Shinji, Toshiyuki, Kyaw, Yi Yi, Gokan, Katsunori, Tanaka, Yasuhito, Ochi, Koji, Kusano, Nobuchika, ...
The prevalence of hepatitis C virus (HCV) genotypes in Myanmar in comparison with the rest of Southeast Asia is not well known. Serum samples were obtained from 201 HCV antibody-positive volunteer...
Journal of General Virology (2005), 86, 2047–2056 DOI 10.1099/vir.0.80922-0 Correspondence (2005)
According to the World Health Organization, hepatitis B virus (HBV) infection is one of the major global public health problems. Of the two billion people who have been infected with HBV worldwide,...
Yuen, Man-Fung, Tanaka, Yasuhito, Mizokami, Masashi, Yuen, John Chi-Hang, Wong, Danny Ka-Ho, Yuan, He-Jun, ...
The role of hepatitis B virus (HBV) genotypes, core promoter (CP) and precore mutants on hepatocellular carcinoma (HCC) is still controversial. We aimed to determine their role on the development and...
Yuen, Man-Fung, Tanaka, Yasuhito, Mizokami, Masashi, Yuen, John Chi-Hang, Wong, Danny Ka-Ho, Yuan, He-Jun, ...
The role of hepatitis B virus (HBV) genotypes, core promoter (CP) and precore mutants on hepatocellular carcinoma (HCC) is still controversial. We aimed to determine their role on the development and...
The Core, Nsb Regions, Ling Lu, Tatsunori Nakano, Etsuro Orito, Masashi Mizokami, ...
Four hepatitis C virus genome regions (the core, E1, HVR1, and NS5b) were amplified and sequenced from yearly samples obtained from a chronically infected chimpanzee over a 12-year span. Nucleotide...
Development of a TT Virus DNA Quantification System Using Real-Time Detection PCR
Kato, Takanobu, Mizokami, Masashi, Mukaide, Motokazu, Orito, Etsuro, Ohno, Tomoyoshi, Nakano, Tatsunori, ...
Although TT virus (TTV) was isolated from a cryptogenic posttransfusion hepatitis patient, its pathogenic role remains unclear. It has been reported that the majority of the healthy population is...
Lu, Ling, Nakano, Tatsunori, Orito, Etsuro, Mizokami, Masashi, Robertson, Betty H.
Four hepatitis C virus genome regions (the core, E1, HVR1, and NS5b) were amplified and sequenced from yearly samples obtained from a chronically infected chimpanzee over a 12-year span. Nucleotide...
Kato, Hideaki, Orito, Etsuro, Gish, Robert G., Sugauchi, Fuminaka, Suzuki, Seiji, Ueda, Ryuzo, ...
Eight hepatitis B virus (HBV) isolates of genotype G were recovered from patients and sequenced over the entire genome. Six of them had a genomic length of 3,248 bp and two had genomic lengths of...
Sugauchi, Fuminaka, Orito, Etsuro, Ichida, Takafumi, Kato, Hideaki, Sakugawa, Hiroshi, Kakumu, Shinichi, ...
The entire nucleotide sequences of 70 hepatitis B virus (HBV) isolates of genotype B (HBV/B), including 38 newly determined and 32 retrieved from the international DNA database (DDBJ/EMBL/GenBank),...
Tanaka, Yasuhito, Hanada, Kousuke, Mizokami, Masashi, Yeo, Anthony E. T., Shih, J. Wai-Kuo, Gojobori, Takashi, ...
The prevalence of hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) is considerably lower in the U.S. than in Japan. To elucidate this difference, we determined the time origin of the...
Hasegawa, Izumi, Tanaka, Yasuhito, Kramvis, Anna, Kato, Takanobu, Sugauchi, Fuminaka, Acharya, Subrat K., ...
The eight genotypes of hepatitis B virus (HBV) have different geographical distributions, virological characteristics, and clinical manifestations. A unique subtype of HBV genotype A (HBV/A) was...
Yuen, Man-Fung, Fung, Scott K., Tanaka, Yasuhito, Kato, Takanobu, Mizokami, Masashi, Yuen, John Chi-Hang, ...
The aims of this study were to compare chronic hepatitis B (CHB) patients with genotypes B and C for the probability of HBeAg seroconversion, hepatitis activity, and viral replication before and...
Kato, Takanobu, Date, Tomoko, Miyamoto, Michiko, Zhao, Zijiang, Mizokami, Masashi, Wakita, Takaji
The hepatitis C virus (HCV) genotype 2a subgenomic replicon can replicate in two human non-hepatocyte-derived cell lines, HeLa and 293, with in vitro-transcribed replicon RNA. Sequencing analysis...
Fujiwara, Kei, Tanaka, Yasuhito, Paulon, Emma, Orito, Etsuro, Sugiyama, Masaya, Ito, Kiyoaki, ...
The genetic diversity of hepatitis B virus (HBV) strains has evolved through mutations such as point mutations, deletions or insertions, and recombination. We identified and characterized a novel...
Kato, Takanobu, Date, Tomoko, Miyamoto, Michiko, Sugiyama, Masaya, Tanaka, Yasuhito, Orito, Etsuro, ...
Although combination therapy with interferon and ribavirin has improved the treatment for chronic hepatitis C virus (HCV) infection, the detailed anti-HCV effect of ribavirin in clinical...
Development of a TT Virus DNA Quantification System Using Real-Time Detection PCR
Kato, Takanobu, Mizokami, Masashi, Mukaide, Motokazu, Orito, Etsuro, Ohno, Tomoyoshi, Nakano, Tatsunori, ...
Although TT virus (TTV) was isolated from a cryptogenic posttransfusion hepatitis patient, its pathogenic role remains unclear. It has been reported that the majority of the healthy population is...
Lu, Ling, Nakano, Tatsunori, Orito, Etsuro, Mizokami, Masashi, Robertson, Betty H.
Four hepatitis C virus genome regions (the core, E1, HVR1, and NS5b) were amplified and sequenced from yearly samples obtained from a chronically infected chimpanzee over a 12-year span. Nucleotide...
Kato, Hideaki, Orito, Etsuro, Gish, Robert G., Sugauchi, Fuminaka, Suzuki, Seiji, Ueda, Ryuzo, ...
Eight hepatitis B virus (HBV) isolates of genotype G were recovered from patients and sequenced over the entire genome. Six of them had a genomic length of 3,248 bp and two had genomic lengths of...
Sugauchi, Fuminaka, Orito, Etsuro, Ichida, Takafumi, Kato, Hideaki, Sakugawa, Hiroshi, Kakumu, Shinichi, ...
The entire nucleotide sequences of 70 hepatitis B virus (HBV) isolates of genotype B (HBV/B), including 38 newly determined and 32 retrieved from the international DNA database (DDBJ/EMBL/GenBank),...
Tanaka, Yasuhito, Hanada, Kousuke, Mizokami, Masashi, Yeo, Anthony E. T., Shih, J. Wai-Kuo, Gojobori, Takashi, ...
The prevalence of hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) is considerably lower in the U.S. than in Japan. To elucidate this difference, we determined the time origin of the...
Hasegawa, Izumi, Tanaka, Yasuhito, Kramvis, Anna, Kato, Takanobu, Sugauchi, Fuminaka, Acharya, Subrat K., ...
The eight genotypes of hepatitis B virus (HBV) have different geographical distributions, virological characteristics, and clinical manifestations. A unique subtype of HBV genotype A (HBV/A) was...
Yuen, Man-Fung, Fung, Scott K., Tanaka, Yasuhito, Kato, Takanobu, Mizokami, Masashi, Yuen, John Chi-Hang, ...
The aims of this study were to compare chronic hepatitis B (CHB) patients with genotypes B and C for the probability of HBeAg seroconversion, hepatitis activity, and viral replication before and...
Kato, Takanobu, Date, Tomoko, Miyamoto, Michiko, Zhao, Zijiang, Mizokami, Masashi, Wakita, Takaji
The hepatitis C virus (HCV) genotype 2a subgenomic replicon can replicate in two human non-hepatocyte-derived cell lines, HeLa and 293, with in vitro-transcribed replicon RNA. Sequencing analysis...
Fujiwara, Kei, Tanaka, Yasuhito, Paulon, Emma, Orito, Etsuro, Sugiyama, Masaya, Ito, Kiyoaki, ...
The genetic diversity of hepatitis B virus (HBV) strains has evolved through mutations such as point mutations, deletions or insertions, and recombination. We identified and characterized a novel...
Kato, Takanobu, Date, Tomoko, Miyamoto, Michiko, Sugiyama, Masaya, Tanaka, Yasuhito, Orito, Etsuro, ...
Although combination therapy with interferon and ribavirin has improved the treatment for chronic hepatitis C virus (HCV) infection, the detailed anti-HCV effect of ribavirin in clinical...
Molecular Evolution of Hepatitis B Virus over 25 Years
Osiowy, Carla, Giles, Elizabeth, Tanaka, Yasuhito, Mizokami, Masashi, Minuk, Gerald Y.
Determining the longitudinal molecular evolution of hepatitis B virus (HBV) is difficult due to HBV's genomic complexity and the need to study paired samples collected over long periods of time. In...
Liu, Wen-Chun, Mizokami, Masashi, Buti, Maria, Lindh, Magnus, Young, Kung-Chia, Sun, Koun-Tem, ...
Both the viral titer and the genotype significantly determine clinical outcomes and responses to antiviral treatment in chronic hepatitis B virus (HBV) infection. A method was developed for...
Clinical and Virological Characteristics of Hepatitis B Virus Subgenotypes Ba, C1, and C2 in China▿
Wang, Zhanhui, Tanaka, Yasuhito, Huang, Yuehua, Kurbanov, Fuat, Chen, Jinjun, Zeng, Guobing, ...
Hepatitis B virus (HBV) subgenotypes Ba, C1 (Cs), and C2 (Ce) are the most prevalent HBV variants in China. To investigate the virological characteristics of these subgenotypes and their clinical...
Lok, Anna S., Zoulim, Fabien, Locarnini, Stephen, Bartholomeusz, Angeline, Ghany, Marc G., Pawlotsky, Jean-Michel, ...
Substantial advances have been made in the treatment of chronic hepatitis B in the past decade. Approved treatments for chronic hepatitis B include 2 formulations of interferon and 4 nucleos(t)ide...
Murayama, Asako, Date, Tomoko, Morikawa, Kenichi, Akazawa, Daisuke, Miyamoto, Michiko, Kaga, Minako, ...
The JFH-1 strain of hepatitis C virus (HCV) is a genotype 2a strain that can replicate autonomously in Huh7 cells. The J6 strain is also a genotype 2a strain, but its full genomic RNA does not...
Shinkai, Noboru, Tanaka, Yasuhito, Ito, Kiyoaki, Mukaide, Motokazu, Hasegawa, Izumi, Asahina, Yasuhiro, ...
Hepatitis B virus (HBV) genotypes/subgenotypes and their related mutations in the HBV genome have been reported to be associated with hepatocellular carcinoma (HCC). To determine the HCC-associated...
Hepatitis B Virus Core-Related Antigens as Markers for Monitoring Chronic Hepatitis B Infection▿
Wong, Danny Ka-Ho, Tanaka, Yasuhito, Lai, Ching-Lung, Mizokami, Masashi, Fung, James, Yuen, Man-Fung
A sensitive chemiluminescence enzyme immunoassay has been developed for hepatitis B virus (HBV) core-related antigen (HBcrAg) detection. We aimed to investigate the usefulness of HBcrAg measurement...
When Should “I” Consider a New Hepatitis B Virus Genotype?
Kurbanov, Fuat, Tanaka, Yasuhito, Kramvis, Anna, Simmonds, Peter, Mizokami, Masashi
Matsuura, Kentaro, Tanaka, Yasuhito, Hasegawa, Izumi, Ohno, Tomoyoshi, Tokuda, Hiroshi, Kurbanov, Fuat, ...
Two commercial real-time PCR assays are currently available for sensitive hepatitis C virus (HCV) RNA quantification: the Abbott RealTime HCV assay (ART) and Roche Cobas AmpliPrep/Cobas TaqMan HCV...
Matsuura, Kentaro, Tanaka, Yasuhito, Hige, Shuhei, Yamada, Gotaro, Murawaki, Yoshikazu, Komatsu, Masafumi, ...
Acute hepatitis B virus (HBV) infection has been increasing through promiscuous sexual contacts, and HBV genotype A (HBV/A) is frequent in patients with acute hepatitis B (AHB) in Japan. To compare...
Hepatitis B Virus Genotype C Prevails Among Chronic Carriers of the Virus in Korea
Bae, Si Hyun, Yoon, Seung Kew, Jang, Jeong Won, Kim, Chang Wook, Nam, Soon Woo, Choi, Jong Young, ...
Hepatitis B virus (HBV) is one of the major causative agents of chronic liver diseases in Korea. HBV has been classified into 8 genotypes by a divergence of >8% in the entire genomic sequence, and...