Amoebae promote persistence of epidemic strains of MRSA. (2006)
Huws, Sharon A, Smith, Anthony W, Enright, Mark C, Wood, Pauline J, Brown, Michael R W
The control of healthcare-associated methicillin-resistant Staphylococcus aureus (MRSA) infection is of concern worldwide. Given the evidence that several pathogenic species replicate within amoebae...
Feil, Edward J., Holmes, Edward C., Bessen, Debra E., Chan, Man-Suen, Day, Nicholas P. J., Enright, Mark C., ...
The identification of clones within bacterial populations is often taken as evidence for a low rate of recombination, but the validity of this inference is rarely examined. We have used statistical...
Enright, Mark C., Fenoll, Asunción, Griffiths, David, Spratt, Brian G.
One hundred six isolates of Streptococcus pneumoniae recovered in Spain from patients with meningitis in 1997 and 1998 were characterized by multilocus sequence typing. A heterogeneous collection of...
Zhou, Jiaji, Enright, Mark C., Spratt, Brian G.
Multilocus sequence typing was used to characterize isolates of the major Spanish clones of penicillin-resistant and multiple-antibiotic-resistant Streptococcus pneumoniae. Isolates of the...
Enright, Mark C., Day, Nicholas P. J., Davies, Catrin E., Peacock, Sharon J., Spratt, Brian G.
A multilocus sequence typing (MLST) scheme has been developed for Staphylococcus aureus. The sequences of internal fragments of seven housekeeping genes were obtained for 155 S. aureus isolates from...
Enright, Mark C., Spratt, Brian G., Kalia, Awdhesh, Cross, John H., Bessen, Debra E.
Multilocus sequence typing (MLST) is a tool that can be used to study the molecular epidemiology and population genetic structure of microorganisms. A MLST scheme was developed for Streptococcus...
Directional Gene Movement from Human-Pathogenic to Commensal-Like Streptococci
Kalia, Awdhesh, Enright, Mark C., Spratt, Brian G., Bessen, Debra E.
Group A streptococci (GAS) are highly pathogenic for humans, and their closest genetic relatives, group C and G streptococci (GCS and GGS, respectively), are generally regarded as commensals,...
Shi, Zhi-Yuan, Enright, Mark C., Wilkinson, Paul, Griffiths, David, Spratt, Brian G.
In this paper we demonstrate the advantages of a new molecular typing procedure, multilocus sequence typing, for the unambiguous characterization of penicillin-resistant pneumococci. The sequences of...
The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA)
Enright, Mark C., Robinson, D. Ashley, Randle, Gaynor, Feil, Edward J., Grundmann, Hajo, Spratt, Brian G.
Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital-acquired infections that are becoming increasingly difficult to combat because of emerging resistance to all current...
Kalia, Awdhesh, Spratt, Brian G., Enright, Mark C., Bessen, Debra E.
The throat and skin of the human host are the principal reservoirs for the bacterial pathogen Streptococcus pyogenes. The emm locus encodes structurally heterogeneous surface fibrils that play...
Stability of Serotypes during Nasopharyngeal Carriage of Streptococcus pneumoniae
Meats, Emma, Brueggemann, Angela B., Enright, Mark C., Sleeman, Karen, Griffiths, David T., Crook, Derrick W., ...
Serotype changes among natural isolates of Streptococcus pneumoniae are well documented and occur by recombinational exchanges at the capsular biosynthetic locus. However, the frequency with which...
Grundmann, Hajo, Hori, Satoshi, Enright, Mark C., Webster, Carol, Tami, Adriana, Feil, Edward J., ...
We used a sample of Staphylococcus aureus strains that are carried by humans and that are representative of the natural population of S. aureus strains in order to assess the value of multilocus...
Multilocus Sequence Typing of Staphylococcus aureus with DNA Array Technology
Van Leeuwen, Willem B., Jay, Corinne, Snijders, Susan, Durin, Nathalia, Lacroix, Bruno, Verbrugh, Henry A., ...
A newly developed oligonucleotide array suited for multilocus sequence typing (MLST) of Staphylococcus aureus strains was analyzed with two strain collections in a two-center study. MLST allele...
Wisplinghoff, Hilmar, Rosato, Adriana E., Enright, Mark C., Noto, Michael, Craig, William, Archer, Gordon L.
SCCmec is a mobile genetic element that carries the gene (mecA) mediating methicillin resistance in staphylococci. For Staphylococcus aureus, four SCCmec types have been described, one (type IV) of...
Evolutionary Models of the Emergence of Methicillin-Resistant Staphylococcus aureus
Robinson, D. Ashley, Enright, Mark C.
Five major lineages of methicillin-resistant Staphylococcus aureus (MRSA) have evolved since the introduction of methicillin for the treatment of infections caused by penicillin-resistant S. aureus...
Evolution of Staphylococcus aureus by Large Chromosomal Replacements
Robinson, D. Ashley, Enright, Mark C.
Conjugative transfer and replacement of hundreds of kilobases of a bacterial chromosome can occur in vitro, but replacements in nature are either an order of magnitude smaller or involve the movement...
Holden, Matthew T. G., Feil, Edward J., Lindsay, Jodi A., Peacock, Sharon J., Day, Nicholas P. J., Enright, Mark C., ...
Staphylococcus aureus is an important nosocomial and community-acquired pathogen. Its genetic plasticity has facilitated the evolution of many virulent and drug-resistant strains, presenting a major...
Shore, Anna, Rossney, Angela S., Keane, Conor T., Enright, Mark C., Coleman, David C.
Methicillin-resistant Staphylococcus aureus (MRSA) isolates recovered in Irish hospitals between 1971 and 2002 were characterized using multilocus sequence typing (MLST) (n = 130) and SCCmec typing...
Genetic Background Affects Stability of mecA in Staphylococcus aureus
Katayama, Yuki, Robinson, D. Ashley, Enright, Mark C., Chambers, Henry F.
The staphylococcal methicillin resistance determinant, mecA, resides on a mobile genetic element, staphylococcus chromosomal cassette mec (SCCmec). The distribution of SCCmec in nature is limited to...
Evolutionary Genetics of the Accessory Gene Regulator (agr) Locus in Staphylococcus aureus†
Robinson, D. Ashley, Monk, Alastair B., Cooper, Jessica E., Feil, Edward J., Enright, Mark C.
The accessory gene regulator (agr) locus influences the expression of many virulence genes in the human pathogen Staphylococcus aureus. Four allelic groups of agr, which generally inhibit the...
How Clonal Is Staphylococcus aureus?
Feil, Edward J., Cooper, Jessica E., Grundmann, Hajo, Robinson, D. Ashley, Enright, Mark C., Berendt, Tony, ...
Staphylococcus aureus is an important human pathogen and represents a growing public health burden owing to the emergence and spread of antibiotic-resistant clones, particularly within the hospital...
Durand, Geraldine, Bes, Michèle, Meugnier, Helene, Enright, Mark C., Forey, Françoise, Liassine, Nadia, ...
Methicillin-resistant Staphylococcus aureus (MRSA) clones harboring the toxic shock syndrome toxin 1 (tst) gene have been detected in France and in Switzerland since 2002. During a passive survey...
Durand, Geraldine, Bes, Michèle, Meugnier, Helene, Enright, Mark C., Forey, Françoise, Liassine, Nadia, ...
Feil, Edward J., Holmes, Edward C., Bessen, Debra E., Chan, Man-Suen, Day, Nicholas P. J., Enright, Mark C., ...
The identification of clones within bacterial populations is often taken as evidence for a low rate of recombination, but the validity of this inference is rarely examined. We have used statistical...
Enright, Mark C., Fenoll, Asunción, Griffiths, David, Spratt, Brian G.
One hundred six isolates of Streptococcus pneumoniae recovered in Spain from patients with meningitis in 1997 and 1998 were characterized by multilocus sequence typing. A heterogeneous collection of...
Zhou, Jiaji, Enright, Mark C., Spratt, Brian G.
Multilocus sequence typing was used to characterize isolates of the major Spanish clones of penicillin-resistant and multiple-antibiotic-resistant Streptococcus pneumoniae. Isolates of the...
Enright, Mark C., Day, Nicholas P. J., Davies, Catrin E., Peacock, Sharon J., Spratt, Brian G.
A multilocus sequence typing (MLST) scheme has been developed for Staphylococcus aureus. The sequences of internal fragments of seven housekeeping genes were obtained for 155 S. aureus isolates from...
Enright, Mark C., Spratt, Brian G., Kalia, Awdhesh, Cross, John H., Bessen, Debra E.
Multilocus sequence typing (MLST) is a tool that can be used to study the molecular epidemiology and population genetic structure of microorganisms. A MLST scheme was developed for Streptococcus...
Directional Gene Movement from Human-Pathogenic to Commensal-Like Streptococci
Kalia, Awdhesh, Enright, Mark C., Spratt, Brian G., Bessen, Debra E.
Group A streptococci (GAS) are highly pathogenic for humans, and their closest genetic relatives, group C and G streptococci (GCS and GGS, respectively), are generally regarded as commensals,...
Shi, Zhi-Yuan, Enright, Mark C., Wilkinson, Paul, Griffiths, David, Spratt, Brian G.
In this paper we demonstrate the advantages of a new molecular typing procedure, multilocus sequence typing, for the unambiguous characterization of penicillin-resistant pneumococci. The sequences of...
The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA)
Enright, Mark C., Robinson, D. Ashley, Randle, Gaynor, Feil, Edward J., Grundmann, Hajo, Spratt, Brian G.
Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital-acquired infections that are becoming increasingly difficult to combat because of emerging resistance to all current...
Kalia, Awdhesh, Spratt, Brian G., Enright, Mark C., Bessen, Debra E.
The throat and skin of the human host are the principal reservoirs for the bacterial pathogen Streptococcus pyogenes. The emm locus encodes structurally heterogeneous surface fibrils that play...
Stability of Serotypes during Nasopharyngeal Carriage of Streptococcus pneumoniae
Meats, Emma, Brueggemann, Angela B., Enright, Mark C., Sleeman, Karen, Griffiths, David T., Crook, Derrick W., ...
Serotype changes among natural isolates of Streptococcus pneumoniae are well documented and occur by recombinational exchanges at the capsular biosynthetic locus. However, the frequency with which...
Grundmann, Hajo, Hori, Satoshi, Enright, Mark C., Webster, Carol, Tami, Adriana, Feil, Edward J., ...
We used a sample of Staphylococcus aureus strains that are carried by humans and that are representative of the natural population of S. aureus strains in order to assess the value of multilocus...
How Clonal Is Staphylococcus aureus?
Feil, Edward J., Cooper, Jessica E., Grundmann, Hajo, Robinson, D. Ashley, Enright, Mark C., Berendt, Tony, ...
Staphylococcus aureus is an important human pathogen and represents a growing public health burden owing to the emergence and spread of antibiotic-resistant clones, particularly within the hospital...
Multilocus Sequence Typing of Staphylococcus aureus with DNA Array Technology
Van Leeuwen, Willem B., Jay, Corinne, Snijders, Susan, Durin, Nathalia, Lacroix, Bruno, Verbrugh, Henry A., ...
A newly developed oligonucleotide array suited for multilocus sequence typing (MLST) of Staphylococcus aureus strains was analyzed with two strain collections in a two-center study. MLST allele...
Wisplinghoff, Hilmar, Rosato, Adriana E., Enright, Mark C., Noto, Michael, Craig, William, Archer, Gordon L.
SCCmec is a mobile genetic element that carries the gene (mecA) mediating methicillin resistance in staphylococci. For Staphylococcus aureus, four SCCmec types have been described, one (type IV) of...
Evolutionary Models of the Emergence of Methicillin-Resistant Staphylococcus aureus
Robinson, D. Ashley, Enright, Mark C.
Five major lineages of methicillin-resistant Staphylococcus aureus (MRSA) have evolved since the introduction of methicillin for the treatment of infections caused by penicillin-resistant S. aureus...
Evolution of Staphylococcus aureus by Large Chromosomal Replacements
Robinson, D. Ashley, Enright, Mark C.
Conjugative transfer and replacement of hundreds of kilobases of a bacterial chromosome can occur in vitro, but replacements in nature are either an order of magnitude smaller or involve the movement...
Holden, Matthew T. G., Feil, Edward J., Lindsay, Jodi A., Peacock, Sharon J., Day, Nicholas P. J., Enright, Mark C., ...
Staphylococcus aureus is an important nosocomial and community-acquired pathogen. Its genetic plasticity has facilitated the evolution of many virulent and drug-resistant strains, presenting a major...
Shore, Anna, Rossney, Angela S., Keane, Conor T., Enright, Mark C., Coleman, David C.
Methicillin-resistant Staphylococcus aureus (MRSA) isolates recovered in Irish hospitals between 1971 and 2002 were characterized using multilocus sequence typing (MLST) (n = 130) and SCCmec typing...
Genetic Background Affects Stability of mecA in Staphylococcus aureus
Katayama, Yuki, Robinson, D. Ashley, Enright, Mark C., Chambers, Henry F.
The staphylococcal methicillin resistance determinant, mecA, resides on a mobile genetic element, staphylococcus chromosomal cassette mec (SCCmec). The distribution of SCCmec in nature is limited to...
Evolutionary Genetics of the Accessory Gene Regulator (agr) Locus in Staphylococcus aureus†
Robinson, D. Ashley, Monk, Alastair B., Cooper, Jessica E., Feil, Edward J., Enright, Mark C.
The accessory gene regulator (agr) locus influences the expression of many virulence genes in the human pathogen Staphylococcus aureus. Four allelic groups of agr, which generally inhibit the...
Durand, Geraldine, Bes, Michèle, Meugnier, Helene, Enright, Mark C., Forey, Françoise, Liassine, Nadia, ...
Methicillin-resistant Staphylococcus aureus (MRSA) clones harboring the toxic shock syndrome toxin 1 (tst) gene have been detected in France and in Switzerland since 2002. During a passive survey...
Durand, Geraldine, Bes, Michèle, Meugnier, Helene, Enright, Mark C., Forey, Françoise, Liassine, Nadia, ...
Improved Multilocus Sequence Typing Scheme for Staphylococcus epidermidis▿
Thomas, Jonathan C., Vargas, Miguel R., Miragaia, Maria, Peacock, Sharon J., Archer, Gordon L., Enright, Mark C.
We evaluated three multilocus sequence typing (MLST) schemes for Staphylococcus epidermidis and selected the seven most discriminatory loci for the formation of a new, more powerful MLST scheme. This...
Cookson, Barry D., Robinson, D. Ashley, Monk, Alastair B., Murchan, Stephen, Deplano, Ariane, De Ryck, Rafaël, ...
We analyzed a representative sample of methicillin-resistant Staphylococcus aureus (MRSA) from 11 European countries (referred to as the HARMONY collection) using three molecular typing methods used...