84 electrophoretic types (ETs) of Neisseria meningitidis serogroup A previously defined by...
Vogel, Ulrich, Morelli, Giovanna, Zurth, Kerstin, Claus, Heike, Kriener, Eugen, Achtman, Mark, ...
Serogroup C strains of Neisseria meningitidis were isolated from a Germany patient with severe meningococcal disease after a trip to the Czech Republic. These strains (case isolates) were...
Malorny, Burkhard, Morelli, Giovanna, Kusecek, Barica, Kolberg, Jan, Achtman, Mark
The sequence diversity of 45 Opa outer membrane proteins from Neisseria meningitidis, Neisseria gonorrhoeae, Neisseria sicca, and Neisseria flava indicates that horizontal genetic exchange of opa...
Crystal structure of the OpcA integral membrane adhesin from Neisseria meningitidis
Prince, Stephen M., Achtman, Mark, Derrick, Jeremy P.
OpcA is an integral outer membrane protein from Neisseria meningitidis, the causative agent of meningococcal meningitis and septicemia. It mediates the adhesion of N. meningitidis to epithelial and...
Conjugational Complementation Analysis of Transfer-Deficient Mutants of Flac in Escherichia coli
Achtman, Mark, Willetts, Neil, Clark, Alvin J.
A series of 102 transfer-deficient (tra−) mutants of Flac (84 of which have been previously described) were classified as carrying frameshift, amber, ochre, UGA, and nonsuppressible mutations....
P1 transduction has been used to perform a complementation analysis of a series of transfer-deficient mutants of Flac. The results define ten cistrons and are consistent with the results of a...
Achtman, Mark, Willetts, Neil, Clark, Alvin J.
Eighty-four transfer-deficient mutants of Flac have been isolated; 27 of these bear amber mutations and 1 mutant is temperature-sensitive. All the mutants transfer between 10−2 and
traG protein of the F sex factor of Escherichia coli K-12 and its role in conjugation
Manning, Paul A., Morelli, Giovanna, Achtman, Mark
The traG protein of the F sex factor is an inner membrane protein with a molecular weight of 116,000. Mutants in traG (or in traN) are able to trigger conjugal DNA replication even though they cannot...
Wirth, Thierry, Wang, Xiaoyan, Linz, Bodo, Novick, Richard P., Lum, J. Koji, Blaser, Martin, ...
The history of mankind remains one of the most challenging fields of study. However, the emergence of anatomically modern humans has been so recent that only a few genetically informative...
Timmis, Kenneth N., Andrés, Isabel, Achtman, Mark
The locations of the fertility inhibition genes finO and finP of the F-like conjugative multiple antibiotic-resistance plasmid R6-5 have been determined. As found previously for that of the fertility...
Microevolution and history of the plague bacillus, Yersinia pestis
Achtman, Mark, Morelli, Giovanna, Zhu, Peixuan, Wirth, Thierry, Diehl, Ines, Kusecek, Barica, ...
The association of historical plague pandemics with Yersinia pestis remains controversial, partly because the evolutionary history of this largely monomorphic bacterium was unknown. The...
Gain and Loss of Multiple Genes During the Evolution of Helicobacter pylori
Gressmann, Helga, Linz, Bodo, Ghai, Rohit, Pleissner, Klaus-Peter, Schlapbach, Ralph, Yamaoka, Yoshio, ...
Sequence diversity and gene content distinguish most isolates of Helicobacter pylori. Even greater sequence differences differentiate distinct populations of H. pylori from different continents, but...
Eppinger, Mark, Baar, Claudia, Linz, Bodo, Raddatz, Günter, Lanz, Christa, Keller, Heike, ...
Helicobacter pylori infection of humans is so old that its population genetic structure reflects that of ancient human migrations. A closely related species, Helicobacter acinonychis, is specific for...
Sex and virulence in Escherichia coli: an evolutionary perspective
Wirth, Thierry, Falush, Daniel, Lan, Ruiting, Colles, Frances, Mensa, Patience, Wieler, Lothar H, ...
Pathogenic Escherichia coli cause over 160 million cases of dysentery and one million deaths per year, whereas non-pathogenic E. coli constitute part of the normal intestinal flora of healthy mammals...
Andrzejewska, Joanna, Lee, Sae Kyung, Olbermann, Patrick, Lotzing, Nina, Katzowitsch, Elena, Linz, Bodo, ...
The Helicobacter pylori cag pathogenicity island (cag PAI) encodes components of a type IV secretion system (T4SS) involved in host interaction and pathogenicity. Previously, seven cag PAI proteins...
Maiden, Martin C. J., Bygraves, Jane A., Feil, Edward, Morelli, Giovanna, Russell, Joanne E., Urwin, Rachel, ...
Traditional and molecular typing schemes for the characterization of pathogenic microorganisms are poorly portable because they index variation that is difficult to compare among laboratories. To...
Free recombination within Helicobacter pylori
Suerbaum, Sebastian, Smith, John Maynard, Bapumia, Khairun, Morelli, Giovanna, Smith, Noel H., Kunstmann, Erdmute, ...
Sequences of three gene fragments (flaA, flaB, and vacA) from Helicobacter pylori strains isolated from patients in Germany, Canada, and South Africa were analyzed for diversity and for linkage...
Yersinia pestis, the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis
Achtman, Mark, Zurth, Kerstin, Morelli, Giovanna, Torrea, Gabriela, Guiyoule, Annie, Carniel, Elisabeth
Plague, one of the most devastating diseases of human history, is caused by Yersinia pestis. In this study, we analyzed the population genetic structure of Y. pestis and the two other pathogenic...
Zhu, Peixuan, Van Der Ende, Arie, Falush, Daniel, Brieske, Norbert, Morelli, Giovanna, Linz, Bodo, ...
The genetic variability at six polymorphic loci was examined within a global collection of 502 isolates of subgroup III, serogroup A Neisseria meningitidis. Nine “genoclouds” were identified,...
Falush, Daniel, Kraft, Christian, Taylor, Nancy S., Correa, Pelayo, Fox, James G., Achtman, Mark, ...
The bacterium Helicobacter pylori colonizes the gastric mucosa of half of the human population, resulting in chronic gastritis, ulcers, and cancer. We sequenced ten gene fragments from pairs of...
Wang, Jianfu, Jarvis, Gary A., Achtman, Mark, Rosenqvist, Einar, Michaelsen, Terje E., Aase, Audun, ...
The meningococcal PorA protein is considered a promising vaccine candidate. Although much is understood regarding the structure of PorA proteins, little is known about the structure-function...
Klee, Silke R., Nassif, Xavier, Kusecek, Barica, Merker, Petra, Beretti, Jean-Luc, Achtman, Mark, ...
The pathogenic species Neisseria meningitidis and Neisseria gonorrhoeae cause dramatically different diseases despite strong relatedness at the genetic and biochemical levels. N. meningitidis can...
Muenzner, Petra, Dehio, Christoph, Fujiwara, Taku, Achtman, Mark, Meyer, Thomas F., Gray-Owen, Scott D.
The carcinoembryonic antigen (CEA) family member CEACAM1 (previously called biliary glycoprotein or CD66a) was previously shown to function as a receptor that can mediate the binding of Opa...
Bart, Aldert, Schuurman, Ilse G. A., Achtman, Mark, Caugant, Dominique A., Dankert, Jacob, Van Der Ende, Arie
Randomly amplified polymorphic DNA (RAPD) genotyping was applied to one representative strain of each of the 84 electrophoretic types (ETs) of Neisseria meningitidis serogroup A previously defined by...
Vogel, Ulrich, Morelli, Giovanna, Zurth, Kerstin, Claus, Heike, Kriener, Eugen, Achtman, Mark, ...
Serogroup C strains of Neisseria meningitidis were isolated from a Germany patient with severe meningococcal disease after a trip to the Czech Republic. These strains (case isolates) were...
Malorny, Burkhard, Morelli, Giovanna, Kusecek, Barica, Kolberg, Jan, Achtman, Mark
The sequence diversity of 45 Opa outer membrane proteins from Neisseria meningitidis, Neisseria gonorrhoeae, Neisseria sicca, and Neisseria flava indicates that horizontal genetic exchange of opa...
Crystal structure of the OpcA integral membrane adhesin from Neisseria meningitidis
Prince, Stephen M., Achtman, Mark, Derrick, Jeremy P.
OpcA is an integral outer membrane protein from Neisseria meningitidis, the causative agent of meningococcal meningitis and septicemia. It mediates the adhesion of N. meningitidis to epithelial and...
Conjugational Complementation Analysis of Transfer-Deficient Mutants of Flac in Escherichia coli
Achtman, Mark, Willetts, Neil, Clark, Alvin J.
A series of 102 transfer-deficient (tra−) mutants of Flac (84 of which have been previously described) were classified as carrying frameshift, amber, ochre, UGA, and nonsuppressible mutations....
P1 transduction has been used to perform a complementation analysis of a series of transfer-deficient mutants of Flac. The results define ten cistrons and are consistent with the results of a...
Achtman, Mark, Willetts, Neil, Clark, Alvin J.
Eighty-four transfer-deficient mutants of Flac have been isolated; 27 of these bear amber mutations and 1 mutant is temperature-sensitive. All the mutants transfer between 10−2 and
traG protein of the F sex factor of Escherichia coli K-12 and its role in conjugation
Manning, Paul A., Morelli, Giovanna, Achtman, Mark
The traG protein of the F sex factor is an inner membrane protein with a molecular weight of 116,000. Mutants in traG (or in traN) are able to trigger conjugal DNA replication even though they cannot...
Wirth, Thierry, Wang, Xiaoyan, Linz, Bodo, Novick, Richard P., Lum, J. Koji, Blaser, Martin, ...
The history of mankind remains one of the most challenging fields of study. However, the emergence of anatomically modern humans has been so recent that only a few genetically informative...
Timmis, Kenneth N., Andrés, Isabel, Achtman, Mark
The locations of the fertility inhibition genes finO and finP of the F-like conjugative multiple antibiotic-resistance plasmid R6-5 have been determined. As found previously for that of the fertility...
Microevolution and history of the plague bacillus, Yersinia pestis
Achtman, Mark, Morelli, Giovanna, Zhu, Peixuan, Wirth, Thierry, Diehl, Ines, Kusecek, Barica, ...
The association of historical plague pandemics with Yersinia pestis remains controversial, partly because the evolutionary history of this largely monomorphic bacterium was unknown. The...
Gain and Loss of Multiple Genes During the Evolution of Helicobacter pylori
Gressmann, Helga, Linz, Bodo, Ghai, Rohit, Pleissner, Klaus-Peter, Schlapbach, Ralph, Yamaoka, Yoshio, ...
Sequence diversity and gene content distinguish most isolates of Helicobacter pylori. Even greater sequence differences differentiate distinct populations of H. pylori from different continents, but...
Eppinger, Mark, Baar, Claudia, Linz, Bodo, Raddatz, Günter, Lanz, Christa, Keller, Heike, ...
Helicobacter pylori infection of humans is so old that its population genetic structure reflects that of ancient human migrations. A closely related species, Helicobacter acinonychis, is specific for...
Andrzejewska, Joanna, Lee, Sae Kyung, Olbermann, Patrick, Lotzing, Nina, Katzowitsch, Elena, Linz, Bodo, ...
The Helicobacter pylori cag pathogenicity island (cag PAI) encodes components of a type IV secretion system (T4SS) involved in host interaction and pathogenicity. Previously, seven cag PAI proteins...
Sex and virulence in Escherichia coli: an evolutionary perspective
Wirth, Thierry, Falush, Daniel, Lan, Ruiting, Colles, Frances, Mensa, Patience, Wieler, Lothar H, ...
Pathogenic Escherichia coli cause over 160 million cases of dysentery and one million deaths per year, whereas non-pathogenic E. coli constitute part of the normal intestinal flora of healthy mammals...
Bentley, Stephen D, Vernikos, George S, Snyder, Lori A. S, Churcher, Carol, Arrowsmith, Claire, Chillingworth, Tracey, ...
The bacterium Neisseria meningitidis is commonly found harmlessly colonising the mucosal surfaces of the human nasopharynx. Occasionally strains can invade host tissues causing septicaemia and...
Leimkugel, Julia, Hodgson, Abraham, Forgor, Abudulai Adams, Pflüger, Valentin, Dangy, Jean-Pierre, Smith, Tom, ...
An analysis of pharyngeal carriage of meningococci in one district of Ghana examined the features of the isolates that might contribute to the susceptibility to meningococcal epidemics in the African...
Leimkugel, Julia, Hodgson, Abraham, Forgor, Abudulai Adams, Pflüger, Valentin, Dangy, Jean-Pierre, Smith, Tom, ...
Didelot, Xavier, Achtman, Mark, Parkhill, Julian, Thomson, Nicholas R., Falush, Daniel
All Salmonella can cause disease but severe systemic infections are primarily caused by a few lineages. Paratyphi A and Typhi are the deadliest human restricted serovars, responsible for ∼600,000...
Mismatch induced speciation in Salmonella: model and data
Falush, Daniel, Torpdahl, Mia, Didelot, Xavier, Conrad, Donald F, Wilson, Daniel J, Achtman, Mark
In bacteria, DNA sequence mismatches act as a barrier to recombination between distantly related organisms and can potentially promote the cohesion of species. We have performed computer simulations...
The rise and spread of a new pathogen: Seroresistant Moraxella catarrhalis
Wirth, Thierry, Morelli, Giovanna, Kusecek, Barica, Van Belkum, Alex, Van Der Schee, Cindy, Meyer, Axel, ...
The nosocomial human pathogen Moraxella catarrhalis is one the most important agents of human respiratory tract infections. This species is composed of two distinct lineages, one of only moderate...
Baker, Stephen, Holt, Kathryn, Van De Vosse, Esther, Roumagnac, Philippe, Whitehead, Sally, King, Emma, ...
High-throughput epidemiological typing systems that provide phylogenetic and genotypic information are beneficial for tracking bacterial pathogens in the field. The incidence of Salmonella enterica...
Horizontal versus Familial Transmission of Helicobacter pylori
Schwarz, Sandra, Morelli, Giovanna, Kusecek, Barica, Manica, Andrea, Balloux, Francois, Owen, Robert J., ...
Transmission of Helicobacter pylori is thought to occur mainly during childhood, and predominantly within families. However, due to the difficulty of obtaining H. pylori isolates from large...
Ceftriaxone-Resistant Salmonella enterica Serotype Newport, France
Egorova, Svetlana, Timinouni, Mohammed, Demartin, Marie, Granier, Sophie A., Whichard, Jean M., Sangal, Vartul, ...
The multidrug-resistant (MDR) Salmonella enterica serotype Newport strain that produces CMY-2 β-lactamase (Newport MDR-AmpC) was the source of sporadic cases and outbreaks in humans in France during...
Fate of the H-NS–Repressed bgl Operon in Evolution of Escherichia coli
Sankar, T. Sabari, Neelakanta, Girish, Sangal, Vartul, Plum, Georg, Achtman, Mark, Schnetz, Karin
In the enterobacterial species Escherichia coli and Salmonella enterica, expression of horizontally acquired genes with a higher than average AT content is repressed by the nucleoid-associated...
Frequent emergence and limited geographic dispersal of methicillin-resistant Staphylococcus aureus
Nübel, Ulrich, Roumagnac, Philippe, Feldkamp, Mirjam, Song, Jae-Hoon, Ko, Kwan Soo, Huang, Yhu-Chering, ...
A small number of clonal lineages dominates the global population structure of methicillin-resistant Staphylococcus aureus (MRSA), resulting in the concept that MRSA has emerged on a few occasions...
Clonal Groupings in Serogroup X Neisseria meningitidis
Gagneux, Sébastien, Wirth, Thierry, Hodgson, Abraham, Ehrhard, Ingrid, Morelli, Giovanna, Kriz, Paula, ...
The genetic diversity of 134 serogroup X Neisseria meningitis isolates from Africa, Europe, and North America was analyzed by multilocus sequence typing and pulsed-field gel electrophoresis. Although...