Interplay of Mre11 nuclease with Dna2 plus Sgs1 in Rad51-dependent recombinational repair (2009)
Budd, Martin E., Campbell, Judith L.
The Mre11/Rad50/Xrs2 complex initiates IR repair by binding to the end of a double-strand break, resulting in 5′ to 3′ exonuclease degradation creating a single-stranded 3′ overhang competent...
Interplay of Mre11 nuclease with Dna2 plus Sgs1 in Rad51-dependent recombinational repair (2009)
Budd, Martin E., Campbell, Judith L.
The Mre11/Rad50/Xrs2 complex initiates IR repair by binding to the end of a double-strand break, resulting in 5′ to 3′ exonuclease degradation creating a single-stranded 3′ overhang competent...
Budd, Martin E., Reis, Clara C., Smith, Stephanie, Myung, Kyungjae, Campbell, Judith L.
The precise machineries required for two aspects of eukaryotic DNA replication, Okazaki fragment processing (OFP) and telomere maintenance, are poorly understood. In this work, we present evidence...
A Network of Multi-Tasking Proteins at the DNA Replication Fork Preserves Genome Stability (2005)
Budd, Martin E., Tong, Amy Hin Yan, Polaczek, Piotr, Peng, Xiao, Boone, Charles, Campbell, Judith L.
To elucidate the network that maintains high fidelity genome replication, we have introduced two conditional mutant alleles of DNA2, an essential DNA replication gene, into each of the approximately...
A Network of Multi-Tasking Proteins at the DNA Replication Fork Preserves Genome Stability (2005)
Martin E. Budd, Piotr Polaczek, Xiao Peng, Charles Boone, Judith L. Campbell
To elucidate the network that maintains high fidelity genome replication, we have introduced two conditional mutant alleles of DNA2, an essential DNA replication gene, into each of the approximately...
A Network of Multi-tasking Proteins at the DNA replication Fork Preserves Genome Stability (2005)
Martin E. Budd, Piotr Polaczek, Xiao Peng, Charles Boone, Judith Campbell
Synthetic lethal screens in yeast have been carried out primarily using non-essential genes as queries. To elucidate the network that maintains high fidelity genome replication, we have introduced...
Budd, Martin E., Choe, Won-chae, Campbell, Judith L.
Saccharomyces cerevisiae Dna2 protein is required for DNA replication and repair and is associated with multiple biochemical activities: DNA-dependent ATPase, DNA helicase, and DNA nuclease. To...
Budd, Martin E., Campbell, Judith L.
We have recently described a new helicase, the Dna2 helicase, that is essential for yeast DNA replication. We now show that the yeast FEN-1 (yFEN-1) nuclease interacts genetically and biochemically...
DNA2 Encodes a DNA Helicase Essential for Replication of Eukaryotic Chromosomes (1995)
Budd, Martin E., Choe, Won-Chae, Campbell, Judith L.
Although a number of eukaryotic DNA helicases have been identified biochemically and still more have been inferred from the amino acid sequences of the products of cloned genes, none of the cellular...
A Yeast Gene Required for DNA Replication Encodes a Protein with Homology to DNA Helicases (1995)
Budd, Martin E., Campbell, Judith L.
A yeast gene has been identified by screening for DNA replication mutants using a permeabilized cell replication assay. The mutant is temperature sensitive for growth and shows a cell cycle phenotype...
DNA polymerases required for repair of UV-induced damage in Saccharomyces cerevisiae (1995)
Budd, Martin E., Campbell, Judith L.
The ability of yeast DNA polymerase mutant strains to carry out repair synthesis after UV irradiation was studied by analysis of postirradiation molecular weight changes in cellular DNA. Neither DNA...
Budd, Martin E., Campbell, Judith L.
Three DNA polymerases, alpha, delta, and epsilon are required for viability in Saccharomyces cerevisiae. We have investigated whether DNA polymerases epsilon and delta are required for DNA...
Budd, Martin E., Wittrup, K. Dane, Bailey, J. E., Campbell, Judith L.
We have used a set of seven temperature-sensitive mutants in the DNA polymerase I gene of Saccharomyces cerevisiae to investigate the role of DNA polymerase I in various aspects of DNA synthesis in...
A Network of Multi-Tasking Proteins at the DNA Replication Fork Preserves Genome Stability
Budd, Martin E, Tong, Amy Hin Yan, Polaczek, Piotr, Peng, Xiao, Boone, Charles, Campbell, Judith L
To elucidate the network that maintains high fidelity genome replication, we have introduced two conditional mutant alleles of DNA2, an essential DNA replication gene, into each of the approximately...
Budd, Martin E., Reis, Clara C., Smith, Stephanie, Myung, Kyungjae, Campbell, Judith L.
The precise machineries required for two aspects of eukaryotic DNA replication, Okazaki fragment processing (OFP) and telomere maintenance, are poorly understood. In this work, we present evidence...
A Network of Multi-Tasking Proteins at the DNA Replication Fork Preserves Genome Stability
Budd, Martin E, Tong, Amy Hin Yan, Polaczek, Piotr, Peng, Xiao, Boone, Charles, Campbell, Judith L
To elucidate the network that maintains high fidelity genome replication, we have introduced two conditional mutant alleles of DNA2, an essential DNA replication gene, into each of the approximately...
Budd, Martin E., Reis, Clara C., Smith, Stephanie, Myung, Kyungjae, Campbell, Judith L.
The precise machineries required for two aspects of eukaryotic DNA replication, Okazaki fragment processing (OFP) and telomere maintenance, are poorly understood. In this work, we present evidence...
Jaszczur, Malgorzata, Flis, Krzysztof, Rudzka, Justyna, Kraszewska, Joanna, Budd, Martin E., Polaczek, Piotr, ...
Most replicases are multi-subunit complexes. DNA polymerase epsilon from Saccharomyces cerevisiae is composed of four subunits: Pol2p, Dpb2p, Dpb3p, and Dpb4p. Pol2p and Dpb2p are essential. To...
Interplay of Mre11 Nuclease with Dna2 plus Sgs1 in Rad51-Dependent Recombinational Repair
Budd, Martin E., Campbell, Judith L.
The Mre11/Rad50/Xrs2 complex initiates IR repair by binding to the end of a double-strand break, resulting in 5′ to 3′ exonuclease degradation creating a single-stranded 3′ overhang competent...