A Role for PPARβ/δ in Tumor Stroma and Tumorigenesis (2008)
Rolf Müller, Martin Kömhoff, Jeffrey M. Peters, Sabine Müller-Brüsselbach
Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) is a transcription factor that is activated by endogenous fatty acid ligands and by synthetic agonists. Its role in the regulation of...
Klein, Thomas, Eltze, Manfrid, Grebe, Thomas, Hatzelmann, Armin, Kömhoff, Martin
Objective Celecoxib carries a smaller cardiovascular risk for myocardial infarction and hypertension than other cyclooxygenase-2 (COX-2)-selective non-steroidal anti-inflammatory drugs NSAIDs...
Increased systolic blood pressure with rofecoxib in congenital furosemide-like salt loss (2006)
Kömhoff, Martin, Klaus, Günter, Nazarowa, Sofia, Reinalter, Stephan C., Seyberth, Hannsjörg W.
Background. To analyse whether congenital furosemide- or thiazide-like renal salt loss protects against the potential prohypertensive effects of two cyclooxygenase (COX) inhibitors: rofecoxib, a...
Increased systolic blood pressure with rofecoxib in congenital furosemide-like salt loss (2006)
Kömhoff, Martin, Klaus, Günter, Nazarowa, Sofia, Reinalter, Stephan C., Seyberth, Hannsjörg W.
Background. To analyse whether congenital furosemide- or thiazide-like renal salt loss protects against the potential prohypertensive effects of two cyclooxygenase (COX) inhibitors: rofecoxib, a...
Increased systolic blood pressure with rofecoxib in congenital furosemide-like salt loss (2006)
Kömhoff, Martin, Klaus, Günter, Nazarowa, Sofia, Reinalter, Stephan C., Seyberth, Hannsjörg W.
Background. To analyse whether congenital furosemide- or thiazide-like renal salt loss protects against the potential prohypertensive effects of two cyclooxygenase (COX) inhibitors: rofecoxib, a...
Hao, Chuan-Ming, Yull, Fiona, Blackwell, Timothy, Kömhoff, Martin, Davis, Linda S., Breyer, Matthew D.
Renal prostaglandin (PG) synthesis is mediated by cyclooxygenase-1 and -2 (COX1 and COX2). After dehydration, the maintenance of normal renal function becomes particularly dependent upon PG...
Hao, Chuan-Ming, Yull, Fiona, Blackwell, Timothy, Kömhoff, Martin, Davis, Linda S., Breyer, Matthew D.
Renal prostaglandin (PG) synthesis is mediated by cyclooxygenase-1 and -2 (COX1 and COX2). After dehydration, the maintenance of normal renal function becomes particularly dependent upon PG...
Enhanced Expression of Cyclooxygenase-2 in High Grade Human Transitional Cell Bladder Carcinomas
Kömhoff, Martin, Guan, Youfei, Shappell, Heidi W., Davis, Linda, Jack, Greg, Shyr, Yu, ...
Studies in human and animal models have shown that cyclooxygenase (COX)-2 is up-regulated in several epithelial carcinomas including colon, breast, and lung. To elucidate the possible involvement of...
A Role for PPARβ/δ in Tumor Stroma and Tumorigenesis
Müller, Rolf, Kömhoff, Martin, Peters, Jeffrey M., Müller-Brüsselbach, Sabine
Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) is a transcription factor that is activated by endogenous fatty acid ligands and by synthetic agonists. Its role in the regulation of...
Deregulation of tumor angiogenesis and blockade of tumor growth in PPARβ-deficient mice
Müller-Brüsselbach, Sabine, Kömhoff, Martin, Rieck, Markus, Meissner, Wolfgang, Kaddatz, Kerstin, Adamkiewicz, Jürgen, ...
The peroxisome proliferator-activated receptor-β (PPARβ) has been implicated in tumorigenesis, but its precise role remains unclear. Here, we show that the growth of syngeneic Pparb wild-type...