Ito, Toshihiro, Hasegawa, Akihiro, Hosokawa, Hiroyuki, Yamashita, Masakatsu, Motohashi, Shinichiro, Naka, Takashi, ...
Mycobacterium tuberculosis (tubercle bacilli) and the related acid-fast bacteria including Mycobacterium bovis Bacille Calmett–Guerin (BCG) have a characteristic cell wall (CW) containing various...
Schnurri-2 regulates Th2-dependent airway inflammation and airway hyperresponsiveness (2007)
Iwamura, Chiaki, Kimura, Motoko Y., Shinoda, Kenta, Endo, Yusuke, Hasegawa, Akihiro, Yamashita, Masakatsu, ...
Schnurri (Shn)-2 is a large zinc finger-containing protein, which plays a critical role in cell growth, signal transduction and lymphocyte development. In Shn-2-deficient (Shn-2−/−) CD4 T cells,...
Prolonged skin allograft survival by IL-10 gene-introduced CD4 T cell administration (2005)
Miyamoto, Takeshi, Kaneko, Takaaki, Yamashita, Masakatsu, Tenda, Yoshiyuki, Inami, Masamichi, Suzuki, Akane, ...
Both CD4 and CD8 T cells play crucial roles in immune responses in transplantation. Immunosuppressive drugs, such as FK506 and cyclosporin A, block the priming of alloreactive CD4 Th cells and the...
Prolonged skin allograft survival by IL-10 gene-introduced CD4 T cell administration (2005)
Miyamoto, Takeshi, Kaneko, Takaaki, Yamashita, Masakatsu, Tenda, Yoshiyuki, Inami, Masamichi, Suzuki, Akane, ...
Both CD4 and CD8 T cells play crucial roles in immune responses in transplantation. Immunosuppressive drugs, such as FK506 and cyclosporin A, block the priming of alloreactive CD4 Th cells and the...
CD69-null mice protected from arthritis induced with anti-type II collagen antibodies (2003)
Murata, Kaoru, Inami, Masamichi, Hasegawa, Akihiro, Kubo, Shuichi, Kimura, Motoko, Yamashita, Masakatsu, ...
CD69, known as an early activation marker antigen on T and B cells, is also expressed on platelets and activated neutrophils, suggesting certain roles in inflammatory diseases. In order to address...
Th1/Th2 cell differentiation of developing CD4 single-positive thymocytes (2002)
Kikkawa, Emiko, Yamashita, Masakatsu, Kimura, Motoko, Omori, Miyuki, Sugaya, Kaoru, Shimizu, Chiori, ...
In this study we investigate the stage at which developing T cells in the thymus acquire the ability to differentiate into Th1 and Th2 cells. We addressed this question by using sorted...
Shimizu, Chiori, Kawamoto, Hiroshi, Yamashita, Masakatsu, Kimura, Motoko, Kondou, Eisuke, Kaneko, Yoshikatsu, ...
The proximal promoter of lck directs gene expression exclusively in T cells. To investigate the developmental regulation of the lck proximal promoter activity and its relationship to T cell lineage...
Impaired Ca/calcineurin pathway in in vivo anergized CD4 T cells (2000)
Kimura, Motoko, Yamashita, Masakatsu, Kubo, Masato, Iwashima, Makio, Shimizu, Chiori, Tokoyoda, Koji, ...
Clonal anergy is one of the mechanisms that may account for self tolerance induced in T cells in the periphery. In this study we used the well-documented system of in vivo administration of a...
Mizuguchi, Hiroyuki, Ito, Seiji, Shevchenko, Valery I., Nagasawa, Yasuyuki, Yamashita, Masakatsu, Imamura, Ikuo, ...
Rat C6 astroglioma cells (C6-bH1R cells) expressing cloned bovine histamine H1 receptors were established by transfection with a vector (pEF-BOS-bH1R) which carried a 2.7-kbp EcoRI fragment of the...
Yamashita, Masakatsu, Kimura, Motoko, Kubo, Masato, Shimizu, Chiori, Tada, Tomio, Perlmutter, Roger M., ...
The central role of type-2 helper T (Th2) cells in the development of allergic responses and immune responses against helminthic parasites is well documented. The differentiation of Th2 cells from...
Involvement of decidual Vα14 NKT cells in abortion
Ito, Katsura, Karasawa, Mika, Kawano, Tetsu, Akasaka, Takeshi, Koseki, Haruhiko, Akutsu, Yasunori, ...
The immunological mechanisms that regulate abortion are largely unknown. Here, we found that a distinct subset of lymphocytes, Vα14 NKT cells expressing an invariant antigen receptor encoded by...
Sato, Hiroshi, Nakayama, Toshinori, Tanaka, Yujiro, Yamashita, Masakatsu, Shibata, Yoichi, Kondo, Eisuke, ...
Vα14 NKT cells express an invariant antigen receptor encoded by Vα14 and Jα281 gene segments as well as natural killer (NK) markers, including NK1.1. Here, we describe a precursor population of...
Kamata, Tohru, Yamashita, Masakatsu, Kimura, Motoko, Murata, Kaoru, Inami, Masamichi, Shimizu, Chiori, ...
Th2 cells are generated from naive CD4 T cells upon T cell receptor (TCR) recognition of antigen and IL-4 stimulation and play crucial roles in humoral immunity against infectious microorganisms and...
Nigo, Yukiko I., Yamashita, Masakatsu, Hirahara, Kiyoshi, Shinnakasu, Ryo, Inami, Masamichi, Kimura, Motoko, ...
In a mouse experimental asthma model, the administration of bacterial lipopolysaccharide (LPS), particularly at low doses, enhances the levels of ovalbumin (OVA)-induced eosinophilic airway...
Yamashita, Masakatsu, Kimura, Motoko, Kubo, Masato, Shimizu, Chiori, Tada, Tomio, Perlmutter, Roger M., ...
The central role of type-2 helper T (Th2) cells in the development of allergic responses and immune responses against helminthic parasites is well documented. The differentiation of Th2 cells from...
Involvement of decidual Vα14 NKT cells in abortion
Ito, Katsura, Karasawa, Mika, Kawano, Tetsu, Akasaka, Takeshi, Koseki, Haruhiko, Akutsu, Yasunori, ...
The immunological mechanisms that regulate abortion are largely unknown. Here, we found that a distinct subset of lymphocytes, Vα14 NKT cells expressing an invariant antigen receptor encoded by...
Sato, Hiroshi, Nakayama, Toshinori, Tanaka, Yujiro, Yamashita, Masakatsu, Shibata, Yoichi, Kondo, Eisuke, ...
Vα14 NKT cells express an invariant antigen receptor encoded by Vα14 and Jα281 gene segments as well as natural killer (NK) markers, including NK1.1. Here, we describe a precursor population of...
Kamata, Tohru, Yamashita, Masakatsu, Kimura, Motoko, Murata, Kaoru, Inami, Masamichi, Shimizu, Chiori, ...
Th2 cells are generated from naive CD4 T cells upon T cell receptor (TCR) recognition of antigen and IL-4 stimulation and play crucial roles in humoral immunity against infectious microorganisms and...
Nigo, Yukiko I., Yamashita, Masakatsu, Hirahara, Kiyoshi, Shinnakasu, Ryo, Inami, Masamichi, Kimura, Motoko, ...
In a mouse experimental asthma model, the administration of bacterial lipopolysaccharide (LPS), particularly at low doses, enhances the levels of ovalbumin (OVA)-induced eosinophilic airway...
Regulation of T helper type 2 cell differentiation by murine Schnurri-2
Kimura, Motoko Y., Hosokawa, Hiroyuki, Yamashita, Masakatsu, Hasegawa, Akihiro, Iwamura, Chiaki, Watarai, Hiroshi, ...
Schnurri (Shn) is a large zinc finger protein implicated in cell growth, signal transduction, and lymphocyte development. Vertebrates possess at least three Shn orthologues (Shn-1, Shn-2, and Shn-3),...
Cui, Junqing, Watanabe, Naohiro, Kawano, Tetsu, Yamashita, Masakatsu, Kamata, Tohru, Shimizu, Chiori, ...
Murine Vα14 natural killer T (NKT) cells are thought to play a crucial role in various immune responses, including infectious, allergic, and autoimmune diseases. Because Vα14 NKT cells produce...
Kaneko, Yoshikatsu, Harada, Michishige, Kawano, Tetsu, Yamashita, Masakatsu, Shibata, Youichi, Gejyo, Fumitake, ...
The administration of concanavalin A (Con A) induces a rapid severe injury of hepatocytes in mice. Although the Con A–induced hepatitis is considered to be an experimental model of human autoimmune...
Yamashita, Masakatsu, Katsumata, Makoto, Iwashima, Makio, Kimura, Motoko, Shimizu, Chiori, Kamata, Tohru, ...
The activation of downstream signaling pathways of both T cell receptor (TCR) and interleukin 4 receptor (IL-4R) is essential for T helper type 2 (Th2) cell development, which is central to...
Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene
Yamashita, Masakatsu, Kuwahara, Makoto, Suzuki, Akane, Hirahara, Kiyoshi, Shinnaksu, Ryo, Hosokawa, Hiroyuki, ...
The maintenance of memory T cells is central to the establishment of immunological memory, although molecular details of the process are poorly understood. In the absence of the polycomb group (PcG)...
Gfi1-mediated Stabilization of GATA3 Protein Is Required for Th2 Cell Differentiation*S⃞
Shinnakasu, Ryo, Yamashita, Masakatsu, Kuwahara, Makoto, Hosokawa, Hiroyuki, Hasegawa, Akihiro, Motohashi, Shinichiro, ...
The differentiation of naive CD4 T cells into Th2 cells requires the T cell receptor-mediated activation of the ERK MAPK cascade. Little is known, however, in regard to how the ERK MAPK cascade...
Lymphoid enhancer factor interacts with GATA-3 and controls its function in T helper type 2 cells
Hossain, Mohammad B, Hosokawa, Hiroyuki, Hasegawa, Akihiro, Watarai, Hiroshi, Taniguchi, Masaru, Yamashita, Masakatsu, ...
GATA-3 is the master transcription factor for T helper 2 (Th2) cell differentiation and is critical for the expression of Th2 cytokines. Little is known, however, about the nature of the functional...