Endoplasmic reticulum stress induces autophagy in renal proximal tubular cells (2009)
Kawakami, Takahisa, Inagi, Reiko, Takano, Hideki, Sato, Shigeru, Ingelfinger, Julie R., Fujita, Toshiro, ...
Background. Autophagy, an intracellular self-degradation system conserved throughout eukaryotes, plays an important role in a variety of biological processes, including cell death, development,...
Hideki Kato, Junji Ishida, Shigehiko Imagawa, Tomoko Saito, Norio Suzuki, Masaomi Nangaku, ...
Enhanced erythropoiesis mediated by activation of the renin-angiotensin system via angiotensin II type 1a receptor
Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model (2008)
Ohtomo, Shuichi, Nangaku, Masaomi, Izuhara, Yuko, Takizawa, Shunya, Miyata, Toshio
Background. Chronic renal hypoxia is suspected to play a pathogenic role in the genesis of diabetic nephropathy (DN). Cobalt enhances the activity of the hypoxia-inducible factor (HIF), a key factor...
Izuhara, Yuko, Nangaku, Masaomi, Takizawa, Shunya, Takahashi, Satoru, Shao, Jing, Oishi, Hisashi, ...
Background. The reno- and cardiovascular-protective effects of angiotensin II receptor blockers (ARBs), have been ascribed, at least in part, to their ability to inhibit the formation of advanced...
Inagi, Reiko, Izuhara, Yuko, Tominaga, Naoto, Nangaku, Masaomi, Kurokawa, Kiyoshi, Miyata, Toshio
Background. We previously identified a novel serine protease inhibitor (serpin), megsin, which is predominantly expressed in the kidney. Megsin expression is up-regulated in human and experimental...
Nishi, Hiroshi, Tojo, Akihiro, Onozato, Maristela Lika, Jimbo, Rika, Nangaku, Masaomi, Uozaki, Hiroshi, ...
Nishi, Hiroshi, Tojo, Akihiro, Onozato, Maristela Lika, Jimbo, Rika, Nangaku, Masaomi, Uozaki, Hiroshi, ...
Nangaku, Masaomi, Izuhara, Yuko, Usuda, Nobuteru, Inagi, Reiko, Shibata, Takeo, Sugiyama, Satoshi, ...
Background. The present study has been undertaken to unravel the critical factors involved in the progression of diabetic nephropathy (DN). Methods. A unique type 2 diabetic rat model with a wide...
Nangaku, Masaomi, Izuhara, Yuko, Usuda, Nobuteru, Inagi, Reiko, Shibata, Takeo, Sugiyama, Satoshi, ...
Background. The present study has been undertaken to unravel the critical factors involved in the progression of diabetic nephropathy (DN). Methods. A unique type 2 diabetic rat model with a wide...
Nangaku, Masaomi, Izuhara, Yuko, Usuda, Nobuteru, Inagi, Reiko, Shibata, Takeo, Sugiyama, Satoshi, ...
Background. The present study has been undertaken to unravel the critical factors involved in the progression of diabetic nephropathy (DN). Methods. A unique type 2 diabetic rat model with a wide...
Sphingosine 1-phosphate stimulates rat mesangial cell proliferation from outside the cells (2002)
Hanafusa, Norio, Yatomi, Yutaka, Yamada, Koei, Hori, Yuichi, Nangaku, Masaomi, Okuda, Toshihiro, ...
Background. Proliferation of mesangial cells (MCs) is the initial step in glomerulonephritis, and platelet‐derived mediators have been shown to play a significant role in this...
Mesangial cell-predominant gene, megsin (2002)
Inagi, Reiko, Miyata, Toshio, Imasawa, Toshiyuki, Nangaku, Masaomi, Kurokawa, Kiyoshi
We identified a novel gene, termed megsin, predominantly expressed in mesangial cells utilizing a 3′‐directed regional cDNA library from cultured human mesangial cells. Megsin is a novel...
Hanafusa, Norio, Sogabe, Hajime, Yamada, Koei, Wada, Takehiko, Fujita, Toshiro, Nangaku, Masaomi
The complement system is indispensable for host defence. Unregulated activation, however, is related to various diseases. In order to elucidate the significance of complement, methodology that...
Overexpression of the serpin megsin induces progressive mesangial cell proliferation and expansion
Miyata, Toshio, Inagi, Reiko, Nangaku, Masaomi, Imasawa, Toshiyuki, Sato, Masahiro, Izuhara, Yuko, ...
Mesangial cells maintain normal glomerular function by mediating ECM remodeling and immune complex disposal. We have recently identified megsin, a novel member of the serine protease inhibitor...
Overexpression of the serpin megsin induces progressive mesangial cell proliferation and expansion
Miyata, Toshio, Inagi, Reiko, Nangaku, Masaomi, Imasawa, Toshiyuki, Sato, Masahiro, Izuhara, Yuko, ...
Mesangial cells maintain normal glomerular function by mediating ECM remodeling and immune complex disposal. We have recently identified megsin, a novel member of the serine protease inhibitor...
Hypoxia in Renal Disease with Proteinuria and/or Glomerular Hypertension
Tanaka, Tetsuhiro, Miyata, Toshio, Inagi, Reiko, Fujita, Toshiro, Nangaku, Masaomi
Despite the increasing need to identify and quantify tissue oxygenation at the cellular level, relatively few methods have been available. In this study, we developed a new hypoxia-responsive...
Inagi, Reiko, Kumagai, Takanori, Nishi, Hiroshi, Kawakami, Takahisa, Miyata, Toshio, Fujita, Toshiro, ...
Accumulating evidence suggests a pathophysiologic role of endoplasmic reticulum (ER) stress in kidney disease. This study investigated the potential of therapeutic approaches targeting ER stress in...
Hemoglobin Is Expressed by Mesangial Cells and Reduces Oxidant Stress
Nishi, Hiroshi, Inagi, Reiko, Kato, Hideki, Tanemoto, Masayuki, Kojima, Ichiro, Son, Daisuke, ...
Hemoglobin (Hb) serves as the main oxygen transporter in erythrocytes, but it is also expressed in nonhematopoietic organs, where it serves an unknown function. In this study, microarray and...
Eto, Nobuaki, Miyagishi, Makoto, Inagi, Reiko, Fujita, Toshiro, Nangaku, Masaomi
Genome-wide screening using a small interfering RNA (siRNA) library has revealed novel molecules that are involved in a wide range of physiological responses. The expression of vascular endothelial...