Parkash, Vimal, Lindholm, Päivi, Peränen, Johan, Kalkkinen, Nisse, Oksanen, Esko, Saarma, Mart, ...
We have solved the structures of mammalian mesencephalic astrocyte-derived neurotrophic factor (MANF) and conserved dopamine neurotrophic factor (CDNF). CDNF protects and repairs midbrain...
Keijo Luukko Mart, Mart Saarma, Irma Thesleff
Neurturin (NTN) is a recently characterized member of the glial cell line-- derived neurotrophic factor (GDNF)-family which, like GDNF, can promote the survival of certain populations of neuronal...
Aalto, Antti P., Sarin, L. Peter, Van Dijk, Alberdina A., Saarma, Mart, Poranen, Minna M., Arumäe, Urmas, ...
The discovery of RNA interference (RNAi) has revolutionized biological research and has a huge potential for therapy. Since small double-stranded RNAs (dsRNAs) are required for various RNAi...
Aalto, Antti P., Sarin, L. Peter, Van Dijk, Alberdina A., Saarma, Mart, Poranen, Minna M., Arumäe, Urmas, ...
The discovery of RNA interference (RNAi) has revolutionized biological research and has a huge potential for therapy. Since small double-stranded RNAs (dsRNAs) are required for various RNAi...
Lonka, Liina, Aalto, Antti, Kopra, Outi, Kuronen, Mervi, Kokaia, Zaal, Saarma, Mart, ...
Abstract Background The neuronal ceroid lipofuscinoses (NCLs) are a group of inherited neurodegenerative disorders characterized by accumulation of autofluorescent material in many tissues,...
Petro Suvanto, Kirmo Wartiovaara, Maria Lindahl, Urmas Arumäe, Maxim Moshnyakov, Nina Horelli-kuitunen, ...
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Two distinct conformations of rat liver ribosomal 5S RNA (1982)
Toots, Indrek, Misselwitz, Rolf, Böhm, Siegfried, Welfle, Heinz, Villems, Richard, Saarma, Mart
Three different conformers of rat liver 5S ribosomal RNA were investigated by partial nuclease cleavage technique using S nuclease and cobra venom endoribonuclease (CVE) as conformational probes....
Toots, Indrek, Metspalu, Andres, Villems, Richard, Saarma, Mart
Rat liver 5S rRNA and 5.8S rRNA were end-labelled with 32P at 5′-end or 3′-end of the polynucleotide chain and partially digested with single-strand specific S1 nuclease and double-strand...
Nanobashvili, Avtandil, Airaksinen, Matti S., Kokaia, Merab, Rossi, Jari, Asztély, Fredrik, Olofsdotter, Klara, ...
Seizure activity regulates gene expression for glial cell line-derived neurotrophic factor (GDNF) and neurturin (NRTN), and their receptor components, the transmembrane c-Ret tyrosine kinase and the...
The structure of GFRα1 domain 3 reveals new insights into GDNF binding and RET activation
Leppänen, Veli-Matti, Bespalov, Maxim M, Runeberg-Roos, Pia, Puurand, Ülo, Merits, Andres, Saarma, Mart, ...
Glial cell line-derived neurotrophic factor (GDNF) binds to the GDNF family co-receptor α1 (GFRα1) and activates RET receptor tyrosine kinase. GFRα1 has a putative domain structure of three...
Ozone-Induced Programmed Cell Death in the Arabidopsis radical-induced cell death1 Mutant1
Overmyer, Kirk, Brosché, Mikael, Pellinen, Riikka, Kuittinen, Tero, Tuominen, Hannele, Ahlfors, Reetta, ...
Short, high-concentration peaks of the atmospheric pollutant ozone (O3) cause the formation of cell death lesions on the leaves of sensitive plants. Numerous similarities between the plant responses...
The first cysteine-rich domain of the receptor GFRα1 stabilizes the binding of GDNF
Virtanen, Heidi, Yang, Jianmin, Bespalov, Maxim M., Hiltunen, Jukka O., Leppänen, Veli-Matti, Kalkkinen, Nisse, ...
The GDNF (glial cell line-derived neurotrophic factor)-binding receptor GFRα1 (GDNF family receptor α1) is attached to the membrane by a GPI (glycosylphosphatidylinositol) anchor and consists of...
Nanobashvili, Avtandil, Airaksinen, Matti S., Kokaia, Merab, Rossi, Jari, Asztély, Fredrik, Olofsdotter, Klara, ...
Seizure activity regulates gene expression for glial cell line-derived neurotrophic factor (GDNF) and neurturin (NRTN), and their receptor components, the transmembrane c-Ret tyrosine kinase and the...
The structure of GFRα1 domain 3 reveals new insights into GDNF binding and RET activation
Leppänen, Veli-Matti, Bespalov, Maxim M, Runeberg-Roos, Pia, Puurand, Ülo, Merits, Andres, Saarma, Mart, ...
Glial cell line-derived neurotrophic factor (GDNF) binds to the GDNF family co-receptor α1 (GFRα1) and activates RET receptor tyrosine kinase. GFRα1 has a putative domain structure of three...
Ozone-Induced Programmed Cell Death in the Arabidopsis radical-induced cell death1 Mutant1
Overmyer, Kirk, Brosché, Mikael, Pellinen, Riikka, Kuittinen, Tero, Tuominen, Hannele, Ahlfors, Reetta, ...
Short, high-concentration peaks of the atmospheric pollutant ozone (O3) cause the formation of cell death lesions on the leaves of sensitive plants. Numerous similarities between the plant responses...
The first cysteine-rich domain of the receptor GFRα1 stabilizes the binding of GDNF
Virtanen, Heidi, Yang, Jianmin, Bespalov, Maxim M., Hiltunen, Jukka O., Leppänen, Veli-Matti, Kalkkinen, Nisse, ...
The GDNF (glial cell line-derived neurotrophic factor)-binding receptor GFRα1 (GDNF family receptor α1) is attached to the membrane by a GPI (glycosylphosphatidylinositol) anchor and consists of...
Aalto, Antti P., Sarin, L. Peter, Van Dijk, Alberdina A., Saarma, Mart, Poranen, Minna M., Arumäe, Urmas, ...
The discovery of RNA interference (RNAi) has revolutionized biological research and has a huge potential for therapy. Since small double-stranded RNAs (dsRNAs) are required for various RNAi...
Popsueva, Anna, Poteryaev, Dmitry, Arighi, Elena, Meng, Xiaojuan, Angers-Loustau, Alexandre, Kaplan, David, ...
Glial cell line–derived neurotrophic factor (GDNF) and hepatocyte growth factor (HGF) are multifunctional signaling molecules in embryogenesis. HGF binds to and activates Met receptor tyrosine...
Rivera, Claudio, Li, Hong, Thomas-Crusells, Judith, Lahtinen, Hannele, Viitanen, Tero, Nanobashvili, Avtandil, ...
Pathophysiological activity and various kinds of traumatic insults are known to have deleterious long-term effects on neuronal Cl− regulation, which can lead to a suppression of fast postsynaptic...
GDNF-deprived sympathetic neurons die via a novel nonmitochondrial pathway
Yu, Li-Ying, Jokitalo, Eija, Sun, Yun-Fu, Mehlen, Patrick, Lindholm, Dan, Saarma, Mart, ...
The mitochondrial death pathway is triggered in cultured sympathetic neurons by deprivation of nerve growth factor (NGF), but the death mechanisms activated by deprivation of other neurotrophic...
Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons
Palgi, Mari, Lindström, Riitta, Peränen, Johan, Piepponen, T. Petteri, Saarma, Mart, Heino, Tapio I.
In vertebrates the development and function of the nervous system is regulated by neurotrophic factors (NTFs). Despite extensive searches no neurotrophic factors have been found in invertebrates....