A Screen for Genes That Interact With the Drosophila Pair-Rule Segmentation Gene fushi tarazu
Kankel, Mark W., Duncan, Dianne M., Duncan, Ian
The pair-rule gene fushi tarazu (ftz) of Drosophila is expressed at the blastoderm stage in seven stripes that serve to define the even-numbered parasegments. ftz encodes a DNA-binding homeodomain...
Arabidopsis MET1 cytosine methyltransferase mutants.
Kankel, Mark W, Ramsey, Douglas E, Stokes, Trevor L, Flowers, Susan K, Haag, Jeremy R, Jeddeloh, Jeffrey A, ...
We describe the isolation and characterization of two missense mutations in the cytosine-DNA-methyltransferase gene, MET1, from the flowering plant Arabidopsis thaliana. Both missense mutations,...
A Screen for Genes That Interact With the Drosophila Pair-Rule Segmentation Gene fushi tarazu
Kankel, Mark W., Duncan, Dianne M., Duncan, Ian
The pair-rule gene fushi tarazu (ftz) of Drosophila is expressed at the blastoderm stage in seven stripes that serve to define the even-numbered parasegments. ftz encodes a DNA-binding homeodomain...
Arabidopsis MET1 cytosine methyltransferase mutants.
Kankel, Mark W, Ramsey, Douglas E, Stokes, Trevor L, Flowers, Susan K, Haag, Jeremy R, Jeddeloh, Jeffrey A, ...
We describe the isolation and characterization of two missense mutations in the cytosine-DNA-methyltransferase gene, MET1, from the flowering plant Arabidopsis thaliana. Both missense mutations,...
Investigating the Genetic Circuitry of Mastermind in Drosophila, a Notch Signal Effector
Kankel, Mark W., Hurlbut, Gregory D., Upadhyay, Geeta, Yajnik, Vijay, Yedvobnick, Barry, Artavanis-Tsakonas, Spyros
Notch signaling regulates multiple developmental processes and is implicated in various human diseases. Through use of the Notch transcriptional co-activator mastermind, we conducted a screen for...
Modeling Spinal Muscular Atrophy in Drosophila
Chang, Howard Chia-Hao, Dimlich, Douglas N., Yokokura, Takakazu, Mukherjee, Ashim, Kankel, Mark W., Sen, Anindya, ...
Spinal Muscular Atrophy (SMA), a recessive hereditary neurodegenerative disease in humans, has been linked to mutations in the survival motor neuron (SMN) gene. SMA patients display early onset...
Nodal points and complexity of Notch-Ras signal integration
Hurlbut, Gregory D., Kankel, Mark W., Artavanis-Tsakonas, Spyros
Metazoans use a handful of highly conserved signaling pathways to create a signaling backbone that governs development. How these few signals have such a versatile action likely depends upon the...