Julia Leimkugel, Abraham Hodgson, Abudulai Adams Forgor, Valentin Pflüger, Jean-Pierre Dangy, Tom Smith, ...
Julia Leimkugel, Abraham Hodgson, Abudulai Adams Forgor, Valentin Pflüger, Jean-Pierre Dangy, Tom Smith, ...
BackgroundThe Kassena-Nankana District of northern Ghana lies in the African “meningitis belt” where epidemics of meningococcal meningitis have been reoccurring every eight to 12 years for the...
Stephen D. Bentley, George S. Vernikos, Carol Churcher, Claire Arrowsmith, Tracey Chillingworth, ...
The bacterium Neisseria meningitidis is commonly found harmlessly colonising the mucosal surfaces of the human nasopharynx. Occasionally strains can invade host tissues causing septicaemia and...
Andrzejewska, Joanna, Lee, Sae Kyun, Olbermann, Patrick, Lotzing, Nina, Katzowitsch, Elena, Linz, Bodo, ...
Leimkugel, Julia, Hodgson, Abraham, Forgor, Abudulai Adams, Pflüger, Valentin, Dangy, Jean-Pierre, Smith, Tom, ...
Background The Kassena-Nankana District of northern Ghana lies in the African “meningitis belt” where epidemics of meningococcal meningitis have been reoccurring every eight to 12 years for the...
An African origin for the intimate association between humans and Helicobacter pylori (2007)
Linz, Bodo, Balloux, François, Moodley, Yoshan, Manica, Andrea, Liu, Hua, Roumagnac, Philippe, ...
Bentley, Stephen D., Vernikos, George S., Snyder, Lori A. S., Churcher, Carol, Arrowsmith, Claire, Chillingworth, Tracey, ...
The bacterium Neisseria meningitidis is commonly found harmlessly colonising the mucosal surfaces of the human nasopharynx. Occasionally strains can invade host tissues causing septicaemia and...
The rise and spread of a new pathogen: seroresistant Moraxella catarrhalis. (2007)
Wirth, Thierry, Morelli, Giovanna, Kusecek, Barica, Van Belkum, Alex, Van Der Schee, Cindy, Meyer, Axel, ...
Stephen D. Bentley, George Vernikos, Carol Churcher, Claire Arrowsmith, Tracey Chillingworth, ...
The bacterium, Neisseria meningitidis, is commonly found harmlessly colonising the mucosal surfaces of the human nasopharynx. Occasionally strains can invade host tissues causing septicaemia and...
Mark Eppinger, Claudia Baar, Bodo Linz, Günter Raddatz, Christa Lanz, Heike Keller, ...
Helicobacter pylori infection of humans is so old that its population genetic structure reflects that of ancient human migrations. A closely related species, Helicobacter acinonychis, is specific for...
Mark Eppinger, Claudia Baar, Bodo Linz, Günter Raddatz, Christa Lanz, Heike Keller, ...
Helicobacter pylori infection of humans is so old that the population genetic structure of H. pylori reflects ancient human migrations. A closely related species, Helicobacter acinonychis, is...
Eppinger, Mark, Baar, Claudia, Linz, Bodo, Raddatz, Günter, Lanz, Christa, Keller, Heike, ...
Helicobacter pylori infection of humans is so old that its population genetic structure reflects that of ancient human migrations. A closely related species, Helicobacter acinonychis, is specific for...
Mismatch induced speciation in Salmonella: model and data (2006)
Falush, Daniel, Torpdahl, Mia, Didelot, Xavier, Conrad, Donald F., Wilson, Daniel J., Achtman, Mark
Evolutionary history of Salmonella Typhi (2006)
Roumagnac, Philippe, Weill, François-Xavier, Dolecek, Christiane, Baker, Stephen, Brisse, Sylvain, Chinh, Nguyen Tran, ...
Andrzejewska, Joanna, Lee, Sae Kyung, Olbermann, Patrick, Lotzing, Nina, Katzowitsch, Elena, Linz, Bodo, ...
Sex and virulence in Escherichia coli: an evolutionary perspective (2006)
Wirth, Thierry, Falush, Daniel, Lan, Ruiting, Colles, Frances, Mensa, Patience, Wieler, Lothar H., ...
Pathogenic Escherichia coli cause over 160 million cases of dysentery and one million deaths per year, whereas non-pathogenic E. coli constitute part of the normal intestinal flora of healthy mammals...
Structural variation and immune recognition of the P1.2 subtype meningococcal antigen (2006)
Tzitzilonis, Christos, Prince, Stephen. M., Collins, Richard F., Achtman, Mark, Feavers, Ian M., Maiden, Martin C. J., ...
Olbermann, Patrick, Linz, Bodo, Andrzejewska, Joanna, Lotzing, Nina, Achtman, Mark, Suerbaum, Sebastian, ...
Gain and Loss of Multiple Genes During the Evolution of Helicobacter pylori (2005)
Helga Gressmann, Bodo Linz, Rohit Ghai, Klaus-Peter Pleissner, Ralph Schlapbach, Yoshio Yamaoka, ...
Sequence diversity and gene content distinguish most isolates of Helicobacter pylori. Even greater sequence differences differentiate distinct populations of H. pylori from different continents, but...
Gain and loss of multiple genes during the evolution of Helicobacter pylori (2005)
Gressmann, Helga, Linz, Bodo, Ghai, Rohit, Pleissner, Klaus-Peter, Schlapbach, Ralph, Yamaoka, Yoshio, ...
Sequence diversity and gene content distinguish most isolates of Helicobacter pylori. Even greater sequence differences differentiate distinct populations of H. pylori from different continents, but...
Population identification of Helicobacter pylori isolates from Russia (2005)
Momynaliev, K. T., Chelysheva, V. V., Acopian, T. A., Selezneva, O. V., Linz, Bodo, Achtman, Mark, ...
Microevolution and history of the plague bacillus, Yersinia pestis (2004)
Achtman,Mark, Morelli,Giovanna, Zhu,Peixuan X., Wirth,Thierry, Diehl,Ines, Kusecek,Barica, ...
The association of historical plague pandemics with Yersinia pestis remains controversial, partly because the evolutionary history of this largely monomorphic bacterium was unknown. The...
Proteome analysis of Neisseria meningitidis serogroup A (2004)
Bernardini,Giulia, Renzone,Giovanni, Comanducci,Maurizio, Mini,Roberta, Arena,Simona, D'Ambrosio,Chiara, ...
Neisseria meningitidis is an encapsulated Gram-negative bacterium responsible for significant morbidity and mortality worldwide. Meningococci are opportunistic pathogens, carried in the nasopharynx...
Helicobacter pylori: recombination, population structure and human migrations (2004)
Suerbaum,Sebastian, Achtman,Mark
Helicobacter pylori shows extensive genetic diversity and variability due to frequent intraspecific recombination during mixed infection. In the last years, modern genetic and genomic technology as...
Wirth,Thierry, Wang,Xiaoyan, Linz,Bodo, Novick,Richard P., Lum,J. Koji, Blaser,Martin, ...
The history of mankind remains one of the most challenging fields of study. However, the emergence of anatomically modern humans has been so recent that only a few genetically informative...
Genetics of capsule O-acetylation in serogroup C, W-135 and Y meningococci (2004)
Claus,Heike, Borrow,Ray, Achtman,Mark, Morelli,Giovanna, Kantelberg,Carmen, Longworth,Emma, ...
Capsular polysaccharides of serogroup C, W-135 and Y meningococci were previously reported to be O-acetylated at the sialic acid residues. There is evidence that O-acetylation affects the...
Genetics of capsule O-acetylation in serogroup C, W-135 and Y meningococci (2004)
Claus, Heike, Borrow, Ray, Achtman, Mark, Morelli, Giovanna, Kantelberg, Carmen, Longworth, Emma, ...
Microevolution and history of the plague bacillus, Yersinia pestis (2004)
Achtman, Mark, Morelli, Giovanna, Zhu, Peixuan X., Wirth, Thierry, Diehl, Ines, Kusecek, Barica, ...
Proteome analysis of Neisseria meningitidis serogroup A (2004)
Bernardini, Giulia, Renzone, Giovanni, Comanducci, Maurizio, Mini, Roberta, Arena, Simona, D'Ambrosio, Chiara, ...
Parkhill,Julian, Sebaihia,Mohammed, Preston,Andrew, Murphy,Lee D., Thomson,Nicholas, Harris,David E., ...
Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica are closely related Gram-negative -proteobacteria that colonize the respiratory tracts of mammals. B. pertussis is a...
Traces of human migrations in Helicobacter pylori populations (2003)
Falush,Daniel, Wirth,Thierry, Linz,Bodo, Pritchard,Jonathan K., Stephens,Matthew, Kidd,Mark, ...
Helicobacter pylori, a chronic gastric pathogen of human beings, can be divided into seven populations and subpopulations with distinct geographical distributions. These modern populations derive...
Traces of human migrations in Helicobacter pylori populations (2003)
Falush, Daniel, Wirth, Thierry, Linz, Bodo, Pritchard, Jonathan K., Stephens, Matthew, Kidd, Mark, ...
Parkhill, Julian, Sebaihia, Mohammed, Preston, Andrew, Murphy, Lee D., Thomson, Nicholas, Harris, David E., ...
Clonal groupings in serogroup X Neisseria meningitis (2002)
Gagneux,Sébastien, Wirth,Thierry, Hodgson,Abraham, Ehrhard,Ingrid, Morelli,Giovanna, Kriz,Paula, ...
The genetic diversity of 134 serogroup X Neisseria meningitis isolates from Africa, Europe, and North America was analyzed by multilocus sequence typing and pulsed-field gel electrophoresis. Although...
Crystal structure of the OpcA integral membrane adhesin from Neisseria meningitidis (2002)
Prince,Stephen M., Achtman,Mark, Derrick,Jeremy P.
OpcA is an integral outer membrane protein from Neisseria meningitidis, the causative agent of meningococcal meningitis and septicemia. It mediates the adhesion of N. meningitidis to epithelial and...
Prospective study of a serogroup X Neisseria meningitidis outbreak in northern Ghana (2002)
Gagneux,Sebastien P., Hodgson,Abraham, Smith,Tom A., Wirth,Thierry, Ehrhard,Ingrid, Morelli,Giovanna, ...
After an epidemic of serogroup A meningococcal meningitis in northern Ghana, a gradual disappearance of the epidemic strain was observed in a series of five 6-month carriage surveys of 37 randomly...
Prospective study of a serogroup X Neisseria meningitidis outbreak in northern Ghana (2002)
Gagneux, Sébastien, Hodgson, Abraham, Smith, Tom A., Wirth, Thierry, Ehrhard, Ingrid, Morelli, Giovanna, ...
Clonal groupings in serogroup X Neisseria meningitis (2002)
Gagneux, Sébastien, Wirth, Thierry, Hodgson, Abraham, Ehrhard, Ingrid, Morelli, Giovanna, Kriz, Paula, ...
Falush,Daniel, Kraft,Christian, Taylor,Nancy S., Correa,Pelayo, Fox,James G., Achtman,Mark, ...
The bacterium Helicobacter pylori colonizes the gastric mucosa of half of the human population, resulting in chronic gastritis, ulcers, and cancer. We sequenced ten gene fragments from pairs of...
Falush, Daniel, Kraft, Christian, Taylor, Nancy S., Correa, Pelayo, Fox, James G., Achtman, Mark, ...
Microevolution and History of the Plague Bacillus, Yersinia pestis (1998)
Achtman, Mark, Morelli, Giovanna, Zhu, Peixuan, Wirth, Thierry, Diehl, Ines
The association of historical plague pandemics with Yersinia pestis remains controversial, partly because the evolutionary history of this largely monomorphic bacterium was unknown. The...
A genetic study of the F-factor. (1969)
Thesis (Ph. D. in Molecular Biology)--University of California, June 1969.
Maiden, Martin C. J., Bygraves, Jane A., Feil, Edward, Morelli, Giovanna, Russell, Joanne E., Urwin, Rachel, ...
Traditional and molecular typing schemes for the characterization of pathogenic microorganisms are poorly portable because they index variation that is difficult to compare among laboratories. To...
Free recombination within Helicobacter pylori
Suerbaum, Sebastian, Smith, John Maynard, Bapumia, Khairun, Morelli, Giovanna, Smith, Noel H., Kunstmann, Erdmute, ...
Sequences of three gene fragments (flaA, flaB, and vacA) from Helicobacter pylori strains isolated from patients in Germany, Canada, and South Africa were analyzed for diversity and for linkage...
Yersinia pestis, the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis
Achtman, Mark, Zurth, Kerstin, Morelli, Giovanna, Torrea, Gabriela, Guiyoule, Annie, Carniel, Elisabeth
Plague, one of the most devastating diseases of human history, is caused by Yersinia pestis. In this study, we analyzed the population genetic structure of Y. pestis and the two other pathogenic...
Zhu, Peixuan, Van Der Ende, Arie, Falush, Daniel, Brieske, Norbert, Morelli, Giovanna, Linz, Bodo, ...
The genetic variability at six polymorphic loci was examined within a global collection of 502 isolates of subgroup III, serogroup A Neisseria meningitidis. Nine “genoclouds” were identified,...
Falush, Daniel, Kraft, Christian, Taylor, Nancy S., Correa, Pelayo, Fox, James G., Achtman, Mark, ...
The bacterium Helicobacter pylori colonizes the gastric mucosa of half of the human population, resulting in chronic gastritis, ulcers, and cancer. We sequenced ten gene fragments from pairs of...
Wang, Jianfu, Jarvis, Gary A., Achtman, Mark, Rosenqvist, Einar, Michaelsen, Terje E., Aase, Audun, ...
The meningococcal PorA protein is considered a promising vaccine candidate. Although much is understood regarding the structure of PorA proteins, little is known about the structure-function...
Klee, Silke R., Nassif, Xavier, Kusecek, Barica, Merker, Petra, Beretti, Jean-Luc, Achtman, Mark, ...
The pathogenic species Neisseria meningitidis and Neisseria gonorrhoeae cause dramatically different diseases despite strong relatedness at the genetic and biochemical levels. N. meningitidis can...
Muenzner, Petra, Dehio, Christoph, Fujiwara, Taku, Achtman, Mark, Meyer, Thomas F., Gray-Owen, Scott D.
The carcinoembryonic antigen (CEA) family member CEACAM1 (previously called biliary glycoprotein or CD66a) was previously shown to function as a receptor that can mediate the binding of Opa...
Bart, Aldert, Schuurman, Ilse G. A., Achtman, Mark, Caugant, Dominique A., Dankert, Jacob, Van Der Ende, Arie
Randomly amplified polymorphic DNA (RAPD) genotyping was applied to one representative strain of each of the 84 electrophoretic types (ETs) of Neisseria meningitidis serogroup A previously defined by...
Vogel, Ulrich, Morelli, Giovanna, Zurth, Kerstin, Claus, Heike, Kriener, Eugen, Achtman, Mark, ...
Serogroup C strains of Neisseria meningitidis were isolated from a Germany patient with severe meningococcal disease after a trip to the Czech Republic. These strains (case isolates) were...
Malorny, Burkhard, Morelli, Giovanna, Kusecek, Barica, Kolberg, Jan, Achtman, Mark
The sequence diversity of 45 Opa outer membrane proteins from Neisseria meningitidis, Neisseria gonorrhoeae, Neisseria sicca, and Neisseria flava indicates that horizontal genetic exchange of opa...
Crystal structure of the OpcA integral membrane adhesin from Neisseria meningitidis
Prince, Stephen M., Achtman, Mark, Derrick, Jeremy P.
OpcA is an integral outer membrane protein from Neisseria meningitidis, the causative agent of meningococcal meningitis and septicemia. It mediates the adhesion of N. meningitidis to epithelial and...
Conjugational Complementation Analysis of Transfer-Deficient Mutants of Flac in Escherichia coli
Achtman, Mark, Willetts, Neil, Clark, Alvin J.
A series of 102 transfer-deficient (tra−) mutants of Flac (84 of which have been previously described) were classified as carrying frameshift, amber, ochre, UGA, and nonsuppressible mutations....