Gibala, Martin J., McGee, Sean L, Garnham, Andrew P., Howlett, Kirsten F., Snow, Rodney J., Hargreaves, Mark
From a cell signaling perspective, short-duration intense muscular work is typically associated with resistance training and linked to pathways that stimulate growth. However, brief...
Howlett, Kirsten, Sakamoto, Kei, Garnham, Andrew, Cameron-Smith, David, Hargreaves, Mark
A single bout of aerobic exercise can enhance insulin action, but whether a similar effect occurs after resistance exercise is unknown. Hyperinsulinemic-euglycemic clamps were performed on eight male...
Reduced plasma free fatty acid availability during exercise: effect on gene expression (2007)
Tunstall, Rebecca J., McAinch, Andrew J., Hargreaves, Mark, Loon, Luc J. C., Cameron-Smith, David
Endurance exercise transiently increases the mRNA of key regulatory proteins involved in skeletal muscle metabolism. During prolonged exercise and subsequent recovery, circulating plasma fatty acid...
Reduced plasma free fatty acid availability during exercise: effect on gene expression (2007)
Tunstall, Rebecca J., McAinch, Andrew J., Hargreaves, Mark, Loon, Luc J. C., Cameron-Smith, David
Endurance exercise transiently increases the mRNA of key regulatory proteins involved in skeletal muscle metabolism. During prolonged exercise and subsequent recovery, circulating plasma fatty acid...
Howlett, Kirsten, Sakamoto, Kei, Garnham, Andrew, Cameron-Smith, David, Hargreaves, Mark
A single bout of aerobic exercise can enhance insulin action, but whether a similar effect occurs after resistance exercise is unknown. Hyperinsulinemic-euglycemic clamps were performed on eight male...
Howlett, Kirsten, Sakamoto, Kei, Yu, Haiyan, Goodyear, Laurie J., Hargreaves, Mark
Exercise increases skeletal muscle insulin action but the underlying mechanisms mediating this are equivocal. In mouse skeletal muscle, prior exercise enhances insulin-stimulated insulin receptor...
Acute exercise and GLUT4 expression in human skeletal muscle: influence of exercise intensity (2006)
Kraniou, Giorgos N., Cameron-Smith, David, Hargreaves, Mark
To examine the influence of exercise intensity on the increases in vastus lateralis GLUT4 mRNA and protein after exercise, six untrained men exercised for 60 min at 39 ± 3% peak oxygen...
Wilson, Chris, Hargreaves, Mark, Howlett, Kirsten
The subcellular localization of insulin signaling proteins is altered by various stimuli such as insulin, insulin-like growth factor I, and oxidative stress and is thought to be an important...
Wadley, Glenn D., Konstantopoulos, Nicky, Macaulay, Lance, Howlett, Kirsten, Garnham, Andrew, Hargreaves, Mark, ...
The purpose of the present study was to determine in human skeletal muscle whether a single exercise bout and 7 days of consecutive endurance (cycling) training 1) increased insulin-stimulated Akt...
Howlett, Kirsten, Sakamoto, Kei, Yu, Haiyan, Goodyear, Laurie J., Hargreaves, Mark
Exercise increases skeletal muscle insulin action but the underlying mechanisms mediating this are equivocal. In mouse skeletal muscle, prior exercise enhances insulin-stimulated insulin receptor...
Wilson, Chris, Hargreaves, Mark, Howlett, Kirsten
The subcellular localization of insulin signaling proteins is altered by various stimuli such as insulin, insulin-like growth factor I, and oxidative stress and is thought to be an important...
Acute exercise and GLUT4 expression in human skeletal muscle: influence of exercise intensity (2006)
Kraniou, Giorgos N., Cameron-Smith, David, Hargreaves, Mark
To examine the influence of exercise intensity on the increases in vastus lateralis GLUT4 mRNA and protein after exercise, six untrained men exercised for 60 min at 39 ± 3% peak oxygen...
Wadley, Glenn D., Konstantopoulos, Nicky, Macaulay, Lance, Howlett, Kirsten, Garnham, Andrew, Hargreaves, Mark, ...
The purpose of the present study was to determine in human skeletal muscle whether a single exercise bout and 7 days of consecutive endurance (cycling) training 1) increased insulin-stimulated Akt...
Lee-Young, Robert S., Palmer, Matthew J., Linden, Kelly C., LePlastrier, Kieran, Canny, Benedict J., Hargreaves, Mark, ...
There is evidence that increasing carbohydrate (CHO) availability during exercise by raising preexercise muscle glycogen levels attenuates the activation of AMPK{alpha}2 during exercise in humans....
Effect of short-term training on GLUT-4 mRNA and protein expression in human skeletal muscle (2004)
Kraniou, Giorgos, Cameron-Smith, David, Hargreaves, Mark
Six untrained, male subjects (23 ± 1 years old, 84 ± 5 kg, VO2peak= 3.7 ± 0.8 l min–1) exercised for 60 min at 75 ± 1%VO2peak on 7 consecutive days. Muscle...
Spriet, Lawrence L., Tunstall, Rebecca J., Watt, Matthew J., Mehan, Kate A., Hargreaves, Mark, Cameron-Smith, David
Fasting forces adaptive changes in whole body and skeletal muscle metabolism that increase fat oxidation and decrease the oxidation of carbohydrate. We tested the hypothesis that 40 h of fasting...
Murphy, Robyn, Oosterlaar, Audrey M., Cameron-Smith, David, Hargreaves, Mark, Wagenmakers, Anton J. M., ...
It has been speculated that creatine supplementation affects muscle glucose metabolism in humans by increasing muscle glycogen storage and up-regulating GLUT-4 protein expression. In the present...
Exercise and myocyte enhancer factor 2 regulation in human skeletal muscle (2004)
Overexpression of GLUT4 in skeletal muscle enhances whole-body insulin action. Exercise increases GLUT4 gene and protein expression, and a binding site for the myocyte enhancer factor 2 (MEF-2) is...
Chan, M.H. Stanley, McGee, Sean, Watt, Matthew J., Hargreaves, Mark, Febbraio, Mark A.
To determine the effect of glycogen availability and contraction on intracellular signaling and IL-6 gene transcription, eight males performed 60 min of exercise on two occasions: either with prior...
Exercise and myocyte enhancer factor 2 regulation in human skeletal muscle (2004)
Overexpression of GLUT4 in skeletal muscle enhances whole-body insulin action. Exercise increases GLUT4 gene and protein expression, and a binding site for the myocyte enhancer factor 2 (MEF-2) is...
Effect of short-term training on GLUT-4 mRNA and protein expression in human skeletal muscle (2004)
Kraniou, Giorgos, Cameron-Smith, David, Hargreaves, Mark
Six untrained, male subjects (23 ± 1 years old, 84 ± 5 kg, VO2peak= 3.7 ± 0.8 l min–1) exercised for 60 min at 75 ± 1%VO2peak on 7 consecutive days. Muscle...
Murphy, Robyn, Oosterlaar, Audrey M., Cameron-Smith, David, Hargreaves, Mark, Wagenmakers, Anton J. M., ...
It has been speculated that creatine supplementation affects muscle glucose metabolism in humans by increasing muscle glycogen storage and up-regulating GLUT-4 protein expression. In the present...
Spriet, Lawrence L., Tunstall, Rebecca J., Watt, Matthew J., Mehan, Kate A., Hargreaves, Mark, Cameron-Smith, David
Fasting forces adaptive changes in whole body and skeletal muscle metabolism that increase fat oxidation and decrease the oxidation of carbohydrate. We tested the hypothesis that 40 h of fasting...
Chan, M.H. Stanley, McGee, Sean, Watt, Matthew J., Hargreaves, Mark, Febbraio, Mark A.
To determine the effect of glycogen availability and contraction on intracellular signaling and IL-6 gene transcription, eight males performed 60 min of exercise on two occasions: either with prior...
Cameron-Smith, David, Burke, Louise M., Angus, Damien J., Tunstall, Rebecca J ., Cox, Gregory R., Bonen, Arend, ...
Background: Dietary fatty acids may be important in regulating gene expression. However, little is known about the effect of changes in dietary fatty acids on gene regulation in human skeletal...
Effect of alcohol intake on muscle glycogen storage after prolonged exercise (2003)
Burke, Louise, Collier, Greg, Broad, Elizabeth, Davis, Peter, Martin, David, Sanigorski, Andrew, ...
We studied the effects of alcohol intake on postexercise muscle glycogen restoration with samples from vastus lateralis being collected immediately after glycogen-depleting cycling and after a set...
Effect of creatine ingestion on glucose tolerance and insulin sensitivity in men (2003)
Newman, Jackie, Hargreaves, Mark, Garnham, Andrew, Snow, Rodney
Purpose: This study investigated whether acute (5 d) and/or short-term (28 d) creatine (Cr) ingestion altered glucose tolerance or insulin action in healthy, untrained men (aged 26.9 ± 5.7 yr;...
Murphy, Robyn M., Tunstall, Rebecca J., Mehan, Kate A., Cameron-Smith, David, McKenna, Michael J., Spriet, Lawrence L., ...
The present study investigated whether there were any differences between males and females in respect to creatine transporter (CreaT) gene expression and/or total creatine (TCr) content in human...
Exercise increases nuclear AMPK α2 in human skeletal muscle (2003)
McGee, Sean, Howlett, Kirsten, Starkie, Rebecca L., Cameron-Smith, David, Kemp, Bruce E., Hargreaves, Mark
An acute bout of exercise increases skeletal muscle glucose uptake, improves glucose homeostasis and insulin sensitivity, and enhances muscle oxidative capacity. Recent studies have shown an...
Exercise increases nuclear AMPK α2 in human skeletal muscle (2003)
McGee, Sean, Howlett, Kirsten, Starkie, Rebecca L., Cameron-Smith, David, Kemp, Bruce E., Hargreaves, Mark
An acute bout of exercise increases skeletal muscle glucose uptake, improves glucose homeostasis and insulin sensitivity, and enhances muscle oxidative capacity. Recent studies have shown an...
Howlett, Kirsten, Watt, Matthew J., Hargreaves, Mark, Febbraio, Mark A.
This study examined the effect of combined α- and β-adrenergic blockade on glucose kinetics during intense exercise. Six endurance-trained men exercised for 20 minutes at approximately 78%...
Effect of alcohol intake on muscle glycogen storage after prolonged exercise (2003)
Burke, Louise, Collier, Greg, Broad, Elizabeth, Davis, Peter, Martin, David, Sanigorski, Andrew, ...
We studied the effects of alcohol intake on postexercise muscle glycogen restoration with samples from vastus lateralis being collected immediately after glycogen-depleting cycling and after a set...
Cameron-Smith, David, Burke, Louise M., Angus, Damien J., Tunstall, Rebecca J ., Cox, Gregory R., Bonen, Arend, ...
Background: Dietary fatty acids may be important in regulating gene expression. However, little is known about the effect of changes in dietary fatty acids on gene regulation in human skeletal...
Effect of creatine ingestion on glucose tolerance and insulin sensitivity in men (2003)
Newman, Jackie, Hargreaves, Mark, Garnham, Andrew, Snow, Rodney
Purpose: This study investigated whether acute (5 d) and/or short-term (28 d) creatine (Cr) ingestion altered glucose tolerance or insulin action in healthy, untrained men (aged 26.9 ± 5.7 yr;...
Murphy, Robyn M., Tunstall, Rebecca J., Mehan, Kate A., Cameron-Smith, David, McKenna, Michael J., Spriet, Lawrence L., ...
The present study investigated whether there were any differences between males and females in respect to creatine transporter (CreaT) gene expression and/or total creatine (TCr) content in human...
Burke, Louise M., Hawley, John A., Angus, Damien J., Cox, Gregory R., Clark, Sally A., Cummings, Nicola K., ...
Yes
Burke, Louise M., Hawley, John A., Angus, Damien J., Cox, Gregory R., Clark, Sally A., Cummings, Nicola K., ...
Yes
Burke, Louise M., Hawley, John A., Angus, Damien J., Cox, Gregory R., Clark, Sally A., Cummings, Nicola K., ...
Custom-built insulin resistance gene chip (2002)
Walder, Ken, Segal, David, Chehab, Sam, Augert, Guy, Cameron-Smith, David, Hargreaves, Mark, ...
Objectives/Aim—Microarray (gene chip) technology offers a powerful new tool for analyzing the expression of large numbers of genes in many experimental samples. The aim of this study was to...
Tunstall, Rebecca, Mehan, Kate, Hargreaves, Mark, Spriet, Lawrence, Cameron-Smith, David
Fasting triggers a complex array of adaptive metabolic and hormonal responses including an augmentation in the capacity for mitochondrial fatty acid (FA) oxidation in skeletal muscle. This study...
Exercise, diet and skeletal muscle gene expression (2002)
Hargreaves, Mark, Cameron-Smith, David
Skeletal muscle, as a consequence of its mass and great capacity for altered metabolism, has a major impact on whole-body metabolic homeostasis and is capable of remarkable adaptation in response to...
Exercise training increases lipid metabolism gene expression in human skeletal muscle (2002)
Tunstall, Rebecca J., Mehan, Kate A., Wadley, Glenn D., Collier, Greg, Bonen, Arend, Hargreaves, Mark, ...
The effects of a single bout of exercise and exercise training on the expression of genes necessary for the transport and beta -oxidation of fatty acids (FA), together with the gene expression of...
Burke, Louise M., Hawley, John A., Angus, Damien J., Cox, Gregory R., Clark, Sally A., Cummings, Nicola K., ...
Tunstall, Rebecca, Mehan, Kate, Hargreaves, Mark, Spriet, Lawrence, Cameron-Smith, David
Fasting triggers a complex array of adaptive metabolic and hormonal responses including an augmentation in the capacity for mitochondrial fatty acid (FA) oxidation in skeletal muscle. This study...
A custom-built insulin resistance gene chip (2002)
Walder, Ken, Segal, David, Chehab, Sam, Augert, Guy, Cameron-Smith, David, Hargreaves, Mark, ...
Objectives/Aim—Microarray (gene chip) technology offers a powerful new tool for analyzing the expression of large numbers of genes in many experimental samples. The aim of this study was to...
Exercise, diet and skeletal muscle gene expression (2002)
Hargreaves, Mark, Cameron-Smith, David
Skeletal muscle, as a consequence of its mass and great capacity for altered metabolism, has a major impact on whole-body metabolic homeostasis and is capable of remarkable adaptation in response to...
Exercise training increases lipid metabolism gene expression in human skeletal muscle (2002)
Tunstall, Rebecca J., Mehan, Kate A., Wadley, Glenn D., Collier, Greg, Bonen, Arend, Hargreaves, Mark, ...
The effects of a single bout of exercise and exercise training on the expression of genes necessary for the transport and beta -oxidation of fatty acids (FA), together with the gene expression of...
Amino acids and endurance exercise (2001)
Hargreaves, Mark, Snow, Rodney
Provides information on a study which examined the role of amino acids during endurance exercise and the implications for sports nutrition and performance. Description of amino acid utilization...
Watt, Matthew J., Howlett, Kirsten, Febbraio, Mark A., Spriet, Lawrence L., Hargreaves, Mark
# 1. To evaluate the role of adrenaline in regulating carbohydrate metabolism during moderate exercise, 10 moderately trained men completed two 20 min exercise bouts at 58 ± 2 % peak pulmonary...
Wadley, Glenn, Tunstall, Rebecca, Sanigorski, Andrew, Collier, Gregory, Hargreaves, Mark, Cameron-Smith, David
Skeletal muscle insulin sensitivity is enhanced after acute exercise and short-term endurance training. We investigated the impact of exercise on the gene expression of key insulin-signaling proteins...
Effect of prior exercise on glucose metabolism in trained men. (2001)
Rose, Adam, Howlett, Kirsten, King, Douglas, Hargreaves, Mark
Several studies have demonstrated that oral glucose tolerance is impaired in the immediate postexercise period. A double-tracer technique was used to examine glucose kinetics during a 2-h oral...
Carbohydrate metabolism during exercise in females: effect of reduced fat availability (2001)
Howlett, Kirsten, Spriet, Lawrence, Hargreaves, Mark
This study examined the effect of reduced plasma free fatty acid (FFA) availability on carbohydrate metabolism during exercise. Six untrained women cycled for 60 minutes at approximately 58% of...
Amino acids and endurance exercise (2001)
Hargreaves, Mark, Snow, Rodney
Provides information on a study which examined the role of amino acids during endurance exercise and the implications for sports nutrition and performance. Description of amino acid utilization...
Effect of prior exercise on glucose metabolism in trained men. (2001)
Rose, Adam, Howlett, Kirsten, King, Douglas, Hargreaves, Mark
Several studies have demonstrated that oral glucose tolerance is impaired in the immediate postexercise period. A double-tracer technique was used to examine glucose kinetics during a 2-h oral...
Watt, Matthew J., Howlett, Kirsten, Febbraio, Mark A., Spriet, Lawrence L., Hargreaves, Mark
# 1. To evaluate the role of adrenaline in regulating carbohydrate metabolism during moderate exercise, 10 moderately trained men completed two 20 min exercise bouts at 58 ± 2 % peak pulmonary...
Carbohydrate metabolism during exercise in females: effect of reduced fat availability (2001)
Howlett, Kirsten, Spriet, Lawrence, Hargreaves, Mark
This study examined the effect of reduced plasma free fatty acid (FFA) availability on carbohydrate metabolism during exercise. Six untrained women cycled for 60 minutes at approximately 58% of...
Wadley, Glenn, Tunstall, Rebecca, Sanigorski, Andrew, Collier, Gregory, Hargreaves, Mark, Cameron-Smith, David
Skeletal muscle insulin sensitivity is enhanced after acute exercise and short-term endurance training. We investigated the impact of exercise on the gene expression of key insulin-signaling proteins...
Pre-exercise carbohydrate feedings and endurance performance /--by Mark Hargreaves. (1984)
Thesis (M.A.)--Ball State University, 1984.
Effect of exercise on protein kinase C activity and localization in human skeletal muscle
Rose, Adam J, Michell, Belinda J, Kemp, Bruce E, Hargreaves, Mark
To investigate the effect of exercise on protein kinase C (PKC) activity and localization in human skeletal muscle, eight healthy men performed cycle ergometer exercise for 40 min at 76 ± 1% the...
Effect of exercise on protein kinase C activity and localization in human skeletal muscle
Rose, Adam J, Michell, Belinda J, Kemp, Bruce E, Hargreaves, Mark
To investigate the effect of exercise on protein kinase C (PKC) activity and localization in human skeletal muscle, eight healthy men performed cycle ergometer exercise for 40 min at 76 ± 1% the...
Watt, Matthew J, Howlett, Kirsten F, Febbraio, Mark A, Spriet, Lawrence L, Hargreaves, Mark
To evaluate the role of adrenaline in regulating carbohydrate metabolism during moderate exercise, 10 moderately trained men completed two 20 min exercise bouts at 58 ± 2 % peak pulmonary oxygen...
Watt, Matthew J, Heigenhauser, G J F, Stellingwerff, Trent, Hargreaves, Mark, Spriet, Lawrence L
This study investigated the effect of reduced acetylcarnitine availability on oxidative metabolism during the transition from rest to steady-state exercise. Eight male subjects completed two...
Exercise increases Ca2+–calmodulin-dependent protein kinase II activity in human skeletal muscle
Rose, Adam J, Hargreaves, Mark
There is evidence in rodents that Ca2+-calmodulin-dependent protein kinase II (CaMKII) activity is higher in contracting skeletal muscle, and this kinase may regulate skeletal muscle function and...