Liu, Wen-Tao, Han, Yuan, Li, Hao-Chuan, Adams, Brandt, Zheng, Ji-Hong, Wu, Yong-Ping, ...
Abstract Background Long-term potentiation (LTP), a much studied cellular model of synaptic plasticity, has not been demonstrated at synapses between primary afferent C-fibers and spinal dorsal horn...
Han, Yuan, Song, Xue-Song, Liu, Wen-Tao, Henkemeyer, Mark, Song, Xue-Jun
Abstract EphB receptor tyrosine kinases, which play important roles in synaptic connection and plasticity during development and in matured nervous system, have recently been implicated in processing...
Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling (2004)
Juha-Pekka Himanen, Michael J Chumley, Martin Lackmann, Chen Li, William A Barton, Phillip D Jeffrey, ...
This paper was part of our studies of Eph structure-function, in this case analysing the ability of Eph proteins to bind a number of ephrin ligands. Citations = 43
Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling (2004)
Juha-Pekka Himanen, Michael J Chumley, Martin Lackmann, Chen Li, William A Barton, Phillip D Jeffrey, ...
This paper was part of our studies of Eph structure-function, in this case analysing the ability of Eph proteins to bind a number of ephrin ligands. Citations = 43
Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands (1996)
Holland, Sacha J., Gale, Nicholas W., Mbamalu, Geraldine, Yancopoulos, George D., Henkemeyer, Mark, Pawson, Tony
Receptor tyrosine kinases of the EPH class have been implicated in the control of axon guidance and fasciculation [1-7], in regulating cell migration [8], and in defining compartments in the...
Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands (1996)
Holland, Sacha J., Gale, Nicholas W., Mbamalu, Geraldine, Yancopoulos, George D., Henkemeyer, Mark, Pawson, Tony
Receptor tyrosine kinases of the EPH class have been implicated in the control of axon guidance and fasciculation [1-7], in regulating cell migration [8], and in defining compartments in the...
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Inability to enter S phase and defective RNA polymerase II CTD phosphorylation in mice lacking Mat1
Rossi, Derrick J., Londesborough, Anou, Korsisaari, Nina, Pihlak, Arno, Lehtonen, Eero, Henkemeyer, Mark, ...
The trimeric Cdk7–cyclin H–Mat1 complex comprises the kinase subunit of basal transcription factor TFIIH and has been shown to function as a cyclin-dependent kinase (Cdk)-activating kinase....
Induction of cyclooxygenase-2 in a mouse model of Peutz–Jeghers polyposis
Rossi, Derrick J., Ylikorkala, Antti, Korsisaari, Nina, Salovaara, Reijo, Luukko, Keijo, Launonen, Virpi, ...
Inactivating germ-line mutations of LKB1 lead to Peutz–Jeghers syndrome (PJS). We have generated mice heterozygous for a targeted inactivating allele of Lkb1 and found that they develop severe...
Ephrin-B3 is a myelin-based inhibitor of neurite outgrowth
Benson, M. Douglas, Romero, Mario I., Lush, Mark E., Lu, Q. Richard, Henkemeyer, Mark, Parada, Luis F.
The inability of CNS axons to regenerate after traumatic spinal cord injury is due, in part, to the inhibitory effects of myelin. The three major previously identified constituents of this activity...
The Histidine Triad Protein Hint Is Not Required for Murine Development or Cdk7 Function
Korsisaari, Nina, Rossi, Derrick J., Luukko, Keijo, Huebner, Kay, Henkemeyer, Mark, Mäkelä, Tomi P.
The histidine triad (HIT) protein Hint has been found to associate with mammalian Cdk7, as well as to interact both physically and genetically with the budding yeast Cdk7 homologue Kin28. To study...
Multiple EphB receptor tyrosine kinases shape dendritic spines in the hippocampus
Henkemeyer, Mark, Itkis, Olga S., Ngo, Michelle, Hickmott, Peter W., Ethell, Iryna M.
Here, using a genetic approach, we dissect the roles of EphB receptor tyrosine kinases in dendritic spine development. Analysis of EphB1, EphB2, and EphB3 double and triple mutant mice lacking these...
Inability to enter S phase and defective RNA polymerase II CTD phosphorylation in mice lacking Mat1
Rossi, Derrick J., Londesborough, Anou, Korsisaari, Nina, Pihlak, Arno, Lehtonen, Eero, Henkemeyer, Mark, ...
The trimeric Cdk7–cyclin H–Mat1 complex comprises the kinase subunit of basal transcription factor TFIIH and has been shown to function as a cyclin-dependent kinase (Cdk)-activating kinase....
Induction of cyclooxygenase-2 in a mouse model of Peutz–Jeghers polyposis
Rossi, Derrick J., Ylikorkala, Antti, Korsisaari, Nina, Salovaara, Reijo, Luukko, Keijo, Launonen, Virpi, ...
Inactivating germ-line mutations of LKB1 lead to Peutz–Jeghers syndrome (PJS). We have generated mice heterozygous for a targeted inactivating allele of Lkb1 and found that they develop severe...
The Histidine Triad Protein Hint Is Not Required for Murine Development or Cdk7 Function
Korsisaari, Nina, Rossi, Derrick J., Luukko, Keijo, Huebner, Kay, Henkemeyer, Mark, Mäkelä, Tomi P.
The histidine triad (HIT) protein Hint has been found to associate with mammalian Cdk7, as well as to interact both physically and genetically with the budding yeast Cdk7 homologue Kin28. To study...
Ephrin-B3 is a myelin-based inhibitor of neurite outgrowth
Benson, M. Douglas, Romero, Mario I., Lush, Mark E., Lu, Q. Richard, Henkemeyer, Mark, Parada, Luis F.
The inability of CNS axons to regenerate after traumatic spinal cord injury is due, in part, to the inhibitory effects of myelin. The three major previously identified constituents of this activity...
Multiple EphB receptor tyrosine kinases shape dendritic spines in the hippocampus
Henkemeyer, Mark, Itkis, Olga S., Ngo, Michelle, Hickmott, Peter W., Ethell, Iryna M.
Here, using a genetic approach, we dissect the roles of EphB receptor tyrosine kinases in dendritic spine development. Analysis of EphB1, EphB2, and EphB3 double and triple mutant mice lacking these...
Role of P120 Ras-Gap in Directed Cell Movement
Kulkarni, Sarang V., Gish, Gerald, Van Der Geer, Peter, Henkemeyer, Mark, Pawson, Tony
We have used cell lines deficient in p120 Ras GTPase activating protein (Ras-GAP) to investigate the roles of Ras-GAP and the associated p190 Rho-GAP (p190) in cell polarity and cell migration. Cell...
Han, Yuan, Song, Xue-Song, Liu, Wen-Tao, Henkemeyer, Mark, Song, Xue-Jun
EphB receptor tyrosine kinases, which play important roles in synaptic connection and plasticity during development and in matured nervous system, have recently been implicated in processing of pain...