Subversion of Cellular Autophagosomal Machinery by RNA Viruses (2005)
William T. Jackson, Thomas H. Giddings, Matthew P. Taylor, Sara Mulinyawe, Marlene Rabinovitch, Ron R. Kopito, ...
Poliovirus is a well-studied positive-strand RNA virus, and here it is shown to subvert the machinery of the cellular autophagy pathway at several stages in the viral life cycle.
Subversion of Cellular Autophagosomal Machinery by RNA Viruses (2005)
William T. Jackson, Matthew P. Taylor, Sara Mulinyawe, Marlene Rabinovitch, Ron R. Kopito, ...
Infection of human cells with poliovirus induces the proliferation of double-membraned cytoplasmic vesicles whose surfaces are used as the sites of viral RNA replication and whose origin is unknown....
Conditional and targeted overexpression of vascular chymase causes hypertension in transgenic mice
Ju, Haisong, Gros, Robert, You, Xiaomang, Tsang, Sarah, Husain, Mansoor, Rabinovitch, Marlene
We cloned a rat vascular chymase (RVCH) from smooth muscle cells (SMCs) that converts angiotensin I to II and is up-regulated in SMC from spontaneously hypertensive vs. normotensive rats. To...
Enhanced ERK-1/2 activation in mice susceptible to coxsackievirus-induced myocarditis
Opavsky, Mary Anne, Martino, Tami, Rabinovitch, Marlene, Penninger, Josef, Richardson, Chris, Petric, Martin, ...
Group B coxsackieviral (CVB) infection commonly causes viral myocarditis. Mice are protected from CVB3 myocarditis by gene-targeted knockout of p56Lck(Lck), the Src family kinase (Src) essential for...
A novel vascular smooth muscle chymase is upregulated in hypertensive rats
Guo, Caiying, Ju, Haisong, Leung, Debbie, Massaeli, Hamid, Shi, Mingda, Rabinovitch, Marlene
While greater than 80% of angiotensin II (Ang II) formation in the human heart and greater than 60% in arteries appears to result from chymase activity, no cardiovascular cell–expressed chymase has...
Zaidi, Syed H.E., You, Xiao-Mang, Ciura, Sorana, O’Blenes, Stacey, Husain, Mansoor, Rabinovitch, Marlene
Elastases degrade the extracellular matrix, releasing growth factors and chemotactic peptides, inducing glycoproteins such as tenascin, and thereby promoting vascular cell proliferation and...
Cowan, Kyle Northcote, Jones, Peter Lloyd, Rabinovitch, Marlene
Increased expression of the glycoprotein tenascin-C (TN) is associated with progression of clinical and experimental pulmonary hypertension. In cultured smooth muscle cells (SMCs) TN is induced by...
Zaidi, Syed H.E., Hui, Chi-Chung, Cheah, Alexander Y.L., You, Xiao-Mang, Husain, Mansoor, Rabinovitch, Marlene
Serine elastases degrade elastin, stimulate vascular smooth muscle cell migration and proliferation, and are associated with myocardial damage. To evaluate the impact of elastase inhibition on...
Subversion of Cellular Autophagosomal Machinery by RNA Viruses
Jackson, William T, Giddings, Thomas H, Taylor, Matthew P, Mulinyawe, Sara, Rabinovitch, Marlene, Kopito, Ron R, ...
Infection of human cells with poliovirus induces the proliferation of double-membraned cytoplasmic vesicles whose surfaces are used as the sites of viral RNA replication and whose origin is unknown....
Conditional and targeted overexpression of vascular chymase causes hypertension in transgenic mice
Ju, Haisong, Gros, Robert, You, Xiaomang, Tsang, Sarah, Husain, Mansoor, Rabinovitch, Marlene
We cloned a rat vascular chymase (RVCH) from smooth muscle cells (SMCs) that converts angiotensin I to II and is up-regulated in SMC from spontaneously hypertensive vs. normotensive rats. To...
Enhanced ERK-1/2 activation in mice susceptible to coxsackievirus-induced myocarditis
Opavsky, Mary Anne, Martino, Tami, Rabinovitch, Marlene, Penninger, Josef, Richardson, Chris, Petric, Martin, ...
Group B coxsackieviral (CVB) infection commonly causes viral myocarditis. Mice are protected from CVB3 myocarditis by gene-targeted knockout of p56Lck(Lck), the Src family kinase (Src) essential for...
A novel vascular smooth muscle chymase is upregulated in hypertensive rats
Guo, Caiying, Ju, Haisong, Leung, Debbie, Massaeli, Hamid, Shi, Mingda, Rabinovitch, Marlene
While greater than 80% of angiotensin II (Ang II) formation in the human heart and greater than 60% in arteries appears to result from chymase activity, no cardiovascular cell–expressed chymase has...
Zaidi, Syed H.E., You, Xiao-Mang, Ciura, Sorana, O’Blenes, Stacey, Husain, Mansoor, Rabinovitch, Marlene
Elastases degrade the extracellular matrix, releasing growth factors and chemotactic peptides, inducing glycoproteins such as tenascin, and thereby promoting vascular cell proliferation and...
Cowan, Kyle Northcote, Jones, Peter Lloyd, Rabinovitch, Marlene
Increased expression of the glycoprotein tenascin-C (TN) is associated with progression of clinical and experimental pulmonary hypertension. In cultured smooth muscle cells (SMCs) TN is induced by...
Zaidi, Syed H.E., Hui, Chi-Chung, Cheah, Alexander Y.L., You, Xiao-Mang, Husain, Mansoor, Rabinovitch, Marlene
Serine elastases degrade elastin, stimulate vascular smooth muscle cell migration and proliferation, and are associated with myocardial damage. To evaluate the impact of elastase inhibition on...
Subversion of Cellular Autophagosomal Machinery by RNA Viruses
Jackson, William T, Giddings, Thomas H, Taylor, Matthew P, Mulinyawe, Sara, Rabinovitch, Marlene, Kopito, Ron R, ...
Infection of human cells with poliovirus induces the proliferation of double-membraned cytoplasmic vesicles whose surfaces are used as the sites of viral RNA replication and whose origin is unknown....
Greenway, Steven, Van Suylen, Robert Jan, Sarvaas, Gideon Du Marchie, Kwan, Edwin, Ambartsumian, Noona, Lukanidin, Eugene, ...
S100A4/Mts1 confers a metastatic phenotype in tumor cells and may also be related to resistance to apoptosis and angiogenesis. Approximately 5% of transgenic mice overexpressing S100A4/Mts1 develop...
Alvira, Cristina M., Abate, Aida, Yang, Guang, Dennery, Phyllis A., Rabinovitch, Marlene
Rationale: Injurious agents often cause less severe injury in neonates as compared with adults.
Jones, Peter Lloyd, Crack, Julie, Rabinovitch, Marlene
Tenascin-C (TN-C) is induced in pulmonary vascular disease, where it colocalizes with proliferating smooth muscle cells (SMCs) and epidermal growth factor (EGF). Furthermore, cultured SMCs require...
Hansmann, Georg, De Jesus Perez, Vinicio A., Alastalo, Tero-Pekka, Alvira, Cristina M., Guignabert, Christophe, Bekker, Janine M., ...
Loss-of-function mutations in bone morphogenetic protein receptor II (BMP-RII) are linked to pulmonary arterial hypertension (PAH); the ligand for BMP-RII, BMP-2, is a negative regulator of SMC...
Molecular pathogenesis of pulmonary arterial hypertension
Recent investigations have suggested that it might be possible to reverse the pathology of pulmonary arterial hypertension (PAH), a disorder that can be rapidly progressive and fatal despite current...
Pulmonary arterial remodeling induced by a Th2 immune response
Daley, Eleen, Emson, Claire, Guignabert, Christophe, De Waal Malefyt, Rene, Louten, Jennifer, Kurup, Viswanath P., ...
Pulmonary arterial remodeling characterized by increased vascular smooth muscle density is a common lesion seen in pulmonary arterial hypertension (PAH), a deadly condition. Clinical correlation...
De Jesus Perez, Vinicio A., Alastalo, Tero-Pekka, Wu, Jenny C., Axelrod, Jeffrey D., Cooke, John P., Amieva, Manuel, ...
Mutations in bone morphogenetic protein (BMP) receptor II (BMPRII) are associated with pulmonary artery endothelial cell (PAEC) apoptosis and the loss of small vessels seen in idiopathic pulmonary...
VEGF blockade inhibits angiogenesis and reepithelialization of endometrium
Fan, Xiujun, Krieg, Sacha, Kuo, Calvin J., Wiegand, Stanley J., Rabinovitch, Marlene, Druzin, Maurice L., ...
Despite extensive literature on vascular endothelial growth factor (VEGF) expression and regulation by steroid hormones, the lack of clear understanding of the mechanisms of angiogenesis in the...