Martin Budd

Mrc1 and DNA polymerase epsilon function together in linking DNA replication and the S phase checkpoint (2008)

Lou, Huiqiang, Komata, Makiko, Katou, Yuki, Guan, Zhiyun, Reis, Clara C., Budd, Martin, ...

Yeast Mrc1, ortholog of metazoan Claspin, is both a central component of normal DNA replication forks and a mediator of the S phase checkpoint. We report that Mrc1 interacts with Pol2, the catalytic...

Dna2 Helicase/Nuclease Causes Replicative Fork Stalling and Double-strand Breaks in the Ribosomal DNA of Saccharomyces cerevisiae (2003)

Weitao, Tao, Budd, Martin, Mays Hoopes, Laura L., Campbell, Judith L.

We have proposed that faulty processing of arrested replication forks leads to increases in recombination and chromosome instability in Saccharomyces cerevisiae and contributes to the shortened...

Mutations in DNA Replication Genes Reduce Yeast Life Span (2002)

Mays Hoopes, Laura L., Budd, Martin, Choe, Wonchae, Weitao, Tao, Campbell, Judith L.

Surprisingly, the contribution of defects in DNA replication to the determination of yeast life span has never been directly investigated. We show that a replicative yeast helicase/nuclease, encoded...

Dynamic Localization of an Okazaki Fragment Processing Protein Suggests a Novel Role in Telomere Replication (2002)

Choe, Wonchae, Budd, Martin, Imamura, Osamu, Hoopes, Laura, Campbell, Judith L.

We have found that the Dna2 helicase-nuclease, thought to be involved in maturation of Okazaki fragments, is a component of telomeric chromatin. We demonstrate a dynamic localization of Dna2p to...

Temperature-Sensitive Mutations in the Yeast DNA Polymerase I Gene (1987)

Budd, Martin, Campbell, Judith L.

Seven mutations that yield thermolabile DNA polymerases have been isolated in the DNA polymerase I gene, POL1, of Saccharomyces cerevisiae. Strains carrying the mutant genes are temperature sensitive...

Dynamic Localization of an Okazaki Fragment Processing Protein Suggests a Novel Role in Telomere Replication

Choe, Wonchae, Budd, Martin, Imamura, Osamu, Hoopes, Laura, Campbell, Judith L.

We have found that the Dna2 helicase-nuclease, thought to be involved in maturation of Okazaki fragments, is a component of telomeric chromatin. We demonstrate a dynamic localization of Dna2p to...

Mutations in DNA Replication Genes Reduce Yeast Life Span

Mays Hoopes, Laura L., Budd, Martin, Choe, Wonchae, Weitao, Tao, Campbell, Judith L.

Surprisingly, the contribution of defects in DNA replication to the determination of yeast life span has never been directly investigated. We show that a replicative yeast helicase/nuclease, encoded...

Dynamic Localization of an Okazaki Fragment Processing Protein Suggests a Novel Role in Telomere Replication

Choe, Wonchae, Budd, Martin, Imamura, Osamu, Hoopes, Laura, Campbell, Judith L.

We have found that the Dna2 helicase-nuclease, thought to be involved in maturation of Okazaki fragments, is a component of telomeric chromatin. We demonstrate a dynamic localization of Dna2p to...

Mutations in DNA Replication Genes Reduce Yeast Life Span

Mays Hoopes, Laura L., Budd, Martin, Choe, Wonchae, Weitao, Tao, Campbell, Judith L.

Surprisingly, the contribution of defects in DNA replication to the determination of yeast life span has never been directly investigated. We show that a replicative yeast helicase/nuclease, encoded...