THE CROSS CONTAMINATION OF MAIL (2009)
Glenn F. Webb, Martin J. Blaser
(1) Develop a mathematical model of the fall 2001 anthrax attack on the US Postal System (2) Use the model to estimate the number of cross contaminated letters produced, the number of anthrax spores...
The equilibria that allow bacterial persistence in human hosts (2007)
Blaser, Martin J., Kirschner, Denise
We propose that microbes that have developed persistent relationships with human hosts have evolved cross-signalling mechanisms that permit homeostasis that conforms to Nash equilibria and, more...
Correction: Early-Life Family Structure and Microbially Induced Cancer Risk (2007)
Martin J. Blaser, Abraham Nomura, James Lee, Grant N. Stemmerman
Early-Life Family Structure and Microbially Induced Cancer Risk (2007)
Martin J. Blaser, Abraham Nomura, James Lee, Grant N. Stemmerman
BackgroundCancer may follow exposure to an environmental agent after many decades. The bacterium Helicobacter pylori, known to be acquired early in life, increases risk for gastric adenocarcinoma,...
Humoral Immune Response to Lipopolysaccharide Antigens of Campylobacter jejuni (2007)
Blaser, Martin J., Perez-Perez, Guillermo I.
Campylobacter jejuni and the closely related organism Campylobacter coli have been established as among the most common bacterial causes of acute diarrheal disease of humans in developed and...
Cover, Timothy L., Perez-Perez, Guillermo I., Blaser, Martin J.
Although Campylobacter jejuni and C. coli are important causes of diarrheal illness worldwide, the pathophysiologic mechanisms whereby these organisms cause human disease remain poorly understood...
Role of Infection Due to Campylobacter jejuni in the Initiation of Guillain-Barre Syndrome (2007)
Recent reports suggest that infection with Campylobacter jejuni, a common enteric pathogen, may cause Guillain-Barre syndrome (GBS) by triggering demyelination of peripheral nerves. GBS is preceded...
Lack of Evidence of Enterotoxin Involvement in Pathogenesis of Campylobacter Diarrhea (2007)
Perez-Perez, Guillermo I., Taylor, David N., Echerverria, Peter D., Blaser, Martin J.
Several Campylobacter species are now recognized as important pathogens causing human diarrheal disease (7,8), but specific virulence mechanisms are not yet well defined. Campylobacter jejuni and C....
Pei, Shiheng, Blaser, Martin J.
The protein PEB1 (28 kDa) is a common antigen and a major cell adherence molecule of Campylobacter jejuni and Campylobacter coli. We created a bank of chromosomal DNA fragments of C. jejuni strain...
Human Volunteer Studies with Campylobacter jejuni (2007)
Black, Robert E., Perlman, Daniel, Clements, Mary L., Levine, Myron M., Blaser, Martin J.
Campylobacter jejuni and closely related organisms are established enteropathogens, resulting in diarrhea and often dysentery in susceptible children and adults (6). These organisms also cause...
An Outbreak of Bacteremic Campylobacter jejuni Infection (2007)
Shandera, Wayne X., Tormey, Michael P., Blaser, Martin J.
During September 1980, an outbreak of bacteremic Campylobacter jejuni infection occurred in metropolitan Los Angeles. The outbreak was recognized when blood cultures obtained from 11 previously...
Campylobacter Immunity and Quantitative Excretion Rates in Thai Children (2007)
Taylor, David N., Perlman, Daniel M., Echeverria, Peter D., Lexomboon, Udom, Blaser, Martin J.
Campylobacter species were isolated from 61 (15%) of 416 Thai children
Pei, Zhiheng, Blaser, Martin J.
Evidence from developing countries and volunteer studies indicates that immunity to Campylobacter jejuni and Campylobacter coli maybe acquired, but the antigenic basis for this protection is poorly...
Kervella, Michele, Pages, Jean-Marie, Pei, Zhiheng, Grollier, Chislaine, Blaser, Martin J.
Two immunogenic proteins of 27 (CBF1) and 29 (CBF2) kDa from enteropathogenic Campylobacter species appear to bind to mammalian cells. We purified these two proteins from a pathogenic and adherent...
Detection of Pathogenic Campylobacter Species in Blood Culture Systems (2007)
Wang, Wen-Lang, Blaser, Martin J.
Because differences in recognition of Campylobacter fetus and Campylobacter jejuni in systemic infectious may be due partially to differences in the ability to cultivate these organisms, we studied...
Pride, David T, Wassenaar, Trudy M, Ghose, Chandrabali, Blaser, Martin J
Abstract Background Virus taxonomy is based on morphologic characteristics, as there are no widely used non-phenotypic measures for comparison among virus families. We examined whether there is...
Kamangar, Farin, Dawsey, Sanford M., Blaser, Martin J., Perez-Perez, Guillermo I., Pietinen, Pirjo, Newschaffer, Craig J., ...
Background: Colonization with Helicobacter pylori is a risk factor for gastric adenocarcinoma, but the magnitude of this association and its relationship to anatomic location of the cancer, duration...
Cho, Ilseung, Blaser, Martin J., François, Fritz, Mathew, Jomol P., Ye, Xiang Y., Goldberg, Judith D., ...
Obesity is an important public health problem in the United States. Because of its potential effects on gastric leptin homeostasis, Helicobacter pylori may play a role in regulating body weight. The...
Cho, Ilseung, Blaser, Martin J., François, Fritz, Mathew, Jomol P., Ye, Xiang Y., Goldberg, Judith D., ...
Obesity is an important public health problem in the United States. Because of its potential effects on gastric leptin homeostasis, Helicobacter pylori may play a role in regulating body weight. The...
Cho, Ilseung, Blaser, Martin J., François, Fritz, Mathew, Jomol P., Ye, Xiang Y., Goldberg, Judith D., ...
Obesity is an important public health problem in the United States. Because of its potential effects on gastric leptin homeostasis, Helicobacter pylori may play a role in regulating body weight. The...
Functional Adaptation of BabA, the H. pylori ABO Blood Group Antigen Binding Adhesin (2004)
Aspholm-Hurtig, Marina, Dailide, Giedrius, Lahmann, Martina, Kalia, Awdhesh, Ilver, Dag, Roche, Niamh, ...
Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens...
Traces of human migrations in Helicobacter pylori populations (2003)
Falush,Daniel, Wirth,Thierry, Linz,Bodo, Pritchard,Jonathan K., Stephens,Matthew, Kidd,Mark, ...
Helicobacter pylori, a chronic gastric pathogen of human beings, can be divided into seven populations and subpopulations with distinct geographical distributions. These modern populations derive...
Traces of human migrations in Helicobacter pylori populations (2003)
Falush, Daniel, Wirth, Thierry, Linz, Bodo, Pritchard, Jonathan K., Stephens, Matthew, Kidd, Mark, ...
Evolutionary Implications of Microbial Genome Tetranucleotide Frequency Biases (2003)
Pride, David T., Meinersmann, Richard J., Wassenaar, Trudy M., Blaser, Martin J.
Evolutionary Implications of Microbial Genome Tetranucleotide Frequency Biases (2003)
Pride, David T., Meinersmann, Richard J., Wassenaar, Trudy M., Blaser, Martin J.
We compared nucleotide usage pattern conservation for related prokaryotes by examining the representation of DNA tetranucleotide combinations in 27 representative microbial genomes. For each of the...
The Ecology of Height: The Effect of Microbial Transmission on Human Height (2002)
Beard, Albertine S., Blaser, Martin J.
Perspectives in Biology and Medicine - Volume 45, Number 4, Autumn 2002
Relation between Helicobacter pylori cagA Status and Risk of Peptic Ulcer Disease (2002)
Nomura, Abraham M. Y., Pérez-Pérez, Guillermo I., Lee, James, Stemmermann, Grant, Blaser, Martin J.
Although colonization with any Helicobacter pylori strain is associated with peptic ulcer, it is uncertain whether the risk is greater with cagA+ or cagA− strains, which differ in their...
Takata, Tohru, Aras, Rahul, Tavakoli, Donald, Ando, Takafumi, Olivares, Asalia Z., Blaser, Martin J.
To determine relationships between Helicobacter pylori geographical origin and type II methylase activity, we examined 122 strains from various locations around the world for methylase expression....
Aras, Rahul A., Small, Aaron J., Ando, Takafumi, Blaser, Martin J.
Helicobacter pylori, bacteria that colonize the human gastric mucosa, possess a large number of genes for restriction‐modification (R‐M) systems, and essentially, every strain possesses a...
Limburg, Paul J., Qiao, You-Lin, Mark, Steven D., Wang, Guo-Qing, Perez-Perez, Guillermo I., Blaser, Martin J., ...
Background: Helicobacter pylori carriage (i.e., persistent exposure to the organism without gastric epithelial cell invasion) is an established risk factor for noncardia gastric cancer. However, its...
Helicobacter pylori Seropositivity as a Risk Factor for Pancreatic Cancer (2001)
Stolzenberg-Solomon, Rachael Z., Blaser, Martin J., Limburg, Paul J., Perez-Perez, Guillermo, Taylor, Philip R., Virtamo, Jarmo, ...
Background: Pancreatic cancer is among the most fatal cancers worldwide and one for which few preventable risk factors have been established. Gastric carriage of Helicobacter pylori, particularly...
You, Wei-cheng, Zhang, Lian, Gail, Mitchell H., Chang, Yun-sheng, Liu, Wei-dong, Ma, Jun-ling, ...
Background: Gastric cancer is generally thought to arise through a series of gastric mucosal changes, but the determinants of the precancerous lesions are not well understood. To identify such...
Erythromycin-Resistant Campylobacter Infections in Thailand, (1998)
Taylor, David N., Blaser, Martin J., Echeverria, Peter, Pitarangsi, Chittima, Bodhidatta, Ladaporn
Erythromycin therapy was compared with no treatment in a prospective trial of acute diarrheal disease among 100 infants in an orphanage in Bangkok. Within 24 h of the onset of diarrhea, 50 children...
Re: Helicobacter pylori and Atrophic Gastritis: Importance of the cagA Status (1996)
KUIPERS, ERNST J., MEUWISSEN, STEPHAN G. M., PÉREZ-PÉREZ, GUILLERMO I., BLASER, MARTIN J.
Helicobacter pylori and Atrophic Gastritis: Importance of the cagA Status (1995)
Kuipers, Ernst J., Pérez-Pérez, Guillermo I., Meuwissen, Stephan G. M., Blaser, Martin J.
Background: Infection with Helicobacter pylori is a major risk factor for the development of atrophic gastritis and gastric cancer. H. pylori strains can differ with respect to the presence of cagA...
Nachamkin, Irving, Blaser, Martin J, Tomplins, Lucy S
Incluye bibliografía e índice
Molecular Probe Analysis of Shigella dysenteriae type 1 Isolates from 1940 to 1987 (1992)
BLASER, MARTIN J, MIOTTO, KAREN, HOPKINS, JANET A
Fourteen strains of Shigeila dysenteriae type 1 (Shiga bacillus) isolated from people in diverse locations from 1940 to 1987 were studied. Southern hybridization with three cloned Escherichia coli...
Gastric Adenocarcinoma and Helicobacter pylori Infection (1991)
Talley, Nicholas J., Zinsmeister, Alan R., Weaver, Amy, DiMagno, Eugene P., Carpenter, Herschel A., Perez-Perez, Guillermo I., ...
Helicobacter pylori infection, thought to be causally related to chronic gastritis, may also be associated with an increased risk of gastric cancer. To determine whether an association with gastric...
Campylobacter jejuni-specific serum antibodies are elevated in healthy Bangladeshi children (1985)
Blaser, Martin J., Black, Robert E., Amer, Jules
In Bangladesh and other developing countries, isolation of Campylobacter jejuni is common in healthy children, and the illness/infection ratio falls with age. To determine whether specific serum...
HUMAN CAMPYLOBACTER INFECTION ASSOCIATED WITH CERTIFIED RAW MILK (1983)
POTTER, MORRIS E., BLASER, MARTIN J., SIKES, R. KEITH, KAUFMANN, ARNOLD F., WELLS, JOY G.
Potter, M. E. (Bacterial Diseases Division, CDC, Atlanta, GA 30333), M. J. Blaser, R. K. Sikes, A. F. Kaufmann and J. G. Wells. Human Campylobacter infection associated with certified raw milk. Am J...
Blaser, Martin J., Huq, M. Imdadul, Glass, Roger I., Zimicki, Susan, Birkness, Kristin A.
The authors studied the frequency of diarrheal illness associated with non-typhi Salmonella at two clinics in Bangladesh for the years 1977-1979. Non-typhi salmonellae were isolated from 0.29% of...
BLASER, MARTIN J., HUQ, M. IMDADUL, GLASS, ROGER I., ZIMICKI, SUSAN, BIRKNESS, KRISTIN A.
The authors studied the frequency of diarrheal Illness associated with non-typhi Salmonella at two clinics in Bangladesh for the years 1977–1979. Non-typhl saimoneilae were isolated from...
AN OUTBREAK OF SALMONELLOSIS INVOLVING MULTIPLE VEHICLES (1981)
BLASER, MARTIN J., RAFUSE, EARLE M., WELLS, JOY G., POLLARD, ROBERT A., FELDMAN, ROGER A.
A biphasic outbreak of salmonellosis affected customers and employees of a restaurant in Maine, in October and November, 1979. Salmonella typhimurium was isolated from 27 customers and nine...
Isolation of Campylobacter fetus subsp. jejuni from Bangladeshi children (1980)
Blaser, Martin J., Glass, Roger I., Huq, M. Imdadul, Stoll, Barbara, Kibriya, G.M.
To determine the prevalence of infection with Campylobacter fetus subsp. jejuni in Bangladesh, culture surveys were conducted among three populations. In Dacca, Campylobacter was isolated from 5.2%...
Xu, Qing, Morgan, Richard D., Roberts, Richard J., Blaser, Martin J.
A total of 22 type II restriction endonucleases with 18 distinct specificities have been identified in six Helicobacter pylori strains. Among these 18 specificities are three completely new...
Dynamics of Helicobacter pylori colonization in relation to the host response
Blaser, Martin J., Kirschner, Denise
The dynamics of Helicobacter pylori colonization from its acquisition through the development of steady-state are examined through a mathematical model that includes the host response. The model...
Epithelial attachment alters the outcome of Helicobacter pylori infection
Guruge, Janaki L., Falk, Per G., Lorenz, Robin G., Dans, Maria, Wirth, Hans-Peter, Blaser, Martin J., ...
Genetically defined in vivo models are needed to assess the importance of target cell attachment in bacterial pathogenesis. Gastric colonization by Helicobacter pylori in human populations is common...
Van Doorn, Leen-Jan, Burnens, André, Huysmans, Michael, Vandamme, Peter, Giesendorf, Belinda A. J., ...
Recently, a gene from Campylobacter jejuni encoding a putative GTPase was identified. Based on two semiconserved GTP-binding sites encoded within this gene, PCR primers were selected that allow...
Distinct Variants of Helicobacter pylori cagA Are Associated with vacA Subtypes
Van Doorn, Leen-Jan, Figueiredo, Céu, Sanna, Ricardo, Blaser, Martin J., Quint, Wim G. V.
The diversity of the cytotoxin-associated gene (cagA) of Helicobacter pylori was analyzed in 45 isolates obtained from nine countries. We examined variation in the 5′ end of the cagA open reading...
CagA Antibodies in Japanese Children with Nodular Gastritis or Peptic Ulcer Disease
Kato, Seiichi, Sugiyama, Toshiro, Kudo, Mineo, Ohnuma, Kenji, Ozawa, Kyoko, Iinuma, Kazuie, ...
cagA+ Helicobacter pylori strains have been linked to more severe gastric inflammation, peptic ulcer disease, and gastric cancer in adults, but there have been few studies of cagA in children. We...
Fujimoto, Shuji, Umene, Kenichi, Saito, Mitsumasa, Horikawa, Kazumi, Blaser, Martin J.
We have evaluated the ability of a new genotyping method for Campylobacter jejuni based on restriction fragment length polymorphisms using random chromosomal gene probes. DNAs from C. jejuni strains...
Expanding Allelic Diversity of Helicobacter pylori vacA
Van Doorn, Leen-Jan, Figueiredo, Céu, Sanna, Ricardo, Pena, Salvador, Midolo, Peter, Ng, Enders K. W., ...
Distinct Variants of Helicobacter pylori cagA Are Associated with vacA Subtypes
Van Doorn, Leen-Jan, Figueiredo, Céu, Sanna, Ricardo, Blaser, Martin J., Quint, Wim G. V.
Assessment of Helicobacter pylori vacA and cagA Genotypes and Host Serological Response
Figueiredo, Céu, Quint, Wim, Nouhan, Nathalie, Van Den Munckhof, Henk, Herbrink, Paul, Scherpenisse, Joost, ...
Helicobacter pylori strains can be distinguished by genotyping of virulence-associated genes, such as vacA and cagA. Because serological discrimination between strain types would reduce the need for...
HP0333, a Member of the dprA Family, Is Involved in Natural Transformation in Helicobacter pylori
Ando, Takafumi, Israel, Dawn A., Kusugami, Kazuo, Blaser, Martin J.
Helicobacter pylori is naturally competent for DNA transformation, but the mechanism by which transformation occurs is not known. For Haemophilus influenzae, dprA is required for transformation by...
Helicobacter pylori strains can be divided into two groups, based on the presence of two unrelated genes, iceA1 and iceA2, that occupy the same genomic locus. hpyIM, located immediately downstream of...
Tu, Zheng-Chao, Ray, Kevin C., Thompson, Stuart A., Blaser, Martin J.
Campylobacter fetus cells possess multiple promoterless sap homologs, each capable of expressing a surface layer protein (SLP) by utilizing a unique promoter present on a 6.2-kb invertible element....
Perez-Perez, Guillermo I., Peek, Richard M., Atherton, John C., Blaser, Martin J., Cover, Timothy L.
Several different families of vacuolating toxin (vacA) alleles are present in Helicobacter pylori, and they encode products with differing functional activities. H. pylori strains containing certain...
Ando, Takafumi, Perez-Perez, Guillermo I., Kusugami, Kazuo, Ohsuga, Masahiro, Bloch, Karen C., Blaser, Martin J.
Helicobacter pylori persists in the human stomach despite eliciting both cellular and humoral immune responses and inducing proinflammatory cytokines. To determine whether local humoral and cytokine...
Detection and Characterization of Autoagglutination Activity by Campylobacter jejuni
Misawa, Naoaki, Blaser, Martin J.
In several gram-negative bacterial pathogens, autoagglutination (AAG) activity is a marker for interaction with host cells and virulence. Campylobacter jejuni strains also show AAG, but this property...
Allelic Variation within Helicobacter pylori babA and babB
Pride, David T., Meinersmann, Richard J., Blaser, Martin J.
Helicobacter pylori strains show both geographic and disease-associated allelic variation. We investigated the diversity present in two genes, babA and babB, which are members of a paralogous family...
Tu, Zheng-Chao, Dewhirst, Floyd E., Blaser, Martin J.
Campylobacter fetus bacteria, isolated from both mammals and reptiles, may be either subsp. fetus or subsp. venerealis and either serotype A or serotype B. Surface layer proteins, expressed and...
Peek, Richard M., Van Doorn, Leen-Jan, Donahue, John P., Tham, Kyi T., Figueiredo, Ceu, Blaser, Martin J., ...
The iceA locus of Helicobacter pylori includes one of two mutually exclusive gene families, iceA1 and iceA2. Colonization with iceA1 strains is associated with enhanced acute mucosal inflammation,...
Campylobacter fetus sap Inversion Occurs in the Absence of RecA Function
Ray, Kevin C., Tu, Zheng-Chao, Grogono-Thomas, Rosemary, Newell, Diane G., Thompson, Stuart A., Blaser, Martin J.
Phase variation of Campylobacter fetus surface layer proteins (SLPs) occurs by inversion of a 6.2-kb DNA segment containing the unique sap promoter, permitting expression of a single SLP-encoding...
Helicobacter pylori Heat Shock Protein A: Serologic Responses and Genetic Diversity
Ng, Enders K. W., Thompson, Stuart A., Pérez-Pérez, Guillermo I., Kansau, Imad, Van Der Ende, Arie, Labigne, Agnès, ...
Helicobacter pylori synthesizes an unusual GroES homolog, heat shock protein A (HspA). The present study was aimed at an assessment of the serological response to HspA in a group of Chinese patients...
Expanding Allelic Diversity of Helicobacter pylori vacA
Van Doorn, Leen-Jan, Figueiredo, Céu, Sanna, Ricardo, Pena, Salvador, Midolo, Peter, Ng, Enders K. W., ...
The diversity of the gene encoding the vacuolating cytotoxin (vacA) of Helicobacter pylori was analyzed in 98 isolates obtained from different geographic locations. The studies focused on variation...
Differentiation of Campylobacter jejuni Serotype O19 Strains from Non-O19 Strains by PCR
Misawa, Naoaki, Allos, Ban Mishu, Blaser, Martin J.
Guillain-Barré syndrome (GBS), a neurologic disease characterized by acute paralysis, is frequently preceded by Campylobacter jejuni infection. Serotype O19 strains are overrepresented among...
Evidence for a Conjugation-Like Mechanism of DNA Transfer in Helicobacter pylori
Kuipers, Ernst J., Israel, Dawn A., Kusters, Johannes G., Blaser, Martin J.
Many strains of Helicobacter pylori are naturally competent for transformation in vitro. Since there is a high degree of genetic variation among H. pylori strains, we sought to determine whether...
Campylobacter fetus Surface Layer Proteins Are Transported by a Type I Secretion System
Thompson, Stuart A., Shedd, Omer L., Ray, Kevin C., Beins, Michael H., Jorgensen, Jesse P., Blaser, Martin J.
The virulence of Campylobacter fetus, a bacterial pathogen of ungulates and humans, is mediated in part by the presence of a paracrystalline surface layer (S-layer) that confers serum resistance. The...
Pei, Zhiheng, Burucoa, Christophe, Grignon, Bernadette, Baqar, Shahida, Huang, Xiao-Zhe, Kopecko, Dennis J., ...
Campylobacter jejuni is one of the leading causes of bacterial diarrhea throughout the world. We previously found that PEB1 is a homolog of cluster 3 binding proteins of bacterial ABC transporters...
Ando, Takafumi, Kusugami, Kazuo, Ohsuga, Masahiro, Ina, Kenji, Shinoda, Masataka, Konagaya, Toshihiro, ...
There is differential resolution of mucosal infiltration with neutrophils and mononuclear cells following successful Helicobacter pylori eradication. We investigated the effects of H. pylori...
Experimental Infection of Mongolian Gerbils with Wild-Type and Mutant Helicobacter pylori Strains
Wirth, Hans-Peter, Beins, Michael H., Yang, Manqiao, Tham, Kyi T., Blaser, Martin J.
Experimental Helicobacter pylori infection was studied in Mongolian gerbils with fresh human isolates that carry or do not carry cagA (cagA-positive or cagA-negative, respectively), multiply passaged...
Takata, Tohru, Aras, Rahul, Tavakoli, Donald, Ando, Takafumi, Olivares, Asalia Z., Blaser, Martin J.
To determine relationships between Helicobacter pylori geographical origin and type II methylase activity, we examined 122 strains from various locations around the world for methylase expression....
Ando, Takafumi, Peek, Richard M., Lee, Yong-Chan, Krishna, Uma, Kusugami, Kazuo, Blaser, Martin J.
Associations of Helicobacter pylori genotypes with disease differ between Western countries and Asia. Therefore, we directly compared histopathological and in vitro responses to clinical isolates...
Mailborne transmission of anthrax: Modeling and implications
Webb, Glenn F., Blaser, Martin J.
A mathematical model is developed to analyze the transmission of inhalational anthrax through the postal system by cross-contamination of mail. The model consists of state vectors describing the...
Helicobacter pylori Does Not Require Lewis X or Lewis Y Expression To Colonize C3H/HeJ mice
Takata, Tohru, El-Omar, Emad, Camorlinga, Margarita, Thompson, Stuart A., Minohara, Yutaka, Ernst, Peter B., ...
Helicobacter pylori strains frequently express Lewis X (Lex) and/or Ley on their cell surfaces as constituents of the O antigens of their lipopolysaccharide molecules. To assess the effect of Lex and...
Romero-Gallo, Judith, Pérez-Pérez, Guillermo I., Novick, Richard P., Kamath, Patrick, Norbu, Tsering, Blaser, Martin J.
Although Helicobacter pylori is a cosmopolitan colonizer of the human stomach, the responses among persons in remote populations from whom H. pylori was cultured have not been studied. We report on...
Xu, Qing, Morgan, R. D., Roberts, R. J., Xu, S. Y., Van Doorn, L. J., Donahue, J. P., ...
iceA1 in Helicobacter pylori is a homolog of nlaIIIR, which encodes the CATG-specific restriction endonuclease NlaIII in Neisseria lactamica. Analysis of iceA1 sequences from 49 H.pylori strains...
Ghose, Chandrabali, Perez-Perez, Guillermo I., Dominguez-Bello, Maria-Gloria, Pride, David T., Bravi, Claudio M., Blaser, Martin J.
Phylogenies of indigenous microbes have been used as surrogates for the origins of the hosts that carry them. Conversely, polymorphisms may be used to date the spread of a microbial species when...
Levine, Steven M., Perez-Perez, Guillermo, Olivares, Asalia, Yee, Herman, Hanna, Bruce A., Blaser, Martin J.
We demonstrate that Bacillus anthracis may be detected from a formalin-fixed, paraffin-embedded biopsy specimen, even after the patient has received antibiotic treatment. Although traditional PCR...
Aras, Rahul A., Small, Aaron J., Ando, Takafumi, Blaser, Martin J.
Helicobacter pylori, bacteria that colonize the human gastric mucosa, possess a large number of genes for restriction-modification (R-M) systems, and essentially, every strain possesses a unique...
Transient and Persistent Helicobacter pylori Colonization in Native American Children
Pérez-Pérez, Guillermo I., Sack, R. Bradley, Reid, Raymond, Santosham, Mathuram, Croll, Janne, Blaser, Martin J.
Helicobacter pylori is chiefly acquired in childhood, but the exact timing of acquisition is not well understood. The main goal of this study was to assess H. pylori acquisition in a pediatric...
Detection of a luxS-Signaling Molecule in Bacillus anthracis
Jones, Marcus B., Blaser, Martin J.
Quorum-sensing regulation of density-dependent genes has been described for numerous bacterial species. The partially annotated genome sequence of Bacillus anthracis contains an open reading frame...
Israel, Dawn A., Salama, Nina, Arnold, Carrie N., Moss, Steven F., Ando, Takafumi, Wirth, Hans-Peter, ...
Helicobacter pylori enhances the risk for ulcer disease and gastric cancer, yet only a minority of H. pylori–colonized individuals develop disease. We examined the ability of two H. pylori isolates...
Extensive repetitive DNA facilitates prokaryotic genome plasticity
Aras, Rahul A., Kang, Josephine, Tschumi, Ariane I., Harasaki, Yasuaki, Blaser, Martin J.
Prokaryotic genomes are substantially diverse, even when from closely related species, with the resulting phenotypic diversity representing a repertoire of adaptations to specific constraints. Within...
Helicobacter pylori persistence: biology and disease
Blaser, Martin J., Atherton, John C.
Helicobacter pylori are bacteria that have coevolved with humans to be transmitted from person to person and to persistently colonize the stomach. Their population structure is a model for the...
Experimental Campylobacter jejuni Infection of Adult Mice
Blaser, Martin J., Duncan, Deborah J., Warren, George H., Wang, Wen-Lan L.
HA-ICR adult mice were studied to develop an animal model for Campylobacter jejuni enteritis in humans. Fecal and ileal cultures made by selective and nonselective methods showed that C. jejuni and...
Tu, Zheng-Chao, Hui, John, Blaser, Martin J.
Campylobacter fetus surface layer proteins (SLPs), encoded by sapA homologues, are important in virulence. In wild-type C. fetus strain 23D, all eight sapA homologues are located in the 54-kb sap...
Bacterial biota in the human distal esophagus
Pei, Zhiheng, Bini, Edmund J., Yang, Liying, Zhou, Meisheng, Francois, Fritz, Blaser, Martin J.
The esophagus, like other luminal organs of the digestive system, provides a potential environment for bacterial colonization, but little is known about the presence of a bacterial biota or its...
Evolutionary Implications of Microbial Genome Tetranucleotide Frequency Biases
Pride, David T., Meinersmann, Richard J., Wassenaar, Trudy M., Blaser, Martin J.
We compared nucleotide usage pattern conservation for related prokaryotes by examining the representation of DNA tetranucleotide combinations in 27 representative microbial genomes. For each of the...
Campylobacter fetus of Reptile Origin as a Human Pathogen
Tu, Zheng-Chao, Zeitlin, Gary, Gagner, Jean-Pierre, Keo, Thormika, Hanna, Bruce A., Blaser, Martin J.
A Campylobacter species was isolated from blood from a febrile patient with precursor T-cell acute lymphoblastic leukemia, and after antibiotic treatment, a similar bacterium was isolated from blood...
Effect of Host Species on RecG Phenotypes in Helicobacter pylori and Escherichia coli
Kang, Josephine, Tavakoli, Don, Tschumi, Ariane, Aras, Rahul A., Blaser, Martin J.
Recombination is a fundamental mechanism for the generation of genetic variation. Helicobacter pylori strains have different frequencies of intragenomic recombination, arising from deletions and...
Kang, Josephine, Huang, Shuyan, Blaser, Martin J.
MutS homologs, identified in nearly all bacteria and eukaryotes, include the bacterial proteins MutS1 and MutS2 and the eukaryotic MutS homologs 1 to 7, and they often are involved in recognition and...
Genetic Divergence of Campylobacter fetus Strains of Mammal and Reptile Origins
Tu, Zheng-Chao, Eisner, William, Kreiswirth, Barry N., Blaser, Martin J.
Campylobacter fetus is a gram-negative bacterial pathogen of both humans and animals. Two subspecies have been identified, Campylobacter fetus subsp. fetus and Campylobacter fetus subsp. venerealis,...
Campylobacter Enteritis in Denver
Blaser, Martin J., Reller, L. Barth, Luechtefeld, Nancy W., Wang, Wen-Lan Lou
To determine the relative importance of Campylobacter jejuni as a cause of diarrheal illness in patients coming to three hospitals in Denver, we cultured stool specimens from 2,670 patients over a...
Local and Systemic Immune and Inflammatory Responses to Helicobacter pylori Strains
Bhat, Niranjan, Gaensbauer, James, Peek, Richard M., Bloch, Karen, Tham, Kyi-Toe, Blaser, Martin J., ...
Colonization with Helicobacter pylori eventuates in varied clinical outcomes, which relate to both bacterial and host factors. Here we examine the relationships between cagA status, serum and gastric...
Molecular analysis of the bacterial microbiota in the human stomach
Bik, Elisabeth M., Eckburg, Paul B., Gill, Steven R., Nelson, Karen E., Purdom, Elizabeth A., Francois, Fritz, ...
The microbiota of the human stomach and the influence of Helicobacter pylori colonization on its composition remain largely unknown. We characterized bacterial diversity within the human gastric...
Theodore E. Woodward Award: Global Warming and the Human Stomach: Microecology Follows Macroecology
Just as there have been 20th century changes in our “macroecology,” including global warming, there have been alterations in our “microecology,” involving the microbial populations that...
An Email Alert System for Internal Medicine Physicians
Triola, Marc M., Blaser, Martin J.
This study evaluated the effectiveness of an email-based alerting system for internal medicine house staff and faculty in geographically dispersed locales. Responses to a test alert email message...
UvrD Helicase Suppresses Recombination and DNA Damage-Induced Deletions†
Kang, Josephine, Blaser, Martin J.
UvrD, a highly conserved helicase involved in mismatch repair, nucleotide excision repair (NER), and recombinational repair, plays a critical role in maintaining genomic stability and facilitating...
Molecular Analysis of Fungal Microbiota in Samples from Healthy Human Skin and Psoriatic Lesions
Paulino, Luciana C., Tseng, Chi-Hong, Strober, Bruce E., Blaser, Martin J.
Psoriasis, a common cutaneous disease of unknown etiology, may be triggered by infections, including those due to fungi. Since the fungal community of human skin is poorly characterized, we aimed to...
Xu, Qing, Morgan, Richard D., Roberts, Richard J., Blaser, Martin J.
A total of 22 type II restriction endonucleases with 18 distinct specificities have been identified in six Helicobacter pylori strains. Among these 18 specificities are three completely new...
Dynamics of Helicobacter pylori colonization in relation to the host response
Blaser, Martin J., Kirschner, Denise
The dynamics of Helicobacter pylori colonization from its acquisition through the development of steady-state are examined through a mathematical model that includes the host response. The model...
Epithelial attachment alters the outcome of Helicobacter pylori infection
Guruge, Janaki L., Falk, Per G., Lorenz, Robin G., Dans, Maria, Wirth, Hans-Peter, Blaser, Martin J., ...
Genetically defined in vivo models are needed to assess the importance of target cell attachment in bacterial pathogenesis. Gastric colonization by Helicobacter pylori in human populations is common...
Van Doorn, Leen-Jan, Burnens, André, Huysmans, Michael, Vandamme, Peter, Giesendorf, Belinda A. J., ...
Recently, a gene from Campylobacter jejuni encoding a putative GTPase was identified. Based on two semiconserved GTP-binding sites encoded within this gene, PCR primers were selected that allow...
Distinct Variants of Helicobacter pylori cagA Are Associated with vacA Subtypes
Van Doorn, Leen-Jan, Figueiredo, Céu, Sanna, Ricardo, Blaser, Martin J., Quint, Wim G. V.
The diversity of the cytotoxin-associated gene (cagA) of Helicobacter pylori was analyzed in 45 isolates obtained from nine countries. We examined variation in the 5′ end of the cagA open reading...
CagA Antibodies in Japanese Children with Nodular Gastritis or Peptic Ulcer Disease
Kato, Seiichi, Sugiyama, Toshiro, Kudo, Mineo, Ohnuma, Kenji, Ozawa, Kyoko, Iinuma, Kazuie, ...
cagA+ Helicobacter pylori strains have been linked to more severe gastric inflammation, peptic ulcer disease, and gastric cancer in adults, but there have been few studies of cagA in children. We...
Fujimoto, Shuji, Umene, Kenichi, Saito, Mitsumasa, Horikawa, Kazumi, Blaser, Martin J.
We have evaluated the ability of a new genotyping method for Campylobacter jejuni based on restriction fragment length polymorphisms using random chromosomal gene probes. DNAs from C. jejuni strains...
Expanding Allelic Diversity of Helicobacter pylori vacA
Van Doorn, Leen-Jan, Figueiredo, Céu, Sanna, Ricardo, Pena, Salvador, Midolo, Peter, Ng, Enders K. W., ...
Distinct Variants of Helicobacter pylori cagA Are Associated with vacA Subtypes
Van Doorn, Leen-Jan, Figueiredo, Céu, Sanna, Ricardo, Blaser, Martin J., Quint, Wim G. V.
Assessment of Helicobacter pylori vacA and cagA Genotypes and Host Serological Response
Figueiredo, Céu, Quint, Wim, Nouhan, Nathalie, Van Den Munckhof, Henk, Herbrink, Paul, Scherpenisse, Joost, ...
Helicobacter pylori strains can be distinguished by genotyping of virulence-associated genes, such as vacA and cagA. Because serological discrimination between strain types would reduce the need for...
HP0333, a Member of the dprA Family, Is Involved in Natural Transformation in Helicobacter pylori
Ando, Takafumi, Israel, Dawn A., Kusugami, Kazuo, Blaser, Martin J.
Helicobacter pylori is naturally competent for DNA transformation, but the mechanism by which transformation occurs is not known. For Haemophilus influenzae, dprA is required for transformation by...
Helicobacter pylori strains can be divided into two groups, based on the presence of two unrelated genes, iceA1 and iceA2, that occupy the same genomic locus. hpyIM, located immediately downstream of...
Tu, Zheng-Chao, Ray, Kevin C., Thompson, Stuart A., Blaser, Martin J.
Campylobacter fetus cells possess multiple promoterless sap homologs, each capable of expressing a surface layer protein (SLP) by utilizing a unique promoter present on a 6.2-kb invertible element....
Perez-Perez, Guillermo I., Peek, Richard M., Atherton, John C., Blaser, Martin J., Cover, Timothy L.
Several different families of vacuolating toxin (vacA) alleles are present in Helicobacter pylori, and they encode products with differing functional activities. H. pylori strains containing certain...
Ando, Takafumi, Perez-Perez, Guillermo I., Kusugami, Kazuo, Ohsuga, Masahiro, Bloch, Karen C., Blaser, Martin J.
Helicobacter pylori persists in the human stomach despite eliciting both cellular and humoral immune responses and inducing proinflammatory cytokines. To determine whether local humoral and cytokine...
Detection and Characterization of Autoagglutination Activity by Campylobacter jejuni
Misawa, Naoaki, Blaser, Martin J.
In several gram-negative bacterial pathogens, autoagglutination (AAG) activity is a marker for interaction with host cells and virulence. Campylobacter jejuni strains also show AAG, but this property...
Allelic Variation within Helicobacter pylori babA and babB
Pride, David T., Meinersmann, Richard J., Blaser, Martin J.
Helicobacter pylori strains show both geographic and disease-associated allelic variation. We investigated the diversity present in two genes, babA and babB, which are members of a paralogous family...
Tu, Zheng-Chao, Dewhirst, Floyd E., Blaser, Martin J.
Campylobacter fetus bacteria, isolated from both mammals and reptiles, may be either subsp. fetus or subsp. venerealis and either serotype A or serotype B. Surface layer proteins, expressed and...
Peek, Richard M., Van Doorn, Leen-Jan, Donahue, John P., Tham, Kyi T., Figueiredo, Ceu, Blaser, Martin J., ...
The iceA locus of Helicobacter pylori includes one of two mutually exclusive gene families, iceA1 and iceA2. Colonization with iceA1 strains is associated with enhanced acute mucosal inflammation,...
Campylobacter fetus sap Inversion Occurs in the Absence of RecA Function
Ray, Kevin C., Tu, Zheng-Chao, Grogono-Thomas, Rosemary, Newell, Diane G., Thompson, Stuart A., Blaser, Martin J.
Phase variation of Campylobacter fetus surface layer proteins (SLPs) occurs by inversion of a 6.2-kb DNA segment containing the unique sap promoter, permitting expression of a single SLP-encoding...
Helicobacter pylori Heat Shock Protein A: Serologic Responses and Genetic Diversity
Ng, Enders K. W., Thompson, Stuart A., Pérez-Pérez, Guillermo I., Kansau, Imad, Van Der Ende, Arie, Labigne, Agnès, ...
Helicobacter pylori synthesizes an unusual GroES homolog, heat shock protein A (HspA). The present study was aimed at an assessment of the serological response to HspA in a group of Chinese patients...
Expanding Allelic Diversity of Helicobacter pylori vacA
Van Doorn, Leen-Jan, Figueiredo, Céu, Sanna, Ricardo, Pena, Salvador, Midolo, Peter, Ng, Enders K. W., ...
The diversity of the gene encoding the vacuolating cytotoxin (vacA) of Helicobacter pylori was analyzed in 98 isolates obtained from different geographic locations. The studies focused on variation...
Differentiation of Campylobacter jejuni Serotype O19 Strains from Non-O19 Strains by PCR
Misawa, Naoaki, Allos, Ban Mishu, Blaser, Martin J.
Guillain-Barré syndrome (GBS), a neurologic disease characterized by acute paralysis, is frequently preceded by Campylobacter jejuni infection. Serotype O19 strains are overrepresented among...
Evidence for a Conjugation-Like Mechanism of DNA Transfer in Helicobacter pylori
Kuipers, Ernst J., Israel, Dawn A., Kusters, Johannes G., Blaser, Martin J.
Many strains of Helicobacter pylori are naturally competent for transformation in vitro. Since there is a high degree of genetic variation among H. pylori strains, we sought to determine whether...
Campylobacter fetus Surface Layer Proteins Are Transported by a Type I Secretion System
Thompson, Stuart A., Shedd, Omer L., Ray, Kevin C., Beins, Michael H., Jorgensen, Jesse P., Blaser, Martin J.
The virulence of Campylobacter fetus, a bacterial pathogen of ungulates and humans, is mediated in part by the presence of a paracrystalline surface layer (S-layer) that confers serum resistance. The...
Pei, Zhiheng, Burucoa, Christophe, Grignon, Bernadette, Baqar, Shahida, Huang, Xiao-Zhe, Kopecko, Dennis J., ...
Campylobacter jejuni is one of the leading causes of bacterial diarrhea throughout the world. We previously found that PEB1 is a homolog of cluster 3 binding proteins of bacterial ABC transporters...
Ando, Takafumi, Kusugami, Kazuo, Ohsuga, Masahiro, Ina, Kenji, Shinoda, Masataka, Konagaya, Toshihiro, ...
There is differential resolution of mucosal infiltration with neutrophils and mononuclear cells following successful Helicobacter pylori eradication. We investigated the effects of H. pylori...
Experimental Infection of Mongolian Gerbils with Wild-Type and Mutant Helicobacter pylori Strains
Wirth, Hans-Peter, Beins, Michael H., Yang, Manqiao, Tham, Kyi T., Blaser, Martin J.
Experimental Helicobacter pylori infection was studied in Mongolian gerbils with fresh human isolates that carry or do not carry cagA (cagA-positive or cagA-negative, respectively), multiply passaged...
Takata, Tohru, Aras, Rahul, Tavakoli, Donald, Ando, Takafumi, Olivares, Asalia Z., Blaser, Martin J.
To determine relationships between Helicobacter pylori geographical origin and type II methylase activity, we examined 122 strains from various locations around the world for methylase expression....
Ando, Takafumi, Peek, Richard M., Lee, Yong-Chan, Krishna, Uma, Kusugami, Kazuo, Blaser, Martin J.
Associations of Helicobacter pylori genotypes with disease differ between Western countries and Asia. Therefore, we directly compared histopathological and in vitro responses to clinical isolates...
Mailborne transmission of anthrax: Modeling and implications
Webb, Glenn F., Blaser, Martin J.
A mathematical model is developed to analyze the transmission of inhalational anthrax through the postal system by cross-contamination of mail. The model consists of state vectors describing the...
Helicobacter pylori Does Not Require Lewis X or Lewis Y Expression To Colonize C3H/HeJ mice
Takata, Tohru, El-Omar, Emad, Camorlinga, Margarita, Thompson, Stuart A., Minohara, Yutaka, Ernst, Peter B., ...
Helicobacter pylori strains frequently express Lewis X (Lex) and/or Ley on their cell surfaces as constituents of the O antigens of their lipopolysaccharide molecules. To assess the effect of Lex and...
Romero-Gallo, Judith, Pérez-Pérez, Guillermo I., Novick, Richard P., Kamath, Patrick, Norbu, Tsering, Blaser, Martin J.
Although Helicobacter pylori is a cosmopolitan colonizer of the human stomach, the responses among persons in remote populations from whom H. pylori was cultured have not been studied. We report on...
Xu, Qing, Morgan, R. D., Roberts, R. J., Xu, S. Y., Van Doorn, L. J., Donahue, J. P., ...
iceA1 in Helicobacter pylori is a homolog of nlaIIIR, which encodes the CATG-specific restriction endonuclease NlaIII in Neisseria lactamica. Analysis of iceA1 sequences from 49 H.pylori strains...
Ghose, Chandrabali, Perez-Perez, Guillermo I., Dominguez-Bello, Maria-Gloria, Pride, David T., Bravi, Claudio M., Blaser, Martin J.
Phylogenies of indigenous microbes have been used as surrogates for the origins of the hosts that carry them. Conversely, polymorphisms may be used to date the spread of a microbial species when...
Levine, Steven M., Perez-Perez, Guillermo, Olivares, Asalia, Yee, Herman, Hanna, Bruce A., Blaser, Martin J.
We demonstrate that Bacillus anthracis may be detected from a formalin-fixed, paraffin-embedded biopsy specimen, even after the patient has received antibiotic treatment. Although traditional PCR...
Aras, Rahul A., Small, Aaron J., Ando, Takafumi, Blaser, Martin J.
Helicobacter pylori, bacteria that colonize the human gastric mucosa, possess a large number of genes for restriction-modification (R-M) systems, and essentially, every strain possesses a unique...
Transient and Persistent Helicobacter pylori Colonization in Native American Children
Pérez-Pérez, Guillermo I., Sack, R. Bradley, Reid, Raymond, Santosham, Mathuram, Croll, Janne, Blaser, Martin J.
Helicobacter pylori is chiefly acquired in childhood, but the exact timing of acquisition is not well understood. The main goal of this study was to assess H. pylori acquisition in a pediatric...
Detection of a luxS-Signaling Molecule in Bacillus anthracis
Jones, Marcus B., Blaser, Martin J.
Quorum-sensing regulation of density-dependent genes has been described for numerous bacterial species. The partially annotated genome sequence of Bacillus anthracis contains an open reading frame...
Israel, Dawn A., Salama, Nina, Arnold, Carrie N., Moss, Steven F., Ando, Takafumi, Wirth, Hans-Peter, ...
Helicobacter pylori enhances the risk for ulcer disease and gastric cancer, yet only a minority of H. pylori–colonized individuals develop disease. We examined the ability of two H. pylori isolates...
Extensive repetitive DNA facilitates prokaryotic genome plasticity
Aras, Rahul A., Kang, Josephine, Tschumi, Ariane I., Harasaki, Yasuaki, Blaser, Martin J.
Prokaryotic genomes are substantially diverse, even when from closely related species, with the resulting phenotypic diversity representing a repertoire of adaptations to specific constraints. Within...
Helicobacter pylori persistence: biology and disease
Blaser, Martin J., Atherton, John C.
Helicobacter pylori are bacteria that have coevolved with humans to be transmitted from person to person and to persistently colonize the stomach. Their population structure is a model for the...
Experimental Campylobacter jejuni Infection of Adult Mice
Blaser, Martin J., Duncan, Deborah J., Warren, George H., Wang, Wen-Lan L.
HA-ICR adult mice were studied to develop an animal model for Campylobacter jejuni enteritis in humans. Fecal and ileal cultures made by selective and nonselective methods showed that C. jejuni and...
Tu, Zheng-Chao, Hui, John, Blaser, Martin J.
Campylobacter fetus surface layer proteins (SLPs), encoded by sapA homologues, are important in virulence. In wild-type C. fetus strain 23D, all eight sapA homologues are located in the 54-kb sap...
Bacterial biota in the human distal esophagus
Pei, Zhiheng, Bini, Edmund J., Yang, Liying, Zhou, Meisheng, Francois, Fritz, Blaser, Martin J.
The esophagus, like other luminal organs of the digestive system, provides a potential environment for bacterial colonization, but little is known about the presence of a bacterial biota or its...
Evolutionary Implications of Microbial Genome Tetranucleotide Frequency Biases
Pride, David T., Meinersmann, Richard J., Wassenaar, Trudy M., Blaser, Martin J.
We compared nucleotide usage pattern conservation for related prokaryotes by examining the representation of DNA tetranucleotide combinations in 27 representative microbial genomes. For each of the...
Campylobacter fetus of Reptile Origin as a Human Pathogen
Tu, Zheng-Chao, Zeitlin, Gary, Gagner, Jean-Pierre, Keo, Thormika, Hanna, Bruce A., Blaser, Martin J.
A Campylobacter species was isolated from blood from a febrile patient with precursor T-cell acute lymphoblastic leukemia, and after antibiotic treatment, a similar bacterium was isolated from blood...
Effect of Host Species on RecG Phenotypes in Helicobacter pylori and Escherichia coli
Kang, Josephine, Tavakoli, Don, Tschumi, Ariane, Aras, Rahul A., Blaser, Martin J.
Recombination is a fundamental mechanism for the generation of genetic variation. Helicobacter pylori strains have different frequencies of intragenomic recombination, arising from deletions and...
Kang, Josephine, Huang, Shuyan, Blaser, Martin J.
MutS homologs, identified in nearly all bacteria and eukaryotes, include the bacterial proteins MutS1 and MutS2 and the eukaryotic MutS homologs 1 to 7, and they often are involved in recognition and...
Genetic Divergence of Campylobacter fetus Strains of Mammal and Reptile Origins
Tu, Zheng-Chao, Eisner, William, Kreiswirth, Barry N., Blaser, Martin J.
Campylobacter fetus is a gram-negative bacterial pathogen of both humans and animals. Two subspecies have been identified, Campylobacter fetus subsp. fetus and Campylobacter fetus subsp. venerealis,...
Campylobacter Enteritis in Denver
Blaser, Martin J., Reller, L. Barth, Luechtefeld, Nancy W., Wang, Wen-Lan Lou
To determine the relative importance of Campylobacter jejuni as a cause of diarrheal illness in patients coming to three hospitals in Denver, we cultured stool specimens from 2,670 patients over a...
Local and Systemic Immune and Inflammatory Responses to Helicobacter pylori Strains
Bhat, Niranjan, Gaensbauer, James, Peek, Richard M., Bloch, Karen, Tham, Kyi-Toe, Blaser, Martin J., ...
Colonization with Helicobacter pylori eventuates in varied clinical outcomes, which relate to both bacterial and host factors. Here we examine the relationships between cagA status, serum and gastric...
Molecular analysis of the bacterial microbiota in the human stomach
Bik, Elisabeth M., Eckburg, Paul B., Gill, Steven R., Nelson, Karen E., Purdom, Elizabeth A., Francois, Fritz, ...
The microbiota of the human stomach and the influence of Helicobacter pylori colonization on its composition remain largely unknown. We characterized bacterial diversity within the human gastric...
Theodore E. Woodward Award: Global Warming and the Human Stomach: Microecology Follows Macroecology
Just as there have been 20th century changes in our “macroecology,” including global warming, there have been alterations in our “microecology,” involving the microbial populations that...
An Email Alert System for Internal Medicine Physicians
Triola, Marc M., Blaser, Martin J.
This study evaluated the effectiveness of an email-based alerting system for internal medicine house staff and faculty in geographically dispersed locales. Responses to a test alert email message...
UvrD Helicase Suppresses Recombination and DNA Damage-Induced Deletions†
Kang, Josephine, Blaser, Martin J.
UvrD, a highly conserved helicase involved in mismatch repair, nucleotide excision repair (NER), and recombinational repair, plays a critical role in maintaining genomic stability and facilitating...
Molecular Analysis of Fungal Microbiota in Samples from Healthy Human Skin and Psoriatic Lesions
Paulino, Luciana C., Tseng, Chi-Hong, Strober, Bruce E., Blaser, Martin J.
Psoriasis, a common cutaneous disease of unknown etiology, may be triggered by infections, including those due to fungi. Since the fungal community of human skin is poorly characterized, we aimed to...
Antimutator Role of the DNA Glycosylase mutY Gene in Helicobacter pylori
Huang, Shuyan, Kang, Josephine, Blaser, Martin J.
Helicobacter pylori has a highly variable genome with ongoing diversification via inter- and intragenomic recombination and spontaneous mutation. DNA repair genes modulating mutation and...
Early-Life Family Structure and Microbially Induced Cancer Risk
Blaser, Martin J, Nomura, Abraham, Lee, James, Stemmerman, Grant N, Perez-Perez, Guillermo I
This study suggests that early-life social environment has a significant role in risk of microbially induced malignancies such as gastric adenocarcinoma occuring five to eight decades later.
Correction: Early-Life Family Structure and Microbially Induced Cancer Risk
Blaser, Martin J, Nomura, Abraham, Lee, James, Stemmerman, Grant N, Perez-Perez, Guillermo I
Ghose, Chandrabali, Perez-Perez, Guillermo I., Torres, Victor J., Crosatti, Marialuisa, Nomura, Abraham, Peek, Richard M., ...
The Helicobacter pylori vacA gene encodes a secreted protein (VacA) that alters the function of gastric epithelial cells and T lymphocytes. H. pylori strains containing particular vacA alleles are...
Molecular analysis of human forearm superficial skin bacterial biota
Gao, Zhan, Tseng, Chi-hong, Pei, Zhiheng, Blaser, Martin J.
The microbial ecology of human skin is complex, but little is known about its species composition. We examined the diversity of the skin biota from the superficial volar left and right forearms in...
Plasticity of Repetitive DNA Sequences within a Bacterial (Type IV) Secretion System Component
Aras, Rahul A., Fischer, Wolfgang, Perez-Perez, Guillermo I., Crosatti, MariaLuisa, Ando, Takafumi, Haas, Rainer, ...
DNA rearrangement permits bacteria to regulate gene content and expression. In Helicobacter pylori, cagY, which contains an extraordinary number of direct DNA repeats, encodes a surface-exposed...
Reactive Nitrogen Species Contribute to Innate Host Defense against Campylobacter jejuni▿
Iovine, Nicole M., Pursnani, Seema, Voldman, Alex, Wasserman, Gregory, Blaser, Martin J., Weinrauch, Yvette
Campylobacter jejuni, a gram-negative, invasive organism, is a common cause of food-borne bacterial diarrheal disease. However, the relationship between C. jejuni and the innate immune system is not...
Substantial Alterations of the Cutaneous Bacterial Biota in Psoriatic Lesions
Gao, Zhan, Tseng, Chi-hong, Strober, Bruce E., Pei, Zhiheng, Blaser, Martin J.
For psoriasis, an idiopathic inflammatory disorder of the skin, the microbial biota has not been defined using cultivation-independent methods. We used broad-range 16S rDNA PCR for archaea and...
Repair and Antirepair DNA Helicases in Helicobacter pylori▿ †
Kang, Josephine, Blaser, Martin J.
Orthologs of RecG and RuvABC are highly conserved among prokaryotes; in Escherichia coli, they participate in independent pathways that branch migrate Holliday junctions during recombinational DNA...
Asthma Is Inversely Associated with Helicobacter pylori Status in an Urban Population
Reibman, Joan, Marmor, Michael, Filner, Joshua, Fernandez-Beros, Maria-Elena, Rogers, Linda, Perez-Perez, Guillermo I., ...
Lin, Edward A., Zhang, Xue-Song, Levine, Steven M., Gill, Steven R., Falush, Daniel, Blaser, Martin J.
Helicobacter pylori are gram-negative bacteria notable for their high level of genetic diversity and plasticity, features that may play a key role in the organism's ability to colonize the human...
Bacterial Community in the Crop of the Hoatzin, a Neotropical Folivorous Flying Bird▿ †
Godoy-Vitorino, Filipa, Ley, Ruth E., Gao, Zhan, Pei, Zhiheng, Ortiz-Zuazaga, Humberto, Pericchi, Luis R., ...
The hoatzin is unique among known avian species because of the fermentative function of its enlarged crop. A small-bodied flying foregut fermenter is a paradox, and this bird provides an interesting...
Diversity of 23S rRNA Genes within Individual Prokaryotic Genomes
Pei, Anna, Nossa, Carlos W., Chokshi, Pooja, Blaser, Martin J., Yang, Liying, Rosmarin, David M., ...
Leptin and Ghrelin in Relation to Helicobacter pylori Status in Adult Males
Roper, Jatin, Francois, Fritz, Shue, Peter L., Mourad, Michelle S., Pei, Zhiheng, Olivares De Perez, Asalia Z., ...
Context: Leptin and ghrelin, hormones involved in human energy homeostasis, are both produced in the stomach.
Molecular Analysis of Sarcoidosis Tissues for Mycobacterium Species DNA
Drake, Wonder Puryear, Pei, Zhiheng, Pride, David T., Collins, Robert D., Cover, Timothy L., Blaser, Martin J.
We performed polymerase chain reaction analysis, for Mycobacterium species 16S rRNA, rpoB, and IS6110 sequences, on 25 tissue specimens from patients with sarcoidosis and on 25 control tissue...