Hinsch, Nora, Frank, Matthias, Döring, Claudia, Vorländer, Christian, Hansmann, Martin-Leo
Abstract Background The differential diagnosis between follicular thyroid adenoma and minimal invasive follicular thyroid carcinoma is often difficult for several reasons. One major aspect is the...
A Biologic Definition of Burkitt's Lymphoma from Transcriptional and Genomic Profiling (2006)
Hummel, Michael, Bentink, Stefan, Berger, Hilmar, Klapper, Wolfram, Wessendorf, Swen, Barth, Thomas F.E., ...
Background: The distinction between Burkitt's lymphoma and diffuse large-B-cell lymphoma is unclear. We used transcriptional and genomic profiling to define Burkitt's lymphoma more precisely and to...
The major subtypes of human B-cell lymphomas lack mutations in BCL-2 family member BAD (2006)
Schmitz, Roland, Thomas, Roman K., Harttrampf, Anne C., Wickenhauser, Claudia, Schultze, Joachim L., Hansmann, Martin-Leo, ...
Isolation of viable Hodgkin and Reed-Sternberg cells from Hodgkin disease tissues
Irsch, Johannes, Nitsch, Silke, Hansmann, Martin-Leo, Rajewsky, Klaus, Tesch, Hans, Diehl, Volker, ...
Hodgkin disease (HD) is characterized by a small number of malignant Hodgkin and Reed-Sternberg (H/RS) cells among a major population of nonmalignant cells. The analysis of H/RS cells has been...
Braeuninger, Andreas, Küppers, Ralf, Strickler, John G., Wacker, Hans-Heinrich, Rajewsky, Klaus, Hansmann, Martin-Leo
Among the four subtypes of Hodgkin disease (HD), lymphocyte-predominant (LP) HD is now generally considered as a separate entity. The B cell nature of the typical Hodgkin and Reed–Sternberg (HRS)...
Identification of Hodgkin and Reed-Sternberg cell-specific genes by gene expression profiling
Küppers, Ralf, Klein, Ulf, Schwering, Ines, Distler, Verena, Bräuninger, Andreas, Cattoretti, Giorgio, ...
Hodgkin lymphoma (HL) is a malignancy of unknown pathogenesis. The malignant Hodgkin and Reed/Sternberg (HRS) cells derive from germinal center B cells (or rarely, T cells) but have a heterogeneous...
Kurth, Julia, Hansmann, Martin-Leo, Rajewsky, Klaus, Küppers, Ralf
To assess the impact of the germinal center (GC) reaction on viral spread in Epstein–Barr virus (EBV) infection, we isolated EBV+ GC B cells from the tonsils of two infectious mononucleosis...
Schwering, Ines, Bräuninger, Andreas, Distler, Verena, Jesdinsky, Julia, Diehl, Volker, Hansmann, Martin-Leo, ...
The malignant cells of classical Hodgkin’s lymphoma (cHL), Hodgkin and Reed-Sternberg (HRS) cells, appear to be derived from germinal center (GC) B cells in most cases of the disease. Apart from...
Isolation of viable Hodgkin and Reed-Sternberg cells from Hodgkin disease tissues
Irsch, Johannes, Nitsch, Silke, Hansmann, Martin-Leo, Rajewsky, Klaus, Tesch, Hans, Diehl, Volker, ...
Hodgkin disease (HD) is characterized by a small number of malignant Hodgkin and Reed-Sternberg (H/RS) cells among a major population of nonmalignant cells. The analysis of H/RS cells has been...
Braeuninger, Andreas, Küppers, Ralf, Strickler, John G., Wacker, Hans-Heinrich, Rajewsky, Klaus, Hansmann, Martin-Leo
Among the four subtypes of Hodgkin disease (HD), lymphocyte-predominant (LP) HD is now generally considered as a separate entity. The B cell nature of the typical Hodgkin and Reed–Sternberg (HRS)...
Identification of Hodgkin and Reed-Sternberg cell-specific genes by gene expression profiling
Küppers, Ralf, Klein, Ulf, Schwering, Ines, Distler, Verena, Bräuninger, Andreas, Cattoretti, Giorgio, ...
Hodgkin lymphoma (HL) is a malignancy of unknown pathogenesis. The malignant Hodgkin and Reed/Sternberg (HRS) cells derive from germinal center B cells (or rarely, T cells) but have a heterogeneous...
Kurth, Julia, Hansmann, Martin-Leo, Rajewsky, Klaus, Küppers, Ralf
To assess the impact of the germinal center (GC) reaction on viral spread in Epstein–Barr virus (EBV) infection, we isolated EBV+ GC B cells from the tonsils of two infectious mononucleosis...
Schwering, Ines, Bräuninger, Andreas, Distler, Verena, Jesdinsky, Julia, Diehl, Volker, Hansmann, Martin-Leo, ...
The malignant cells of classical Hodgkin’s lymphoma (cHL), Hodgkin and Reed-Sternberg (HRS) cells, appear to be derived from germinal center (GC) B cells in most cases of the disease. Apart from...
Aberrant Expression of ID2, a Suppressor of B-Cell-Specific Gene Expression, in Hodgkin’s Lymphoma
Renné, Christoph, Martin-Subero, Jose Ignacio, Eickernjäger, Maren, Hansmann, Martin-Leo, Küppers, Ralf, Siebert, Reiner, ...
The global loss of B-cell-specific gene expression is a distinctive feature of the Hodgkin-Reed/Sternberg (HRS) cells of classical Hodgkin’s lymphoma (HL). The reasons for this loss remained...
Willenbrock, Klaus, Roers, Axel, Blöhbaum, Birgit, Rajewsky, Klaus, Hansmann, Martin-Leo
A minor component (about 25%) of lymphocytes in Hodgkin’s disease (HD) are CD8+ T cells. It is unclear whether the presence of these cells reflects an antitumor cytotoxic response. The goal of the...
Willenbrock, Klaus, Roers, Axel, Seidl, Christian, Wacker, Hans-Heinrich, Küppers, Ralf, Hansmann, Martin-Leo
Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) is defined in the current lymphoma classifications as a T-cell non-Hodgkin’s lymphoma. However, in approximately one third of the cases...
Renné, Christoph, Martín-Subero, José Ignacio, Hansmann, Martin-Leo, Siebert, Reiner
Chromosomal translocations juxtaposing different oncogenes to the immunoglobulin (IG) loci are the hallmark of various B-cell lymphomas. Because the tumor cells in nodular lymphocyte predominant...
Bräuninger, Andreas, Spieker, Tilmann, Willenbrock, Klaus, Gaulard, Philippe, Wacker, Hans-Heinrich, Rajewsky, Klaus, ...
Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) is a peculiar T cell lymphoma, as expanding B cell clones are often present besides the malignant T cell clones. In addition, large...
Clonal Deleterious Mutations in the Iκbα Gene in the Malignant Cells in Hodgkin's Lymphoma
Jungnickel, Berit, Staratschek-Jox, Andrea, Bräuninger, Andreas, Spieker, Tilmann, Wolf, Jürgen, Diehl, Volker, ...
Members of the nuclear factor (NF)-κB family of transcription factors play a crucial role in cellular activation, immune responses, and oncogenesis. In most cells, they are kept inactive in the...
Rare Occurrence of Classical Hodgkin's Disease as a T Cell Lymphoma
Müschen, Markus, Rajewsky, Klaus, Bräuninger, Andreas, Baur, Audrey Sylvia, Oudejans, Joost J., Roers, Axel, ...
Recent work identified Hodgkin and Reed-Sternberg (H/RS) cells in classical Hodgkin's disease (cHD) as clonal progeny of mature B cells. Therefore, it is generally assumed that cHD homogenously...
Brune, Verena, Tiacci, Enrico, Pfeil, Ines, Döring, Claudia, Eckerle, Susan, ...
The pathogenesis of nodular lymphocyte–predominant Hodgkin lymphoma (NLPHL) and its relationship to other lymphomas are largely unknown. This is partly because of the technical challenge of...
Translocation detection in lymphoma diagnosis by split-signal FISH: a standardised approach
Van Rijk, Anke, Mason, David, Jones, Margaret, Cabeçadas, José, Crespo, Mateus, Cigudosa, Juan Cruz, ...
Lymphomas originating from the lymphatic system comprise about 30 entities classified according to the World Health Organization (WHO). The histopathological diagnosis is generally considered...
A Comprehensive Microarray-Based DNA Methylation Study of 367 Hematological Neoplasms
Martin-Subero, Jose I., Ammerpohl, Ole, Bibikova, Marina, Wickham-Garcia, Eliza, Agirre, Xabier, Alvarez, Sara, ...
Bernd, Heinz-Wolfram, Ziepert, Marita, Thorns, Christoph, Klapper, Wolfram, Wacker, Hans-Heinrich, Hummel, Michael, ...
The evaluation of biomarkers as prognostic factors in lymphomas requires studies in the context of well designed clinical trials. In this study, the authors show the predictive value of immunoblastic...
TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma
Schmitz, Roland, Hansmann, Martin-Leo, Bohle, Verena, Martin-Subero, Jose Ignacio, Hartmann, Sylvia, Mechtersheimer, Gunhild, ...
Proliferation and survival of Hodgkin and Reed/Sternberg (HRS) cells, the malignant cells of classical Hodgkin lymphoma (cHL), are dependent on constitutive activation of nuclear factor κB (NF-κB)....