Short-term genome evolution of Listeria monocytogenesin a non-controlled environment (2008)
Orsi, Renato H, Borowsky, Mark L, Lauer, Peter, Young, Sarah K, Nusbaum, Chad, Galagan, James E, ...
Abstract Background While increasing data on bacterial evolution in controlled environments are available, our understanding of bacterial genome evolution in natural environments is limited. We thus...
Lineage specific recombination rates and microevolution in Listeria monocytogenes (2008)
Den Bakker, Henk C, Didelot, Xavier, Fortes, Esther D, Nightingale, Kendra K, Wiedmann, Martin
Abstract Background The bacterium Listeria monocytogenes is a saprotroph as well as an opportunistic human foodborne pathogen, which has previously been shown to consist of at least two widespread...
Lineage specific recombination rates and microevolution in Listeria monocytogenes (2008)
Den Bakker, Henk C., Didelot, Xavier, Fortes, Esther D, Nightingale, Kendra K, Wiedmann, Martin
Background: The bacterium Listeria monocytogenes is a saprotroph as well as an opportunistic human foodborne pathogen, which has previously been shown to consist of at least two widespread lineages...
Orsi, Renato H, Sun, Qi, Wiedmann, Martin
Abstract Background The genus Listeria includes two closely related pathogenic and non-pathogenic species, L. monocytogenes and L. innocua . L. monocytogenes is an opportunistic human foodborne and...
Short-term genome evolution of Listeria monocytogenes in a non-controlled environment (2008)
Orsi, Renato H., Borowsky, Mark L., Lauer, Peter, Young, Sarah K., Nusbaum, Chad, Galagan, James E., ...
Background: While increasing data on bacterial evolution in controlled environments are available, our understanding of bacterial genome evolution in natural environments is limited. We thus...
BMC Evolutionary Biology (2007)
Renato H Orsi, Qi Sun, Martin Wiedmann
Research article Genome-wide analyses reveal lineage specific contributions of positive selection and recombination to the evolution of Listeria monocytogenes
Klæboe, Halvdan, Rosef, Olav, Fortes, Esther, Wiedmann, Martin
The purpose of this study was to use automated ribotyping procedure to track Listeria monocytogenes transmission in the cold smoked fish production chain and to characterize L. monocytogenes subtypes...
Alcaine, Samuel D, Sukhnanand, Sharinne S, Warnick, Lorin D, Su, Wan-lin, McGann, Patrick, McDonough, Patrick, ...
Salmonella enterica is a gram-negative, rod shaped bacillus, which inhabits the intestines of mammals, reptiles and birds. In the United States, Salmonella is one of the leading causes of food-borne...
Alcaine, Samuel D, Sukhnanand, Sharinne S, Warnick, Lorin D, Su, Wan-lin, McGann, Patrick, McDonough, Patrick, ...
Salmonella enterica is a gram-negative, rod shaped bacillus, which inhabits the intestines of mammals, reptiles and birds. In the United States, Salmonella is one of the leading causes of food-borne...
Mattiazzi, Marina, Vijayvergiya, Chetan, Gajewski, Carl D., DeVivo, Darryl C., Lenaz, Giorgio, Wiedmann, Martin, ...
A T8993G point mutation in the mtDNA results in a Leu156Arg substitution in the MTATP6 subunit of the mitochondrial F1F0-ATPase. The T8993G mutation causes impaired oxidative phosphorylation (OXPHOS)...
Mattiazzi, Marina, Vijayvergiya, Chetan, Gajewski, Carl D., DeVivo, Darryl C., Lenaz, Giorgio, Wiedmann, Martin, ...
A T8993G point mutation in the mtDNA results in a Leu156Arg substitution in the MTATP6 subunit of the mitochondrial F1F0-ATPase. The T8993G mutation causes impaired oxidative phosphorylation (OXPHOS)...
Mattiazzi, Marina, Vijayvergiya, Chetan, Gajewski, Carl D., DeVivo, Darryl C., Lenaz, Giorgio, Wiedmann, Martin, ...
A T8993G point mutation in the mtDNA results in a Leu156Arg substitution in the MTATP6 subunit of the mitochondrial F1F0-ATPase. The T8993G mutation causes impaired oxidative phosphorylation (OXPHOS)...
Characterization of Listeria monocytogenes isolates and epidemiology of listeriosis / (1997)
Thesis (Ph. D.)--Cornell University.
Thesis (doctoral)--Ludwig-Maximilians-Universität München, 1994.
Söllner, Thomas, Rassow, Joachim, Wiedmann, Martin, Schlossmann, Jens, Keil, Petra, Neupert, Walter, ...
Mitochondria contain a complex machinery for the import of nuclear-encoded proteins. Receptor proteins exposed on the outer membrane surface are required for the specific binding of precursor...
High, Stephen, Görlich, Dirk, Wiedmann, Martin, Rapoport, Tom A., Dobberstein, Bernhard
Using a photocross-linking approach we have investigated the cytosolic and membrane components involved in the targeting and insertion of signalanchor proteins into the membrane of the ER. The...
Görlich, Dirk, Prehn, Siegfried, Hartmann, Enno, Herz, Joachim, Otto, Albrecht, Kraft, Regine, ...
Bifunctional cross-linking reagents were used to probe the protein environment in the ER membrane of the signal sequence receptor (SSR), a 34-kD integral membrane glycoprotein (Wiedmann, M., T. V....
Ryazanov, Alexey G., Ward, Michael D., Mendola, Charmaine E., Pavur, Karen S., Dorovkov, Maxim V., Wiedmann, Martin, ...
The several hundred members of the eukaryotic protein kinase superfamily characterized to date share a similar catalytic domain structure, consisting of 12 conserved subdomains. Here we report the...
Möller, Ines, Jung, Martin, Beatrix, Birgitta, Levy, Robert, Kreibich, Gert, Zimmermann, Richard, ...
For proteins to enter the secretory pathway, the membrane attachment site (M-site) on ribosomes must bind cotranslationally to the Sec61 complex present in the endoplasmic reticulum membrane. The...
De Cesare, Alessandra, Bruce, James L., Dambaugh, Timothy R., Guerzoni, Maria E., Wiedmann, Martin
To develop improved automated subtyping approaches for Listeria monocytogenes, we characterized the discriminatory power of different restriction enzymes for ribotyping. When 15 different restriction...
Molecular Studies on the Ecology of Listeria monocytogenes in the Smoked Fish Processing Industry
Norton, Dawn M., McCamey, Meghan A., Gall, Kenneth L., Scarlett, Janet M., Boor, Kathryn J., Wiedmann, Martin
We have applied molecular approaches, including PCR-based detection strategies and DNA fingerprinting methods, to study the ecology of Listeria monocytogenes in food processing environments. A total...
Norton, Dawn M., Scarlett, Janet M., Horton, Kelly, Sue, David, Thimothe, Joanne, Boor, Kathryn J., ...
This study was designed to evaluate the hypothesis that some of the Listeria monocytogenes subtypes associated with foods, specifically smoked fish, may have an attenuated ability to cause human...
Molecular and Phenotypic Characterization of Pseudomonas spp. Isolated from Milk
Wiedmann, Martin, Weilmeier, Denise, Dineen, Sean S., Ralyea, Robert, Boor, Kathryn J.
Putative Pseudomonas spp. isolated predominantly from raw and processed milk were characterized by automated ribotyping and by biochemical reactions. Isolates were biochemically profiled using the...
Wiedmann, Martin, Arvik, Torey J., Hurley, Richard J., Boor, Kathryn J.
The gene encoding the general stress transcription factor ςB in the gram-positive bacterium Listeria monocytogenes was isolated with degenerate PCR primers followed by inverse PCR amplification....
Hundley, Heather, Eisenman, Helene, Walter, William, Evans, Tara, Hotokezaka, Yuka, Wiedmann, Martin, ...
Two proteins of the Hsp70 class (Ssb and Ssz1) and one of the J-type class (Zuo1) of molecular chaperones reside on the yeast ribosome, with Ssz1 forming a stable heterodimer with Zuo1. We designed...
Sigma B Contributes to PrfA-Mediated Virulence in Listeria monocytogenes
Nadon, Celine A., Bowen, Barbara M., Wiedmann, Martin, Boor, Kathryn J.
Transcription of the Listeria monocytogenes positive regulatory factor A protein (PrfA) is initiated from either of two promoters immediately upstream of prfA (prfAp1 and prfAp2) or from the upstream...
Rational Design of DNA Sequence-Based Strategies for Subtyping Listeria monocytogenes
Cai, Steven, Kabuki, Dirce Yorika, Kuaye, Arnaldo Yoshiteru, Cargioli, Theresa Gina, Chung, Michael S., Nielsen, Rasmus, ...
The ability to differentiate bacteria beyond the species level is essential for identifying and tracking infectious disease outbreaks and to improve our knowledge of the population genetics,...
Fraser, Katy R., Sue, David, Wiedmann, Martin, Boor, Kathryn, O'Byrne, Conor P.
The regulation of the compatible solute transport systems in Listeria monocytogenes by the stress-inducible sigma factor σB was investigated. Using wild-type strain 10403S and an otherwise isogenic...
Zhang, Chaomei, Zhang, Min, Ju, Jingliang, Nietfeldt, Joseph, Wise, John, Terry, Philip M., ...
Thirteen different serotypes of Listeria monocytogenes can be distinguished on the basis of variation in somatic and flagellar antigens. Although the known virulence genes are present in all...
Listeria monocytogenes σB Regulates Stress Response and Virulence Functions
Kazmierczak, Mark J., Mithoe, Sharon C., Boor, Kathryn J., Wiedmann, Martin
While the stress-responsive alternative sigma factor σB has been identified in different species of Bacillus, Listeria, and Staphylococcus, the σB regulon has been extensively characterized only in...
Meinersmann, Richard J., Phillips, Robert W., Wiedmann, Martin, Berrang, Mark E.
In an attempt to develop a method to discriminate among isolates of Listeria monocytogenes, the sequences of all of the annotated genes from the fully sequenced strain L. monocytogenes EGD-e...
Evaluation of “Helicobacter heilmannii” Subtypes in the Gastric Mucosas of Cats and Dogs
Priestnall, Simon L., Wiinberg, Bo, Spohr, Anette, Neuhaus, Britta, Kuffer, Manuela, Wiedmann, Martin, ...
Infection with candidatus “Helicobacter heilmannii” is associated with gastritis and mucosa-associated lymphoid tissue lymphoma in people. Infection with “H. heilmannii” type 1 predominates...
Listeria monocytogenes Isolates from Foods and Humans Form Distinct but Overlapping Populations
Gray, Michael J., Zadoks, Ruth N., Fortes, Esther D., Dogan, Belgin, Cai, Steven, Chen, Yuhuan, ...
A total of 502 Listeria monocytogenes isolates from food and 492 from humans were subtyped by EcoRI ribotyping and PCR-restriction fragment length polymorphism analysis of the virulence gene hly....
Protein translocation across wheat germ microsomal membranes requires an SRP-like component
Prehn, Siegfried, Wiedmann, Martin, Rapoport, Tom A., Zwieb, Christian
Different wheat germ extracts were tested for the presence of membranes capable of translocating and processing nascent secretory proteins. One lysate was found in which nascent prehuman-placental...
Molecular Subtyping and Characterization of Bovine and Human Streptococcus agalactiae Isolates
Sukhnanand, Sharinne, Dogan, Belgin, Ayodele, Maranatha O., Zadoks, Ruth N., Craver, Mary Patricia J., Dumas, Nellie B., ...
Streptococcus agalactiae causes severe invasive disease in humans and mastitis in cattle. Temporally matched bovine milk isolates and clinical human invasive isolates (52 each) collected in New York...
Zadoks, Ruth N., Schukken, Ynte H., Wiedmann, Martin
Control of the bovine mastitis pathogen Streptococcus uberis requires sensitive and epidemiologically meaningful subtyping methods that can provide insight into this pathogen's epidemiology and...
DNA Sequence-Based Subtyping and Evolutionary Analysis of Selected Salmonella enterica Serotypes
Sukhnanand, Sharinne, Alcaine, Sam, Warnick, Lorin D., Su, Wan-Lin, Hof, Jessica, Craver, Mary Pat J., ...
While serotyping and phage typing have been used widely to characterize Salmonella isolates, sensitive subtyping methods that allow for evolutionary analyses are essential for examining Salmonella...
Alternative Sigma Factors and Their Roles in Bacterial Virulence
Kazmierczak, Mark J., Wiedmann, Martin, Boor, Kathryn J.
Sigma factors provide promoter recognition specificity to RNA polymerase holoenzyme, contribute to DNA strand separation, and then dissociate from the core enzyme following transcription initiation....
Tyedmers, Jens, Lerner, Monika, Wiedmann, Martin, Volkmer, Jörg, Zimmermann, Richard
The first step in the secretion of most mammalian proteins is their transport into the lumen of the endoplasmic reticulum (ER). Transport of pre-secretory proteins into the mammalian ER requires...
Roberts, Angela, Chan, Yvonne, Wiedmann, Martin
Listeria monocytogenes is a foodborne pathogen able to cause serious disease in humans and animals. Not all isolates are equally pathogenic, however, and several isolates have been characterized as...
Garner, Matthew R., James, Karen E., Callahan, Michelle C., Wiedmann, Martin, Boor, Kathryn J.
The effects of environmental stress exposure on Listeria monocytogenes growth and virulence-associated characteristics were investigated. Specifically, we measured the effects of temperature (7 or...
Ryazanov, Alexey G., Ward, Michael D., Mendola, Charmaine E., Pavur, Karen S., Dorovkov, Maxim V., Wiedmann, Martin, ...
The several hundred members of the eukaryotic protein kinase superfamily characterized to date share a similar catalytic domain structure, consisting of 12 conserved subdomains. Here we report the...
Möller, Ines, Jung, Martin, Beatrix, Birgitta, Levy, Robert, Kreibich, Gert, Zimmermann, Richard, ...
For proteins to enter the secretory pathway, the membrane attachment site (M-site) on ribosomes must bind cotranslationally to the Sec61 complex present in the endoplasmic reticulum membrane. The...
De Cesare, Alessandra, Bruce, James L., Dambaugh, Timothy R., Guerzoni, Maria E., Wiedmann, Martin
To develop improved automated subtyping approaches for Listeria monocytogenes, we characterized the discriminatory power of different restriction enzymes for ribotyping. When 15 different restriction...
Molecular Studies on the Ecology of Listeria monocytogenes in the Smoked Fish Processing Industry
Norton, Dawn M., McCamey, Meghan A., Gall, Kenneth L., Scarlett, Janet M., Boor, Kathryn J., Wiedmann, Martin
We have applied molecular approaches, including PCR-based detection strategies and DNA fingerprinting methods, to study the ecology of Listeria monocytogenes in food processing environments. A total...
Norton, Dawn M., Scarlett, Janet M., Horton, Kelly, Sue, David, Thimothe, Joanne, Boor, Kathryn J., ...
This study was designed to evaluate the hypothesis that some of the Listeria monocytogenes subtypes associated with foods, specifically smoked fish, may have an attenuated ability to cause human...
Molecular and Phenotypic Characterization of Pseudomonas spp. Isolated from Milk
Wiedmann, Martin, Weilmeier, Denise, Dineen, Sean S., Ralyea, Robert, Boor, Kathryn J.
Putative Pseudomonas spp. isolated predominantly from raw and processed milk were characterized by automated ribotyping and by biochemical reactions. Isolates were biochemically profiled using the...
Wiedmann, Martin, Arvik, Torey J., Hurley, Richard J., Boor, Kathryn J.
The gene encoding the general stress transcription factor ςB in the gram-positive bacterium Listeria monocytogenes was isolated with degenerate PCR primers followed by inverse PCR amplification....
Hundley, Heather, Eisenman, Helene, Walter, William, Evans, Tara, Hotokezaka, Yuka, Wiedmann, Martin, ...
Two proteins of the Hsp70 class (Ssb and Ssz1) and one of the J-type class (Zuo1) of molecular chaperones reside on the yeast ribosome, with Ssz1 forming a stable heterodimer with Zuo1. We designed...
Sigma B Contributes to PrfA-Mediated Virulence in Listeria monocytogenes
Nadon, Celine A., Bowen, Barbara M., Wiedmann, Martin, Boor, Kathryn J.
Transcription of the Listeria monocytogenes positive regulatory factor A protein (PrfA) is initiated from either of two promoters immediately upstream of prfA (prfAp1 and prfAp2) or from the upstream...
Rational Design of DNA Sequence-Based Strategies for Subtyping Listeria monocytogenes
Cai, Steven, Kabuki, Dirce Yorika, Kuaye, Arnaldo Yoshiteru, Cargioli, Theresa Gina, Chung, Michael S., Nielsen, Rasmus, ...
The ability to differentiate bacteria beyond the species level is essential for identifying and tracking infectious disease outbreaks and to improve our knowledge of the population genetics,...
Fraser, Katy R., Sue, David, Wiedmann, Martin, Boor, Kathryn, O'Byrne, Conor P.
The regulation of the compatible solute transport systems in Listeria monocytogenes by the stress-inducible sigma factor σB was investigated. Using wild-type strain 10403S and an otherwise isogenic...
Zhang, Chaomei, Zhang, Min, Ju, Jingliang, Nietfeldt, Joseph, Wise, John, Terry, Philip M., ...
Thirteen different serotypes of Listeria monocytogenes can be distinguished on the basis of variation in somatic and flagellar antigens. Although the known virulence genes are present in all...
Listeria monocytogenes σB Regulates Stress Response and Virulence Functions
Kazmierczak, Mark J., Mithoe, Sharon C., Boor, Kathryn J., Wiedmann, Martin
While the stress-responsive alternative sigma factor σB has been identified in different species of Bacillus, Listeria, and Staphylococcus, the σB regulon has been extensively characterized only in...
Meinersmann, Richard J., Phillips, Robert W., Wiedmann, Martin, Berrang, Mark E.
In an attempt to develop a method to discriminate among isolates of Listeria monocytogenes, the sequences of all of the annotated genes from the fully sequenced strain L. monocytogenes EGD-e...
Evaluation of “Helicobacter heilmannii” Subtypes in the Gastric Mucosas of Cats and Dogs
Priestnall, Simon L., Wiinberg, Bo, Spohr, Anette, Neuhaus, Britta, Kuffer, Manuela, Wiedmann, Martin, ...
Infection with candidatus “Helicobacter heilmannii” is associated with gastritis and mucosa-associated lymphoid tissue lymphoma in people. Infection with “H. heilmannii” type 1 predominates...
Listeria monocytogenes Isolates from Foods and Humans Form Distinct but Overlapping Populations
Gray, Michael J., Zadoks, Ruth N., Fortes, Esther D., Dogan, Belgin, Cai, Steven, Chen, Yuhuan, ...
A total of 502 Listeria monocytogenes isolates from food and 492 from humans were subtyped by EcoRI ribotyping and PCR-restriction fragment length polymorphism analysis of the virulence gene hly....
Protein translocation across wheat germ microsomal membranes requires an SRP-like component
Prehn, Siegfried, Wiedmann, Martin, Rapoport, Tom A., Zwieb, Christian
Different wheat germ extracts were tested for the presence of membranes capable of translocating and processing nascent secretory proteins. One lysate was found in which nascent prehuman-placental...
Molecular Subtyping and Characterization of Bovine and Human Streptococcus agalactiae Isolates
Sukhnanand, Sharinne, Dogan, Belgin, Ayodele, Maranatha O., Zadoks, Ruth N., Craver, Mary Patricia J., Dumas, Nellie B., ...
Streptococcus agalactiae causes severe invasive disease in humans and mastitis in cattle. Temporally matched bovine milk isolates and clinical human invasive isolates (52 each) collected in New York...
Zadoks, Ruth N., Schukken, Ynte H., Wiedmann, Martin
Control of the bovine mastitis pathogen Streptococcus uberis requires sensitive and epidemiologically meaningful subtyping methods that can provide insight into this pathogen's epidemiology and...
Roberts, Angela, Chan, Yvonne, Wiedmann, Martin
Listeria monocytogenes is a foodborne pathogen able to cause serious disease in humans and animals. Not all isolates are equally pathogenic, however, and several isolates have been characterized as...
DNA Sequence-Based Subtyping and Evolutionary Analysis of Selected Salmonella enterica Serotypes
Sukhnanand, Sharinne, Alcaine, Sam, Warnick, Lorin D., Su, Wan-Lin, Hof, Jessica, Craver, Mary Pat J., ...
While serotyping and phage typing have been used widely to characterize Salmonella isolates, sensitive subtyping methods that allow for evolutionary analyses are essential for examining Salmonella...
Alternative Sigma Factors and Their Roles in Bacterial Virulence
Kazmierczak, Mark J., Wiedmann, Martin, Boor, Kathryn J.
Sigma factors provide promoter recognition specificity to RNA polymerase holoenzyme, contribute to DNA strand separation, and then dissociate from the core enzyme following transcription initiation....
Tyedmers, Jens, Lerner, Monika, Wiedmann, Martin, Volkmer, Jörg, Zimmermann, Richard
The first step in the secretion of most mammalian proteins is their transport into the lumen of the endoplasmic reticulum (ER). Transport of pre-secretory proteins into the mammalian ER requires...
Garner, Matthew R., James, Karen E., Callahan, Michelle C., Wiedmann, Martin, Boor, Kathryn J.
The effects of environmental stress exposure on Listeria monocytogenes growth and virulence-associated characteristics were investigated. Specifically, we measured the effects of temperature (7 or...
Liu, Dongyou, Lawrence, Mark L., Wiedmann, Martin, Gorski, Lisa, Mandrell, Robert E., Ainsworth, A. Jerald, ...
Listeria monocytogenes lineage III strains belonging to subgroups IIIA (n = 8), IIIB (n = 5), and IIIC (n = 6) were examined along with other known serotype strains (n = 11) by PCR and Southern...
Fugett, Eric B., Schoonmaker-Bopp, Dianna, Dumas, Nellie B., Corby, Joseph, Wiedmann, Martin
A total of 495 temporally and geographically matched Listeria monocytogenes isolates from human clinical cases, foods, ruminant farms, and urban and natural environments were used to investigate L....
McGann, Patrick, Wiedmann, Martin, Boor, Kathryn J.
Some Listeria monocytogenes internalins are recognized as contributing to invasion of mammalian tissue culture cells. While PrfA is well established as a positive regulator of L. monocytogenes...
McGann, Patrick, Ivanek, Renata, Wiedmann, Martin, Boor, Kathryn J.
The Listeria monocytogenes genome contains genes encoding several internalins and internalin-like proteins. As L. monocytogenes is present in many environments and can infect numerous, diverse host...
Chan, Yvonne C., Boor, Kathryn J., Wiedmann, Martin
The role of the stress response regulator σB (encoded by sigB) in directing the expression of selected putative and confirmed cold response genes was evaluated using Listeria monocytogenes 10403S...
Chan, Yvonne C., Raengpradub, Sarita, Boor, Kathryn J., Wiedmann, Martin
Whole-genome microarray experiments were performed to define the Listeria monocytogenes cold growth regulon and to identify genes differentially expressed during growth at 4 and 37°C. Microarray...
Hu, Yuewei, Raengpradub, Sarita, Schwab, Ute, Loss, Chris, Orsi, Renato H., Wiedmann, Martin, ...
Listeria monocytogenes σB positively regulates the transcription of class II stress response genes; CtsR negatively regulates class III stress response genes. To identify interactions between these...
Hu, Yuewei, Oliver, Haley F., Raengpradub, Sarita, Palmer, M. Elizabeth, Orsi, Renato H., Wiedmann, Martin, ...
Listeria monocytogenes HrcA and CtsR negatively regulate class I and III stress response genes, respectively, while σB positively regulates the transcription of class II stress response genes. To...
Raengpradub, Sarita, Wiedmann, Martin, Boor, Kathryn J.
The alternative sigma factor σB contributes to transcription of stress response and virulence genes in diverse gram-positive bacterial species. The composition and functions of the Listeria...
Lineage specific recombination rates and microevolution in Listeria monocytogenes
Den Bakker, Henk C, Didelot, Xavier, Fortes, Esther D, Nightingale, Kendra K, Wiedmann, Martin
Short-term genome evolution of Listeria monocytogenes in a non-controlled environment
Orsi, Renato H, Borowsky, Mark L, Lauer, Peter, Young, Sarah K, Nusbaum, Chad, Galagan, James E, ...
Listeria monocytogenes σB Modulates PrfA-Mediated Virulence Factor Expression▿ †
Ollinger, Juliane, Bowen, Barbara, Wiedmann, Martin, Boor, Kathryn J., Bergholz, Teresa M.
Listeria monocytogenes σB and positive regulatory factor A (PrfA) are pleiotropic transcriptional regulators that coregulate a subset of virulence genes. A positive regulatory role for σB in prfA...