Mark von Itzstein

Crystallisation and preliminary X-ray diffraction analysis of the carbohydrate-recognizing domain (VP8*) of bovine rotavirus strain NCDV (2008)

Yes

Yu, Xing, Guillion, Annabel, Szyczew, Alexander Jeffery, Kiefel, Milton, Coulson, Barbara S., Von Itzstein, Mark, ...

Infectivity of rotavirus is dramatically enhanced by proteolytic cleavage of its outer layer VP4 spike protein into two function domains, VP8* and VP5*. The carbohydrate-recognising domain VP8* is...

Avian influenza H5-containing virus-like particles (VLPs): host-cell receptor specificity by STD NMR spectroscopy (2008)

Haselhorst, Thomas Erwin, Garcia, Jean-Michel, Islam, Tasneem, Lai, Jimmy C. C., Rose, Faith Josephine, Nicholls, John M., ...

Yes

Influenza C virus and bovine coronavirus esterase reveal a similar catalytic mechanism: new insights for drug discovery (2008)

Mayr, Juliane, Haselhorst, Thomas Erwin, Langereis, Martijn A., Dyason, Jeffrey Clifford, Huber, Wolfgang, Frey, Barbara, ...

Hot, sweet and sticky: the glycobiology of Plasmodium falciparum (2008)

Von Itzstein, Mark, Plebanksi, Magdalena, Cook, Brian M., Coppel, Ross L.

Avian influenza virus, a very sticky situation (2008)

Crystallisation and preliminary X-ray diffraction analysis of the carbohydrate-recognizing domain (VP8*) of bovine rotavirus strain NCDV (2008)

Yu, Xing, Guillion, Annabel, Szyczew, Alexander Jeffery, Kiefel, Milton, Coulson, Barbara S., Von Itzstein, Mark, ...

Infectivity of rotavirus is dramatically enhanced by proteolytic cleavage of its outer layer VP4 spike protein into two function domains, VP8* and VP5*. The carbohydrate-recognising domain VP8* is...

Avian influenza H5-containing virus-like particles (VLPs): host-cell receptor specificity by STD NMR spectroscopy (2008)

Haselhorst, Thomas Erwin, Garcia, Jean-Michel, Islam, Tasneem, Lai, Jimmy C. C., Rose, Faith Josephine, Nicholls, John M., ...

Limited inhibitory effects of Oseltamivir and Zanamivir on human sialidases (2008)

Hata, Keiko, Koseki, Koichi, Yamaguchi, Kazunori, Moriya, Setsuko, Suzuki, Yasuo, Yingsakmongkon, Sangchai, ...

Yes

Detection of ligand binding to nucleotide sugar transporters by STD NMR spectroscopy (2008)

Maggioni, Andrea, Von Itzstein, Mark, Tiralongo, Giuseppe, Haselhorst, Thomas Erwin

Yes

Limited inhibitory effects of Oseltamivir and Zanamivir on human sialidases (2008)

Hata, Keiko, Koseki, Koichi, Yamaguchi, Kazunori, Moriya, Setsuko, Suzuki, Yasuo, Yingsakmongkon, Sangchai, ...

Detection of ligand binding to nucleotide sugar transporters by STD NMR spectroscopy (2008)

Maggioni, Andrea, Von Itzstein, Mark, Tiralongo, Giuseppe, Haselhorst, Thomas Erwin

Disease-associated carbohydrate-recognising proteins and structure-based inhibitor design (2008)

The evolution of galactose α2,3-sialyltransferase: Ciona intestinalis ST3GAL I/II and Takifugu rubripes ST3GAL II sialylate Galβ1,3GalNAc structures on glycoproteins but not glycolipids (2008)

Lehmann, Friederike, Kelm, Sorge, Dietz, Frank, Von Itzstein, Mark, Tiralongo, Giuseppe

Disease-associated carbohydrate-recognising proteins and structure-based inhibitor design (2008)

The evolution of galactose α2,3-sialyltransferase: Ciona intestinalis ST3GAL I/II and Takifugu rubripes ST3GAL II sialylate Galβ1,3GalNAc structures on glycoproteins but not glycolipids (2008)

Yes

Lehmann, Friederike, Kelm, Sorge, Dietz, Frank, Von Itzstein, Mark, Tiralongo, Giuseppe

Yes

Influenza C virus and bovine coronavirus esterase reveal a similar catalytic mechanism: new insights for drug discovery (2008)

Mayr, Juliane, Haselhorst, Thomas Erwin, Langereis, Martijn A., Dyason, Jeffrey Clifford, Huber, Wolfgang, Frey, Barbara, ...

Hot, sweet and sticky: the glycobiology of Plasmodium falciparum (2008)

Von Itzstein, Mark, Plebanksi, Magdalena, Cook, Brian M., Coppel, Ross L.

Avian influenza virus, a very sticky situation (2008)

Crystallisation and preliminary X-ray diffraction analysis of the carbohydrate-recognizing domain (VP8*) of bovine rotavirus strain NCDV (2008)

Yu, Xing, Guillion, Annabel, Szyczew, Alexander Jeffery, Kiefel, Milton, Coulson, Barbara S., Von Itzstein, Mark, ...

Infectivity of rotavirus is dramatically enhanced by proteolytic cleavage of its outer layer VP4 spike protein into two function domains, VP8* and VP5*. The carbohydrate-recognising domain VP8* is...

Avian influenza H5-containing virus-like particles (VLPs): host-cell receptor specificity by STD NMR spectroscopy (2008)

Haselhorst, Thomas Erwin, Garcia, Jean-Michel, Islam, Tasneem, Lai, Jimmy C. C., Rose, Faith Josephine, Nicholls, John M., ...

Limited inhibitory effects of Oseltamivir and Zanamivir on human sialidases (2008)

Hata, Keiko, Koseki, Koichi, Yamaguchi, Kazunori, Moriya, Setsuko, Suzuki, Yasuo, Yingsakmongkon, Sangchai, ...

Detection of ligand binding to nucleotide sugar transporters by STD NMR spectroscopy (2008)

Maggioni, Andrea, Von Itzstein, Mark, Tiralongo, Giuseppe, Haselhorst, Thomas Erwin

Disease-associated carbohydrate-recognising proteins and structure-based inhibitor design (2008)

The evolution of galactose α2,3-sialyltransferase: Ciona intestinalis ST3GAL I/II and Takifugu rubripes ST3GAL II sialylate Galβ1,3GalNAc structures on glycoproteins but not glycolipids (2008)

Lehmann, Friederike, Kelm, Sorge, Dietz, Frank, Von Itzstein, Mark, Tiralongo, Giuseppe

Insight into host cell carbohydrate-recognition by human and porcine rotavirus from crystal structures of the virion spike associated carbohydrate-binding domain (VP8*) (2007)

Blanchard, Helen, Yu, Xing, Coulson, Barbara S., Von Itzstein, Mark

Rotavirus infection leads to the death of half a million children annually. The exact specifics of interaction between rotavirus particles and host cells enabling invasion and infection have remained...

Insight into host cell carbohydrate-recognition by human and porcine rotavirus from crystal structures of the virion spike associated carbohydrate-binding domain (VP8*) (2007)

Blanchard, Helen, Yu, Xing, Coulson, Barbara S., Von Itzstein, Mark

Rotavirus infection leads to the death of half a million children annually. The exact specifics of interaction between rotavirus particles and host cells enabling invasion and infection have remained...

Optimisation of Glycan and Small Molecule Arrays for analysis of Campylobacter chemotaxis and adherence. (2007)

Day, Christopher, Tiralongo, Giuseppe, Hartnell, Regan David, Von Itzstein, Mark, Wilson, Jenny, Korolik, Victoria

No

Insight into host cell carbohydrate-recognition by human and porcine rotavirus from crystal structures of the virion spike associated carbohydrate-binding domain (VP8*) (2007)

Blanchard, Helen, Yu, Xing, Coulson, Barbara S., Von Itzstein, Mark

Rotavirus infection leads to the death of half a million children annually. The exact specifics of interaction between rotavirus particles and host cells enabling invasion and infection have remained...

Optimisation of Glycan and Small Molecule Arrays for analysis of Campylobacter chemotaxis and adherence. (2007)

Day, Christopher, Tiralongo, Giuseppe, Hartnell, Regan David, Von Itzstein, Mark, Wilson, Jenny, Korolik, Victoria

Synthesis and Biological Evaluation of Galactofuranosyl Alkyl Thioglycosides as Inhibitors of Mycobacteria (2007)

Davis, Christopher, Hartnell, Regan David, Madge, Paul David, Owen, David James, Thomson, Robin Joy, Chong, Andrew, ...

As part of our research interest directed toward the development of antimycobacterial agents, we have investigated compounds based on galactofuranose (Galf), an essential cell wall component of...

Synthesis and Biological Evaluation of Galactofuranosyl Alkyl Thioglycosides as Inhibitors of Mycobacteria (2007)

Davis, Christopher, Hartnell, Regan David, Madge, Paul David, Owen, David James, Thomson, Robin Joy, Chong, Andrew, ...

As part of our research interest directed toward the development of antimycobacterial agents, we have investigated compounds based on galactofuranose (Galf), an essential cell wall component of...

Targeting the expression of functional murine CMP-sialic acid transporter to the E. coli inner membrane (2007)

Maggioni, Andrea, Von Itzstein, Mark, Gerardy-Schahn, Rita, Tiralongo, Giuseppe

Yes

Synthesis and evaluation of galactofuranosyl N,N-dialkyl sulfenamides and sulfonamides as antimycobacterial agents (2007)

Owen, David James, Davis, Christopher, Hartnell, Regan David, Madge, Paul David, Thomson, Robin Joy, Chong, Andrew, ...

Yes

The war against influenza: discovery and development of sialidase inhibitors (2007)

Synthesis and evaluation of 4-O-alkylated 2-deoxy-2,3-didehydro-N-acetylneuraminic acid derivatives as inhibitors of human parainfluenza virus type-3 sialidase activity (2007)

Yes

Tindal, David James, Dyason, Jeffrey Clifford, Thomson, Robin Joy, Suzuki, Takashi, Ueyama, Hiroo, Kuwahara, Yohta, ...

Yes

Direct detection of ligand binding to Sepharose-immobilised protein using saturation transfer double difference (STDD) NMR spectroscopy (2007)

Haselhorst, Thomas Erwin, Munster-Kuhnel, Anja K., Oschlies, Melanie, Tiralongo, Giuseppe, Gerardy-Schahn, Rita, Von Itzstein, Mark

Yes

Targeting the expression of functional murine CMP-sialic acid transporter to the E. coli inner membrane (2007)

Maggioni, Andrea, Von Itzstein, Mark, Gerardy-Schahn, Rita, Tiralongo, Giuseppe

Synthesis and evaluation of galactofuranosyl N,N-dialkyl sulfenamides and sulfonamides as antimycobacterial agents (2007)

Owen, David James, Davis, Christopher, Hartnell, Regan David, Madge, Paul David, Thomson, Robin Joy, Chong, Andrew, ...

The war against influenza: discovery and development of sialidase inhibitors (2007)

Synthesis and evaluation of 4-O-alkylated 2-deoxy-2,3-didehydro-N-acetylneuraminic acid derivatives as inhibitors of human parainfluenza virus type-3 sialidase activity (2007)

Tindal, David James, Dyason, Jeffrey Clifford, Thomson, Robin Joy, Suzuki, Takashi, Ueyama, Hiroo, Kuwahara, Yohta, ...

Direct detection of ligand binding to Sepharose-immobilised protein using saturation transfer double difference (STDD) NMR spectroscopy (2007)

Haselhorst, Thomas Erwin, Munster-Kuhnel, Anja K., Oschlies, Melanie, Tiralongo, Giuseppe, Gerardy-Schahn, Rita, Von Itzstein, Mark

Towards the Synthesis of the Core Trisaccharide Region of Gangliosides (2007)

Szyczew, Alexander Jeffery, Kiefel, Milton, Von Itzstein, Mark

Cell surface carbohydrates (e.g. gangliosides) are known to be involved in several important biological processes, including cell regulation [1], cellular interactions [2] and cell proliferation [3]....

Anti-Influenza Drug Discovery: Are We Ready for the Next Pandemic? (2007)

Islam, Tasneem, Von Itzstein, Mark

Yes

Design and synthesis of sialidase inhibitors for influenza virus infections (2007)

Rich, Jamie, Gehle, Dietmar, Von Itzstein, Mark

Yes

Towards the Synthesis of the Core Trisaccharide Region of Gangliosides (2007)

Szyczew, Alexander Jeffery, Kiefel, Milton, Von Itzstein, Mark

Cell surface carbohydrates (e.g. gangliosides) are known to be involved in several important biological processes, including cell regulation [1], cellular interactions [2] and cell proliferation [3]....

Anti-Influenza Drug Discovery: Are We Ready for the Next Pandemic? (2007)

Islam, Tasneem, Von Itzstein, Mark

Design and synthesis of sialidase inhibitors for influenza virus infections (2007)

Rich, Jamie, Gehle, Dietmar, Von Itzstein, Mark

Insight into host cell carbohydrate-recognition by human and porcine rotavirus from crystal structures of the virion spike associated carbohydrate-binding domain (VP8*) (2007)

Blanchard, Helen, Yu, Xing, Coulson, Barbara S., Von Itzstein, Mark

Rotavirus infection leads to the death of half a million children annually. The exact specifics of interaction between rotavirus particles and host cells enabling invasion and infection have remained...

Optimisation of Glycan and Small Molecule Arrays for analysis of Campylobacter chemotaxis and adherence. (2007)

Day, Christopher, Tiralongo, Giuseppe, Hartnell, Regan David, Von Itzstein, Mark, Wilson, Jenny, Korolik, Victoria

Synthesis and Biological Evaluation of Galactofuranosyl Alkyl Thioglycosides as Inhibitors of Mycobacteria (2007)

Davis, Christopher, Hartnell, Regan David, Madge, Paul David, Owen, David James, Thomson, Robin Joy, Chong, Andrew, ...

As part of our research interest directed toward the development of antimycobacterial agents, we have investigated compounds based on galactofuranose (Galf), an essential cell wall component of...

Targeting the expression of functional murine CMP-sialic acid transporter to the E. coli inner membrane (2007)

Maggioni, Andrea, Von Itzstein, Mark, Gerardy-Schahn, Rita, Tiralongo, Giuseppe

The heterologous expression of functional mammalian integral membrane proteins still represents a significant hurdle towards their crystallization and structure elucidation. We have therefore...

Synthesis and evaluation of galactofuranosyl N,N-dialkyl sulfenamides and sulfonamides as antimycobacterial agents (2007)

Owen, David James, Davis, Christopher, Hartnell, Regan David, Madge, Paul David, Thomson, Robin Joy, Chong, Andrew, ...

The recent emergence of clinically oppressive superbugs, some with resistance to nearly all frontline drug therapies, has challenged our ability to combat such infectious organisms as Mycobacterium...

The war against influenza: discovery and development of sialidase inhibitors (2007)

Synthesis and evaluation of 4-O-alkylated 2-deoxy-2,3-didehydro-N-acetylneuraminic acid derivatives as inhibitors of human parainfluenza virus type-3 sialidase activity (2007)

The threat of a major human influenza pandemic, in particular from highly aggressive strains such as avian H5N1, has emphasized the need for therapeutic strategies to combat these pathogens. At...

Tindal, David James, Dyason, Jeffrey Clifford, Thomson, Robin Joy, Suzuki, Takashi, Ueyama, Hiroo, Kuwahara, Yohta, ...

The X-ray crystal structure of the paramyxoviral surface glycoprotein haemagglutinin-neuraminidase (HN) from Newcastle Disease virus was used as a template to design inhibitors of the HN from human...

Direct detection of ligand binding to Sepharose-immobilised protein using saturation transfer double difference (STDD) NMR spectroscopy (2007)

Haselhorst, Thomas Erwin, Munster-Kuhnel, Anja K., Oschlies, Melanie, Tiralongo, Giuseppe, Gerardy-Schahn, Rita, Von Itzstein, Mark

We report an easy and direct application of 'Saturation Transfer Double Difference' (STDD) NMR spectroscopy to identify ligands that bind to a Sepharose-immobilised target protein. The model protein,...

Towards the Synthesis of the Core Trisaccharide Region of Gangliosides (2007)

Szyczew, Alexander Jeffery, Kiefel, Milton, Von Itzstein, Mark

Cell surface carbohydrates (e.g. gangliosides) are known to be involved in several important biological processes, including cell regulation [1], cellular interactions [2] and cell proliferation [3]....

Anti-Influenza Drug Discovery: Are We Ready for the Next Pandemic? (2007)

Islam, Tasneem, Von Itzstein, Mark

Design and synthesis of sialidase inhibitors for influenza virus infections (2007)

Rich, Jamie, Gehle, Dietmar, Von Itzstein, Mark

STD NMR spectroscopy and molecular modeling investigation of the binding of N-acetylneuraminic acid derivatives to rhesus rotavirus VP8* core (2007)

Haselhorst, Thomas, Blanchard, Helen, Frank, Martin, Kraschnefski, Mark J., Kiefel, Milton J., Szyczew, Alex J., ...

The VP8* subunit of rotavirus spike protein VP4 contains a sialic acid (Sia)-binding domain important for host cell attachment and infection. In this study, the binding epitope of the...

Lysosomal Sialidase (Neurominidase-1) Is Targeted to Cell Surface in the Multiprotein Complex That Facilitates Elastic Fiber Assembly (2006)

Hinek, Alexsander, Pshezhetsky, Alexey V., Von Itzstein, Mark, Starcher, Barry

Yes

Functional expression of the CMP-sialic acid transporter in Escherichia coli and its identification as a simple mobile carrier (2006)

Tiralongo, Giuseppe, Ashikov, Angel, Routier, Françoise, Eckhardt, Matthias, Bakker, Hans, Gerardy-Schahn, Rita, ...

Yes

Molecular Cloning of the Leishmania major UDP-glucose Pyrophosphorylase, Functional Characterization, and Ligand Binding Analyses Using NMR Spectroscopy (2006)

Lamerz, Anne-Christin, Haselhorst, Thomas Erwin, Bergfeld, Ann, Von Itzstein, Mark, Gerardy-Schahn, Rita

Yes

Structural analysis of a designed inhibitor complexed with the hemagglutinin-neuraminidase of Newcastle disease virus (2006)

Ryan, Charlotte, Zaitsev, Viateslav, Tindal, David James, Dyason, Jeffrey Clifford, Thomson, Robin Joy, Alymova, Irina, ...

Yes

The synthesis and biological evaluation of lactose-based sialylmimetics as inhibitors of rotaviral infection (2006)

Liakatos, Angela, Kiefel, Milton, Fleming, Fiona, Coulson, Barbara, Von Itzstein, Mark

Yes

Modelling, synthesis and biological evaluation of novel glucoronide-based probes of Vibrio cholerae sialidase (2006)

Mann, Maretta, Thomson, Robin Joy, Dyason, Jeffrey Clifford, McAtamney, Sarah, Von Itzstein, Mark

Yes

Unsaturated N-acetyl-D-glycosaminuronic acid glycosides as inhibitors of influenza virus sialidase (2006)

Mann, Maretta, Islam, Tasneem, Dyason, Jeffrey Clifford, Florio, Pas, Trower, Carolyn J., Thomson, Robin Joy, ...

Yes

A 1H STD NMR spectroscopic investigation of sialylnucleoside mimetics as probes of CMP-Kdn synthetase (2006)

Haselhorst, Thomas Erwin, Oschlies, Melanie, Abu-Izneid, Tareq, Kiefel, Milton, Tiralongo, Giuseppe, Münster-Kühnel, Anja K., ...

Yes

STD NMR spectroscopy and molecular modeling investigation of the binding of N-acetylneuraminic acid derivatives to rhesus rotavirus VP8* core (2006)

Haselhorst, Thomas Erwin, Blanchard, Helen, Frank, Martin, Kraschnefski, Mark, Kiefel, Milton, Szyczew, Alexander Jeffery, ...

The VP8* subunit of rotavirus spike protein VP4 contains a sialic acid (Sia)-binding domain important for host cell attachment and infection. In this study, the binding epitope of the...

Endosialidase NF Appears To Bind PolySia DP5 in a Helical Conformation (2006)

Haselhorst, Thomas Erwin, Stummeyer, Katharina, Mühlenhoff, Martina, Schaper, Wiebke, Gerardy-Schahn, Rita, Von Itzstein, Mark

Yes

Economic and practical challenges to the formulation of vaccines against endemic infectious diseases such as malaria (2006)

Plebanski, Magdalena, Lopez, Ester, Proudfoot, Owen, Cook, Brian M., Von Itzstein, Mark, Coppel, Ross L.

Yes

Lysosomal Sialidase (Neurominidase-1) Is Targeted to Cell Surface in the Multiprotein Complex That Facilitates Elastic Fiber Assembly (2006)

Hinek, Alexsander, Pshezhetsky, Alexey V., Von Itzstein, Mark, Starcher, Barry

Yes

Functional expression of the CMP-sialic acid transporter in Escherichia coli and its identification as a simple mobile carrier (2006)

Tiralongo, Giuseppe, Ashikov, Angel, Routier, Françoise, Eckhardt, Matthias, Bakker, Hans, Gerardy-Schahn, Rita, ...

Yes

Molecular Cloning of the Leishmania major UDP-glucose Pyrophosphorylase, Functional Characterization, and Ligand Binding Analyses Using NMR Spectroscopy (2006)

Lamerz, Anne-Christin, Haselhorst, Thomas Erwin, Bergfeld, Ann, Von Itzstein, Mark, Gerardy-Schahn, Rita

Yes

Structural analysis of a designed inhibitor complexed with the hemagglutinin-neuraminidase of Newcastle disease virus (2006)

Ryan, Charlotte, Zaitsev, Viateslav, Tindal, David James, Dyason, Jeffrey Clifford, Thomson, Robin Joy, Alymova, Irina, ...

Yes

The synthesis and biological evaluation of lactose-based sialylmimetics as inhibitors of rotaviral infection (2006)

Liakatos, Angela, Kiefel, Milton, Fleming, Fiona, Coulson, Barbara, Von Itzstein, Mark

Yes

Modelling, synthesis and biological evaluation of novel glucoronide-based probes of Vibrio cholerae sialidase (2006)

Mann, Maretta, Thomson, Robin Joy, Dyason, Jeffrey Clifford, McAtamney, Sarah, Von Itzstein, Mark

Yes

Unsaturated N-acetyl-D-glycosaminuronic acid glycosides as inhibitors of influenza virus sialidase (2006)

Mann, Maretta, Islam, Tasneem, Dyason, Jeffrey Clifford, Florio, Pas, Trower, Carolyn J., Thomson, Robin Joy, ...

Yes

A 1H STD NMR spectroscopic investigation of sialylnucleoside mimetics as probes of CMP-Kdn synthetase (2006)

Haselhorst, Thomas Erwin, Oschlies, Melanie, Abu-Izneid, Tareq, Kiefel, Milton, Tiralongo, Giuseppe, Münster-Kühnel, Anja K., ...

Yes

STD NMR spectroscopy and molecular modeling investigation of the binding of N-acetylneuraminic acid derivatives to rhesus rotavirus VP8* core (2006)

Haselhorst, Thomas Erwin, Blanchard, Helen, Frank, Martin, Kraschnefski, Mark, Kiefel, Milton, Szyczew, Alexander Jeffery, ...

Yes

Endosialidase NF Appears To Bind PolySia DP5 in a Helical Conformation (2006)

Haselhorst, Thomas Erwin, Stummeyer, Katharina, Mühlenhoff, Martina, Schaper, Wiebke, Gerardy-Schahn, Rita, Von Itzstein, Mark

Yes

Economic and practical challenges to the formulation of vaccines against endemic infectious diseases such as malaria (2006)

Plebanski, Magdalena, Lopez, Ester, Proudfoot, Owen, Cook, Brian M., Von Itzstein, Mark, Coppel, Ross L.

Yes

Lysosomal Sialidase (Neurominidase-1) Is Targeted to Cell Surface in the Multiprotein Complex That Facilitates Elastic Fiber Assembly (2006)

Hinek, Alexsander, Pshezhetsky, Alexey V., Von Itzstein, Mark, Starcher, Barry

Functional expression of the CMP-sialic acid transporter in Escherichia coli and its identification as a simple mobile carrier (2006)

Tiralongo, Giuseppe, Ashikov, Angel, Routier, Françoise, Eckhardt, Matthias, Bakker, Hans, Gerardy-Schahn, Rita, ...

Molecular Cloning of the Leishmania major UDP-glucose Pyrophosphorylase, Functional Characterization, and Ligand Binding Analyses Using NMR Spectroscopy (2006)

Lamerz, Anne-Christin, Haselhorst, Thomas Erwin, Bergfeld, Ann, Von Itzstein, Mark, Gerardy-Schahn, Rita

Structural analysis of a designed inhibitor complexed with the hemagglutinin-neuraminidase of Newcastle disease virus (2006)

Ryan, Charlotte, Zaitsev, Viateslav, Tindal, David James, Dyason, Jeffrey Clifford, Thomson, Robin Joy, Alymova, Irina, ...

The synthesis and biological evaluation of lactose-based sialylmimetics as inhibitors of rotaviral infection (2006)

Liakatos, Angela, Kiefel, Milton, Fleming, Fiona, Coulson, Barbara, Von Itzstein, Mark

Modelling, synthesis and biological evaluation of novel glucoronide-based probes of Vibrio cholerae sialidase (2006)

Mann, Maretta, Thomson, Robin Joy, Dyason, Jeffrey Clifford, McAtamney, Sarah, Von Itzstein, Mark

Unsaturated N-acetyl-D-glycosaminuronic acid glycosides as inhibitors of influenza virus sialidase (2006)

Mann, Maretta, Islam, Tasneem, Dyason, Jeffrey Clifford, Florio, Pas, Trower, Carolyn J., Thomson, Robin Joy, ...

A 1H STD NMR spectroscopic investigation of sialylnucleoside mimetics as probes of CMP-Kdn synthetase (2006)

Haselhorst, Thomas Erwin, Oschlies, Melanie, Abu-Izneid, Tareq, Kiefel, Milton, Tiralongo, Giuseppe, Münster-Kühnel, Anja K., ...

STD NMR spectroscopy and molecular modeling investigation of the binding of N-acetylneuraminic acid derivatives to rhesus rotavirus VP8* core (2006)

Haselhorst, Thomas Erwin, Blanchard, Helen, Frank, Martin, Kraschnefski, Mark, Kiefel, Milton, Szyczew, Alexander Jeffery, ...

The VP8* subunit of rotavirus spike protein VP4 contains a sialic acid (Sia)-binding domain important for host cell attachment and infection. In this study, the binding epitope of the...

Endosialidase NF Appears To Bind PolySia DP5 in a Helical Conformation (2006)

Haselhorst, Thomas Erwin, Stummeyer, Katharina, Mühlenhoff, Martina, Schaper, Wiebke, Gerardy-Schahn, Rita, Von Itzstein, Mark

Economic and practical challenges to the formulation of vaccines against endemic infectious diseases such as malaria (2006)

Plebanski, Magdalena, Lopez, Ester, Proudfoot, Owen, Cook, Brian M., Von Itzstein, Mark, Coppel, Ross L.

Lysosomal Sialidase (Neurominidase-1) Is Targeted to Cell Surface in the Multiprotein Complex That Facilitates Elastic Fiber Assembly (2006)

Hinek, Alexsander, Pshezhetsky, Alexey V., Von Itzstein, Mark, Starcher, Barry

We have established previously that the 67-kDa elastin-binding protein (EBP), identical to the spliced variant of β-galactosidase, acts as a recyclable chaperone that facilitates secretion of...

Functional expression of the CMP-sialic acid transporter in Escherichia coli and its identification as a simple mobile carrier (2006)

Tiralongo, Giuseppe, Ashikov, Angel, Routier, Françoise, Eckhardt, Matthias, Bakker, Hans, Gerardy-Schahn, Rita, ...

The architectural conservation of nucleotide sugar transport proteins (NSTs) enabled the theoretical prediction of putative NSTs in diverse gene databases. In the human genome, 17 NST sequences have...

Molecular Cloning of the Leishmania major UDP-glucose Pyrophosphorylase, Functional Characterization, and Ligand Binding Analyses Using NMR Spectroscopy (2006)

Lamerz, Anne-Christin, Haselhorst, Thomas Erwin, Bergfeld, Ann, Von Itzstein, Mark, Gerardy-Schahn, Rita

The dense glycocalyx surrounding the protozoan parasite Leishmania is an essential virulence factor. It protects the parasite from hostile environments in the sandfly vector and mammalian host and...

Structural analysis of a designed inhibitor complexed with the hemagglutinin-neuraminidase of Newcastle disease virus (2006)

Ryan, Charlotte, Zaitsev, Viateslav, Tindal, David James, Dyason, Jeffrey Clifford, Thomson, Robin Joy, Alymova, Irina, ...

Viruses of the Paramyxoviridae family are the leading cause of respiratory disease in children. The human parainfluenza viruses (hPIV) are members of the Paramyxovirinae subfamily, which also...

The synthesis and biological evaluation of lactose-based sialylmimetics as inhibitors of rotaviral infection (2006)

Liakatos, Angela, Kiefel, Milton, Fleming, Fiona, Coulson, Barbara, Von Itzstein, Mark

Rotaviruses are the most significant cause of gastroenteritis in young children and are responsible for over 600,000 infant deaths annually. The rotaviral haemagglutinin protein (VP8*) of some...

Modelling, synthesis and biological evaluation of novel glucoronide-based probes of Vibrio cholerae sialidase (2006)

Mann, Maretta, Thomson, Robin Joy, Dyason, Jeffrey Clifford, McAtamney, Sarah, Von Itzstein, Mark

The development of sialidase inhibitors is an area of continuing interest due to their potential use as therapeutic agents to combat viral and bacterial infections. Herein, we report our studies...

Unsaturated N-acetyl-D-glycosaminuronic acid glycosides as inhibitors of influenza virus sialidase (2006)

Mann, Maretta, Islam, Tasneem, Dyason, Jeffrey Clifford, Florio, Pas, Trower, Carolyn J., Thomson, Robin Joy, ...

The threat of pandemic influenza is a significant concern of governments worldwide. There is a very limited and relatively expensive armament to tackle such a pandemic should it occur. This fact...

A 1H STD NMR spectroscopic investigation of sialylnucleoside mimetics as probes of CMP-Kdn synthetase (2006)

Haselhorst, Thomas Erwin, Oschlies, Melanie, Abu-Izneid, Tareq, Kiefel, Milton, Tiralongo, Giuseppe, Münster-Kühnel, Anja K., ...

CMP-Kdn synthetase catalyses the reaction of sialic acids (Sia) and CTP to the corresponding activated sugar nucleotide CMP-Sia and pyrophosphate PP i . Saturation Transfer Difference (STD) NMR...

STD NMR spectroscopy and molecular modeling investigation of the binding of N-acetylneuraminic acid derivatives to rhesus rotavirus VP8* core (2006)

Haselhorst, Thomas Erwin, Blanchard, Helen, Frank, Martin, Kraschnefski, Mark, Kiefel, Milton, Szyczew, Alexander Jeffery, ...

The VP8* subunit of rotavirus spike protein VP4 contains a sialic acid (Sia)-binding domain important for host cell attachment and infection. In this study, the binding epitope of the...

Endosialidase NF Appears To Bind PolySia DP5 in a Helical Conformation (2006)

Haselhorst, Thomas Erwin, Stummeyer, Katharina, Mühlenhoff, Martina, Schaper, Wiebke, Gerardy-Schahn, Rita, Von Itzstein, Mark

Phages infecting the polySia-encapsulated human pathogen E. coli K1 are equipped with capsule-degrading tail spikes known as endosialidases, which are the only identified enzymes that specifically...

Economic and practical challenges to the formulation of vaccines against endemic infectious diseases such as malaria (2006)

Plebanski, Magdalena, Lopez, Ester, Proudfoot, Owen, Cook, Brian M., Von Itzstein, Mark, Coppel, Ross L.

Herein, we analyze in general the current vaccine market and identify potential factors driving and modulating supply and demand for vaccines. An emphasis is placed on changes in regulation in the...

STD NMR spectroscopy and molecular modelling investigation of the binding of N-acetylneuraminic acid derivatives to rhesus rotavirus VP8* core (2006)

Haselhorst, Thomas, Blanchard, Helen, Frank, Martin, Kraschnefski, Mark J., Kiefel, Milton J., Szyczew, Alex J., ...

The VP8* subunit of rotavirus spike protein VP4 contains a sialic acid (Sia) binding domain important for host cell attachment and infection. In this study, the binding epitope of the...

STD NMR spectroscopy and molecular modelling investigation of the binding of N-acetylneuraminic acid derivatives to rhesus rotavirus VP8* core (2006)

Haselhorst, Thomas, Blanchard, Helen, Frank, Martin, Kraschnefski, Mark J., Kiefel, Milton J., Szyczew, Alex J., ...

The VP8* subunit of rotavirus spike protein VP4 contains a sialic acid (Sia) binding domain important for host cell attachment and infection. In this study, the binding epitope of the...

Sialic Acids and Sialylmimetics: Useful Chemical Probes of Sialic Acid-Recognizing Proteins (2005)

Wilson, Jenny, Kiefel, Milton, Von Itzstein, Mark, Kevin J. Yarema

Yes

Probing a CMP-Kdn synthetase by 1H, 31P, and STD NMR spectroscopy. (2005)

Haselhorst, Thomas Erwin, Muenster-Kuehnel, Anja K., Stolz, Anita, Oschiles, Melanie, Tiralongo, Giuseppe, Kitajima, Ken, ...

Yes

An approach towards the synthesis of sialyl nucleoside mimetics (2005)

Grice, Darren, Whelan, Catherine Ann, Tredwell, Greg, Von Itzstein, Mark, S.G. Davies, T. Hayashi

An approach towards the synthesis of novel sialyl nucleoside mimetics based on d-fructose is described. The synthesis of these mimetics is achieved in good overall yield in seven steps. The key...

An investigation of the activity of recomibant rat skeletal muscle cytosolic sialidase (2005)

Albouz-Abo, Samia, Turton, Richard, Wilson, Jenny, Von Itzstein, Mark, Gerrit Van Meer

Telomerase activation is regulated by the expression of human telomerase reverse transcriptase (hTERT) and is a key step in the development of human cancers. Interferon-³ (IFN-³) signaling induces...

Crystallisation and preliminary X-ray diffraction analysis of the sialic acid-binding domain (VP8*) of porcine rotavirus strain CRW-8 (2005)

Scott, Stacy, Holloway, Gavan, Coulson, Barbara S., Szyczew, Alexander Jeffery, Kiefel, Milton, Von Itzstein, Mark, ...

Rotavirus recognition and attachment to host cells involves interaction with the spike protein VP4 that projects outwards from the surface of the virus particle. An integral component of these spikes...

Towards the synthesis of aryl glucuronides as potential heparanase probes. An interesting outcome in the glycosidation of glucuronic acid with 4-hydroxycinnamic acid (2005)

Pearson, Andrew, Kiefel, Milton, Ferro, Vito, Von Itzstein, Mark

This work describes our preliminary efforts towards the development of aryl glucuronides as potential probes for heparanase. During the course of these initial investigations, attempted glycosidation...

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the VP8* carbohydrate-binding protein of the human rotavirus strain Wa. (2005)

Kraschnefski, Mark, Scott, Stacy, Holloway, Gavan, Coulson, Barbara S., Von Itzstein, Mark, Blanchard, Helen, ...

Rotaviruses exhibit host-specificity and the first crystallographic information on a rotavirus strain that infects humans is reported here. Recognition and attachment to host cells, leading to...

Functional expression of the CMP-sialic acid transporter in Escherichia coli (2005)

Tiralongo, Giuseppe, Maggioni, Andrea, Gerardy-Schahn, Rita, Von Itzstein, Mark

No

Sialic Acids and Sialylmimetics: Useful Chemical Probes of Sialic Acid-Recognizing Proteins (2005)

Wilson, Jenny, Kiefel, Milton, Von Itzstein, Mark

Yes

Probing a CMP-Kdn synthetase by 1H, 31P, and STD NMR spectroscopy. (2005)

Haselhorst, Thomas Erwin, Muenster-Kuehnel, Anja K., Stolz, Anita, Oschiles, Melanie, Tiralongo, Giuseppe, Kitajima, Ken, ...

Yes

An approach towards the synthesis of sialyl nucleoside mimetics (2005)

Grice, Darren, Whelan, Catherine Ann, Tredwell, Greg, Von Itzstein, Mark

An approach towards the synthesis of novel sialyl nucleoside mimetics based on d-fructose is described. The synthesis of these mimetics is achieved in good overall yield in seven steps. The key...

An investigation of the activity of recomibant rat skeletal muscle cytosolic sialidase (2005)

Albouz-Abo, Samia, Turton, Richard, Wilson, Jenny, Von Itzstein, Mark

Telomerase activation is regulated by the expression of human telomerase reverse transcriptase (hTERT) and is a key step in the development of human cancers. Interferon-³ (IFN-³) signaling induces...

Crystallisation and preliminary X-ray diffraction analysis of the sialic acid-binding domain (VP8*) of porcine rotavirus strain CRW-8 (2005)

Scott, Stacy, Holloway, Gavan, Coulson, Barbara S., Szyczew, Alexander Jeffery, Kiefel, Milton, Von Itzstein, Mark, ...

Rotavirus recognition and attachment to host cells involves interaction with the spike protein VP4 that projects outwards from the surface of the virus particle. An integral component of these spikes...

Towards the synthesis of aryl glucuronides as potential heparanase probes. An interesting outcome in the glycosidation of glucuronic acid with 4-hydroxycinnamic acid (2005)

Pearson, Andrew, Kiefel, Milton, Ferro, Vito, Von Itzstein, Mark

This work describes our preliminary efforts towards the development of aryl glucuronides as potential probes for heparanase. During the course of these initial investigations, attempted glycosidation...

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the VP8* carbohydrate-binding protein of the human rotavirus strain Wa. (2005)

Kraschnefski, Mark, Scott, Stacy, Holloway, Gavan, Coulson, Barbara S., Von Itzstein, Mark, Blanchard, Helen

Rotaviruses exhibit host-specificity and the first crystallographic information on a rotavirus strain that infects humans is reported here. Recognition and attachment to host cells, leading to...

Functional expression of the CMP-sialic acid transporter in Escherichia coli (2005)

Tiralongo, Giuseppe, Maggioni, Andrea, Gerardy-Schahn, Rita, Von Itzstein, Mark

No

Sialic Acids and Sialylmimetics: Useful Chemical Probes of Sialic Acid-Recognizing Proteins (2005)

Wilson, Jenny, Kiefel, Milton, Von Itzstein, Mark

Probing a CMP-Kdn synthetase by 1H, 31P, and STD NMR spectroscopy. (2005)

Haselhorst, Thomas Erwin, Muenster-Kuehnel, Anja K., Stolz, Anita, Oschiles, Melanie, Tiralongo, Giuseppe, Kitajima, Ken, ...

An approach towards the synthesis of sialyl nucleoside mimetics (2005)

Grice, Darren, Whelan, Catherine Ann, Tredwell, Greg, Von Itzstein, Mark

An approach towards the synthesis of novel sialyl nucleoside mimetics based on d-fructose is described. The synthesis of these mimetics is achieved in good overall yield in seven steps. The key...

An investigation of the activity of recomibant rat skeletal muscle cytosolic sialidase (2005)

Albouz-Abo, Samia, Turton, Richard, Wilson, Jenny, Von Itzstein, Mark

Telomerase activation is regulated by the expression of human telomerase reverse transcriptase (hTERT) and is a key step in the development of human cancers. Interferon-³ (IFN-³) signaling induces...

Crystallisation and preliminary X-ray diffraction analysis of the sialic acid-binding domain (VP8*) of porcine rotavirus strain CRW-8 (2005)

Scott, Stacy, Holloway, Gavan, Coulson, Barbara S., Szyczew, Alexander Jeffery, Kiefel, Milton, Von Itzstein, Mark, ...

Rotavirus recognition and attachment to host cells involves interaction with the spike protein VP4 that projects outwards from the surface of the virus particle. An integral component of these spikes...

Towards the synthesis of aryl glucuronides as potential heparanase probes. An interesting outcome in the glycosidation of glucuronic acid with 4-hydroxycinnamic acid (2005)

Pearson, Andrew, Kiefel, Milton, Ferro, Vito, Von Itzstein, Mark

This work describes our preliminary efforts towards the development of aryl glucuronides as potential probes for heparanase. During the course of these initial investigations, attempted glycosidation...

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the VP8* carbohydrate-binding protein of the human rotavirus strain Wa. (2005)

Kraschnefski, Mark, Scott, Stacy, Holloway, Gavan, Coulson, Barbara S., Von Itzstein, Mark, Blanchard, Helen

Rotaviruses exhibit host-specificity and the first crystallographic information on a rotavirus strain that infects humans is reported here. Recognition and attachment to host cells, leading to...

Functional expression of the CMP-sialic acid transporter in Escherichia coli (2005)

Tiralongo, Giuseppe, Maggioni, Andrea, Gerardy-Schahn, Rita, Von Itzstein, Mark

Sialic Acids and Sialylmimetics: Useful Chemical Probes of Sialic Acid-Recognizing Proteins (2005)

Wilson, Jenny, Kiefel, Milton, Von Itzstein, Mark

Probing a CMP-Kdn synthetase by 1H, 31P, and STD NMR spectroscopy. (2005)

Haselhorst, Thomas Erwin, Muenster-Kuehnel, Anja K., Stolz, Anita, Oschiles, Melanie, Tiralongo, Giuseppe, Kitajima, Ken, ...

CMP-Kdn synthetase catalyses the reaction of sialic acids (Sia) and cytidine-5′-triphosphate (CTP) to the corresponding activated sugar nucleotide CMP-Sia and pyrophosphate PPi. STD NMR experiments...

An approach towards the synthesis of sialyl nucleoside mimetics (2005)

Grice, Darren, Whelan, Catherine Ann, Tredwell, Greg, Von Itzstein, Mark

An approach towards the synthesis of novel sialyl nucleoside mimetics based on d-fructose is described. The synthesis of these mimetics is achieved in good overall yield in seven steps. The key...

An investigation of the activity of recomibant rat skeletal muscle cytosolic sialidase (2005)

Albouz-Abo, Samia, Turton, Richard, Wilson, Jenny, Von Itzstein, Mark

Telomerase activation is regulated by the expression of human telomerase reverse transcriptase (hTERT) and is a key step in the development of human cancers. Interferon-γ (IFN-γ) signaling induces...

Crystallisation and preliminary X-ray diffraction analysis of the sialic acid-binding domain (VP8*) of porcine rotavirus strain CRW-8 (2005)

Scott, Stacy, Holloway, Gavan, Coulson, Barbara S., Szyczew, Alexander Jeffery, Kiefel, Milton, Von Itzstein, Mark, ...

Rotavirus recognition and attachment to host cells involves interaction with the spike protein VP4 that projects outwards from the surface of the virus particle. An integral component of these spikes...

Towards the synthesis of aryl glucuronides as potential heparanase probes. An interesting outcome in the glycosidation of glucuronic acid with 4-hydroxycinnamic acid (2005)

Pearson, Andrew, Kiefel, Milton, Ferro, Vito, Von Itzstein, Mark

This work describes our preliminary efforts towards the development of aryl glucuronides as potential probes for heparanase. During the course of these initial investigations, attempted glycosidation...

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the VP8* carbohydrate-binding protein of the human rotavirus strain Wa. (2005)

Kraschnefski, Mark, Scott, Stacy, Holloway, Gavan, Coulson, Barbara S., Von Itzstein, Mark, Blanchard, Helen

Rotaviruses exhibit host-specificity and the first crystallographic information on a rotavirus strain that infects humans is reported here. Recognition and attachment to host cells, leading to...

Functional expression of the CMP-sialic acid transporter in Escherichia coli (2005)

Tiralongo, Giuseppe, Maggioni, Andrea, Gerardy-Schahn, Rita, Von Itzstein, Mark

Functional Expression of the CMP-Sialic Acid Transporter in Escherichia coli and its Identification as a Simple Mobile Carrier (2005)

Tiralongo, Joe, Ashikov, Angel, Routier, Françoise, Eckhardt, Matthias, Bakker, Hans, Gerardy-Schahn, Rita, ...

The architectural conservation of nucleotide sugar transport proteins (NSTs) enabled the theoretical prediction of putative NSTs in diverse gene databases. In the human genome 17 NST sequences have...

Crystallization and preliminary X-ray diffraction analysis of the sialic acid-binding domain (VP8*) of porcine rotavirus strain CRW-8 (2005)

SCOTT, STACEY, HOLLOWAY, GAVAN, COULSON, BARBARA SUE, SZYCZEW, ALEX, KIEFEL, MILTON, VON ITZSTEIN, MARK, ...

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the VP8* carbohydrate-binding protein of the human rotavirus strain Wa (2005)

KRASCHNEFSKI, MARK, SCOTT, STACEY, HOLLOWAY, GAVAN, COULSON, BARBARA SUE, VON ITZSTEIN, MARK, BLANCHARD, HELEN

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the VP8* carbohydrate-binding protein of the human rotavirus strain Wa (2005)

KRASCHNEFSKI, MARK, SCOTT, STACEY, HOLLOWAY, GAVAN, COULSON, BARBARA SUE, VON ITZSTEIN, MARK, BLANCHARD, HELEN

Crystallization and preliminary X-ray diffraction analysis of the sialic acid-binding domain (VP8*) of porcine rotavirus strain CRW-8 (2005)

SCOTT, STACEY, HOLLOWAY, GAVAN, COULSON, BARBARA SUE, SZYCZEW, ALEX, KIEFEL, MILTON, VON ITZSTEIN, MARK, ...

Sialidases: Targets for rational drug design (2004)

Dyason, Jeffrey Clifford, Wilson, Jenny, Von Itzstein, Mark

Yes

NMR spectroscopic and molecular modeling investigations of the trans-sialidase from Trypanosoma cruzi. (2004)

Haselhorst, Thomas Erwin, Wilson, Jenny, Liakatos, Angela, Kiefel, Milton, Dyason, Jeffrey Clifford, Von Itzstein, Mark, ...

Nuclear magnetic resonance (NMR) spectroscopy was used to investigate the transfer of sialic acid from a range of sialic acid donor compounds to acceptor molecules, catalyzed by Trypanosoma cruzi...

An efficient approach to N-acetyl-D-glucosaminuronic acid-based sialylmimetics as potential sialidase inhibitors (2004)

Mann, Maretta, Thomson, Robin Joy, Von Itzstein, Mark

A novel approach to the synthesis of ²-glycosides of N-acetyl-D-glucosaminuronic acid, in six steps and good overall yield from N-acetyl-D-glucosamine, has been developed. The key synthetic step was...

Sialic acid recognition by Vibrio cholerae neuraminidase (2004)

Moustafa, Ibrahim, Connaris, Helen, Taylor, Margaret, Zaitsev, Viateslav, Wilson, Jenny, Kiefel, Milton, ...

Yes

Second sialic acid binding site in Newcastle Disease virus hemagglutinin-neuraminidase: implications for fusion. (2004)

Zaitsev, Viatcheslav, Von Itzstein, Mark, Groves, Darrin, Kiefel, Milton, Takimoto, Toru, Portner, Allen, ...

Paramyxoviruses are the leading cause of respiratory disease in children. Several paramyxoviruses possess a surface glycoprotein, the hemagglutinin-neuraminidase (HN), that is involved in attachment...

Saturation transfer difference (STD) 1H-NMR experiments and in silico docking experiments to probe the binding of N-acetylneuraminic acid and derivatives to Vibrio cholerae sialidase. (2004)

Haselhorst, Thomas Erwin, Wilson, Jenny, Thomson, Robin Joy, McAtamney, Sarah, Menting, John G., Coppel, Ross L., ...

Yes

Sialidases: Targets for rational drug design (2004)

Dyason, Jeffrey Clifford, Wilson, Jenny, Von Itzstein, Mark

Yes

NMR spectroscopic and molecular modeling investigations of the trans-sialidase from Trypanosoma cruzi. (2004)

Haselhorst, Thomas Erwin, Wilson, Jenny, Liakatos, Angela, Kiefel, Milton, Dyason, Jeffrey Clifford, Von Itzstein, Mark

Nuclear magnetic resonance (NMR) spectroscopy was used to investigate the transfer of sialic acid from a range of sialic acid donor compounds to acceptor molecules, catalyzed by Trypanosoma cruzi...

An efficient approach to N-acetyl-D-glucosaminuronic acid-based sialylmimetics as potential sialidase inhibitors (2004)

Mann, Maretta, Thomson, Robin Joy, Von Itzstein, Mark

A novel approach to the synthesis of ²-glycosides of N-acetyl-D-glucosaminuronic acid, in six steps and good overall yield from N-acetyl-D-glucosamine, has been developed. The key synthetic step was...

Sialic acid recognition by Vibrio cholerae neuraminidase (2004)

Moustafa, Ibrahim, Connaris, Helen, Taylor, Margaret, Zaitsev, Viateslav, Wilson, Jenny, Kiefel, Milton, ...

Yes

Second sialic acid binding site in Newcastle Disease virus hemagglutinin-neuraminidase: implications for fusion. (2004)

Zaitsev, Viatcheslav, Von Itzstein, Mark, Groves, Darrin, Kiefel, Milton, Takimoto, Toru, Portner, Allen, ...

Paramyxoviruses are the leading cause of respiratory disease in children. Several paramyxoviruses possess a surface glycoprotein, the hemagglutinin-neuraminidase (HN), that is involved in attachment...

Saturation transfer difference (STD) 1H-NMR experiments and in silico docking experiments to probe the binding of N-acetylneuraminic acid and derivatives to Vibrio cholerae sialidase. (2004)

Haselhorst, Thomas Erwin, Wilson, Jenny, Thomson, Robin Joy, McAtamney, Sarah, Menting, John G., Coppel, Ross L., ...

Yes

Sialidases: Targets for rational drug design (2004)

Dyason, Jeffrey Clifford, Wilson, Jenny, Von Itzstein, Mark

NMR spectroscopic and molecular modeling investigations of the trans-sialidase from Trypanosoma cruzi. (2004)

Haselhorst, Thomas Erwin, Wilson, Jenny, Liakatos, Angela, Kiefel, Milton, Dyason, Jeffrey Clifford, Von Itzstein, Mark

Nuclear magnetic resonance (NMR) spectroscopy was used to investigate the transfer of sialic acid from a range of sialic acid donor compounds to acceptor molecules, catalyzed by Trypanosoma cruzi...

An efficient approach to N-acetyl-D-glucosaminuronic acid-based sialylmimetics as potential sialidase inhibitors (2004)

Mann, Maretta, Thomson, Robin Joy, Von Itzstein, Mark

A novel approach to the synthesis of ²-glycosides of N-acetyl-D-glucosaminuronic acid, in six steps and good overall yield from N-acetyl-D-glucosamine, has been developed. The key synthetic step was...

Sialic acid recognition by Vibrio cholerae neuraminidase (2004)

Moustafa, Ibrahim, Connaris, Helen, Taylor, Margaret, Zaitsev, Viateslav, Wilson, Jenny, Kiefel, Milton, ...

Second sialic acid binding site in Newcastle Disease virus hemagglutinin-neuraminidase: implications for fusion. (2004)

Zaitsev, Viatcheslav, Von Itzstein, Mark, Groves, Darrin, Kiefel, Milton, Takimoto, Toru, Portner, Allen, ...

Paramyxoviruses are the leading cause of respiratory disease in children. Several paramyxoviruses possess a surface glycoprotein, the hemagglutinin-neuraminidase (HN), that is involved in attachment...

Saturation transfer difference (STD) 1H-NMR experiments and in silico docking experiments to probe the binding of N-acetylneuraminic acid and derivatives to Vibrio cholerae sialidase. (2004)

Haselhorst, Thomas Erwin, Wilson, Jenny, Thomson, Robin Joy, McAtamney, Sarah, Menting, John G., Coppel, Ross L., ...

Sialidases: Targets for rational drug design (2004)

Dyason, Jeffrey Clifford, Wilson, Jenny, Von Itzstein, Mark

NMR spectroscopic and molecular modeling investigations of the trans-sialidase from Trypanosoma cruzi. (2004)

Haselhorst, Thomas Erwin, Wilson, Jenny, Liakatos, Angela, Kiefel, Milton, Dyason, Jeffrey Clifford, Von Itzstein, Mark

Nuclear magnetic resonance (NMR) spectroscopy was used to investigate the transfer of sialic acid from a range of sialic acid donor compounds to acceptor molecules, catalyzed by Trypanosoma cruzi...

An efficient approach to N-acetyl-D-glucosaminuronic acid-based sialylmimetics as potential sialidase inhibitors (2004)

Mann, Maretta, Thomson, Robin Joy, Von Itzstein, Mark

A novel approach to the synthesis of β-glycosides of N-acetyl-D-glucosaminuronic acid, in six steps and good overall yield from N-acetyl-D-glucosamine, has been developed. The key synthetic step was...

Sialic acid recognition by Vibrio cholerae neuraminidase (2004)

Moustafa, Ibrahim, Connaris, Helen, Taylor, Margaret, Zaitsev, Viateslav, Wilson, Jenny, Kiefel, Milton, ...

Vibrio cholerae neuraminidase (VCNA) plays a significant role in the pathogenesis of cholera by removing sialic acid from higher order gangliosides to unmask GM1, the receptor for cholera toxin. We...

Second sialic acid binding site in Newcastle Disease virus hemagglutinin-neuraminidase: implications for fusion. (2004)

Zaitsev, Viatcheslav, Von Itzstein, Mark, Groves, Darrin, Kiefel, Milton, Takimoto, Toru, Portner, Allen, ...

Paramyxoviruses are the leading cause of respiratory disease in children. Several paramyxoviruses possess a surface glycoprotein, the hemagglutinin-neuraminidase (HN), that is involved in attachment...

Saturation transfer difference (STD) 1H-NMR experiments and in silico docking experiments to probe the binding of N-acetylneuraminic acid and derivatives to Vibrio cholerae sialidase. (2004)

Haselhorst, Thomas Erwin, Wilson, Jenny, Thomson, Robin Joy, McAtamney, Sarah, Menting, John G., Coppel, Ross L., ...

Saturation transfer difference (STD) 1H NMR experiments were used to probe the epitope binding characteristics of the sialidase [EC 3.2.1.18] from the bacterium Vibrio cholerae, the causative agent...

NMR spectroscopic and molecular modelling investigations of the trans-sialidase from Trypanosoma cruzi (2004)

Haselhorst, Thomas, Wilson, Jennifer C., Liakatos, Angela, Kiefel, Milton J., Dyason, Jeffrey C., Von Itzstein, Mark

NMR spectroscopy was used to investigate the transfer of sialic acid from a range of sialic acid donor compounds to acceptor molecules, catalysed by Trypanosoma cruzi trans-sialidase (TcTS). We...

NMR spectroscopic and molecular modeling investigations of the trans-sialidase from Trypanosoma cruzi (2004)

Haselhorst, Thomas, Wilson, Jennifer C., Liakatos, Angela, Kiefel, Milton J., Dyason, Jeffrey C., Von Itzstein, Mark

Nuclear magnetic resonance (NMR) spectroscopy was used to investigate the transfer of sialic acid from a range of sialic acid donor compounds to acceptor molecules, catalyzed by Trypanosoma cruzi...

NMR spectroscopic and molecular modelling investigations of the trans-sialidase from Trypanosoma cruzi (2004)

Haselhorst, Thomas, Wilson, Jennifer C., Liakatos, Angela, Kiefel, Milton J., Dyason, Jeffrey C., Von Itzstein, Mark

NMR spectroscopy was used to investigate the transfer of sialic acid from a range of sialic acid donor compounds to acceptor molecules, catalysed by Trypanosoma cruzi trans-sialidase (TcTS). We...

Carbohydrates as Inhibitors of Rotaviral Infection (2003)

N-Acetylneuraminic acid derivatives and mimetics as anti-influenza agents (2003)

Yes

Thomson, Robin Joy, Von Itzstein, Mark, Chi-Huey Wong

Yes

Synthesis of lactose-based S-linked sialylmimetics of alpha(2,3)-sialosides. (2003)

Liakatos, Angela, Kiefel, Milton, Von Itzstein, Mark, Amos B Smith, Carol Carr

Yes

Recent strategies in the search for new anti-influenza therapies (2003)

Wilson, Jenny, Von Itzstein, Mark, Francis J Castellino

Yes

Carbohydrates as Inhibitors of Rotaviral Infection (2003)

N-Acetylneuraminic acid derivatives and mimetics as anti-influenza agents (2003)

Yes

Thomson, Robin Joy, Von Itzstein, Mark

Yes

Synthesis of lactose-based S-linked sialylmimetics of alpha(2,3)-sialosides. (2003)

Liakatos, Angela, Kiefel, Milton, Von Itzstein, Mark

Yes

Recent strategies in the search for new anti-influenza therapies (2003)

Wilson, Jenny, Von Itzstein, Mark

Yes

Carbohydrates as Inhibitors of Rotaviral Infection (2003)

N-Acetylneuraminic acid derivatives and mimetics as anti-influenza agents (2003)

Thomson, Robin Joy, Von Itzstein, Mark

Synthesis of lactose-based S-linked sialylmimetics of alpha(2,3)-sialosides. (2003)

Liakatos, Angela, Kiefel, Milton, Von Itzstein, Mark

Recent strategies in the search for new anti-influenza therapies (2003)

Wilson, Jenny, Von Itzstein, Mark

Carbohydrates as Inhibitors of Rotaviral Infection (2003)

N-Acetylneuraminic acid derivatives and mimetics as anti-influenza agents (2003)

Thomson, Robin Joy, Von Itzstein, Mark

Synthesis of lactose-based S-linked sialylmimetics of alpha(2,3)-sialosides. (2003)

Liakatos, Angela, Kiefel, Milton, Von Itzstein, Mark

A new approach toward the synthesis of lactose-based S-linked sialylmimetics of α(2,3)-linked sialosides is described. These compounds, represented by the general structure 3, were prepared from...

Recent strategies in the search for new anti-influenza therapies (2003)

Wilson, Jenny, Von Itzstein, Mark

Influenza is a highly contagious, acute upper respiratory tract disease caused by influenza virus, a member of the Orthomyxoviridae family. The viral particles have two surface antigens,...

Rapid, clean, and mild O-acetylation of alcohols and carbohydrates in an ionic liquid (2002)

Forsyth, Stewart A, MacFarlane, Douglas R, Thomson, Robin Joy, Von Itzstein, Mark

Archetypal O-acetylation reactions of alcohols and carbohydrates proceed rapidly in high yield under mild conditions in a dicyanamide based ionic liquid, that is not only an effective solvent but...

A convenient synthesis of C-galactofuranosylic compounds (C-galactofuranosides) (2002)

Owen, David J., Thomson, Robin Joy, Von Itzstein, Mark

Galactofuranose sugar units are essential for the production of the cell coat of many pathogenic microorganisms. This sugar is not found in mammals, and so compounds that may interfere with the...

Recent advances in the synthesis of sialic acid derivatives and sialylmimetics as biological probes (2002)

Rapid, clean, and mild O-acetylation of alcohols and carbohydrates in an ionic liquid (2002)

Yes

Forsyth, Stewart A, MacFarlane, Douglas R, Thomson, Robin Joy, Von Itzstein, Mark

Archetypal O-acetylation reactions of alcohols and carbohydrates proceed rapidly in high yield under mild conditions in a dicyanamide based ionic liquid, that is not only an effective solvent but...

A convenient synthesis of C-galactofuranosylic compounds (C-galactofuranosides) (2002)

Owen, David J., Thomson, Robin Joy, Von Itzstein, Mark

Galactofuranose sugar units are essential for the production of the cell coat of many pathogenic microorganisms. This sugar is not found in mammals, and so compounds that may interfere with the...

Recent advances in the synthesis of sialic acid derivatives and sialylmimetics as biological probes (2002)

Rapid, clean, and mild O-acetylation of alcohols and carbohydrates in an ionic liquid (2002)

Yes

Forsyth, Stewart A, MacFarlane, Douglas R, Thomson, Robin Joy, Von Itzstein, Mark

Archetypal O-acetylation reactions of alcohols and carbohydrates proceed rapidly in high yield under mild conditions in a dicyanamide based ionic liquid, that is not only an effective solvent but...

A convenient synthesis of C-galactofuranosylic compounds (C-galactofuranosides) (2002)

Owen, David J., Thomson, Robin Joy, Von Itzstein, Mark

Galactofuranose sugar units are essential for the production of the cell coat of many pathogenic microorganisms. This sugar is not found in mammals, and so compounds that may interfere with the...

Recent advances in the synthesis of sialic acid derivatives and sialylmimetics as biological probes (2002)

Rapid, clean, and mild O-acetylation of alcohols and carbohydrates in an ionic liquid (2002)

Forsyth, Stewart A, MacFarlane, Douglas R, Thomson, Robin Joy, Von Itzstein, Mark

Archetypal O-acetylation reactions of alcohols and carbohydrates proceed rapidly in high yield under mild conditions in a dicyanamide based ionic liquid, that is not only an effective solvent but...

A convenient synthesis of C-galactofuranosylic compounds (C-galactofuranosides) (2002)

Owen, David J., Thomson, Robin Joy, Von Itzstein, Mark

Galactofuranose sugar units are essential for the production of the cell coat of many pathogenic microorganisms. This sugar is not found in mammals, and so compounds that may interfere with the...

Recent advances in the synthesis of sialic acid derivatives and sialylmimetics as biological probes (2002)

Bromohydroxylation of glycals - an investigation into the reaction of some 4-N-acylated derivatives of methyl 5-acetamido-7, 8, 9 tri-O acetyl-2, 6-anhydro-3, 4, 5-trideoxy-D-glycero-D-galacto-non-2-enonate and its 4-epimer (2001)

Von Itzstein, Mark, Donald Kiely

Yes

Synthesis of C-3 nitrogen-containg derivatives of N-acetyl-a,b-D-mannosamine as substrates for N-acetylneuraminic acid aldolase (2001)

Kok, Gaik B, Campbell, Michael, Mackey, Brendan L, Von Itzstein, Mark

The synthesis of 3-azido-3-deoxy, 3-amino-3-deoxy and 3-N-tert-butyloxycarbonyl-3-deoxy derivatives of 2-acetamido-2-deoxy-±,²--mannose (N-acetyl-±,²--mannosamine, ManNAc), is presented. The...

Synthesis of Novel Sialylmimetics as Biological Probes (2001)

Bradley, Susan J, Fazli, Ashmath, Kiefel, Milton, Von Itzstein, Mark

Glycomimetics are increasingly being recognised as powerful tools in the search for novel compounds that possess useful biological properties. This paper describes our preliminary efforts towards the...

The synthesis of C-9 modified derivatives of the a-methyl glycoside of KDN Methyl ester (2001)

The synthesis of some C-4 and C-9 substituted derivatives of KDN2EN methyl ester (2001)

Yes

Norton, Adele K, Kok, Gaik B, Von Itzstein, Mark, Donald Kiely

Yes

Synthesis and biological evaluation of sialylmimetics as rotavirus inhibitors (2001)

Fazli, Ashmath, Bradley, Susan J, Kiefel, Milton, Jolly, Clare, Holmes, Ian H, Von Itzstein, Mark

Yes

Anti-Influenza virus drug design: Sialidase inhibitors (2001)

A unique sialidase that cleaves the Neu5Gc alpha 2 -> 5-O(glycolyl)Neu5Gc linkage: Comparison of its specificity with that of three microbial sialidases toward four sialic acid dimers (2001)

Yes

Inoue, Sadako, Lin, Shu-Ling, Inoue, Yasuo, Groves, Darrin R, Thomson, Robin Joy, Von Itzstein, Mark, ...

Yes

Bromohydroxylation of glycals - an investigation into the reaction of some 4-N-acylated derivatives of methyl 5-acetamido-7, 8, 9 tri-O acetyl-2, 6-anhydro-3, 4, 5-trideoxy-D-glycero-D-galacto-non-2-enonate and its 4-epimer (2001)

Synthesis of C-3 nitrogen-containg derivatives of N-acetyl-a,b-D-mannosamine as substrates for N-acetylneuraminic acid aldolase (2001)

Yes

Kok, Gaik B, Campbell, Michael, Mackey, Brendan L, Von Itzstein, Mark

The synthesis of 3-azido-3-deoxy, 3-amino-3-deoxy and 3-N-tert-butyloxycarbonyl-3-deoxy derivatives of 2-acetamido-2-deoxy-±,²--mannose (N-acetyl-±,²--mannosamine, ManNAc), is presented. The...

Synthesis of Novel Sialylmimetics as Biological Probes (2001)

Bradley, Susan J, Fazli, Ashmath, Kiefel, Milton, Von Itzstein, Mark

Glycomimetics are increasingly being recognised as powerful tools in the search for novel compounds that possess useful biological properties. This paper describes our preliminary efforts towards the...

The synthesis of C-9 modified derivatives of the a-methyl glycoside of KDN Methyl ester (2001)

The synthesis of some C-4 and C-9 substituted derivatives of KDN2EN methyl ester (2001)

Yes

Synthesis and biological evaluation of sialylmimetics as rotavirus inhibitors (2001)

Yes

Fazli, Ashmath, Bradley, Susan J, Kiefel, Milton, Jolly, Clare, Holmes, Ian H, Von Itzstein, Mark

Yes

Anti-Influenza virus drug design: Sialidase inhibitors (2001)

A unique sialidase that cleaves the Neu5Gc alpha 2 -> 5-O(glycolyl)Neu5Gc linkage: Comparison of its specificity with that of three microbial sialidases toward four sialic acid dimers (2001)

Yes

Inoue, Sadako, Lin, Shu-Ling, Inoue, Yasuo, Groves, Darrin R, Thomson, Robin Joy, Von Itzstein, Mark, ...

Yes

Bromohydroxylation of glycals - an investigation into the reaction of some 4-N-acylated derivatives of methyl 5-acetamido-7, 8, 9 tri-O acetyl-2, 6-anhydro-3, 4, 5-trideoxy-D-glycero-D-galacto-non-2-enonate and its 4-epimer (2001)

Synthesis of C-3 nitrogen-containg derivatives of N-acetyl-a,b-D-mannosamine as substrates for N-acetylneuraminic acid aldolase (2001)

Kok, Gaik B, Campbell, Michael, Mackey, Brendan L, Von Itzstein, Mark

The synthesis of 3-azido-3-deoxy, 3-amino-3-deoxy and 3-N-tert-butyloxycarbonyl-3-deoxy derivatives of 2-acetamido-2-deoxy-±,²--mannose (N-acetyl-±,²--mannosamine, ManNAc), is presented. The...

Synthesis of Novel Sialylmimetics as Biological Probes (2001)

Bradley, Susan J, Fazli, Ashmath, Kiefel, Milton, Von Itzstein, Mark

Glycomimetics are increasingly being recognised as powerful tools in the search for novel compounds that possess useful biological properties. This paper describes our preliminary efforts towards the...

The synthesis of C-9 modified derivatives of the a-methyl glycoside of KDN Methyl ester (2001)

The synthesis of some C-4 and C-9 substituted derivatives of KDN2EN methyl ester (2001)

Synthesis and biological evaluation of sialylmimetics as rotavirus inhibitors (2001)

Fazli, Ashmath, Bradley, Susan J, Kiefel, Milton, Jolly, Clare, Holmes, Ian H, Von Itzstein, Mark

Anti-Influenza virus drug design: Sialidase inhibitors (2001)

A unique sialidase that cleaves the Neu5Gc alpha 2 -> 5-O(glycolyl)Neu5Gc linkage: Comparison of its specificity with that of three microbial sialidases toward four sialic acid dimers (2001)

Inoue, Sadako, Lin, Shu-Ling, Inoue, Yasuo, Groves, Darrin R, Thomson, Robin Joy, Von Itzstein, Mark, ...

Bromohydroxylation of glycals - an investigation into the reaction of some 4-N-acylated derivatives of methyl 5-acetamido-7, 8, 9 tri-O acetyl-2, 6-anhydro-3, 4, 5-trideoxy-D-glycero-D-galacto-non-2-enonate and its 4-epimer (2001)

Synthesis of C-3 nitrogen-containg derivatives of N-acetyl-a,b-D-mannosamine as substrates for N-acetylneuraminic acid aldolase (2001)

Kok, Gaik B, Campbell, Michael, Mackey, Brendan L, Von Itzstein, Mark

The synthesis of 3-azido-3-deoxy, 3-amino-3-deoxy and 3-N-tert-butyloxycarbonyl-3-deoxy derivatives of 2-acetamido-2-deoxy-±,²--mannose (N-acetyl-±,²--mannosamine, ManNAc), is presented. The...

Synthesis of Novel Sialylmimetics as Biological Probes (2001)

Bradley, Susan J, Fazli, Ashmath, Kiefel, Milton, Von Itzstein, Mark

Glycomimetics are increasingly being recognised as powerful tools in the search for novel compounds that possess useful biological properties. This paper describes our preliminary efforts towards the...

The synthesis of C-9 modified derivatives of the a-methyl glycoside of KDN Methyl ester (2001)

The synthesis of some C-4 and C-9 substituted derivatives of KDN2EN methyl ester (2001)

Synthesis and biological evaluation of sialylmimetics as rotavirus inhibitors (2001)

Fazli, Ashmath, Bradley, Susan J, Kiefel, Milton, Jolly, Clare, Holmes, Ian H, Von Itzstein, Mark

Anti-Influenza virus drug design: Sialidase inhibitors (2001)

A unique sialidase that cleaves the Neu5Gc alpha 2 -> 5-O(glycolyl)Neu5Gc linkage: Comparison of its specificity with that of three microbial sialidases toward four sialic acid dimers (2001)

Inoue, Sadako, Lin, Shu-Ling, Inoue, Yasuo, Groves, Darrin R, Thomson, Robin Joy, Von Itzstein, Mark, ...

Analysis of inhibitor binding in influenza virus neuraminidase (2001)

Smith, Brian J., Colman, Peter M., Von Itzstein, Mark, Danylec, Basil, Varghese, Joseph N.

2,3-didehydro-2-deoxy-N-acetylneuraminic acid (DANA) is a transition state analog inhibitor of influenza virus neuraminidase (NA). Replacement of the hydroxyl at the C9 position in DANA and...

Rapid access to uronic acid-based mimetics of Kdn2en from D-glucurono-6,3-lactone (2000)

Von Itzstein, Mark, Florio, Pas., Thomson, Robin, Thomson,Robin J.

In order to prepare 3-aminopropyl glycosides of Neu5Ac-±-(2 62)-lactosamine trisaccharide 1, and its N-glycolyl containing analogue Neu5Gc-±-(2 62)-lactosamine 2, a series of lactosamine acceptors...

A one-pot synthesis of novel N,N-dialkyl-S-glycosylsulfenamides (2000)

A high-throughput assay for rat liver golgi and Saccharomyces cerevisae-expressed murine CMP-N-acetylneuraminic acid transport proteins (2000)

An efficient new entry into N,N-dialkyl-S-glycosylsulfenamides is reported. The reaction of bis-activated alkyl halides in the presence of a secondary amine base with glycosylic S-acetyl derivatives...

Von Itzstein, Mark, Tiralongo, Joe., Abo, Samia., Danylec, Basil., Gerardy-Schahn, Rita.

Yes

Preliminary 1H NMR investigation of sialic acid transfer by the trans-sialidase from Trypanosoma cruzi (2000)

Wilson, Jenny, Kiefel, Milton, Von Itzstein, Mark, Albouz-Abo, Samia.

1H NMR spectroscopy has been used to investigate the transfer of sialic acid from sialic acid donor molecules to acceptor molecules using the trans-sialidase from Typanosoma cruzi. It is clearly...

The synthesis of biotinylated carbohydrates as probes for carbohydrate-recognizing proteins (2000)

Kiefel, Milton, Von Itzstein, Mark, Angus, Donald I.

The intimate involvement of carbohydrate protein interactions in a number of important biological processes has prompted several research efforts towards developing new methods of investigating these...

Rapid access to uronic acid-based mimetics of Kdn2en from D-glucurono-6,3-lactone (2000)

Von Itzstein, Mark, Florio, Pas., Thomson, Robin, Thomson,Robin J.

In order to prepare 3-aminopropyl glycosides of Neu5Ac-±-(2 62)-lactosamine trisaccharide 1, and its N-glycolyl containing analogue Neu5Gc-±-(2 62)-lactosamine 2, a series of lactosamine acceptors...

A one-pot synthesis of novel N,N-dialkyl-S-glycosylsulfenamides (2000)

A high-throughput assay for rat liver golgi and Saccharomyces cerevisae-expressed murine CMP-N-acetylneuraminic acid transport proteins (2000)

An efficient new entry into N,N-dialkyl-S-glycosylsulfenamides is reported. The reaction of bis-activated alkyl halides in the presence of a secondary amine base with glycosylic S-acetyl derivatives...

Von Itzstein, Mark, Tiralongo, Joe., Abo, Samia., Danylec, Basil., Gerardy-Schahn, Rita.

Yes

Preliminary 1H NMR investigation of sialic acid transfer by the trans-sialidase from Trypanosoma cruzi (2000)

Wilson, Jenny, Kiefel, Milton, Von Itzstein, Mark, Albouz-Abo, Samia.

1H NMR spectroscopy has been used to investigate the transfer of sialic acid from sialic acid donor molecules to acceptor molecules using the trans-sialidase from Typanosoma cruzi. It is clearly...

The synthesis of biotinylated carbohydrates as probes for carbohydrate-recognizing proteins (2000)

Kiefel, Milton, Von Itzstein, Mark, Angus, Donald I.

The intimate involvement of carbohydrate protein interactions in a number of important biological processes has prompted several research efforts towards developing new methods of investigating these...

Rapid access to uronic acid-based mimetics of Kdn2en from D-glucurono-6,3-lactone (2000)

Von Itzstein, Mark, Florio, Pas., Thomson, Robin, Thomson,Robin J.

In order to prepare 3-aminopropyl glycosides of Neu5Ac-±-(2 62)-lactosamine trisaccharide 1, and its N-glycolyl containing analogue Neu5Gc-±-(2 62)-lactosamine 2, a series of lactosamine acceptors...

A one-pot synthesis of novel N,N-dialkyl-S-glycosylsulfenamides (2000)

A high-throughput assay for rat liver golgi and Saccharomyces cerevisae-expressed murine CMP-N-acetylneuraminic acid transport proteins (2000)

An efficient new entry into N,N-dialkyl-S-glycosylsulfenamides is reported. The reaction of bis-activated alkyl halides in the presence of a secondary amine base with glycosylic S-acetyl derivatives...

Von Itzstein, Mark, Tiralongo, Joe., Abo, Samia., Danylec, Basil., Gerardy-Schahn, Rita.

Preliminary 1H NMR investigation of sialic acid transfer by the trans-sialidase from Trypanosoma cruzi (2000)

Wilson, Jenny, Kiefel, Milton, Von Itzstein, Mark, Albouz-Abo, Samia.

1H NMR spectroscopy has been used to investigate the transfer of sialic acid from sialic acid donor molecules to acceptor molecules using the trans-sialidase from Typanosoma cruzi. It is clearly...

The synthesis of biotinylated carbohydrates as probes for carbohydrate-recognizing proteins (2000)

Kiefel, Milton, Von Itzstein, Mark, Angus, Donald I.

The intimate involvement of carbohydrate protein interactions in a number of important biological processes has prompted several research efforts towards developing new methods of investigating these...

The design, synthesis and biological evaluation of neuraminic acid-based probes of Vibrio cholerae sialidase (2000)

Wilson, Jennifer C., Thomson, Robin J., Dyason, Jeffrey C., Florio, Pas, Quelch, Kaylene J., Abo, Samia, ...

A molecular modelling study using the program GRID has been used to investigate the structural requirements of a potential inhibitor binding to Vibrio cholerae sialidase. A number of favourable...

The design, synthesis and biological evaluation of neuraminic acid-based probes of Vibrio cholerae sialidase (2000)

Wilson, Jennifer C., Thomson, Robin J., Dyason, Jeffrey C., Florio, Pas, Quelch, Kaylene J., Abo, Samia, ...

A molecular modelling study using the program GRID has been used to investigate the structural requirements of a potential inhibitor binding to Vibrio cholerae sialidase. A number of favourable...

Rapid access to uronic acid-based mimetics of Kdn2en from D-glucurono-6,3-lactone (2000)

Von Itzstein, Mark, Florio, Pas., Thomson, Robin, Thomson,Robin J.

In order to prepare 3-aminopropyl glycosides of Neu5Ac-±-(2 62)-lactosamine trisaccharide 1, and its N-glycolyl containing analogue Neu5Gc-±-(2 62)-lactosamine 2, a series of lactosamine acceptors...

A one-pot synthesis of novel N,N-dialkyl-S-glycosylsulfenamides (2000)