Mark R. Deziel

Effective Antimicrobial Regimens for Use in Humans for Therapy of Bacillus anthracis Infections and Postexposure Prophylaxis (1998)

Deziel, Mark R., Heine, Henry, Louie, Arnold, Kao, Mark, Byrne, WIlliam R., Basset, Jennifer, ...

Expanded options for treatments directed against pathogens that can be used for bioterrorism are urgently needed. Treatment regimens directed against such pathogens can be identified only by using...

The photodynamic action of bilirubin on biological membranes / (1981)

Deziel, Mark R.

Thesis (Ph. D.)--Medical College of Wisconsin, 1982.

Application of a mathematical model to prevent in vivo amplification of antibiotic-resistant bacterial populations during therapy

Jumbe, Nelson, Louie, Arnold, Leary, Robert, Liu, Weiguo, Deziel, Mark R., Tam, Vincent H., ...

The worldwide increase in the prevalence of multi-antibiotic–resistant bacteria has threatened the physician’s ability to provide appropriate therapy for infections. The relationship between...

Pharmacodynamic Evidence that Ciprofloxacin Failure against Tuberculosis Is Not Due to Poor Microbial Kill but to Rapid Emergence of Resistance

Gumbo, Tawanda, Louie, Arnold, Deziel, Mark R., Drusano, George L.

Studies of early bactericidal activity provide a fast and economic way to evaluate the clinical efficacy of potential agents for the treatment of tuberculosis. Based on good early bactericidal...

Effective Antimicrobial Regimens for Use in Humans for Therapy of Bacillus anthracis Infections and Postexposure Prophylaxis†

Deziel, Mark R., Heine, Henry, Louie, Arnold, Kao, Mark, Byrne, William R., Basset, Jennifer, ...

Expanded options for treatments directed against pathogens that can be used for bioterrorism are urgently needed. Treatment regimens directed against such pathogens can be identified only by using...

Quinolone Efflux Pumps Play a Central Role in Emergence of Fluoroquinolone Resistance in Streptococcus pneumoniae

Jumbe, Nelson L., Louie, Arnold, Miller, Michael H., Liu, Weiguo, Deziel, Mark R., Tam, Vincent H., ...

The preferential use of older antimicrobial agents is, in general, sound public health policy and is meant to maintain susceptibility to newer agents. In the case of fluoroquinolones, however, this...

Application of a mathematical model to prevent in vivo amplification of antibiotic-resistant bacterial populations during therapy

Jumbe, Nelson, Louie, Arnold, Leary, Robert, Liu, Weiguo, Deziel, Mark R., Tam, Vincent H., ...

The worldwide increase in the prevalence of multi-antibiotic–resistant bacteria has threatened the physician’s ability to provide appropriate therapy for infections. The relationship between...

Pharmacodynamic Evidence that Ciprofloxacin Failure against Tuberculosis Is Not Due to Poor Microbial Kill but to Rapid Emergence of Resistance

Gumbo, Tawanda, Louie, Arnold, Deziel, Mark R., Drusano, George L.

Studies of early bactericidal activity provide a fast and economic way to evaluate the clinical efficacy of potential agents for the treatment of tuberculosis. Based on good early bactericidal...

Effective Antimicrobial Regimens for Use in Humans for Therapy of Bacillus anthracis Infections and Postexposure Prophylaxis†

Deziel, Mark R., Heine, Henry, Louie, Arnold, Kao, Mark, Byrne, William R., Basset, Jennifer, ...

Expanded options for treatments directed against pathogens that can be used for bioterrorism are urgently needed. Treatment regimens directed against such pathogens can be identified only by using...

Quinolone Efflux Pumps Play a Central Role in Emergence of Fluoroquinolone Resistance in Streptococcus pneumoniae

Jumbe, Nelson L., Louie, Arnold, Miller, Michael H., Liu, Weiguo, Deziel, Mark R., Tam, Vincent H., ...

The preferential use of older antimicrobial agents is, in general, sound public health policy and is meant to maintain susceptibility to newer agents. In the case of fluoroquinolones, however, this...

Anidulafungin Pharmacokinetics and Microbial Response in Neutropenic Mice with Disseminated Candidiasis▿

Gumbo, Tawanda , Drusano, George L., Liu, Weiguo, Ma, Lei, Deziel, Mark R., Drusano, Michael F. , ...

Candidemia is often fatal, especially in patients with persistent neutropenia. New therapies are needed. We performed 24-h pharmacodynamic studies to compare the efficacies of anidulafungin,...

The Relationship between Quinolone Exposures and Resistance Amplification Is Characterized by an Inverted U: a New Paradigm for Optimizing Pharmacodynamics To Counterselect Resistance▿

Tam, Vincent H., Louie, Arnold, Deziel, Mark R., Liu, Weiguo, Drusano, George L.

We determined the relationship between garenoxacin exposure and quinolone-resistant subpopulations for three bacterial isolates in an in vitro hollow-fiber infection model. An “inverted-U”...

Impact of Resistance Selection and Mutant Growth Fitness on the Relative Efficacies of Streptomycin and Levofloxacin for Plague Therapy▿

Louie, Arnold, Deziel, Mark R., Liu, Weiguo, Drusano, George L.

Yersinia pestis, the bacterium that causes plague, is a potential agent of biowarfare and bioterrorism. The aminoglycoside antibiotic streptomycin is the gold standard for treatment. However, this...

In Vitro Infection Model Characterizing the Effect of Efflux Pump Inhibition on Prevention of Resistance to Levofloxacin and Ciprofloxacin in Streptococcus pneumoniae▿

Louie, Arnold, Brown, David L., Liu, Weiguo, Kulawy, Robert W., Deziel, Mark R., Drusano, George L.

The prevalence of fluoroquinolone-resistant Streptococcus pneumoniae is slowly rising as a consequence of the increased use of fluoroquinolone antibiotics to treat community-acquired pneumonia. We...

Concentration-Dependent Mycobacterium tuberculosis Killing and Prevention of Resistance by Rifampin▿

Gumbo, Tawanda, Louie, Arnold, Deziel, Mark R., Liu, Weiguo, Parsons, Linda M., Salfinger, Max, ...

Rifampin is a cornerstone of modern antituberculosis therapy. However, rifampin's half-life of 3 h is believed to limit its utility for intermittent therapy, so new congeners with long half-lives are...

Pharmacodynamics of Cidofovir for Vaccinia Virus Infection in an In Vitro Hollow-Fiber Infection Model System▿

McSharry, James J., Deziel, Mark R., Zager, Kris, Weng, Qingmei, Drusano, George L.

Variola major virus remains a potent weapon of bioterror. There is currently an investigational-new-drug application for cidofovir for the therapy of variola major virus infections. Stittelaar and...