Structural insights into the degradation of Mcl-1 induced by BH3 domains
Czabotar, Peter E., Lee, Erinna F., Van Delft, Mark F., Day, Catherine L., Smith, Brian J., Huang, David C. S., ...
Apoptosis is held in check by prosurvival proteins of the Bcl-2 family. The distantly related BH3-only proteins bind to and antagonize them, thereby promoting apoptosis. Whereas binding of the...
Lee, Erinna F., Czabotar, Peter E., Van Delft, Mark F., Michalak, Ewa M., Boyle, Michelle J., Willis, Simon N., ...
Like Bcl-2, Mcl-1 is an important survival factor for many cancers, its expression contributing to chemoresistance and disease relapse. However, unlike other prosurvival Bcl-2–like proteins, Mcl-1...