Mark Jedrychowski

Human DDX3 functions in translation and interacts with the translation initiation factor eIF3 (2008)

Lee, Chung-Sheng, Dias, Anusha P., Jedrychowski, Mark, Patel, Arvind H., Hsu, Jeanne L., Reed, Robin

The conserved RNA helicase DDX3 is of major medical importance due to its involvement in numerous cancers, human hepatitis C virus (HCV) and HIV. Although DDX3 has been reported to have a wide...

Hem-1 Complexes Are Essential for Rac Activation, Actin Polymerization, and Myosin Regulation during Neutrophil Chemotaxis (2006)

Orion D. Weiner, Maike C. Rentel, Alex Ott, Glenn E. Brown, Mark Jedrychowski, Michael B. Yaffe, ...

The authors describe a group of multiprotein complexes, scaffolded by Hem-1 (a subset of which also contain WAVE2), that are involved in generating and maintaining cellular polarity in neutrophils.

Hem-1 Complexes Are Essential for Rac Activation, Actin Polymerization, and Myosin Regulation during Neutrophil Chemotaxis (2006)

Orion D. Weiner, Maike C. Rentel, Alex Ott, Glenn E. Brown, Mark Jedrychowski, Michael B. Yaffe, ...

Migrating cells need to make different actin assemblies at the cell's leading and trailing edges and to maintain physical separation of signals for these assemblies. This asymmetric control of...

Large-scale characterization of HeLa cell nuclear phosphoproteins

Beausoleil, Sean A., Jedrychowski, Mark, Schwartz, Daniel, Elias, Joshua E., Villén, Judit, Li, Jiaxu, ...

Determining the site of a regulatory phosphorylation event is often essential for elucidating specific kinase–substrate relationships, providing a handle for understanding essential signaling...

Hem-1 Complexes Are Essential for Rac Activation, Actin Polymerization, and Myosin Regulation during Neutrophil Chemotaxis

Weiner, Orion D, Rentel, Maike C, Ott, Alex, Brown, Glenn E, Jedrychowski, Mark, Yaffe, Michael B, ...

Migrating cells need to make different actin assemblies at the cell's leading and trailing edges and to maintain physical separation of signals for these assemblies. This asymmetric control of...

Large-scale characterization of HeLa cell nuclear phosphoproteins

Beausoleil, Sean A., Jedrychowski, Mark, Schwartz, Daniel, Elias, Joshua E., Villén, Judit, Li, Jiaxu, ...

Determining the site of a regulatory phosphorylation event is often essential for elucidating specific kinase–substrate relationships, providing a handle for understanding essential signaling...

Hem-1 Complexes Are Essential for Rac Activation, Actin Polymerization, and Myosin Regulation during Neutrophil Chemotaxis

Weiner, Orion D, Rentel, Maike C, Ott, Alex, Brown, Glenn E, Jedrychowski, Mark, Yaffe, Michael B, ...

Migrating cells need to make different actin assemblies at the cell's leading and trailing edges and to maintain physical separation of signals for these assemblies. This asymmetric control of...

Human DDX3 functions in translation and interacts with the translation initiation factor eIF3

Lee, Chung-Sheng, Dias, Anusha P., Jedrychowski, Mark, Patel, Arvind H., Hsu, Jeanne L., Reed, Robin

The conserved RNA helicase DDX3 is of major medical importance due to its involvement in numerous cancers, human hepatitis C virus (HCV) and HIV. Although DDX3 has been reported to have a wide...