Martin J. Gibala

Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1α in human skeletal muscle (2009)

Gibala, Martin J., McGee, Sean L, Garnham, Andrew P., Howlett, Kirsten F., Snow, Rodney J., Hargreaves, Mark

From a cell signaling perspective, short-duration intense muscular work is typically associated with resistance training and linked to pathways that stimulate growth. However, brief...

Glycogen availability does not affect the TCA cycle or TAN pools during prolonged, fatiguing exercise (2003)

Baldwin, Jacinta, Snow, Rod, Gibala, Martin J., Garnham, Andrew, Howarth, Krista, Febbraio, Mark A.

The hypothesis that fatigue during prolonged exercise arises from insufficient intramuscular glycogen, which limits tricarboxylic acid cycle (TCA) activity due to reduced TCA cycle intermediates...

Glycogen availability does not affect the TCA cycle or TAN pools during prolonged, fatiguing exercise (2003)

Baldwin, Jacinta, Snow, Rod, Gibala, Martin J., Garnham, Andrew, Howarth, Krista, Febbraio, Mark A.

The hypothesis that fatigue during prolonged exercise arises from insufficient intramuscular glycogen, which limits tricarboxylic acid cycle (TCA) activity due to reduced TCA cycle intermediates...

An acute decrease in TCA cycle intermediates does not affect aerobic energy delivery in contracting rat skeletal muscle

Dawson, Kristen D, Baker, David J, Greenhaff, Paul L, Gibala, Martin J

We tested the hypothesis that an acute decrease in muscle TCA cycle intermediates during contraction would compromise aerobic energy delivery. Male Wistar rats were anaesthetized and the...

An acute decrease in TCA cycle intermediates does not affect aerobic energy delivery in contracting rat skeletal muscle

Dawson, Kristen D, Baker, David J, Greenhaff, Paul L, Gibala, Martin J

We tested the hypothesis that an acute decrease in muscle TCA cycle intermediates during contraction would compromise aerobic energy delivery. Male Wistar rats were anaesthetized and the...

Short-term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance

Gibala, Martin J, Little, Jonathan P, Van Essen, Martin, Wilkin, Geoffrey P, Burgomaster, Kirsten A, Safdar, Adeel, ...

Brief, intense exercise training may induce metabolic and performance adaptations comparable to traditional endurance training. However, no study has directly compared these diverse training...

Myoadenylate deaminase deficiency does not affect muscle anaplerosis during exhaustive exercise in humans

Tarnopolsky, Mark A, Parise, Gianni, Gibala, Martin J, Graham, Terry E, Rush, James W E

Myoadenylate deaminase (AMPD) deficiency is present in 1–2 % of the population. In theory, this deficiency may alter exercise energy metabolism by impairing the purine nucleotide cycle (PNC) and...

Exercise with low muscle glycogen augments TCA cycle anaplerosis but impairs oxidative energy provision in humans

Gibala, Martin J, Peirce, Nick, Constantin-Teodosiu, Dimitru, Greenhaff, Paul L

We tested the hypotheses that: (i) exercise with low muscle glycogen would reduce pyruvate flux through the alanine aminotransferase (AAT) reaction and attenuate the increase in tricarboxylic acid...

Dissociation between muscle tricarboxylic acid cycle pool size and aerobic energy provision during prolonged exercise in humans

Gibala, Martin J, González-Alonso, José, Saltin, Bengt

It has been suggested that a decrease in the total concentration of tricarboxylic acid cycle intermediates (TCAIs) - secondary to a reduction in glycogen availability - compromises oxidative energy...

Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans

Burgomaster, Kirsten A, Howarth, Krista R, Phillips, Stuart M, Rakobowchuk, Mark, MacDonald, Maureen J, McGee, Sean L, ...

Low-volume ‘sprint’ interval training (SIT) stimulates rapid improvements in muscle oxidative capacity that are comparable to levels reached following traditional endurance training (ET) but no...

Sprint interval and traditional endurance training induce similar improvements in peripheral arterial stiffness and flow-mediated dilation in healthy humans

Rakobowchuk, Mark, Tanguay, Sophie, Burgomaster, Kirsten A., Howarth, Krista R., Gibala, Martin J., MacDonald, Maureen J.

Low-volume sprint interval training (SIT), or repeated sessions of brief, intense intermittent exercise, elicits metabolic adaptations that resemble traditional high-volume endurance training (ET)....