Wiegand, Johannes, Deterding, Katja, Cornberg, Markus, Wedemeyer, Heiner
Early control in the acute phase of hepatitis C infection is an attractive therapeutic goal in order to shorten disease duration and infectivity, to prevent chronicity and progression to advanced...
Clearance of low levels of HCV viremia in the absence of a strong adaptive immune response (2007)
Meyer, Manuela F, Lehmann, Marc, Cornberg, Markus, Wiegand, Johannes, Manns, Michael P, Klade, Christoph, ...
Abstract Spontaneous clearance of hepatitis C virus (HCV) has frequently been associated with the presence of HCV-specific cellular immunity. However, there had been also reports in chimpanzees...
Cornberg, Markus, Sheridan, Brian S., Saccoccio, Frances M., Brehm, Michael A., Selin, Liisa K.
Live vaccinia virus (VV) vaccination has been highly successful in eradicating smallpox. However, the mechanisms of immunity involved in mediating this protective effect are still poorly understood,...
The privacy of T cell memory to viruses (2006)
Welsh, Raymond M., Kim, Sung-Kwon, Cornberg, Markus, Clute, Shalyn Catherine, Selin, Liisa K., Naumov, Yuri N.
T cell responses to viral infections can mediate either protective immunity or damaging immunopathology. Viral infections induce the proliferation of T cells specific for viral antigens and cause a...
Memory of mice and men: CD8+ T-cell cross-reactivity and heterologous immunity (2006)
Selin, Liisa K., Brehm, Michael A., Naumov, Yuri N., Cornberg, Markus, Kim, Sung-Kwon, Clute, Shalyn Catherine, ...
The main functions of memory T cells are to provide protection upon re-exposure to a pathogen and to prevent the re-emergence of low-grade persistent pathogens. Memory T cells achieve these functions...
Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity (2006)
Cornberg, Markus, Chen, Alex T., Wilkinson, Lee A., Brehm, Michael A., Kim, Sung-Kwon, Calcagno, Claudia, ...
Why some virus-specific CD8 TCR repertoires are diverse and others restricted or "oligoclonal" has been unknown. We show here that oligoclonality and extreme clonal dominance can be a consequence of...
Wiegand, Johannes, Buggisch, Peter, Boecher, Wulf, Zeuzem, Stefan, Gelbmann, Cornelia M., Berg, Thomas, ...
Early treatment of acute hepatitis C with interferon alpha-2b for 24 weeks prevents chronic infection in almost all patients. Because pegylated interferons have replaced conventional interferon in...
Clute, Shalyn Catherine, Watkins, Levi B., Cornberg, Markus, Naumov, Yuri N., Sullivan, John L., Luzuriaga, Katherine, ...
The marked proliferation of activated CD8+ T cells is pathognomonic of EBV-associated infectious mononucleosis (IM), common in young adults. Since the diversity and size of the memory CD8+ T cell...
Private specificities of CD8 T cell responses control patterns of heterologous immunity (2005)
Kim, Sung-Kwon, Cornberg, Markus, Wang, Xiaoting Z., Chen, Hong D., Selin, Liisa K., Welsh, Raymond M.
CD8 T cell cross-reactivity between viruses can play roles in protective heterologous immunity and damaging immunopathology. This cross-reactivity is sometimes predictable, such as between...
Hannover, Med. Hochsch., Diss., 2000.
Clute, Shalyn C., Watkin, Levi B., Cornberg, Markus, Naumov, Yuri N., Sullivan, John L., Luzuriaga, Katherine, ...
The marked proliferation of activated CD8+ T cells is pathognomonic of EBV-associated infectious mononucleosis (IM), common in young adults. Since the diversity and size of the memory CD8+ T cell...
Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity
Cornberg, Markus, Chen, Alex T., Wilkinson, Lee A., Brehm, Michael A., Kim, Sung-Kwon, Calcagno, Claudia, ...
Why some virus-specific CD8 TCR repertoires are diverse and others restricted or “oligoclonal” has been unknown. We show here that oligoclonality and extreme clonal dominance can be a consequence...
Clute, Shalyn C., Watkin, Levi B., Cornberg, Markus, Naumov, Yuri N., Sullivan, John L., Luzuriaga, Katherine, ...
The marked proliferation of activated CD8+ T cells is pathognomonic of EBV-associated infectious mononucleosis (IM), common in young adults. Since the diversity and size of the memory CD8+ T cell...
Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity
Cornberg, Markus, Chen, Alex T., Wilkinson, Lee A., Brehm, Michael A., Kim, Sung-Kwon, Calcagno, Claudia, ...
Why some virus-specific CD8 TCR repertoires are diverse and others restricted or “oligoclonal” has been unknown. We show here that oligoclonality and extreme clonal dominance can be a consequence...
Protection against Vaccinia Virus Challenge by CD8 Memory T Cells Resolved by Molecular Mimicry▿
Cornberg, Markus, Sheridan, Brian S., Saccoccio, Frances M., Brehm, Michael A., Selin, Liisa K.
Live vaccinia virus (VV) vaccination has been highly successful in eradicating smallpox. However, the mechanisms of immunity involved in mediating this protective effect are still poorly understood,...
Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity
Cornberg, Markus, Chen, Alex T., Wilkinson, Lee A., Brehm, Michael A., Kim, Sung-Kwon, Calcagno, Claudia, ...
Clearance of low levels of HCV viremia in the absence of a strong adaptive immune response
Meyer, Manuela F, Lehmann, Marc, Cornberg, Markus, Wiegand, Johannes, Manns, Michael P, Klade, Christoph, ...
Spontaneous clearance of hepatitis C virus (HCV) has frequently been associated with the presence of HCV-specific cellular immunity. However, there had been also reports in chimpanzees demonstrating...
Private specificities of CD8 T cell responses control patterns of heterologous immunity
Kim, Sung-Kwon, Cornberg, Markus, Wang, Xiaoting Z., Chen, Hong D., Selin, Liisa K., Welsh, Raymond M.
CD8 T cell cross-reactivity between viruses can play roles in protective heterologous immunity and damaging immunopathology. This cross-reactivity is sometimes predictable, such as between...
Ghosh, Arnab, Koestner, Wolfgang, Hapke, Martin, Schlaphoff, Verena, Länger, Florian, Baumann, Rolf, ...
Antigen-presenting cells (APCs) of host origin drive graft-versus-leukemia (GVL) effects but can also trigger life-threatening graft-versus-host disease (GVHD) after hematopoietic cell...