Mark R. Rigby

Hyperglycaemia results from beta-cell dysfunction in critically ill children with respiratory and cardiovascular failure: a prospective observational study (2009)

Preissig, Catherine M, Rigby, Mark R

Abstract Introduction Hyperglycaemia is common in critical illness and associated with poor outcome. Glycaemic control using insulin may decrease morbidity and mortality. Many questions remain about...

A protocolized approach to identify and manage hyperglycemia in a pediatric critical care unit (2008)

Preissig, Catherine M., Hansen, Inger, Roerig, Pei-Ling, Rigby, Mark R.

INTRODUCTION: Hyperglycemia is a risk factor for poor outcome in critically ill patients, and glycemic control may decrease morbidity and mortality in adults. There is limited information regarding...

Endocrine issues in the pediatric intensive care unit (2008)

Clark, Lowell, Preissig, Catherine M., Rigby, Mark R., Bowyer, Frank

This article reviews selected issues of endocrine concerns in the pediatric intensive care unit, exclusive of diabetic ketoacidosis. The sympathoadrenergic arm of the neuroendocrine stress response...

CD28/CD154 blockade prevents autoimmune diabetes by inducing nondeletional tolerance after effector t-cell inhibition and regulatory T-cell expansion (2008)

Rigby, Mark R., Trexler, Alison M., Pearson, Thomas C., Larsen, Christian P.

OBJECTIVE: Blocking T-cell signaling is an effective means to prevent autoimmunity and allograft rejection in many animal models, yet the clinical translation of many of these approaches has not...

Nicotinamide adenine dinucleotide (NAD) and its metabolites inhibit T lymphocyte proliferation: role of cell surface NAD glycohydrolase and pyrophosphatase activities (2001)

Bortell, Rita, Moss, Joel, McKenna, Robert C., Rigby, Mark R., Niedzwiecki, Dena, Stevens, Linda A., ...

The presence of NAD-metabolizing enzymes (e.g., ADP-ribosyltransferase (ART)2) on the surface of immune cells suggests a potential immunomodulatory activity for ecto-NAD or its metabolites at sites...

Mouse RT6 locus 1 and rat RT6.2 are NAD+. Arginine ADP-ribosyltransferases with auto-ADP-ribosylation activity (1997)

Bortell, Rita, Rigby, Mark R., Stevens, Linda A., Moss, Joel, Kanaitsuka, Toshihiro, Mordes, John P., ...

We report that rat RT6.2 and recombinant mouse Rt6 locus 1 proteins possess auto-ADP-ribosyltransferase activity and that Rt6, but not RT6, catalyzes the ADP-ribosylation of exogenous histones. Based...

The T cell marker RT6 in a rat model of autoimmune diabetes (1997)

Greiner, Dale L., Malkani, Samir, Kanaitsuka, Toshihiro, Bortell, Rita, Doukas, John, Rigby, Mark R., ...

The rat T-cell surface protein RT6 is associated with src family tyrosine kinases and generates an activation signal (1996)

Rigby, Mark R., Bortell, Rita, Greiner, Dale L., Czech, Michael P., Klarlund, Jes K., Mordes, John P., ...

RT6 is a glycosyl-phosphatidylinositol-linked surface molecule present on most mature rat T-cells. RT6+ T-cells can prevent the expression of autoimmune diabetes in the BB rat, but the mechanism is...

The BB/Wor rat and the balance hypothesis of autoimmunity (1996)

Mordes, John P., Bortell, Rita, Doukas, John, Rigby, Mark R., Whalen, Barbara J., Zipris, Danny, ...

Rat RT6.2 and mouse Rt6 locus 1 are NAD+: arginine ADP ribosyltransferases with auto-ADP ribosylation activity (1996)

Rigby, Mark R., Bortell, Rita, Stevens, Linda A., Moss, Joel, Kanaitsuka, Toshihiro, Shigeta, Hirofumi, ...

RT6 is a glycosylphosphatidylinositol-linked protein found on the surface of mature rat T lymphocytes. Cells that express RT6 have an immunoregulatory function and modulate the expression of...

R T 6: a Bifunctional Protein of Regulatory T Cells (1995)

Rigby, Mark R.

The immune system is a complex network of cells and molecules that is a powerful and necessary defense mechanism to protect the host from pathogens. When this system is non-functional or...

Hyperglycaemia results from beta-cell dysfunction in critically ill children with respiratory and cardiovascular failure: a prospective observational study

Preissig, Catherine M, Rigby, Mark R

CD28/CD154 Blockade Prevents Autoimmune Diabetes by Inducing Nondeletional Tolerance After Effector T-Cell Inhibition and Regulatory T-Cell Expansion

Rigby, Mark R., Trexler, Alison M., Pearson, Thomas C., Larsen, Christian P.

OBJECTIVE—Blocking T-cell signaling is an effective means to prevent autoimmunity and allograft rejection in many animal models, yet the clinical translation of many of these approaches has not...