Mita,Masaki, Miyake,Kazuaki, Zenibayashi,Masako, Hirota,Yushi, Teranishi,Tetsuya, Kouyama,Kunichi, ...
Mutations of WFS1 gene cause Wolfram syndrome, which is a rare autosomalrecessive disorder characterized by juvenile diabetes mellitus, optic atrophy, deafnessand diabetes insipidus. The product...
Role of Hepatic STAT3 in the Regulation of Lipid Metabolism (2008)
Kinoshita,Shinichi, Ogawa,Wataru, Okamoto,Yasuo, Takashima,Mototsugu, Inoue,Hiroshi, Matsuki,Yasushi, ...
Regulation of hepatic gene expression is largely responsible for the control ofnutrient metabolism. We previously showed that the transcription factor STAT3regulates glucose homeostasis by...
Kawaguchi,Takayuki, Tamori,Yoshikazu, Yoshikawa,Mari, Kanda,Hajime, Kasuga,Masato
It is established that wortmannin which completely inhibits class IA PI 3-kinaseactivation abrogated the insulin-dependent translocation of GLUT4 to the plasmamembrane in adipocytes and skeletal...
Pancreatic β Cell Mass Preserved in Heterozygous PDK1 Knockout Mice (2008)
Takeda, Akihiko, Kido, Yoshiaki, Hashimoto, Naoko, Noda, Tetsuo, Kasuga, Masato
We have demonstrated that 3-phosphoinositide-dependent protein kinase 1 (PDK1)contributes to signaling by insulin or insulin-like growth fctor-1 (IGF-1) that isresponsible for the regulation of both...
Matsuda, Tomokazu, Kido, Yoshiaki, Uchida, Tohru, Kasuga, Masato
The total pancreatic β cell mass is reduced in individuals with type 2 diabetes. Weanalyzed the islets of leptin receptor-deficient (Lepr-/-) mice, a model animal for type 2diabetes with obesity....
Takazawa, Kazuo, Noguchi, Tetsuya, Hosooka, Tetsuya, Yoshioka, Toyo, Tobimatsu, Kazutoshi, Kasuga, Masato
Insulin induces translocation of the glucose transporter GLUT4 from intracellularstorage compartment to the plasma membrane via complex mechanisms that requireintact cytoskeletal networks. In...
Higo, Satomi, Miyata, Satoshi, QING YUN JIANG, Kitazawa, Riko, Kitazawa, Sohei, Kasuga, Masato
Oxidative stress has been postulated to be involved in the development of diabeticnephropathy. In the present study, we evaluated the effect of taurine, an endogenousantioxidant, on diabetic...
Okada, Yuko, Sakaue, Hiroshi, Nagare, Tomoki, Kasuga, Masato
The expansion of white adipose tissue (WAT) mass during the development ofobesity is mediated in part through an increase in adipocyte size. Although geneexpression profiles associated with...
Methylglyoxal Induces Prostaglandin E2 Production in Rat Mesangial Cells (2007)
Uriuhara, Atsuko, Miyata, Satoshi, Liu, BING-FEN, Miyazaki, Hiroyuki, Kusunoki, Hitomi, Kojima, Hiroshi, ...
The formation of methylglyoxal (MG), a reactive dicarbonyl compound, isaccelerated under hyperglycemia, presumably contributing to tissue injury in diabetes.On the other hand, prostaglandin E2 (PGE2)...
Kouyama, Kunichi, Miyake, Kazuaki, Zenibayashi, Masako, Hirota, Yushi, Teranishi, Tetsuya, Tamori, Yoshikazu, ...
Monocyte chemoattractant protein-1 (MCP-1, also known as CCL2) secreted byadipocytes is a member of the CC chemokine family and plays a pivotal role in theinflammatory process. A polymorphism, the...
Nishino, Naonobu, Tamori, Yoshikazu, Kasuga, Masato
White adipose tissue (WAT) is important as an energy reservoir in mammals, butthe precise mechanism by which energy storage in WAT is controlled remains unclear.It is well known that representative...
Hamada, Yasuhiro, Miyata, Satoshi, Nii-Kono, Tomoko, Kitazawa, Riko, Kitazawa, Sohei, Higo, Satomi, ...
Background. Oxidative stress has been suggested to play an important role in the pathogenesis of diabetic nephropathy. In the present study, the effects of thioredoxin1 (TRX1) overexpression, a small...
Hamada, Yasuhiro, Miyata, Satoshi, Nii-Kono, Tomoko, Kitazawa, Riko, Kitazawa, Sohei, Higo, Satomi, ...
Background. Oxidative stress has been suggested to play an important role in the pathogenesis of diabetic nephropathy. In the present study, the effects of thioredoxin1 (TRX1) overexpression, a small...
Nishioka, Chiharu, Sakaeda, Toshiyuki, Nakamura, Tsutomu, Moriya, Yuka, Okamura, Noboru, Tamura, Takao, ...
Nishioka, Chiharu, Sakaeda, Toshiyuki, Nakamura, Tsutomu, Moriya, Yuka, Okamura, Noboru, Tamura, Takao, ...
Nishioka, Chiharu, Sakaeda, Toshiyuki, Nakamura, Tsutomu, Moriya, Yuka, Okamura, Noboru, Tamura, Takao, ...
BRAF mutation associated with dysregulation of apoptosis in human colorectal neoplasms (2005)
Ikehara, Nobunao, Semba, Shuho, Sakashita, Masanori, Aoyama, Nobuo, Kasuga, Masato, Yokozaki, Hiroshi
Inoue, Maki, Sakuraba, Yoshiyuki, Motegi, Hiromi, Kubota, Naoto, Toki, Hideaki, Matsui, Junko, ...
Mutant mouse models are indispensable tools for clarifying the functions of genes and for elucidating the underlying pathogenic mechanisms of human diseases. Currently, several large-scale...
Inoue, Maki, Sakuraba, Yoshiyuki, Motegi, Hiromi, Kubota, Naoto, Toki, Hideaki, Matsui, Junko, ...
Mutant mouse models are indispensable tools for clarifying the functions of genes and for elucidating the underlying pathogenic mechanisms of human diseases. Currently, several large-scale...
Nakaji, Miyuki, Yano, Yoshihiko, Ninomiya, Toshiaki, Seo, Yasushi, Hamano, Kenichi, Yoon, Seitetsu, ...
Interferon (IFN)-alpha treatment is a common therapy for chronic viral hepatitis and contributes to preventing hepatocarcinogenesis. However, it is not clear whether IFN-alpha directly inhibits the...
Inoue, Maki, Sakuraba, Yoshiyuki, Motegi, Hiromi, Kubota, Naoto, Toki, Hideaki, Matsui, Junko, ...
Mutant mouse models are indispensable tools for clarifying the functions of genes and for elucidating the underlying pathogenic mechanisms of human diseases. Currently, several large-scale...
A Case of Well-differentiated Hepatocellular Carcinoma Arising in Primary Biliary Cirrhosis (2003)
Yano, Yoshihiko, Yoon, Seitetsu, Seo, Yasushi, Ninomiya, Toshiaki, Nagano, Hidenobu, Nakaji, Miyuki, ...
A Case of Well-differentiated Hepatocellular Carcinoma Arising in Primary Biliary Cirrhosis (2003)
Yano, Yoshihiko, Yoon, Seitetsu, Seo, Yasushi, Ninomiya, Toshiaki, Nagano, Hidenobu, Nakaji, Miyuki, ...
A Case of Well-differentiated Hepatocellular Carcinoma Arising in Primary Biliary Cirrhosis (2003)
Yano, Yoshihiko, Yoon, Seitetsu, Seo, Yasushi, Ninomiya, Toshiaki, Nagano, Hidenobu, Nakaji, Miyuki, ...
Nakaji, Miyuki, Yano, Yoshihiko, Ninomiya, Toshiaki, Seo, Yasushi, Hamano, Kenichi, Yoon, Seitetsu, ...
Interferon (IFN) -alpha treatment is a common therapy for chronic viral hepatitis and contributes to preventing hepatocarcinogenesis. However, it is not clear whether IFN-alpha directly inhibits the...
Nakaji, Miyuki, Yano, Yoshihiko, Ninomiya, Toshiaki, Seo, Yasushi, Hamano, Kenichi, Yoon, Seitetsu, ...
Interferon (IFN) -alpha treatment is a common therapy for chronic viral hepatitis and contributes to preventing hepatocarcinogenesis. However, it is not clear whether IFN-alpha directly inhibits the...
Requirement of fibroblast growth factor 10 in development of white adipose tissue (2002)
Sakaue, Hiroshi, Konishi, Morichika, Ogawa, Wataru, Asaki, Toshiyuki, Mori, Toshiyuki, Yamasaki, Masahiro, ...
Differential Control of Cellular Gene Expression by Diffusible and Non-Diffusible EGF (2001)
Ito, Yoshihiro, Chen, Guoping, Imanishi, Yukio, Morooka, Takaya, Nishida, Eisuke, Okabayashi, Yoshinori, ...
Cell gene expression is affected by both the kind and mode of growth factor stimulation (diffusive vs. non-diffusive). Epidermal growth factor (EGF) was pattern-immobilized on a polystyrene plate....
Ito, Yoshihiro, Li, Jing-Song, Takahashi, Takashi, Imanishi, Yukio, Okabayashi, Yoshinori, Kido, Yoshiaki, ...
Mouse epidermal growth factor (EGF) was covalently conjugated with the water-soluble polymer, poly(acrylic acid) (EGF-PAA), or with the water-insoluble polymer, surface-hydrolyzed poly(methyl...
Hasegawa, Yutaka, Yokono, Koichl, Taki, Toshiya, Amano, Kazuhiko, Tominaga, Yolchi, Yoneda, Ryoji, ...
Diverse adhesion molecules participate in many important responses and thus would be implicated in the pathogenesis of various autoimmune diseases. However, there is little evidence for the role of...
Regulation of nuclear translocation of Forkhead transcription factor AFX by protein kinase B
Takaishi, Hiroshi, Konishi, Hiroaki, Matsuzaki, Hidenori, Ono, Yoshitaka, Shirai, Yasuhito, Saito, Naoaki, ...
The regulation of intracellular localization of AFX, a human Forkhead transcription factor, was studied. AFX was recovered as a phosphoprotein from transfected COS-7 cells growing in the presence of...
Kitamura, Tadahiro, Kitamura, Yukari, Kuroda, Shoji, Hino, Yasuhisa, Ando, Miwa, Kotani, Ko, ...
Cyclic nucleotide phosphodiesterase (PDE) is an important regulator of the cellular concentrations of the second messengers cyclic AMP (cAMP) and cGMP. Insulin activates the 3B isoform of PDE in...
Hosooka, Tetsuya, Noguchi, Tetsuya, Nagai, Hiroshi, Horikawa, Tatsuya, Matozaki, Takashi, Ichihashi, Masamitsu, ...
Dok-1 (p62Dok) is a multiple-site docking protein that acts downstream of receptor and nonreceptor tyrosine kinases. Although it has been proposed to contribute to the control of cell growth and...
Kitamura, Tadahiro, Ogawa, Wataru, Sakaue, Hiroshi, Hino, Yasuhisa, Kuroda, Shoji, Takata, Masafumi, ...
A wide variety of biological activities including the major metabolic actions of insulin is regulated by phosphatidylinositol (PI) 3-kinase. However, the downstream effectors of the various signaling...
Kotani, Ko, Ogawa, Wataru, Matsumoto, Michihiro, Kitamura, Tadahiro, Sakaue, Hiroshi, Hino, Yasuhisa, ...
Phosphoinositide (PI) 3-kinase contributes to a wide variety of biological actions, including insulin stimulation of glucose transport in adipocytes. Both Akt (protein kinase B), a serine-threonine...
Miyake, Kazuaki, Ogawa, Wataru, Matsumoto, Michihiro, Nakamura, Takehiro, Sakaue, Hiroshi, Kasuga, Masato
The physiological relevance of phosphoinositide 3-kinase (PI 3-K) signaling in the liver to fuel homeostasis was investigated. Systemic infusion of an adenovirus encoding a dominant negative mutant...
Requirement of fibroblast growth factor 10 in development of white adipose tissue
Sakaue, Hiroshi, Konishi, Morichika, Ogawa, Wataru, Asaki, Toshiyuki, Mori, Toshiyuki, Yamasaki, Masahiro, ...
Fibroblast growth factors (FGFs) are important intercellular signaling molecules in developmental processes. Here, we show that FGF10 is secreted by cultured preadipocytes and that prevention of...
Matsumoto, Michihiro, Ogawa, Wataru, Akimoto, Kazunori, Inoue, Hiroshi, Miyake, Kazuaki, Furukawa, Kensuke, ...
PKCλ is implicated as a downstream effector of PI3K in insulin action. We show here that mice that lack PKCλ specifically in the liver (L-λKO mice), produced with the use of the Cre-loxP system,...
SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility
Inagaki, Kenjiro, Yamao, Takuji, Noguchi, Tetsuya, Matozaki, Takashi, Fukunaga, Kaoru, Takada, Toshiyuki, ...
The transmembrane glycoprotein SHPS-1 binds the protein tyrosine phosphatase SHP-2 and serves as its substrate. Although SHPS-1 has been implicated in growth factor- and cell adhesion-induced...
Hashimoto, Naoko, Kido, Yoshiaki, Uchida, Tohru, Matsuda, Tomokazu, Suzuki, Kazuhisa, Inoue, Hiroshi, ...
Altered regulation of insulin secretion by glucose is characteristic of individuals with type 2 diabetes mellitus, although the mechanisms that underlie this change remain unclear. We have now...
Kanda, Hajime, Tamori, Yoshikazu, Shinoda, Hiroaki, Yoshikawa, Mari, Sakaue, Motoyoshi, Udagawa, Jun, ...
Insulin-stimulated glucose uptake in adipocytes is mediated by translocation of vesicles containing the glucose transporter GLUT4 from intracellular storage sites to the cell periphery and the...
Kanda, Hajime, Tateya, Sanshiro, Tamori, Yoshikazu, Kotani, Ko, Hiasa, Ken-ichi, Kitazawa, Riko, ...
Adipocytes secrete a variety of bioactive molecules that affect the insulin sensitivity of other tissues. We now show that the abundance of monocyte chemoattractant protein–1 (MCP-1) mRNA in...
Insulin resistance and pancreatic β cell failure
It is now well accepted that diabetes mellitus is one of the main threats to human health in the twenty-first century. The total number of people with diabetes worldwide was estimated at between 151...
Regulation of nuclear translocation of Forkhead transcription factor AFX by protein kinase B
Takaishi, Hiroshi, Konishi, Hiroaki, Matsuzaki, Hidenori, Ono, Yoshitaka, Shirai, Yasuhito, Saito, Naoaki, ...
The regulation of intracellular localization of AFX, a human Forkhead transcription factor, was studied. AFX was recovered as a phosphoprotein from transfected COS-7 cells growing in the presence of...
Kitamura, Tadahiro, Kitamura, Yukari, Kuroda, Shoji, Hino, Yasuhisa, Ando, Miwa, Kotani, Ko, ...
Cyclic nucleotide phosphodiesterase (PDE) is an important regulator of the cellular concentrations of the second messengers cyclic AMP (cAMP) and cGMP. Insulin activates the 3B isoform of PDE in...
Hosooka, Tetsuya, Noguchi, Tetsuya, Nagai, Hiroshi, Horikawa, Tatsuya, Matozaki, Takashi, Ichihashi, Masamitsu, ...
Dok-1 (p62Dok) is a multiple-site docking protein that acts downstream of receptor and nonreceptor tyrosine kinases. Although it has been proposed to contribute to the control of cell growth and...
Kitamura, Tadahiro, Ogawa, Wataru, Sakaue, Hiroshi, Hino, Yasuhisa, Kuroda, Shoji, Takata, Masafumi, ...
A wide variety of biological activities including the major metabolic actions of insulin is regulated by phosphatidylinositol (PI) 3-kinase. However, the downstream effectors of the various signaling...
Kotani, Ko, Ogawa, Wataru, Matsumoto, Michihiro, Kitamura, Tadahiro, Sakaue, Hiroshi, Hino, Yasuhisa, ...
Phosphoinositide (PI) 3-kinase contributes to a wide variety of biological actions, including insulin stimulation of glucose transport in adipocytes. Both Akt (protein kinase B), a serine-threonine...
Miyake, Kazuaki, Ogawa, Wataru, Matsumoto, Michihiro, Nakamura, Takehiro, Sakaue, Hiroshi, Kasuga, Masato
The physiological relevance of phosphoinositide 3-kinase (PI 3-K) signaling in the liver to fuel homeostasis was investigated. Systemic infusion of an adenovirus encoding a dominant negative mutant...
Requirement of fibroblast growth factor 10 in development of white adipose tissue
Sakaue, Hiroshi, Konishi, Morichika, Ogawa, Wataru, Asaki, Toshiyuki, Mori, Toshiyuki, Yamasaki, Masahiro, ...
Fibroblast growth factors (FGFs) are important intercellular signaling molecules in developmental processes. Here, we show that FGF10 is secreted by cultured preadipocytes and that prevention of...
Matsumoto, Michihiro, Ogawa, Wataru, Akimoto, Kazunori, Inoue, Hiroshi, Miyake, Kazuaki, Furukawa, Kensuke, ...
PKCλ is implicated as a downstream effector of PI3K in insulin action. We show here that mice that lack PKCλ specifically in the liver (L-λKO mice), produced with the use of the Cre-loxP system,...
SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility
Inagaki, Kenjiro, Yamao, Takuji, Noguchi, Tetsuya, Matozaki, Takashi, Fukunaga, Kaoru, Takada, Toshiyuki, ...
The transmembrane glycoprotein SHPS-1 binds the protein tyrosine phosphatase SHP-2 and serves as its substrate. Although SHPS-1 has been implicated in growth factor- and cell adhesion-induced...
Hashimoto, Naoko, Kido, Yoshiaki, Uchida, Tohru, Matsuda, Tomokazu, Suzuki, Kazuhisa, Inoue, Hiroshi, ...
Altered regulation of insulin secretion by glucose is characteristic of individuals with type 2 diabetes mellitus, although the mechanisms that underlie this change remain unclear. We have now...
Kanda, Hajime, Tamori, Yoshikazu, Shinoda, Hiroaki, Yoshikawa, Mari, Sakaue, Motoyoshi, Udagawa, Jun, ...
Insulin-stimulated glucose uptake in adipocytes is mediated by translocation of vesicles containing the glucose transporter GLUT4 from intracellular storage sites to the cell periphery and the...
Kanda, Hajime, Tateya, Sanshiro, Tamori, Yoshikazu, Kotani, Ko, Hiasa, Ken-ichi, Kitazawa, Riko, ...
Adipocytes secrete a variety of bioactive molecules that affect the insulin sensitivity of other tissues. We now show that the abundance of monocyte chemoattractant protein–1 (MCP-1) mRNA in...
Insulin resistance and pancreatic β cell failure
It is now well accepted that diabetes mellitus is one of the main threats to human health in the twenty-first century. The total number of people with diabetes worldwide was estimated at between 151...
Yamamori, Motohiro, Taniguchi, Mayuko, Maeda, Shingo, Nakamura, Tsutomu, Okamura, Noboru, Kuwahara, Akiko, ...
Background: Previously, MDR1 T-129C polymorphism, encoding multidrug resistant transporter MDR1/P-glycoprotein, was reported to be predictive of poorly-differentiated colorectal adenocarcinomas....
Nishino, Naonobu, Tamori, Yoshikazu, Tateya, Sanshiro, Kawaguchi, Takayuki, Shibakusa, Tetsuro, Mizunoya, Wataru, ...
White adipocytes are unique in that they contain large unilocular lipid droplets that occupy most of the cytoplasm. To identify genes involved in the maintenance of mature adipocytes, we expressed...
Biphasic Response of Pancreatic β-Cell Mass to Ablation of Tuberous Sclerosis Complex 2 in Mice▿
Shigeyama, Yutaka, Kobayashi, Toshiyuki, Kido, Yoshiaki, Hashimoto, Naoko, Asahara, Shun-ichiro, Matsuda, Tomokazu, ...
Recent studies have demonstrated the importance of insulin or insulin-like growth factor 1 (IGF-1) for regulation of pancreatic β-cell mass. Given the role of tuberous sclerosis complex 2 (TSC2) as...