Mark Stoneking

An assessment of the portability of ancestry informative markers between human populations (2009)

Myles, Sean, Stoneking, Mark, Timpson, Nic

Abstract Background Recent work has shown that population stratification can have confounding effects on genetic association studies and statistical methods have been developed to correct for these...

Molecular evolution of UCP1 and the evolutionary history of mammalian non-shivering thermogenesis (2009)

Hughes, David A, Jastroch, Martin, Stoneking, Mark, Klingenspor, Martin

Abstract Background Uncoupling protein 1 (UCP1) is a mitochondrial anion carrier, expressed in brown adipose tissue (BAT) of Eutherians. UCP1 is responsible for uncoupling mitochondrial proton...

Genomic complexity of the Y-STR DYS19: inversions, deletions and founder lineages carrying duplications. (2009)

Balaresque, Patricia L., Parkin, Emma J., Roewer, Lutz, Carvalho-Silva, Denise R., Mitchell, R. John, ...

This is the author's final draft of the paper published as International Journal of Legal Medicine, 2009, 123 (1), pp. 15-23. The original publication is available at www.springerlink.com. Doi:...

Genetic Admixture History of Eastern Indonesia as Revealed by Y-Chromosome and Mitochondrial DNA Analysis (2009)

Mona, Stefano, Grunz, Katharina E., Brauer, Silke, Pakendorf, Brigitte, Castrì, Loredana, Sudoyo, Herawati, ...

Eastern Indonesia possesses more linguistic diversity than any other region in Southeast Asia, with both Austronesian (AN) languages that are of East Asian origin, as well as non-Austronesian (NAN)...

Global diversity in the human salivary microbiome (2009)

Nasidze, Ivan, Li, Jing, Quinque, Dominique, Tang, Kun, Stoneking, Mark

The human salivary microbiome may play a role in diseases of the oral cavity and interact with microbiomes from other parts of the human body (in particular, the intestinal tract), but little is...

Worldwide population differentiation at disease-associated SNPs (2008)

Myles, Sean, Davison, Dan, Barrett, Jeffrey, Stoneking, Mark, Timpson, Nic

Abstract Background Recent genome-wide association (GWA) studies have provided compelling evidence of association between genetic variants and common complex diseases. These studies have made use of...

The Impact of the Austronesian Expansion: Evidence from mtDNA and Y Chromosome Diversity in the Admiralty Islands of Melanesia (2008)

Kayser, Manfred, Choi, Ying, Van Oven, Mannis, Mona, Stefano, Brauer, Silke, Trent, Ronald J., ...

The genetic ancestry of Polynesians can be traced to both Asia and Melanesia, which presumably reflects admixture occurring between incoming Austronesians and resident non-Austronesians in Melanesia...

Parallel selection on TRPV6 in human populations (2008)

Tang, Kun, Strotmann, Rainer, Schöneberg, Torsten, Prenen, Jean, ...

We identified and examined a candidate gene for local directional selection in Europeans, TRPV6, and conclude that selection has acted on standing genetic variation at this locus, creating parallel...

A New Approach for Using Genome Scans to Detect Recent Positive Selection in the Human Genome (2007)

Kun Tang, Kevin R. Thornton, Mark Stoneking

Genome-wide scanning for signals of recent positive selection is essential for a comprehensive and systematic understanding of human adaptation. Here, we present a genomic survey of recent local...

Microsatellite polymorphism within pfcrtprovides evidence of continuing evolution of chloroquine-resistant alleles in Papua New Guinea (2007)

DaRe, Jeana T, Mehlotra, Rajeev K, Michon, Pascal, Mueller, Ivo, Reeder, John, Sharma, Yagya D, ...

Abstract Background Polymorphism in the pfcrt gene underlies Plasmodium falciparum chloroquine resistance (CQR), as sensitive strains consistently carry lysine (K), while CQR strains carry threonine...

Microsatellite polymorphism within pfcrt provides evidence of continuing evolution of chloroquine-resistant alleles in Papua New Guinea. (2007)

DaRe, Jeana T, Mehlotra, Rajeev K, Michon, Pascal, Mueller, Ivo, Reeder, John, Sharma, Yagya D, ...

BACKGROUND: Polymorphism in the pfcrt gene underlies Plasmodium falciparum chloroquine resistance (CQR), as sensitive strains consistently carry lysine (K), while CQR strains carry threonine (T) at...

Melanesian and Asian Origins of Polynesians: mtDNA and Y Chromosome Gradients Across the Pacific (2006)

Kayser, Manfred, Brauer, Silke, Cordaux, Richard, Casto, Amanda, Lao, Oscar, Zhivotovsky, Lev A., ...

The human settlement of the Pacific Islands represents one of the most recent major migration events of mankind. Polynesians originated in Asia according to linguistic evidence or in Melanesia...

Melanesian and Asian Origins of Polynesians: mtDNA and Y-chromosome Gradients Across the Pacific (2006)

Kayser, Manfred, Brauer, Silke, Cordaux, Richard, Casto, Amanda, Lao, Oscar, Zhivotovsky, Lev A., ...

The human settlement of the Pacific Islands represents one of the most recent major migration events of mankind. Polynesians originated in Asia according to linguistic evidence or in Melanesia...

Molecular analysis reveals tighter social regulation of immigration in patrilocal populations than in matrilocal populations (2005)

Hamilton, Grant S., Stoneking, Mark, Excoffier, Laurent

Human social organization can deeply affect levels of genetic diversity. This fact implies that genetic information can be used to study social structures, which is the basis of ethnogenetics....

Molecular analysis reveals tighter social regulation of immigration in patrilocal populations than in matrilocal populations (2005)

Hamilton, Grant S., Stoneking, Mark, Excoffier, Laurent

Human social organization can deeply affect levels of genetic diversity. This fact implies that genetic information can be used to study social structures, which is the basis of ethnogenetics....

Molecular analysis reveals tighter social regulation of immigration in patrilocal populations than in matrilocal populations (2005)

Hamilton, Grant S., Stoneking, Mark, Excoffier, Laurent

Human social organization can deeply affect levels of genetic diversity. This fact implies that genetic information can be used to study social structures, which is the basis of ethnogenetics....

Recent Origin and Cultural Reversion of a Hunter–Gatherer Group (2005)

Hiroki Oota, Brigitte Pakendorf, Gunter Weiss, Arndt Von Haeseler, Surin Pookajorn, Wannapa Settheetham-Ishida, ...

Genes, language and culture reveal that the Mlabri reverted from an agricultural to a hunter-gatherer lifestyle, suggesting that hunter-gatherer groups might not always represent the pre-...

Recent Origin and Cultural Reversion of a Hunter–Gatherer Group (2005)

Hiroki Oota, Brigitte Pakendorf, Gunter Weiss, Arndt Von Haeseler, Surin Pookajorn, Wannapa Settheetham-Ishida, ...

Contemporary hunter–gatherer groups are often thought to serve as models of an ancient lifestyle that was typical of human populations prior to the development of agriculture. Patterns of genetic...

Recent Origin and Cultural Reversion of a Hunter–Gatherer Group (2005)

Oota, Hiroki, Pakendorf, Brigitte, Weiss, Gunter, Von Haeseler, Arndt, Pookajorn, Surin, Settheetham-Ishida, Wannapa, ...

Contemporary hunter–gatherer groups are often thought to serve as models of an ancient lifestyle that was typical of human populations prior to the development of agriculture. Patterns of genetic...

MtDNA and Y-chromosome variation in Kurdish groups (2005)

Nasidze, Ivan, Quinque, Dominique, Ozturk, M., Bendukidze, N., Stoneking, Mark

In order to investigate the origins and relationships of Kurdish-speaking groups, mtDNA HV1 sequences, eleven Y chromosome bi-allelic markers, and 9 Y-STR loci were analyzed among three Kurdish...

Molecular analysis reveals tighter social regulation of immigration in patrilocal populations than in matrilocal populations (2005)

Hamilton, Grant S., Stoneking, Mark, Excoffier, Laurent

Human social organization can deeply affect levels of genetic diversity. This fact implies that genetic information can be used to study social structures, which is the basis of ethnogenetics....

Molecular analysis reveals tighter social regulation of immigration in patrilocal populations than in matrilocal populations (2005)

Hamilton, Grant S., Stoneking, Mark, Excoffier, Laurent

Human social organization can deeply affect levels of genetic diversity. This fact implies that genetic information can be used to study social structures, which is the basis of ethnogenetics....

Molecular analysis reveals tighter social regulation of immigration in patrilocal populations than in matrilocal populations (2005)

Hamilton, Grant S., Stoneking, Mark, Excoffier, Laurent

Human social organization can deeply affect levels of genetic diversity. This fact implies that genetic information can be used to study social structures, which is the basis of ethnogenetics....

Molecular analysis reveals tighter social regulation of immigration in patrilocal populations than in matrilocal populations (2005)

Hamilton, Grant S., Stoneking, Mark, Excoffier, Laurent

Human social organization can deeply affect levels of genetic diversity. This fact implies that genetic information can be used to study social structures, which is the basis of ethnogenetics....

Molecular analysis reveals tighter social regulation of immigration in patrilocal populations than in matrilocal populations (2005)

Hamilton, Grant S., Stoneking, Mark, Excoffier, Laurent

Human social organization can deeply affect levels of genetic diversity. This fact implies that genetic information can be used to study social structures, which is the basis of ethnogenetics....

Molecular analysis reveals tighter social regulation of immigration in patrilocal populations than in matrilocal populations (2005)

Hamilton, Grant S., Stoneking, Mark, Excoffier, Laurent

Human social organization can deeply affect levels of genetic diversity. This fact implies that genetic information can be used to study social structures, which is the basis of ethnogenetics....

A Comprehensive Survey of Human Y-Chromosomal Microsatellites (2004)

Kayser, Manfred, Kittler, Ralf, Erler, Axel, Hedman, Minttu, Lee, Andrew C., Mohyuddin, Aisha, ...

This is the version as printed in the American Journal of Human Genetics by the University of Chicago Press. Their website is http://www.journals.uchicago.edu/AJHG/home.html

The Northeast Indian Passageway: A Barrier or Corridor for Human Migrations? (2004)

Cordaux, Richard, Weiss, Gunter, Saha, Nilmani, Stoneking, Mark

The northeast Indian passageway connecting the Indian subcontinent to east/southeast Asia is thought to have been a major corridor for human migrations. Because it is also an important linguistic...

The Northeast Indian Passageway: A Barrier or Corridor for Human Migrations? (2004)

Cordaux, Richard, Weiss, Gunter, Saha, Nilmani, Stoneking, Mark

The northeast Indian passageway connecting the Indian subcontinent to East/Southeast Asia is thought to have been a major corridor for human migrations. Because it is also an important linguistic...

The Northeast Indian Passageway: A Barrier or Corridor for Human Migrations? (2004)

Cordaux, Richard, Weiss, Gunter, Saha, Nilmani, Stoneking, Mark

The northeast Indian passageway connecting the Indian subcontinent to east/southeast Asia is thought to have been a major corridor for human migrations. Because it is also an important linguistic...

Y chromosome STR haplotypes and the genetic structure of U.S. populations of African, European, and Hispanic ancestry. (2003)

Kayser, Manfred, Brauer, Silke, Sch Dlich, Hiltrud, Prinz, Mechthild, Batzer, Mark A., Zimmerman, Peter A., ...

To investigate geographic structure within U.S. ethnic populations, we analyzed 1705 haplotypes on the basis of 9 short tandem repeat (STR) loci on the Y-chromosome from 9-11 groups each of...

A Genome Scan to Detect Candidate Regions Influenced by Local Natural Selection in Human Populations (2003)

Kayser, Manfred, Brauer, Silke, Stoneking, Mark

As human populations dispersed throughout the world, they were subjected to new selective forces, which must have led to local adaptation via natural selection and hence altered patterns of genetic...

A Genome Scan to Detect Candidate Regions Influenced by Local Natural Selection in Human Populations (2003)

Kayser, Manfred, Brauer, Silke, Stoneking, Mark

As human populations dispersed throughout the world, they were subjected to new selective forces, which must have led to local adaptation via natural selection and hence altered patterns of genetic...

Y Chromosome STR Haplotypes and the Genetic Structure of U.S. Populations of African, European, and Hispanic Ancestry (2003)

Kayser, Manfred, Brauer, Silke, Schädlich, Hiltrud, Prinz, Mechthild, Batzer, Mark A., Zimmerman, Peter A., ...

To investigate geographic structure within U.S. ethnic populations, we analyzed 1705 haplotypes on the basis of 9 short tandem repeat (STR) loci on the Y-chromosome from 9–11 groups each of...

A Genome Scan to Detect Candidate Regions Influenced by Local Natural Selection in Human Populations (2003)

Kayser, Manfred, Brauer, Silke, Stoneking, Mark

As human populations dispersed throughout the world, they were subjected to new selective forces, which must have led to local adaptation via natural selection and hence altered patterns of genetic...

Online Y-chromosomal short tandem repeat haplotype reference database (YHRD) for US populations (2002)

Kayser, Manfred, Brauer, Silke, Willuweit, S., Schadlich, H., Batzer, M. A., Zawacki, J., ...

We describe here an online Y-chromosomal short tandem repeat haplotype reference database (YHRD) for U.S. populations, which represents 9-locus Y-STR haplotypes for 1705 African-Americans....

Extreme mtDNA homogeneity in continental Asian populations (2002)

Oota, Hiroshi, Kitano, T., Jin, F., Yuasa, I., Wang, L., Ueda, S., ...

Mitochondrial DNA (mtDNA) variation in continental Asia has not been well-studied. Here, we report mtDNA HV1 sequences for 84 Xi'an and 82 Changsha Han Chinese, 89 Honshu Japanese, and 35 Vietnamese....

Patterns of human diversity, within and among continents, inferred from biallelic DNA polymorphisms (2002)

Romualdi, C., Balding, D., Nasidze, Ivan, Risch, G., Robichaux, M., Sherry, S. T., ...

Previous studies have reported that about 85% of human diversity at Short Tandem Repeat (STR) and Restriction Fragment Length Polymorphism (RFLP) autosomal loci is due to differences between...

A whole genome amplification method to generate long fragments from low quantities of genomic DNA (2002)

Kittler, Ralf, Stoneking, Mark, Kayser, Manfred

Several whole genome amplification strategies have been developed to preamplify the entire genome from minimal amounts of DNA for subsequent molecular genetic analysis. However, none of these...

A Molecular basis for human hypersensitivity of aminoglyscoside antibiotics (1993)

Hutchin, Tim, Haworth, Lan, Higashi, Koichiro, Fischel-Ghodsian, Nathan, Stoneking, Mark, Saha, N., ...

We have investigated the distribution of mitochondrial DNA polymorphisms in a rare maternally transmitted genetic trait that causes hypersensitivity to aminoglycoside antibiotics, In the hope that a...

Conformational mutation in human mtDNA detected by direct sequencing of enzymatically amplified DNA (1988)

Vigilant, Linda, Stoneking, Mark, Wilson, Allan C.

Restriction enzyme analysis of 241 human mtDNAs revealed polymorphism in the electrophoretic mobility of a fragment corresponding to part of the ND4 gene. Enzymatic amplification and direct...

Length mutations in human mitochondrial DNA: direct sequencing of enzymatically amplified DNA (1987)

Wrischnik, Lisa A., Higuchi, Russell G., Stoneking, Mark, Erlich, Henry A., Arnheim, Norman, Wilson, Allan C.

A specific segment of mitochondrial DNA from 18 people was examined by two methods of direct DNA sequencing. This segment includes a small noncoding region (V) shown before by restriction analysis to...

Patterns of Human Diversity, within and among Continents, Inferred from Biallelic DNA Polymorphisms

Romualdi, Chiara, Balding, David, Nasidze, Ivane S., Risch, Gregory, Robichaux, Myles, Sherry, Stephen T., ...

Previous studies have reported that about 85% of human diversity at Short Tandem Repeat (STR) and Restriction Fragment Length Polymorphism (RFLP) autosomal loci is due to differences between...

Alu Insertion Polymorphisms and Human Evolution: Evidence for a Larger Population Size in Africa

Stoneking, Mark, Fontius, Jennifer J., Clifford, Stephanie L., Soodyall, Himla, Arcot, Santosh S., Saha, Nilmani, ...

Alu insertion polymorphisms (polymorphisms consisting of the presence/absence of an Alu element at a particular chromosomal location) offer several advantages over other nuclear DNA polymorphisms for...

Reading between the LINEs: Human Genomic Variation Induced by LINE-1 Retrotransposition

Sheen, Fang-miin, Sherry, Stephen T., Risch, Gregory M., Robichaux, Myles, Nasidze, Ivane, Stoneking, Mark, ...

The insertion of mobile elements into the genome represents a new class of genetic markers for the study of human evolution. Long interspersed elements (LINEs) have amplified to a copy number of...

Y Chromosome STR Haplotypes and the Genetic Structure of U.S. Populations of African, European, and Hispanic Ancestry

Kayser, Manfred, Brauer, Silke, Schädlich, Hiltrud, Prinz, Mechthild, Batzer, Mark A., Zimmerman, Peter A., ...

To investigate geographic structure within U.S. ethnic populations, we analyzed 1705 haplotypes on the basis of 9 short tandem repeat (STR) loci on the Y-chromosome from 9–11 groups each of...

Recent Origin and Cultural Reversion of a Hunter–Gatherer Group

Oota, Hiroki, Pakendorf, Brigitte, Weiss, Gunter, Von Haeseler, Arndt, Pookajorn, Surin, Settheetham-Ishida, Wannapa, ...

Contemporary hunter–gatherer groups are often thought to serve as models of an ancient lifestyle that was typical of human populations prior to the development of agriculture. Patterns of genetic...

Molecular analysis reveals tighter social regulation of immigration in patrilocal populations than in matrilocal populations

Hamilton, Grant, Stoneking, Mark, Excoffier, Laurent

Human social organization can deeply affect levels of genetic diversity. This fact implies that genetic information can be used to study social structures, which is the basis of ethnogenetics....

Independent Histories of Human Y Chromosomes from Melanesia and Australia

Kayser, Manfred, Brauer, Silke, Weiss, Gunter, Schiefenhövel, Wulf, Underhill, Peter A., Stoneking, Mark

To investigate the origins and relationships of Australian and Melanesian populations, 611 males from 18 populations from Australia, Melanesia, and eastern/southeastern Asia were typed for eight...

Hypervariable Sites in the mtDNA Control Region Are Mutational Hotspots

Stoneking, Mark

Hypervariable sites in human mtDNA are readily identified in evolutionary studies and are usually assumed to represent mutational hotspots. Recently, an alternative hypothesis was proposed that holds...

Joint Segregation of Biochemical Loci in Salmonidae. II. Linkage Associations from a Hybridized Salvelinus Genome (S. NAMAYCUSHxS. FONTINALIS)

May, Bernie, Stoneking, Mark, Wright, James E.

The results of more than 300 pairwise examinations of biochemical loci for joint segregation in brook trout (Salvelinus fontinalis) and in the hybridized genome of lake trout (S. namaycush) x brook...

HLA-DQα allele and genotype frequencies in various human populations determined by using enzymatic amplification and oligonucleotide probes

Helmuth, Rhea, Fildes, Nicola, Blake, Edward, Luce, Michael C., Chimera, J., Madej, Roberta, ...

Allele and genotype frequencies at the HLA-DQα locus have been determined by the use of polymerase chain reaction (PCR) amplification and nonradioactive oligonucleotide probes. The probes define six...

Patterns of Human Diversity, within and among Continents, Inferred from Biallelic DNA Polymorphisms

Romualdi, Chiara, Balding, David, Nasidze, Ivane S., Risch, Gregory, Robichaux, Myles, Sherry, Stephen T., ...

Previous studies have reported that about 85% of human diversity at Short Tandem Repeat (STR) and Restriction Fragment Length Polymorphism (RFLP) autosomal loci is due to differences between...

Alu Insertion Polymorphisms and Human Evolution: Evidence for a Larger Population Size in Africa

Stoneking, Mark, Fontius, Jennifer J., Clifford, Stephanie L., Soodyall, Himla, Arcot, Santosh S., Saha, Nilmani, ...

Alu insertion polymorphisms (polymorphisms consisting of the presence/absence of an Alu element at a particular chromosomal location) offer several advantages over other nuclear DNA polymorphisms for...

Reading between the LINEs: Human Genomic Variation Induced by LINE-1 Retrotransposition

Sheen, Fang-miin, Sherry, Stephen T., Risch, Gregory M., Robichaux, Myles, Nasidze, Ivane, Stoneking, Mark, ...

The insertion of mobile elements into the genome represents a new class of genetic markers for the study of human evolution. Long interspersed elements (LINEs) have amplified to a copy number of...

Reduced Y-Chromosome, but Not Mitochondrial DNA, Diversity in Human Populations from West New Guinea

Kayser, Manfred, Brauer, Silke, Weiss, Gunter, Schiefenhövel, Wulf, Underhill, Peter, Shen, Peidong, ...

To investigate the paternal population history of New Guinea, 183 individuals from 11 regional populations of West New Guinea (WNG) and 131 individuals from Papua New Guinea (PNG) were analyzed at 26...

Y Chromosome STR Haplotypes and the Genetic Structure of U.S. Populations of African, European, and Hispanic Ancestry

Kayser, Manfred, Brauer, Silke, Schädlich, Hiltrud, Prinz, Mechthild, Batzer, Mark A., Zimmerman, Peter A., ...

To investigate geographic structure within U.S. ethnic populations, we analyzed 1705 haplotypes on the basis of 9 short tandem repeat (STR) loci on the Y-chromosome from 9–11 groups each of...

Recent Origin and Cultural Reversion of a Hunter–Gatherer Group

Oota, Hiroki, Pakendorf, Brigitte, Weiss, Gunter, Von Haeseler, Arndt, Pookajorn, Surin, Settheetham-Ishida, Wannapa, ...

Contemporary hunter–gatherer groups are often thought to serve as models of an ancient lifestyle that was typical of human populations prior to the development of agriculture. Patterns of genetic...

Molecular analysis reveals tighter social regulation of immigration in patrilocal populations than in matrilocal populations

Hamilton, Grant, Stoneking, Mark, Excoffier, Laurent

Human social organization can deeply affect levels of genetic diversity. This fact implies that genetic information can be used to study social structures, which is the basis of ethnogenetics....

A Comprehensive Survey of Human Y-Chromosomal Microsatellites

Kayser, Manfred, Kittler, Ralf, Erler, Axel, Hedman, Minttu, Lee, Andrew C., Mohyuddin, Aisha, ...

We have screened the nearly complete DNA sequence of the human Y chromosome for microsatellites (short tandem repeats) that meet the criteria of having a repeat-unit size of ⩾3 and a repeat count...

Joint Segregation of Biochemical Loci in Salmonidae. II. Linkage Associations from a Hybridized Salvelinus Genome (S. NAMAYCUSHxS. FONTINALIS)

May, Bernie, Stoneking, Mark, Wright, James E.

The results of more than 300 pairwise examinations of biochemical loci for joint segregation in brook trout (Salvelinus fontinalis) and in the hybridized genome of lake trout (S. namaycush) x brook...

Independent Histories of Human Y Chromosomes from Melanesia and Australia

Kayser, Manfred, Brauer, Silke, Weiss, Gunter, Schiefenhövel, Wulf, Underhill, Peter A., Stoneking, Mark

To investigate the origins and relationships of Australian and Melanesian populations, 611 males from 18 populations from Australia, Melanesia, and eastern/southeastern Asia were typed for eight...

Hypervariable Sites in the mtDNA Control Region Are Mutational Hotspots

Stoneking, Mark

Hypervariable sites in human mtDNA are readily identified in evolutionary studies and are usually assumed to represent mutational hotspots. Recently, an alternative hypothesis was proposed that holds...

HLA-DQα allele and genotype frequencies in various human populations determined by using enzymatic amplification and oligonucleotide probes

Helmuth, Rhea, Fildes, Nicola, Blake, Edward, Luce, Michael C., Chimera, J., Madej, Roberta, ...

Allele and genotype frequencies at the HLA-DQα locus have been determined by the use of polymerase chain reaction (PCR) amplification and nonradioactive oligonucleotide probes. The probes define six...

A New Approach for Using Genome Scans to Detect Recent Positive Selection in the Human Genome

Tang, Kun, Thornton, Kevin R, Stoneking, Mark

Genome-wide scanning for signals of recent positive selection is essential for a comprehensive and systematic understanding of human adaptation. Here, we present a genomic survey of recent local...

Parallel Selection on TRPV6 in Human Populations

Hughes, David A., Tang, Kun, Strotmann, Rainer, Schöneberg, Torsten, Prenen, Jean, Nilius, Bernd, ...

We identified and examined a candidate gene for local directional selection in Europeans, TRPV6, and conclude that selection has acted on standing genetic variation at this locus, creating parallel...

Positive Selection in East Asians for an EDAR Allele that Enhances NF-κB Activation

Bryk, Jarosław, Hardouin, Emilie, Pugach, Irina, Hughes, David, Strotmann, Rainer, Stoneking, Mark, ...

Genome-wide scans for positive selection in humans provide a promising approach to establish links between genetic variants and adaptive phenotypes. From this approach, lists of hundreds of candidate...

Genome-wide Analysis Indicates More Asian than Melanesian Ancestry of Polynesians

Kayser, Manfred, Lao, Oscar, Saar, Kathrin, Brauer, Silke, Wang, Xingyu, Nürnberg, Peter, ...

Analyses of mitochondrial DNA (mtDNA) and nonrecombining Y chromosome (NRY) variation in the same populations are sometimes concordant but sometimes discordant. Perhaps the most dramatic example...

Discordant Patterns of Genetic Variation at Two Chloroquine Resistance Loci in Worldwide Populations of the Malaria Parasite Plasmodium falciparum ▿ †

Mehlotra, Rajeev K., Mattera, Gabriel, Bockarie, Moses J., Maguire, Jason D., Baird, J. Kevin, Sharma, Yagya D., ...

Mutations in the chloroquine resistance (CQR) transporter gene of Plasmodium falciparum (Pfcrt; chromosome 7) play a key role in CQR, while mutations in the multidrug resistance gene (Pfmdr1;...

Positive selection in East Asians for an EDAR allele that enhances NF-kappaB activation

Bryk, Jarosław, Hardouin, Emilie, Pugach, Irina, Hughes, David, Strotmann, Rainer, Stoneking, Mark, ...

Genome-wide scans for positive selection in humans provide a promising approach to establish links between genetic variants and adaptive phenotypes. From this approach, lists of hundreds of candidate...

Global diversity in the human salivary microbiome

Nasidze, Ivan, Li, Jing, Quinque, Dominique, Tang, Kun, Stoneking, Mark

The human salivary microbiome may play a role in diseases of the oral cavity and interact with microbiomes from other parts of the human body (in particular, the intestinal tract), but little is...

Analysis of Y chromosome STR haplotypes in the European part of Russia reveals high diversities but non-significant genetic distances between populations

Roewer, Lutz, Willuweit, Sascha, Krüger, Carmen, Nagy, Marion, Rychkov, Sergey, Morozowa, Irina, ...

A total of 17 Y-specific STR loci were studied in 12 districts of the European part of Russia aiming to ascertain the amount of substructure required for the construction of a representative regional...