Stehle, John R, Blanks, Michael J, Riedlinger, Gregory, Kim-Shapiro, Jung W, Sanders, Anne M, Adams, Jonathan M, ...
Abstract Background Spontaneous Regression/Complete Resistant (SR/CR) mice are resistant to cancer through a mechanism that is mediated entirely by leukocytes of innate immunity. Transfer of...
Kim, Caroline S., Ying, Hao, Willingham, Mark C., Cheng, Sheue-yann
Overexpression of the pituitary tumor-transforming gene (PTTG) has been associated with tumorigenesis. In a mouse model that spontaneously develops follicular thyroid cancer (FTC) with distant...
Furuya, Fumihiko, Lu, Changxue, Willingham, Mark C., Cheng, Sheue-yann
Aberrant activation of the phosphatidylinositol 3-kinase (PI3K)–AKT/protein kinase B-signaling pathway has been associated with multiple human cancers, including thyroid cancer. Recently, we showed...
Schwartz, Gary G., Eads, Dawn, Rao, Anuradha, Cramer, Scott D., Willingham, Mark C., Chen, Tai C., ...
The steroid hormone 1,25-dihydroxyvitamin D3, [1,25(OH)2D3, calcitriol], the active metabolite of vitamin D, exerts pleiotropic antitumor effects against several malignancies. However, the clinical...
Schwartz, Gary G., Eads, Dawn, Rao, Anuranda, Cramer, Scott D., Willingham, Mark C., Chen, Tai C., ...
The steroid hormone 1,25-dihydroxyvitamin D3, (1,25(OH)2D3, calcitriol), the active metabolite of Vitamin D, exerts pleiotropic antitumor effects against several malignancies. However, the clinical...
Ying, Hao, Suzuki, Hideyo, Furumoto, Hiroko, Walker, Robert, Meltzer, Paul, Willingham, Mark C., ...
The molecular genetics underlying thyroid carcinogenesis is not well understood. We have recently created a mutant mouse by targeting a mutation (PV) into the thyroid hormone receptor β gene (TRβPV...
Ying, Hao, Suzuki, Hideyo, Furumoto, Hiroko, Walker, Robert, Meltzer, Paul, Willingham, Mark C., ...
The molecular genetics underlying thyroid carcinogenesis is not well understood. We have recently created a mutant mouse by targeting a mutation (PV) into the thyroid hormone receptor β gene (TRβPV...
Ying, Hao, Suzuki, Hideyo, Furumoto, Hiroko, Walker, Robert, Meltzer, Paul, Willingham, Mark C., ...
The molecular genetics underlying thyroid carcinogenesis is not well understood. We have recently created a mutant mouse by targeting a mutation (PV) into the thyroid hormone receptor β gene (TRβPV...
p53-independent apoptosis mediated by tachpyridine, an anti-cancer iron chelator (2001)
Abeysinghe, Rajeewa D., Greene, Bryan T., Haynes, Robin, Willingham, Mark C., Turner, JoLyn, Planalp, Roy P., ...
Iron is involved in essential biochemical reactions ranging from respiration to DNA synthesis. Consequently, iron deprivation has been proposed as a strategy for inhibition of tumor cell growth. We...
Pastan, Ira, Lovelace, Elizabeth, Rutherford, Angelina V., Kunwar, Sandeep, Willingham, Mark C., Peehl, Donna M.
Background: The principal treatment for prostate cancer is surgery; prostate cancer is resistant to the common anticancer drugs. The only useful therapy for metastases involves diminishing...
Magnetic-Affinity Cell Sorting of Human Multidrug-Resistant Cells (1991)
Padmanabhan, Raji, Tsuruo, Takashi, Kane, Susan E., Willingham, Mark C., Howard, Bruce H., Gottesman, Michael M., ...
We have developed a method for isolating multidrug-resistant cells from a heterogeneous cell population using the magnetic-affinity cell-sorting system. Human KB carcinoma cell lines expressing...
Kaneshige, Masahiro, Kaneshige, Kumiko, Zhu, Xu-guang, Dace, Alexandra, Garrett, Lisa, Carter, Todd A., ...
Patients with mutations in the thyroid hormone receptor β (TRβ) gene manifest resistance to thyroid hormone (RTH), resulting in a constellation of variable phenotypic abnormalities. To understand...
Kaneshige, Masahiro, Suzuki, Hideyo, Kaneshige, Kumiko, Cheng, Jun, Wimbrow, Heather, Barlow, Carrolee, ...
Mutations in the thyroid hormone receptor β (TRβ) gene result in resistance to thyroid hormone. However, it is unknown whether mutations in the TRα gene could lead to a similar disease. To address...
Kopecky, Sarah A., Willingham, Mark C., Lyles, Douglas S.
The induction of apoptosis in host cells is a prominent cytopathic effect of vesicular stomatitis virus (VSV) infection. The viral matrix (M) protein is responsible for several important cytopathic...
Cui, Zheng, Willingham, Mark C., Hicks, Amy M., Alexander-Miller, Martha A., Howard, Timothy D., Hawkins, Gregory A., ...
We have established and studied a colony of mice with a unique trait of host resistance to both ascites and solid cancers induced by transplantable cells. One dramatic manifestation of this trait is...
Schlessinger, Joseph, Shechter, Yoram, Willingham, Mark C., Pastan, Ira
We have studied in detail the binding of fluorescent derivatives of insulin and epidermal growth factor to 3T3 fibroblasts. We have used two types of fluorescent analogues of insulin and epidermal...
Maxfield, Frederick R., Davies, Peter J. A., Klempner, Lev, Willingham, Mark C., Pastan, Ira
We have used inhibitors of receptor-mediated endocytosis to investigate the mechanism and function of epidermal growth factor uptake by cultured cells. When rhodamine-labeled epidermal growth factor...
A Mutant of 3T3 Cells with Cyclic AMP Metabolism Sensitive to Temperature Change
Willingham, Mark C., Carchman, Richard A., Pastan, Ira H.
A mutant line of 3T3 (mouse fibroblast) cells with temperature-sensitive cyclic AMP (cAMP) metabolism was isolated by selecting for low substratum adhesiveness after a change in temperature. Although...
Myosin in a Component of the Cell Surface of Cultured Cells
Willingham, Mark C., Ostlund, Richard E., Pastan, Ira
Antisera to myosin from mouse L929 cells, mouse uterus, and rabbit skeletal muscle have been prepared in goats. Each antiserum shows specific reaction by immunodiffusion only to the myosin against...
Furumoto, Hiroko, Ying, Hao, Chandramouli, G. V. R., Zhao, Li, Walker, Robert L., Meltzer, Paul S., ...
Thyroid-stimulating hormone (TSH)-secreting tumors (TSH-omas) are pituitary tumors that constitutively secrete TSH. The molecular genetics underlying this abnormality are not known. We discovered...
Ying, Hao, Furuya, Fumihiko, Willingham, Mark C., Xu, Jianming, O'Malley, Bert W., Cheng, Sheue-yann
Mutations of the thyroid hormone receptor β (TRβ) gene cause resistance to thyroid hormone (RTH). RTH is characterized by increased serum thyroid hormone associated with nonsuppressible...
Ying, Hao, Furuya, Fumihiko, Zhao, Li, Araki, Osamu, West, Brian L., Hanover, John A., ...
Overexpression of pituitary tumor–transforming 1 (PTTG1) is associated with thyroid cancer. We found elevated PTTG1 levels in the thyroid tumors of a mouse model of follicular thyroid carcinoma...
Transferable anticancer innate immunity in spontaneous regression/complete resistance mice
Hicks, Amy M., Riedlinger, Gregory, Willingham, Mark C., Alexander-Miller, Martha A., Pettenati, Mark J., ...
Spontaneous regression/complete resistance (SR/CR) mice resist very high doses of cancer cells that are lethal to WT mice even at low doses. In this study, we show that this resistance is mediated by...
Kaneshige, Masahiro, Kaneshige, Kumiko, Zhu, Xu-guang, Dace, Alexandra, Garrett, Lisa, Carter, Todd A., ...
Patients with mutations in the thyroid hormone receptor β (TRβ) gene manifest resistance to thyroid hormone (RTH), resulting in a constellation of variable phenotypic abnormalities. To understand...
Kaneshige, Masahiro, Suzuki, Hideyo, Kaneshige, Kumiko, Cheng, Jun, Wimbrow, Heather, Barlow, Carrolee, ...
Mutations in the thyroid hormone receptor β (TRβ) gene result in resistance to thyroid hormone. However, it is unknown whether mutations in the TRα gene could lead to a similar disease. To address...
Kopecky, Sarah A., Willingham, Mark C., Lyles, Douglas S.
The induction of apoptosis in host cells is a prominent cytopathic effect of vesicular stomatitis virus (VSV) infection. The viral matrix (M) protein is responsible for several important cytopathic...
Cui, Zheng, Willingham, Mark C., Hicks, Amy M., Alexander-Miller, Martha A., Howard, Timothy D., Hawkins, Gregory A., ...
We have established and studied a colony of mice with a unique trait of host resistance to both ascites and solid cancers induced by transplantable cells. One dramatic manifestation of this trait is...
Schlessinger, Joseph, Shechter, Yoram, Willingham, Mark C., Pastan, Ira
We have studied in detail the binding of fluorescent derivatives of insulin and epidermal growth factor to 3T3 fibroblasts. We have used two types of fluorescent analogues of insulin and epidermal...
Maxfield, Frederick R., Davies, Peter J. A., Klempner, Lev, Willingham, Mark C., Pastan, Ira
We have used inhibitors of receptor-mediated endocytosis to investigate the mechanism and function of epidermal growth factor uptake by cultured cells. When rhodamine-labeled epidermal growth factor...
A Mutant of 3T3 Cells with Cyclic AMP Metabolism Sensitive to Temperature Change
Willingham, Mark C., Carchman, Richard A., Pastan, Ira H.
A mutant line of 3T3 (mouse fibroblast) cells with temperature-sensitive cyclic AMP (cAMP) metabolism was isolated by selecting for low substratum adhesiveness after a change in temperature. Although...
Myosin in a Component of the Cell Surface of Cultured Cells
Willingham, Mark C., Ostlund, Richard E., Pastan, Ira
Antisera to myosin from mouse L929 cells, mouse uterus, and rabbit skeletal muscle have been prepared in goats. Each antiserum shows specific reaction by immunodiffusion only to the myosin against...
Furumoto, Hiroko, Ying, Hao, Chandramouli, G. V. R., Zhao, Li, Walker, Robert L., Meltzer, Paul S., ...
Thyroid-stimulating hormone (TSH)-secreting tumors (TSH-omas) are pituitary tumors that constitutively secrete TSH. The molecular genetics underlying this abnormality are not known. We discovered...
Ying, Hao, Furuya, Fumihiko, Willingham, Mark C., Xu, Jianming, O'Malley, Bert W., Cheng, Sheue-yann
Mutations of the thyroid hormone receptor β (TRβ) gene cause resistance to thyroid hormone (RTH). RTH is characterized by increased serum thyroid hormone associated with nonsuppressible...
Transferable anticancer innate immunity in spontaneous regression/complete resistance mice
Hicks, Amy M., Riedlinger, Gregory, Willingham, Mark C., Alexander-Miller, Martha A., Pettenati, Mark J., ...
Spontaneous regression/complete resistance (SR/CR) mice resist very high doses of cancer cells that are lethal to WT mice even at low doses. In this study, we show that this resistance is mediated by...
Ying, Hao, Furuya, Fumihiko, Zhao, Li, Araki, Osamu, West, Brian L., Hanover, John A., ...
Overexpression of pituitary tumor–transforming 1 (PTTG1) is associated with thyroid cancer. We found elevated PTTG1 levels in the thyroid tumors of a mouse model of follicular thyroid carcinoma...
Temel, Ryan E., Tang, Weiqing, Ma, Yinyan, Rudel, Lawrence L., Willingham, Mark C., Ioannou, Yiannis A., ...
Niemann-Pick C1–like 1 (NPC1L1) is required for cholesterol absorption. Intestinal NPC1L1 appears to be a target of ezetimibe, a cholesterol absorption inhibitor that effectively lowers plasma...
A Human Bone Morphogenetic Protein Antagonist Is Down-Regulated in Renal Cancer
Blish, Kimberly Rose, Wang, Wei, Willingham, Mark C., Du, Wei, Birse, Charles E., Krishnan, Surekha R., ...
We analyzed expression of candidate genes encoding cell surface or secreted proteins in normal kidney and kidney cancer. This screen identified a bone morphogenetic protein (BMP) antagonist, SOSTDC1...
CYCLIC AMP MEDIATES THE CONCANAVALIN A AGGLUTINABILITY OF MOUSE FIBROBLASTS
Willingham, Mark C., Pastan, Ira
We have devised a quantitative way to measure the agglutination of cells which utilizes the size discrimination feature of an automatic particle counter. With this method we have studied the...
Regulation of β-Catenin by a Novel Nongenomic Action of Thyroid Hormone β Receptor▿
Guigon, Celine J., Zhao, Li, Lu, Changxue, Willingham, Mark C., Cheng, Sheue-yann
We previously created a knock-in mutant mouse harboring a dominantly negative mutant thyroid hormone receptor β (TRβPV/PV mouse) that spontaneously develops a follicular thyroid carcinoma similar...
Lu, Changxue, Willingham, Mark C., Furuya, Fumihiko, Cheng, Sheue-yann
TSH-secreting pituitary tumors (TSHomas) are pituitary tumors that constitutively secrete TSH. Molecular mechanisms underlying this abnormality are largely undefined. We recently created a knock-in...
Zhu, Xuewei, Lee, Ji-Young, Timmins, Jenelle M., Brown, J. Mark, Boudyguina, Elena, Mulya, Anny, ...
Macrophage-specific Abca1 knock-out (Abca1–M/–M) mice were generated to determine the role of macrophage ABCA1 expression in plasma lipoprotein concentrations and the innate immune response of...