Mark J. Pallen

Variation in bacterial flagellins: from sequence to structure (2006)

Beatson, Scott A., Minamino, Tohru, Pallen, Mark J.

Bacterial motility relies chiefly on the rotation of a molecular propeller, the flagellar filament, which is constructed from the protein flagellin. Here, flagellin sequence conservation and...

Bioinformatics analysis of the locus for enterocyte effacement provides novel insights into type-III secretion (2005)

Pallen, Mark J., Beatson, Scott A., Bailey, Christopher M.

Background: Like many other pathogens, enterohaemorrhagic and enteropathogenic strains of Escherichia coli employ a type-III secretion system to translocate bacterial effector proteins into host...

Bioinformatics, genomics and evolution of non-flagellar type-III secretion systems: a Darwinian perpective (2005)

Pallen, Mark J., Beatson, Scott A., Bailey, Christopher M.

We review the biology of non-flagellar type-III secretion systems from a Darwinian perspective, highlighting the themes of evolution, conservation, variation and decay. The presence of these systems...

The Flag-2 locus, an ancestral gene cluster, is potentially associated with a novel flagellar system from Escherichia coli (2005)

Ren, Chuan-Peng, Beatson, Scott A., Parkhill, Julian, Pallen, Mark J.

Escherichia coli K-12 possesses two adjacent, divergent, promoterless flagellar genes, fhiA-mbhA, that are absent from Salmonella enterica. Through bioinformatics analysis, we found that these genes...

Enterohemorrhagic Escherichia coli Exploits EspA Filaments for Attachment to Salad Leaves▿

Shaw, Robert K., Berger, Cedric N., Feys, Bart, Knutton, Stuart, Pallen, Mark J., Frankel, Gad

Enterohemorrhagic Escherichia coli (EHEC) strains are important food-borne pathogens that use a filamentous type III secretion system (fT3SS) for colonization of the gut epithelium. In this study we...