Masahiko Mihara

The combination therapy with alfacalcidol and risedronate improves the mechanical property in lumbar spine by affecting the material properties in an ovariectomized rat model of osteoporosis (2009)

Shiraishi, Ayako, Miyabe, Sayaka, Nakano, Takayoshi, Umakoshi, Yukichi, Ito, Masako, Mihara, Masahiko

Abstract Background We conducted the present study to investigate the therapeutic effects of a combination treatment of alfacalcidol (ALF) and risedronate (RIS) on the bone mechanical properties of...

CTLA4Ig inhibits T cell–dependent B-cell maturation in murine systemic lupus erythematosus

Mihara, Masahiko, Tan, Irene, Chuzhin, Yelena, Reddy, Bhoompally, Budhai, Lalbachan, Holzer, Aton, ...

Long-term administration of CTLA4Ig prevents the onset of disease in systemic lupus erythematosus–prone (SLE-prone) NZB/NZW F1 mice. To determine the mechanism of this effect, we engineered an...

CTLA4Ig inhibits T cell–dependent B-cell maturation in murine systemic lupus erythematosus

Mihara, Masahiko, Tan, Irene, Chuzhin, Yelena, Reddy, Bhoompally, Budhai, Lalbachan, Holzer, Aton, ...

Long-term administration of CTLA4Ig prevents the onset of disease in systemic lupus erythematosus–prone (SLE-prone) NZB/NZW F1 mice. To determine the mechanism of this effect, we engineered an...

Interleukin-6 Receptor-Mediated Activation of Signal Transducer and Activator of Transcription-3 (STAT3) Promotes Choroidal Neovascularization

Izumi-Nagai, Kanako, Nagai, Norihiro, Ozawa, Yoko, Mihara, Masahiko, Ohsugi, Yoshiyuki, Kurihara, Toshihide, ...

Interleukin (IL)-6, a potent proinflammatory cytokine, is suggested to be a risk factor for choroidal neovascularization (CNV) because of its increased levels in the serum of patients with...

IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis

Serada, Satoshi, Fujimoto, Minoru, Mihara, Masahiko, Koike, Nobuo, Ohsugi, Yoshiyuki, Nomura, Shintaro, ...

The development of Th17 cells is a key event in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), a murine model of human multiple sclerosis (MS). Previous studies have...

The combination therapy with alfacalcidol and risedronate improves the mechanical property in lumbar spine by affecting the material properties in an ovariectomized rat model of osteoporosis

Shiraishi, Ayako, Miyabe, Sayaka, Nakano, Takayoshi, Umakoshi, Yukichi, Ito, Masako, Mihara, Masahiko