アンチセンスRNA法の遺伝子治療への応用の可能性 (2007)
徳久, 剛史, トクヒサ, タケシ, Tokuhisa, Takeshi, TOKUHISA, Takeshi, 幡野, 雅彦, ハタノ, マサヒコ, ...
Bcl6 is essential for the generation of long-term memory CD4+ T cells (2007)
Ichii, Hirohito, Sakamoto, Akemi, Arima, Masafumi, Hatano, Masahiko, Kuroda, Yoshikazu, Tokuhisa, Takeshi
Bcl6 plays a role in the generation and maintenance of memory CD8+ T cells. We analyzed here a role for Bcl6 in the generation of long-term memory CD4+ T cells. Naive CD45RB+ CD4+ T cells from...
Bcl6 is essential for the generation of long-term memory CD4+ T cells (2007)
Ichii, Hirohito, Sakamoto, Akemi, Arima, Masafumi, Hatano, Masahiko, Kuroda, Yoshikazu, Tokuhisa, Takeshi
Bcl6 plays a role in the generation and maintenance of memory CD8+ T cells. We analyzed here a role for Bcl6 in the generation of long-term memory CD4+ T cells. Naive CD45RB+ CD4+ T cells from...
Bcl6 is essential for the generation of long-term memory CD4+ T cells (2007)
Ichii, Hirohito, Sakamoto, Akemi, Arima, Masafumi, Hatano, Masahiko, Kuroda, Yoshikazu, Tokuhisa, Takeshi
Bcl6 plays a role in the generation and maintenance of memory CD8+ T cells. We analyzed here a role for Bcl6 in the generation of long-term memory CD4+ T cells. Naive CD45RB+ CD4+ T cells from...
Arguni, Eggi, Arima, Masafumi, Tsuruoka, Nobuhide, Sakamoto, Akemi, Hatano, Masahiko, Tokuhisa, Takeshi
The Bcl6 proto-oncogene, which encodes a transcriptional repressor, is ubiquitously expressed and predominantly in germinal center (GC) B cells. Although the promoter region of the human Bcl6 gene...
Arguni, Eggi, Arima, Masafumi, Tsuruoka, Nobuhide, Sakamoto, Akemi, Hatano, Masahiko, Tokuhisa, Takeshi
The Bcl6 proto-oncogene, which encodes a transcriptional repressor, is ubiquitously expressed and predominantly in germinal center (GC) B cells. Although the promoter region of the human Bcl6 gene...
BAZF is required for activation of naive CD4 T cells by TCR triggering (2004)
Takamori, Mikio, Hatano, Masahiko, Arima, Masafumi, Sakamoto, Akemi, Fujimura, Lisa, Hartatik, Tety, ...
BAZF, a member of the Bcl6 gene family, acts as a sequence-specific transcriptional repressor in association with Bcl6. However, the tissue expression pattern of BAZF differs from that of Bcl6,...
Effect of c-fos overexpression on development and proliferation of peritoneal B cells (2004)
Mori, Satoshi, Sakamoto, Akemi, Yamashita, Kimihiro, Fujimura, Lisa, Arima, Masafumi, Hatano, Masahiko, ...
We examined effects of c-fos overexpression on the development and property of peritoneal B-1 cells using transgenic (H2-c-fos) mice carrying the c-fos gene under the control of the constitutive...
Protective role of Nd1 in doxorubicin-induced cardiotoxicity (2004)
Fujimura, Lisa, Matsudo, Yuji, Kang, Myengmo, Takamori, Yasuyuki, Tokuhisa, Takeshi, Hatano, Masahiko
Objective: The Ndl gene, which encodes a novel kelch family protein, is expressed ubiquitously in mouse tissues. In vitro studies suggest that Ndl protein, which binds to actin filaments, functions...
Okada, Seiji, Obata, Shintaro, Hatano, Masahiko, Tokuhisa, Takeshi
Activation of murine peritoneal macrophages or the macrophage cell line RAW264 with IFN‐γ and bacterial lipopolysaccharide promotes a transient up‐regulation of c‐fos family gene...
Impairment of B lymphopoiesis in precocious aging (klotho) mice (2000)
Okada, Seiji, Yoshida, Toru, Hong, Zhang, Ishii, Genichiro, Hatano, Masahiko, Kuro-o, Makoto, ...
Inactivation of the klotho gene in mice results in multiple disorders that resemble human aging after 3 weeks of age. Because hematopoiesis, especially B lymphopoiesis, is affected in humans and mice...
The role of Bcl6 in mature cardiac myocytes (1999)
Yoshida, Takehiko, Fukuda, Tetsuya, Hatano, Masahiko, Koseki, Haruhiko, Okabe, Shin-ichiro, Ishibashi, Kazuki, ...
Objective: The Bcl6 gene encodes a sequence-specific transcriptional repressor and is ubiquitously expressed in adult murine tissues including heart muscle. The objective of this study was to examine...
IgG response is impaired in H2-c-fos transgenic mice (1991)
Takao, Shintaro, Sakai, Nobuo, Hatano, Masahiko, Koizumi, Tamio, Hanioka, Keisuke, Rüther, Ulrich, ...
Transgenic mice carrying the proto-oncogene c-fos under the control of H-2Kb promoter (c-fos mice) were generated from (C57BL/6 × SJL)F2 mice. One line was backcrossed with C57BL/6 mice for...
Specific inhibition of class II MHC gene expression by anti-sense RNA (1989)
Hatano, Masahiko, Aizawa, Shin-ichi, Soejima, Toshinori, Shigemoto, Kazuhiro, Taniguchi, Masaru, Tokuhisa, Takeshi, ...
We have established an anti-sense RNA system which is capable of regulating expression of the class II (ia) molecule coded for by the major histocompatibility complex in cultured mouse cells. Various...
Kobayashi, Koichi, Hatano, Masahiko, Otaki, Masayuki, Ogasawara, Takeshi, Tokuhisa, Takeshi
The inhibitor of apoptosis (IAP) proteins form a highly conserved gene family that prevents cell death in response to a variety of stimuli. Herein we describe a newly defined murine IAP, designated...
BAZF, a Novel Bcl6 Homolog, Functions as a Transcriptional Repressor
Okabe, Shinichiro, Fukuda, Tetsuya, Ishibashi, Kazuki, Kojima, Satoko, Okada, Seiji, Hatano, Masahiko, ...
The BCL6 gene, which has been identified from the chromosomal translocation breakpoint in B-cell lymphomas, functions as a sequence-specific transcriptional repressor. We cloned a novel...
Nishio, Saori, Hatano, Masahiko, Nagata, Michio, Horie, Shigeo, Koike, Takao, Tokuhisa, Takeshi, ...
Autosomal dominant polycystic kidney disease (ADPKD) is the most common human monogenic genetic disorder and is characterized by progressive bilateral renal cysts and the development of renal...
Kobayashi, Koichi, Hatano, Masahiko, Otaki, Masayuki, Ogasawara, Takeshi, Tokuhisa, Takeshi
The inhibitor of apoptosis (IAP) proteins form a highly conserved gene family that prevents cell death in response to a variety of stimuli. Herein we describe a newly defined murine IAP, designated...
BAZF, a Novel Bcl6 Homolog, Functions as a Transcriptional Repressor
Okabe, Shinichiro, Fukuda, Tetsuya, Ishibashi, Kazuki, Kojima, Satoko, Okada, Seiji, Hatano, Masahiko, ...
The BCL6 gene, which has been identified from the chromosomal translocation breakpoint in B-cell lymphomas, functions as a sequence-specific transcriptional repressor. We cloned a novel...
Nishio, Saori, Hatano, Masahiko, Nagata, Michio, Horie, Shigeo, Koike, Takao, Tokuhisa, Takeshi, ...
Autosomal dominant polycystic kidney disease (ADPKD) is the most common human monogenic genetic disorder and is characterized by progressive bilateral renal cysts and the development of renal...
Honda, Kyoko, Arima, Masafumi, Cheng, Gang, Taki, Shinsuke, Hirata, Hirokuni, Eda, Fukiko, ...
PGD2, a lipid mediator released from mast cells, is known to participate in allergic reactions. However, the mechanism by which PGD2 contributes to such reactions remains unclear. We established a...
Nakao, Atsuhito, Miike, Satoshi, Hatano, Masahiko, Okumura, Ko, Tokuhisa, Takeshi, Ra, Chisei, ...
Transforming growth factor (TGF)-β has been implicated in immunosuppression. However, it remains obscure whether regulation of T cells by TGF-β contributes to the immunosuppression in vivo. To...
Disruption of the Bcl6 Gene Results in an Impaired Germinal Center Formation
Fukuda, Tetsuya, Yoshida, Takehiko, Okada, Seiji, Hatano, Masahiko, Miki, Tohru, Ishibashi, Kazuki, ...
The Bcl6 gene has been identified from the chromosomal translocation breakpoint in B cell lymphomas, and its products are expressed highly in germinal center (GC) B cells. To investigate the function...
Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells
Mizushima, Noboru, Yamamoto, Akitsugu, Hatano, Masahiko, Kobayashi, Yoshinori, Kabeya, Yukiko, Suzuki, Kuninori, ...
In macroautophagy, cytoplasmic components are delivered to lysosomes for degradation via autophagosomes that are formed by closure of cup-shaped isolation membranes. However, how the isolation...