Tavakoli, Tahereh, Xu, Xiangru, Derby, Eric, Serebryakova, Yevgeniya, Reid, Yvonne, Rao, Mahendra S, ...
Abstract Background A unique and essential property of embryonic stem cells is the ability to self-renew and differentiate into multiple cell lineages. However, the possible differences in...
Pivotal role for beta-1 integrin in neurovascular remodelling after ischemic stroke (2009)
Lathia, Justin D., Chigurupati, Srinivasulu, Thundyil, John, Selvaraj, Pradeep K., Mughal, Mohamed R., Woodruff, Trent M., ...
[beta]1 integrin is a cell surface molecule that is critical for endothelial cell adhesion, migration and survival during angiogenesis. In the present study we employed in vivo and in vitro models to...
Age and energy intake interact to modify cell stress pathways and stroke outcome (2009)
Thiruma V. Arumugam, Terry M. Phillips, Aiwu Cheng, Christopher H. Morrell, Mark P. Mattson, Ruiqian Wan
Age and excessive energy intake/obesity are risk factors for cerebrovascular disease, but it is not known if and how these factors affect the extent of brain damage and outcome in ischemic stroke. We...
Ma, Wu, Tavakoli, Tara, Derby, Eric, Serebryakova, Yevgeniya, Rao, Mahendra S, Mattson, Mark P
Abstract Background Interactions of cells with the extracellular matrix (ECM) are critical for the establishment and maintenance of stem cell self-renewal and differentiation. However, the ECM is a...
Targeting ischemic brain injury with infravenous immunoglobulin (2008)
Arumugam, Thiruma V., Selvaraj, Pradeep K., Woodruff, Trent M., Mattson, Mark P.
Kulkarni, Avanti, McNeill, Daniel R., Gleichmann, Marc, Mattson, Mark P., Wilson, David M.
XRCC1 is a critical scaffold protein that orchestrates efficient single-strand break repair (SSBR). Recent data has found an association of XRCC1 with proteins causally linked to human...
Xu, Xiangru, Zhan, Ming, Duan, Wenzhen, Prabhu, Vinayakumar, Brenneman, Randall, Wood, William, ...
Abstract Background The structural and functional complexity of the mammalian central nervous system (CNS) is organized and modified by complicated molecular signaling processes that are poorly...
AGEMAP: A Gene Expression Database for Aging in Mice (2007)
Jacob M. Zahn, Suresh Poosala, Art B. Owen, Donald K. Ingram, Ana Lustig, Arnell Carter, ...
We present the AGEMAP (Atlas of Gene Expression in Mouse Aging Project) gene expression database, which is a resource that catalogs changes in gene expression as a function of age in mice. The AGEMAP...
AGEMAP: a gene expression database for aging in mice (2007)
Jacob M. Zahn, Suresh Poosala, Art B. Owen, Donald Ingram, Ana Lustig, Arnell Carter, ...
We present the AGEMAP gene expression database, which is a resource that catalogs changes in gene expression as a function of age in mice. The AGEMAP database includes expression changes for 8,932...
Weissman, Lior, Jo, Dong-Gyu, Sørensen, Martin M., Markesbery, William R., Mattson, Mark P., ...
Oxidative stress is thought to play a role in the pathogenesis of Alzheimer's disease (AD) and increased oxidative DNA damage has been observed in brain tissue from AD patients. Base excision repair...
Reduced energy intake: the secret to a long and healthy life? (2007)
Bronwen Martin, Erin Golden, Josephine M Egan, Mark P Mattson, Stuart Maudsley
Reduced energy intake, or caloric restriction (CR), is known to extend life-span and to retard age-related health decline in a myriad of species, including nematode worms, flies, fish, mice and rats....
Liu, Ying, Shin, Soojung, Zeng, Xianmin, Zhan, Ming, Gonzalez, Rodolfo, Mueller, Franz-Josef, ...
Abstract Background In order to compare the gene expression profiles of human embryonic stem cell (hESC) lines and their differentiated progeny and to monitor feeder contaminations, we have examined...
Transcriptome coexpression map of human embryonic stem cells (2006)
Li, Huai, Liu, Ying, Shin, Soojung, Sun, Yu, Loring, Jeanne F, Mattson, Mark P, ...
Abstract Background Human embryonic stem (ES) cells hold great promise for medicine and science. The transcriptome of human ES cells has been studied in detail in recent years. However, no systematic...
McCampbell, Alexander, Truong, David, Broom, Daniel C., Allchorne, Andrew, Gable, Ken, Cutler, Roy G., ...
Mutations in enzymes involved in sphingolipid metabolism and trafficking cause a variety of neurological disorders, but details of the molecular pathophysiology remain obscure. SPTLC1 encodes one...
McCampbell, Alexander, Truong, David, Broom, Daniel C., Allchorne, Andrew, Gable, Ken, Cutler, Roy G., ...
Mutations in enzymes involved in sphingolipid metabolism and trafficking cause a variety of neurological disorders, but details of the molecular pathophysiology remain obscure. SPTLC1 encodes one...
Liu, Dong, Slevin, John R., Lu, Chengbiao, Chan, Sic L., Hansson, Magnus, Elmér, Eskil, ...
Abstract is not available
Turchan, Jadwiga, Anderson, Caroline, Hauser, Kurt F, Sun, Qinmiao, Zhang, Jiayou, Liu, Ying, ...
Abstract Background Human immunodeficiency virus (HIV) infection continues to increase at alarming rates in drug abusers, especially in women. Drugs of abuse can cause long-lasting damage to the...
Guo, Zhi Hong, Mattson, Mark P.
Previous studies have shown that several different neurotrophic factors can prevent death of cortical and hippocampal neurons induced by excitotoxic and oxidative insults in cell culture and in vivo....
Signaling Pathways for Ecdysteroid Hormone Synthesis in Crustacean Y-organs (1999)
SPAZIANI, EUGENE, MATTSON, MARK P., WANG, WENAN L., MCDOUGALL, HEATHER E.
The Y-organs of crustaceans secrete steroid hormones (ecdysteroids) which are responsible for molting and regeneration. The Y-organs in turn are controlled (negatively) by the eyestalk peptide,...
Calcium regulation of neurite elongation and growth cone motility (1987)
Mark P. Mattson, Stanley B. Kater
Neurite outgrowth from isolated, identified molluscan (He/i-soma frivolvis) neurons in culture can be suppressed by neurotransmitters and electrical activity, both of which in-crease intraneuronal...
Thesis (M.S.)--North Texas State University, August, 1982.
Guo, Qing, Christakos, Sylvia, Robinson, Nic, Mattson, Mark P.
Mutations in the presenilin 1 (PS-1) gene account for many cases of early-onset autosomal dominant inherited forms of Alzheimer’s disease. Recent findings suggest that PS-1 mutations may sensitize...
Guo, Qing, Sebastian, Lois, Sopher, Bryce L., Miller, Miles W., Glazner, Gordon W., Ware, Carol B., ...
Although an excitotoxic mechanism of neuronal injury has been proposed to play a role in chronic neurodegenerative disorders such as Alzheimer’s disease, and neurotrophic factors have been put...
Estrogen protects against the synergistic toxicity by HIV proteins, methamphetamine and cocaine
Turchan, Jadwiga, Anderson, Caroline, Hauser, Kurt F, Sun, Qinmiao, Zhang, Jiayou, Liu, Ying, ...
Alves Da Costa, Cristine, Paitel, Erwan, Mattson, Mark P., Amson, Robert, Telerman, Adam, Ancolio, Karine, ...
Presenilins 1 and 2 are two homologous proteins that, when mutated, account for most early onset Alzheimer's disease. Several lines of evidence suggest that, among various functions, presenilins...
Effects of cerebral ischemia in mice deficient in Persephin
Tomac, Andreas C., Agulnick, Alan D., Haughey, Norman, Chang, Chen-Fu, Zhang, Yajun, Bäckman, Cristina, ...
Persephin (Pspn), a recently cloned member of the transforming growth factor-β superfamily (TGF-β) and glial cell line-derived neurotrophic factor (GDNF) subfamily, is distributed throughout the...
Duan, Wenzhen, Guo, Zhihong, Jiang, Haiyang, Ware, Melvin, Li, Xiao-Jiang, Mattson, Mark P.
In addition to neurological deficits, Huntington's disease (HD) patients and transgenic mice expressing mutant human huntingtin exhibit reduced levels of brain-derived neurotrophic factor,...
Anson, R. Michael, Guo, Zhihong, De Cabo, Rafael, Iyun, Titilola, Rios, Michelle, Hagepanos, Adrienne, ...
Dietary restriction has been shown to have several health benefits including increased insulin sensitivity, stress resistance, reduced morbidity, and increased life span. The mechanism remains...
Cutler, Roy G., Kelly, Jeremiah, Storie, Kristin, Pedersen, Ward A., Tammara, Anita, Hatanpaa, Kimmo, ...
Alzheimer's disease (AD) is an age-related disorder characterized by deposition of amyloid β-peptide (Aβ) and degeneration of neurons in brain regions such as the hippocampus, resulting in...
Neuroprotective effects of gelsolin during murine stroke
Endres, Matthias, Fink, Klaus, Zhu, Jinmin, Stagliano, Nancy E., Bondada, Vimala, Geddes, James W., ...
Increased Ca2+ influx through activated N-methyl-D-aspartate (NMDA) receptors and voltage-dependent Ca2+ channels (VDCC) is a major determinant of cell injury following brain ischemia. The activity...
Involvement of Notch signaling in hippocampal synaptic plasticity
Wang, Yue, Chan, Sic L., Miele, Lucio, Yao, Pamela J., Mackes, Jennifer, Ingram, Donald K., ...
During development of the nervous system, the fate of stem cells is regulated by a cell surface receptor called Notch. Notch is also present in the adult mammalian brain; however, because Notch null...
Mattson, Mark P., Duan, Wenzhen, Wan, Ruqian, Guo, Zhihong
Summary: It is well established that when most types of cells, including neurons, are exposed to a mild stress they increase their ability to resist more severe stress. This “preconditioning”...
Maswood, Navin, Young, Jennifer, Tilmont, Edward, Zhang, Zhiming, Gash, Don M., Gerhardt, Greg A., ...
We report that a low-calorie diet can lessen the severity of neurochemical deficits and motor dysfunction in a primate model of Parkinson's disease. Adult male rhesus monkeys were maintained for 6...
Transcriptome coexpression map of human embryonic stem cells
Li, Huai, Liu, Ying, Shin, Soojung, Sun, Yu, Loring, Jeanne F, Mattson, Mark P, ...
Guo, Qing, Christakos, Sylvia, Robinson, Nic, Mattson, Mark P.
Mutations in the presenilin 1 (PS-1) gene account for many cases of early-onset autosomal dominant inherited forms of Alzheimer’s disease. Recent findings suggest that PS-1 mutations may sensitize...
Guo, Qing, Sebastian, Lois, Sopher, Bryce L., Miller, Miles W., Glazner, Gordon W., Ware, Carol B., ...
Although an excitotoxic mechanism of neuronal injury has been proposed to play a role in chronic neurodegenerative disorders such as Alzheimer’s disease, and neurotrophic factors have been put...
Estrogen protects against the synergistic toxicity by HIV proteins, methamphetamine and cocaine
Turchan, Jadwiga, Anderson, Caroline, Hauser, Kurt F, Sun, Qinmiao, Zhang, Jiayou, Liu, Ying, ...
Alves Da Costa, Cristine, Paitel, Erwan, Mattson, Mark P., Amson, Robert, Telerman, Adam, Ancolio, Karine, ...
Presenilins 1 and 2 are two homologous proteins that, when mutated, account for most early onset Alzheimer's disease. Several lines of evidence suggest that, among various functions, presenilins...
Effects of cerebral ischemia in mice deficient in Persephin
Tomac, Andreas C., Agulnick, Alan D., Haughey, Norman, Chang, Chen-Fu, Zhang, Yajun, Bäckman, Cristina, ...
Persephin (Pspn), a recently cloned member of the transforming growth factor-β superfamily (TGF-β) and glial cell line-derived neurotrophic factor (GDNF) subfamily, is distributed throughout the...
Duan, Wenzhen, Guo, Zhihong, Jiang, Haiyang, Ware, Melvin, Li, Xiao-Jiang, Mattson, Mark P.
In addition to neurological deficits, Huntington's disease (HD) patients and transgenic mice expressing mutant human huntingtin exhibit reduced levels of brain-derived neurotrophic factor,...
Anson, R. Michael, Guo, Zhihong, De Cabo, Rafael, Iyun, Titilola, Rios, Michelle, Hagepanos, Adrienne, ...
Dietary restriction has been shown to have several health benefits including increased insulin sensitivity, stress resistance, reduced morbidity, and increased life span. The mechanism remains...
Cutler, Roy G., Kelly, Jeremiah, Storie, Kristin, Pedersen, Ward A., Tammara, Anita, Hatanpaa, Kimmo, ...
Alzheimer's disease (AD) is an age-related disorder characterized by deposition of amyloid β-peptide (Aβ) and degeneration of neurons in brain regions such as the hippocampus, resulting in...
Neuroprotective effects of gelsolin during murine stroke
Endres, Matthias, Fink, Klaus, Zhu, Jinmin, Stagliano, Nancy E., Bondada, Vimala, Geddes, James W., ...
Increased Ca2+ influx through activated N-methyl-D-aspartate (NMDA) receptors and voltage-dependent Ca2+ channels (VDCC) is a major determinant of cell injury following brain ischemia. The activity...
Involvement of Notch signaling in hippocampal synaptic plasticity
Wang, Yue, Chan, Sic L., Miele, Lucio, Yao, Pamela J., Mackes, Jennifer, Ingram, Donald K., ...
During development of the nervous system, the fate of stem cells is regulated by a cell surface receptor called Notch. Notch is also present in the adult mammalian brain; however, because Notch null...
Mattson, Mark P., Duan, Wenzhen, Wan, Ruqian, Guo, Zhihong
Summary: It is well established that when most types of cells, including neurons, are exposed to a mild stress they increase their ability to resist more severe stress. This “preconditioning”...
Maswood, Navin, Young, Jennifer, Tilmont, Edward, Zhang, Zhiming, Gash, Don M., Gerhardt, Greg A., ...
We report that a low-calorie diet can lessen the severity of neurochemical deficits and motor dysfunction in a primate model of Parkinson's disease. Adult male rhesus monkeys were maintained for 6...
Transcriptome coexpression map of human embryonic stem cells
Li, Huai, Liu, Ying, Shin, Soojung, Sun, Yu, Loring, Jeanne F, Mattson, Mark P, ...
Evidence that Par-4 Participates in the Pathogenesis of HIV Encephalitis
Kruman, Inna I., Nath, Avindra, Maragos, William F., Chan, Sic L., Jones, Melina, Rangnekar, Vivek M., ...
Progressive neuronal degeneration in brain regions involved in learning and memory processes is a common occurrence in patients infected with human immunodeficiency virus type 1 (HIV-1). We now...
Hyun, Dong-Hoon, Emerson, Scott S., Jo, Dong-Gyu, Mattson, Mark P., De Cabo, Rafael
The plasma membrane (PM) contains redox enzymes that provide electrons for energy metabolism and recycling of antioxidants such as coenzyme Q and α-tocopherol. Brain aging and neurodegenerative...
Weissman, Lior, Jo, Dong-Gyu, Sørensen, Martin M., Markesbery, William R., Mattson, Mark P., ...
Oxidative stress is thought to play a role in the pathogenesis of Alzheimer's disease (AD) and increased oxidative DNA damage has been observed in brain tissue from AD patients. Base excision repair...
Involvement of Notch Signaling in Wound Healing
Chigurupati, Srinivasulu, Arumugam, Thiruma V., Son, Tae Gen, Lathia, Justin D., Jameel, Shafaq, Mughal, Mohamed R., ...
The Notch signaling pathway is critically involved in cell fate decisions during development of many tissues and organs. In the present study we employed in vivo and cell culture models to elucidate...
AGEMAP: A Gene Expression Database for Aging in Mice
Zahn, Jacob M, Poosala, Suresh, Owen, Art B, Ingram, Donald K, Lustig, Ana, Carter, Arnell, ...
We present the AGEMAP (Atlas of Gene Expression in Mouse Aging Project) gene expression database, which is a resource that catalogs changes in gene expression as a function of age in mice. The AGEMAP...
Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits
Tang, Sung-Chun, Arumugam, Thiruma V., Xu, Xiangru, Cheng, Aiwu, Mughal, Mohamed R., Jo, Dong Gyu, ...
The innate immune system senses the invasion of pathogenic microorganisms and tissue injury through Toll-like receptors (TLR), a mechanism thought to be limited to immune cells. We now report that...
Arumugam, Thiruma V., Tang, Sung-Chun, Lathia, Justin D., Cheng, Aiwu, Mughal, Mohamed R., Chigurupati, Srinivasulu, ...
Stroke is among the three leading causes of death worldwide and the most frequent cause of permanent disability. Brain ischemia induces an inflammatory response involving activated complement...
Xu, Xiangru, Zhan, Ming, Duan, Wenzhen, Prabhu, Vinayakumar, Brenneman, Randall, Wood, William, ...
The transcriptional profiles of five regions of the central nervous system (CNS) of mice varying in age, gender and dietary intake were measured by microarray. The resulting data provide insights...
Neuroprotective Action of Cycloheximide Involves Induction of Bcl-2 and Antioxidant Pathways
Furukawa, Katsutoshi, Estus, Steven, Fu, Weiming, Mark, Robert J., Mattson, Mark P.
The ability of the protein synthesis inhibitor cycloheximide (CHX) to prevent neuronal death in different paradigms has been interpreted to indicate that the cell death process requires synthesis of...
Leissring, Malcolm A., Akbari, Yama, Fanger, Christopher M., Cahalan, Michael D., Mattson, Mark P., LaFerla, Frank M.
Dysregulation of calcium signaling has been causally implicated in brain aging and Alzheimer's disease. Mutations in the presenilin genes (PS1, PS2), the leading cause of autosomal dominant familial...
Martin, Bronwen, Pearson, Michele, Brenneman, Randall, Golden, Erin, Keselman, Alex, Iyun, Titilola, ...
The level of dietary energy intake influences metabolism, reproductive function, the development of age-related diseases, and even cognitive behavior. Because males and females typically play...
Viewpoint: Mechanisms of Action and Therapeutic Potential of Neurohormetic Phytochemicals
Mattson, Mark P., Son, Tae Gen, Camandola, Simonetta
The nervous system is of fundamental importance in the adaptive (hormesis) responses of organisms to all types of stress, including environmental “toxins”. Phytochemicals present in vegetables...
XRCC1 protects against the lethality of induced oxidative DNA damage in nondividing neural cells
Kulkarni, Avanti, McNeill, Daniel R., Gleichmann, Marc, Mattson, Mark P., Wilson, David M.
XRCC1 is a critical scaffold protein that orchestrates efficient single-strand break repair (SSBR). Recent data has found an association of XRCC1 with proteins causally linked to human...
Evolutionarily Conserved Transcriptional Co-Expression Guiding Embryonic Stem Cell Differentiation
Sun, Yu, Li, Huai, Liu, Ying, Mattson, Mark P., Rao, Mahendra S., Zhan, Ming
Cell-extracellular matrix interactions regulate neural differentiation of human embryonic stem cells
Ma, Wu, Tavakoli, Tara, Derby, Eric, Serebryakova, Yevgeniya, Rao, Mahendra S, Mattson, Mark P
Martin, Bronwen, Pearson, Michele, Brenneman, Randall, Golden, Erin, Wood, William, Prabhu, Vinayakumar, ...
Reproductive capacity and nutritional input are tightly linked and animals' specific responses to alterations in their physical environment and food availability are crucial to ensuring...
Kim, So Jung, Son, Tae Gen, Park, Hee Ra, Park, Mikyung, Kim, Min-Sun, Kim, Hyung Sik, ...
Curcumin is a natural phenolic component of yellow curry spice, which is used in some cultures for the treatment of diseases associated with oxidative stress and inflammation. Curcumin has been...
Acute Kidney Injury Leads to Inflammation and Functional Changes in the Brain
Liu, Manchang, Liang, Yideng, Chigurupati, Srinivasulu, Lathia, Justin D., Pletnikov, Mikhail, Sun, Zhaoli, ...
Although neurologic sequelae of acute kidney injury (AKI) are well described, the pathogenesis of acute uremic encephalopathy is poorly understood. This study examined the short-term effect of...
Tavakoli, Tahereh, Xu, Xiangru, Derby, Eric, Serebryakova, Yevgeniya, Reid, Yvonne, Rao, Mahendra S, ...
Li, Yazhou, Perry, TracyAnn, Kindy, Mark S., Harvey, Brandon K., Tweedie, David, Holloway, Harold W., ...
Glucagon-like peptide-1 (GLP-1) is an endogenous insulinotropic peptide secreted from the gastrointestinal tract in response to food intake. It enhances pancreatic islet β-cell proliferation and...
β1 Integrin Maintains Integrity of the Embryonic Neocortical Stem Cell Niche
Loulier, Karine, Lathia, Justin D., Marthiens, Veronique, Relucio, Jenne, Mughal, Mohamed R., Tang, Sung-Chun, ...
IInteractions between laminins and integrin receptors hold neural stem cells in place at the ventricular surface of embryonic brain. Transient disruption leads to abnormal stem cell divisions and...
Luo, Yongquan, Lathia, Justin, Mughal, Mohammed, Mattson, Mark P.
Stromal cell-derived factor α (SDF1α) and its cognate receptor CXCR4 play an important role in neuronal development in the hippocampus, but the genes directly regulated by SDF1α/CXCR4 signaling...
Kyriazis, George A., Wei, Zelan, Vandermey, Miriam, Jo, Dong-Gyu, Xin, Ouyang, Mattson, Mark P., ...
Central to the pathogenesis of Alzheimer disease is the aberrant processing of the amyloid precursor protein (APP) to generate amyloid β-peptide (Aβ), the principle component of amyloid plaques....
MMP-7 cleaves the NR1 NMDA receptor subunit and modifies NMDA receptor function
Szklarczyk, Arek, Ewaleifoh, Osefame, Beique, Jean-Claude, Wang, Yue, Knorr, David, Haughey, Norman, ...
Matrix metalloproteinases (MMPs) are zinc-dependent enzymes that play a role in the inflammatory response. These enzymes have been well studied in the context of cancer biology and inflammation....