Wickham, Mark E, Brown, Nat F, Provias, John, Finlay, B Brett, Coombes, Brian K
Abstract Background Salmonella meningitis is a rare and serious infection of the central nervous system following acute Salmonella enterica sepsis. For this pathogen, no appropriate model has been...
Wickham, Mark E., Brown, Nathaniel Francis, Provias, John, Finlay, B. Brett, Coombes, Brian K.
BACKGROUND: Salmonella meningitis is a rare and serious infection of the central nervous system following acute Salmonella enterica sepsis. For this pathogen, no appropriate model has been reported...
Wickham, Mark E., Brown, Nathaniel Francis, Provias, John, Finlay, B. Brett, Coombes, Brian K.
BACKGROUND: Salmonella meningitis is a rare and serious infection of the central nervous system following acute Salmonella enterica sepsis. For this pathogen, no appropriate model has been reported...
Virulence is positively selected by transmission success between mammalian hosts (2007)
Wickham, Mark E., Brown, Nathaniel Francis, Boyle, Erin C., Coombes, Brian K., Finlay, B. Brett
Virulence, defined as damage to the host, is a trait of pathogens that evolutionary theory suggests benefits the pathogen in the ''struggle for existence'' [1]. Pathogens employ virulence mechanisms...
Coombes, Brian K., Lowden, Michael J., Bishop, Jenna L., Wickham, Mark E., Brown, Nathaniel Francis, Duong, Nancy, ...
Bacterial pathogens use horizontal gene transfer to acquire virulence factors that influence host colonization, alter virulence traits, and ultimately shape the outcome of disease following...
Virulence is positively selected by transmission success between mammalian hosts (2007)
Wickham, Mark E., Brown, Nathaniel Francis, Boyle, Erin C., Coombes, Brian K., Finlay, B. Brett
Virulence, defined as damage to the host, is a trait of pathogens that evolutionary theory suggests benefits the pathogen in the ''struggle for existence'' [1]. Pathogens employ virulence mechanisms...
Coombes, Brian K., Lowden, Michael J., Bishop, Jenna L., Wickham, Mark E., Brown, Nathaniel Francis, Duong, Nancy, ...
Bacterial pathogens use horizontal gene transfer to acquire virulence factors that influence host colonization, alter virulence traits, and ultimately shape the outcome of disease following...
Virulence is positively selected by transmission success between mammalian hosts (2007)
Wickham, Mark E., Brown, Nathaniel Francis, Boyle, Erin C., Coombes, Brian K., Finlay, B. Brett
Virulence, defined as damage to the host, is a trait of pathogens that evolutionary theory suggests benefits the pathogen in the ''struggle for existence'' [1]. Pathogens employ virulence mechanisms...
Coombes, Brian K., Lowden, Michael J., Bishop, Jenna L., Wickham, Mark E., Brown, Nathaniel Francis, Duong, Nancy, ...
Bacterial pathogens use horizontal gene transfer to acquire virulence factors that influence host colonization, alter virulence traits, and ultimately shape the outcome of disease following...
Wickham, Mark E., Brown, Nathaniel Francis, Provias, John, Finlay, B. Brett, Coombes, Brian K.
BACKGROUND: Salmonella meningitis is a rare and serious infection of the central nervous system following acute Salmonella enterica sepsis. For this pathogen, no appropriate model has been reported...
Virulence is positively selected by transmission success between mammalian hosts (2007)
Wickham, Mark E., Brown, Nathaniel Francis, Boyle, Erin C., Coombes, Brian K., Finlay, B. Brett
Virulence, defined as damage to the host, is a trait of pathogens that evolutionary theory suggests benefits the pathogen in the ''struggle for existence'' [1]. Pathogens employ virulence mechanisms...
Coombes, Brian K., Lowden, Michael J., Bishop, Jenna L., Wickham, Mark E., Brown, Nathaniel Francis, Duong, Nancy, ...
Bacterial pathogens use horizontal gene transfer to acquire virulence factors that influence host colonization, alter virulence traits, and ultimately shape the outcome of disease following...
Crossing the Line: Selection and Evolution of Virulence Traits (2006)
Nat F. Brown, Mark E. Wickham, Brian K. Coombes, B. Brett Finlay
The evolution of pathogens presents a paradox. Pathogenic species are often absolutely dependent on their host species for their propagation through evolutionary time, yet the pathogenic lifestyle...
Wickham, Mark E., Lupp, Claudia, Mascarenhas, Mariola, Vazquez, Alejandra, Coombes, Brian K., Brown, Nathaniel Francis, ...
Although O157:H7 Shiga toxin–producing Escherichia coli (STEC) are the predominant cause of hemolytic-uremic syndrome (HUS) in the world, non-O157:H7 serotypes are a medically important cause of...
Wickham, Mark E., Lupp, Claudia, Mascarenhas, Mariola, Vazquez, Alejandra, Coombes, Brian K., Brown, Nathaniel Francis, ...
Although O157:H7 Shiga toxin–producing Escherichia coli (STEC) are the predominant cause of hemolytic-uremic syndrome (HUS) in the world, non-O157:H7 serotypes are a medically important cause of...
Wickham, Mark E., Lupp, Claudia, Mascarenhas, Mariola, Vazquez, Alejandra, Coombes, Brian K., Brown, Nathaniel Francis, ...
Although O157:H7 Shiga toxin–producing Escherichia coli (STEC) are the predominant cause of hemolytic-uremic syndrome (HUS) in the world, non-O157:H7 serotypes are a medically important cause of...
Wickham, Mark E., Lupp, Claudia, Mascarenhas, Mariola, Vazquez, Alejandra, Coombes, Brian K., Brown, Nathaniel Francis, ...
Although O157:H7 Shiga toxin–producing Escherichia coli (STEC) are the predominant cause of hemolytic-uremic syndrome (HUS) in the world, non-O157:H7 serotypes are a medically important cause of...
Coombes, Brian K., Lowden, Michael J., Wickham, Mark E., Brown, Nathaniel Francis, Finlay, B. Brett
Short RNA regulatory molecules, microRNAs, and short interfering RNAs participate in a range of developmental gene networks by base-pairing with their target sequences. Consistent with these...
Coombes, Brian K., Wickham, Mark E., Brown, Nathaniel Francis, Lemire, Sebastien, Bossi, Lionello, Hsiao, William W. L., ...
Salmonella enterica serovar Typhimurium is lysogenized by several temperate bacteriophages that encode lysogenic conversion genes, which can act as virulence factors during infection and contribute...
Coombes, Brian K., Lowden, Michael J., Wickham, Mark E., Brown, Nathaniel Francis, Finlay, B. Brett
Short RNA regulatory molecules, microRNAs, and short interfering RNAs participate in a range of developmental gene networks by base-pairing with their target sequences. Consistent with these...
Coombes, Brian K., Wickham, Mark E., Brown, Nathaniel Francis, Lemire, Sebastien, Bossi, Lionello, Hsiao, William W. L., ...
Salmonella enterica serovar Typhimurium is lysogenized by several temperate bacteriophages that encode lysogenic conversion genes, which can act as virulence factors during infection and contribute...
Coombes, Brian K., Lowden, Michael J., Wickham, Mark E., Brown, Nathaniel Francis, Finlay, B. Brett
Short RNA regulatory molecules, microRNAs, and short interfering RNAs participate in a range of developmental gene networks by base-pairing with their target sequences. Consistent with these...
Coombes, Brian K., Wickham, Mark E., Brown, Nathaniel Francis, Lemire, Sebastien, Bossi, Lionello, Hsiao, William W. L., ...
Salmonella enterica serovar Typhimurium is lysogenized by several temperate bacteriophages that encode lysogenic conversion genes, which can act as virulence factors during infection and contribute...
Coombes, Brian K., Lowden, Michael J., Wickham, Mark E., Brown, Nathaniel Francis, Finlay, B. Brett
Short RNA regulatory molecules, microRNAs, and short interfering RNAs participate in a range of developmental gene networks by base-pairing with their target sequences. Consistent with these...
Coombes, Brian K., Wickham, Mark E., Brown, Nathaniel Francis, Lemire, Sebastien, Bossi, Lionello, Hsiao, William W. L., ...
Salmonella enterica serovar Typhimurium is lysogenized by several temperate bacteriophages that encode lysogenic conversion genes, which can act as virulence factors during infection and contribute...
Taylor, Helen M., Triglia, Tony, Thompson, Jenny, Sajid, Mohammed, Fowler, Ruth, Wickham, Mark E., ...
The 235-kDa family of rhoptry proteins in Plasmodium yoelii and the two reticulocyte binding proteins of P. vivax comprise a family of proteins involved in host cell selection and erythrocyte...
Wickham, Mark E., Rug, Melanie, Ralph, Stuart A., Klonis, Nectarios, McFadden, Geoffrey I., Tilley, Leann, ...
After invading human erythrocytes, the malarial parasite Plasmodium falciparum, initiates a remarkable process of secreting proteins into the surrounding erythrocyte cytoplasm and plasma membrane....
Waterkeyn, Jacqueline G., Wickham, Mark E., Davern, Kathleen M., Cooke, Brian M., Coppel, Ross L., Reeder, John C., ...
Adhesion of parasite-infected red blood cells to the vascular endothelium is a critical event in the pathogenesis of malaria caused by Plasmodium falciparum. Adherence is mediated by the variant...
Rug, Melanie, Wickham, Mark E., Foley, Michael, Cowman, Alan F., Tilley, Leann
Following invasion of human erythrocytes, the malaria parasite, Plasmodium falciparum, exports proteins beyond the confines of its own plasma membrane to modify the properties of the host red cell...
Crossing the Line: Selection and Evolution of Virulence Traits
Brown, Nat F, Wickham, Mark E, Coombes, Brian K, Finlay, B. Brett
The evolution of pathogens presents a paradox. Pathogenic species are often absolutely dependent on their host species for their propagation through evolutionary time, yet the pathogenic lifestyle...
Coombes, Brian K., Wickham, Mark E., Lowden, Michael J., Brown, Nat F., Finlay, B. Brett
Salmonella enterica relies on a type III secretion system encoded in Salmonella pathogenicity island-2 (SPI-2) to survive and replicate within macrophages at systemic sites during typhoid. SPI-2...
Taylor, Helen M., Triglia, Tony, Thompson, Jenny, Sajid, Mohammed, Fowler, Ruth, Wickham, Mark E., ...
The 235-kDa family of rhoptry proteins in Plasmodium yoelii and the two reticulocyte binding proteins of P. vivax comprise a family of proteins involved in host cell selection and erythrocyte...
Wickham, Mark E., Rug, Melanie, Ralph, Stuart A., Klonis, Nectarios, McFadden, Geoffrey I., Tilley, Leann, ...
After invading human erythrocytes, the malarial parasite Plasmodium falciparum, initiates a remarkable process of secreting proteins into the surrounding erythrocyte cytoplasm and plasma membrane....
Waterkeyn, Jacqueline G., Wickham, Mark E., Davern, Kathleen M., Cooke, Brian M., Coppel, Ross L., Reeder, John C., ...
Adhesion of parasite-infected red blood cells to the vascular endothelium is a critical event in the pathogenesis of malaria caused by Plasmodium falciparum. Adherence is mediated by the variant...
Rug, Melanie, Wickham, Mark E., Foley, Michael, Cowman, Alan F., Tilley, Leann
Following invasion of human erythrocytes, the malaria parasite, Plasmodium falciparum, exports proteins beyond the confines of its own plasma membrane to modify the properties of the host red cell...
Coombes, Brian K., Wickham, Mark E., Lowden, Michael J., Brown, Nat F., Finlay, B. Brett
Salmonella enterica relies on a type III secretion system encoded in Salmonella pathogenicity island-2 (SPI-2) to survive and replicate within macrophages at systemic sites during typhoid. SPI-2...
Crossing the Line: Selection and Evolution of Virulence Traits
Brown, Nat F, Wickham, Mark E, Coombes, Brian K, Finlay, B. Brett
The evolution of pathogens presents a paradox. Pathogenic species are often absolutely dependent on their host species for their propagation through evolutionary time, yet the pathogenic lifestyle...
Cowman, Alan F, Baldi, Deborah L, Duraisingh, Manoj, Healer, Julie, Mills, Kerry E, O'Donnell, Rebecca A, ...
Malaria is a major human health problem and is responsible for over 2 million deaths per year. It is caused by a number of species of the genus Plasmodium, and Plasmodium falciparum is the causative...
Coombes, Brian K., Lowden, Michael J., Bishop, Jennifer L., Wickham, Mark E., Brown, Nat F., Duong, Nancy, ...
Bacterial pathogens use horizontal gene transfer to acquire virulence factors that influence host colonization, alter virulence traits, and ultimately shape the outcome of disease following...
Coombes, Brian K., Wickham, Mark E., Mascarenhas, Mariola, Gruenheid, Samantha, Finlay, B. Brett, Karmali, Mohamed A.
Shiga toxin-producing Escherichia coli (STEC) strains are commensal bacteria in cattle with high potential for environmental and zoonotic transmission to humans. Although O157:H7 is the most common...
Pathogenic adaptation of intracellular bacteria by rewiring a cis-regulatory input function
Osborne, Suzanne E., Walthers, Don, Tomljenovic, Ana M., Mulder, David T., Silphaduang, Uma, Duong, Nancy, ...
The acquisition of DNA by horizontal gene transfer enables bacteria to adapt to previously unexploited ecological niches. Although horizontal gene transfer and mutation of protein-coding sequences...