Regulatory Roles of JNK in Programmed Cell Death (2004)
Kanda, Hiroshi, Miura, Masayuki
Programmed cell death or apoptosis is the regulatory mechanism for removing unneeded cells during animal development and in tissue homeostasis. Perturbation of the cell death mechanisms leads to...
Qiao, Jingbo, Mitsuhara, Ichiro, Yazaki, Yosiaki, Sakano, Katsuhiro, Gotoh, Yoko, Miura, Masayuki, ...
Overproduction of animal cell death suppressors Bcl-xL and Ced-9 conferred enhanced resistance to UV-B and paraquat treatment in tobacco plants [Mitsuhara et al. (1999) Curr. Biol. 9: 775]....
Tamura, Taka-aki, Miura, Masayuki, Ikenaka, Kazuhiro, Mikoshiba, Katsuhiko
Promoter elements of the mouse myelin basic protein (MBP) gene were analyzed by in vitro transcription using HeLa cell extracts. We demonstrated the MBTE (MBP transcription element), GC-box core and...
Changes in mRNA of Vigna mungo Cotyledons during Seed Germination (1986)
Koshiba, Tomokazu, Tomura, Hideaki, Miura, Masayuki
Quantitative and qualitative changes of mRNA in Vigna mungo cotyledons during seed germination have been investigated. Total RNA is higher in dry cotyledons and declines during germination....
Kanuka, Hirotaka, Hisahara, Shin, Sawamoto, Kazunobu, Shoji, Shin-ichi, Okano, Hideyuki, Miura, Masayuki
CED-4 protein plays an important role in the induction of programmed cell death in Caenorhabditis elegans through the activation of caspases. However, the precise mechanisms by which it activates...
Drob-1, a Drosophila member of the Bcl-2/CED-9 family that promotes cell death
Igaki, Tatsushi, Kanuka, Hirotaka, Inohara, Naohiro, Sawamoto, Kazunobu, Núñez, Gabriel, Okano, Hideyuki, ...
The Bcl-2/CED-9 family of proteins, which includes both antiapoptotic and proapoptotic members, plays key regulating roles in programmed cell death. We report here the identification and...
Akamatsu, Wado, Okano, Hirotaka J., Osumi, Noriko, Inoue, Takayoshi, Nakamura, Shun, Sakakibara, Shin-Ichi, ...
Hu proteins are mammalian embryonic lethal abnormal visual system (ELAV)-like neuronal RNA-binding proteins that contain three RNA recognition motifs. Although Drosophila ELAV is required for the...
Mochizuki, Hideki, Hayakawa, Hideki, Migita, Makoto, Shibata, Mamoru, Tanaka, Ryota, Suzuki, Asuka, ...
Adeno-associated virus (AAV) vector delivery of an Apaf-1-dominant negative inhibitor was tested for its antiapoptotic effect on degenerating nigrostriatal neurons in a...
Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway
Igaki, Tatsushi, Kanda, Hiroshi, Yamamoto-Goto, Yuki, Kanuka, Hirotaka, Kuranaga, Erina, Aigaki, Toshiro, ...
Drosophila provides a powerful genetic model for studying the in vivo regulation of cell death. In our large-scale gain-of-function screen, we identified Eiger, the first invertebrate tumor necrosis...
Kanuka, Hirotaka, Kuranaga, Erina, Hiratou, Tetsuo, Igaki, Tatsushi, Nelson, Bryce, Okano, Hideyuki, ...
Intracellular deposition of aggregated and ubiquitinated proteins is a prominent cytopathological feature of most neurodegenerative disorders frequently correlated with neural cell death. To...
The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model
Inoue, Haruhisa, Tsukita, Kayoko, Iwasato, Takuji, Suzuki, Yasuyuki, Tomioka, Masanori, Tateno, Minako, ...
Mutant copper/zinc superoxide dismutase (SOD1)-overexpressing transgenic mice, a mouse model for familial amyotrophic lateral sclerosis (ALS), provides an excellent resource for developing novel...
Hisahara, Shin, Araki, Takashi, Sugiyama, Fumihiro, Yagami, Ken–ichi, Suzuki, Misao, Abe, Kuniya, ...
The mechanisms underlying oligodendrocyte (OLG) loss and the precise roles played by OLG death in human demyelinating diseases such as multiple sclerosis (MS), and in the rodent model of MS,...
Caspases determine the vulnerability of oligodendrocytes in the ischemic brain
Shibata, Mamoru, Hisahara, Shin, Hara, Hideaki, Yamawaki, Takemori, Fukuuchi, Yasuo, Yuan, Junying, ...
Although oligodendrocytes (OLGs) are thought to be vulnerable to hypoxia and ischemia, little is known about the detailed mechanism by which these insults induce OLG death. From the clinical...
Bax-like protein Drob-1 protects neurons from expanded polyglutamine-induced toxicity in Drosophila
Senoo-Matsuda, Nanami, Igaki, Tatsushi, Miura, Masayuki
Bcl-2 family proteins regulate cell death through the mitochondrial apoptotic pathway. Here, we show that the Drosophila Bax-like Bcl-2 family protein Drob-1 maintains mitochondrial function to...
Drosophila caspase transduces Shaggy/GSK-3β kinase activity in neural precursor development
Kanuka, Hirotaka, Kuranaga, Erina, Takemoto, Kiwamu, Hiratou, Tetsuo, Okano, Hideyuki, Miura, Masayuki
Caspases are well known for their role in the execution of apoptotic programs, in which they cleave specific target proteins, leading to the elimination of cells, and for their role in cytokine...
Kanuka, Hirotaka, Hisahara, Shin, Sawamoto, Kazunobu, Shoji, Shin-ichi, Okano, Hideyuki, Miura, Masayuki
CED-4 protein plays an important role in the induction of programmed cell death in Caenorhabditis elegans through the activation of caspases. However, the precise mechanisms by which it activates...
Drob-1, a Drosophila member of the Bcl-2/CED-9 family that promotes cell death
Igaki, Tatsushi, Kanuka, Hirotaka, Inohara, Naohiro, Sawamoto, Kazunobu, Núñez, Gabriel, Okano, Hideyuki, ...
The Bcl-2/CED-9 family of proteins, which includes both antiapoptotic and proapoptotic members, plays key regulating roles in programmed cell death. We report here the identification and...
Akamatsu, Wado, Okano, Hirotaka J., Osumi, Noriko, Inoue, Takayoshi, Nakamura, Shun, Sakakibara, Shin-Ichi, ...
Hu proteins are mammalian embryonic lethal abnormal visual system (ELAV)-like neuronal RNA-binding proteins that contain three RNA recognition motifs. Although Drosophila ELAV is required for the...
Mochizuki, Hideki, Hayakawa, Hideki, Migita, Makoto, Shibata, Mamoru, Tanaka, Ryota, Suzuki, Asuka, ...
Adeno-associated virus (AAV) vector delivery of an Apaf-1-dominant negative inhibitor was tested for its antiapoptotic effect on degenerating nigrostriatal neurons in a...
Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway
Igaki, Tatsushi, Kanda, Hiroshi, Yamamoto-Goto, Yuki, Kanuka, Hirotaka, Kuranaga, Erina, Aigaki, Toshiro, ...
Drosophila provides a powerful genetic model for studying the in vivo regulation of cell death. In our large-scale gain-of-function screen, we identified Eiger, the first invertebrate tumor necrosis...
Kanuka, Hirotaka, Kuranaga, Erina, Hiratou, Tetsuo, Igaki, Tatsushi, Nelson, Bryce, Okano, Hideyuki, ...
Intracellular deposition of aggregated and ubiquitinated proteins is a prominent cytopathological feature of most neurodegenerative disorders frequently correlated with neural cell death. To...
The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model
Inoue, Haruhisa, Tsukita, Kayoko, Iwasato, Takuji, Suzuki, Yasuyuki, Tomioka, Masanori, Tateno, Minako, ...
Mutant copper/zinc superoxide dismutase (SOD1)-overexpressing transgenic mice, a mouse model for familial amyotrophic lateral sclerosis (ALS), provides an excellent resource for developing novel...
Hisahara, Shin, Araki, Takashi, Sugiyama, Fumihiro, Yagami, Ken–ichi, Suzuki, Misao, Abe, Kuniya, ...
The mechanisms underlying oligodendrocyte (OLG) loss and the precise roles played by OLG death in human demyelinating diseases such as multiple sclerosis (MS), and in the rodent model of MS,...
Caspases determine the vulnerability of oligodendrocytes in the ischemic brain
Shibata, Mamoru, Hisahara, Shin, Hara, Hideaki, Yamawaki, Takemori, Fukuuchi, Yasuo, Yuan, Junying, ...
Although oligodendrocytes (OLGs) are thought to be vulnerable to hypoxia and ischemia, little is known about the detailed mechanism by which these insults induce OLG death. From the clinical...
Bax-like protein Drob-1 protects neurons from expanded polyglutamine-induced toxicity in Drosophila
Senoo-Matsuda, Nanami, Igaki, Tatsushi, Miura, Masayuki
Bcl-2 family proteins regulate cell death through the mitochondrial apoptotic pathway. Here, we show that the Drosophila Bax-like Bcl-2 family protein Drob-1 maintains mitochondrial function to...
Drosophila caspase transduces Shaggy/GSK-3β kinase activity in neural precursor development
Kanuka, Hirotaka, Kuranaga, Erina, Takemoto, Kiwamu, Hiratou, Tetsuo, Okano, Hideyuki, Miura, Masayuki
Caspases are well known for their role in the execution of apoptotic programs, in which they cleave specific target proteins, leading to the elimination of cells, and for their role in cytokine...
DRONC Coordinates Cell Death and Compensatory Proliferation‡
Kondo, Shu, Senoo-Matsuda, Nanami, Hiromi, Yasushi, Miura, Masayuki
Accidental cell death often leads to compensatory proliferation. In Drosophila imaginal discs, for example, γ-irradiation induces extensive cell death, which is rapidly compensated by elevated...
Local initiation of caspase activation in Drosophila salivary gland programmed cell death in vivo
Takemoto, Kiwamu, Kuranaga, Erina, Tonoki, Ayako, Nagai, Takeharu, Miyawaki, Atsushi, Miura, Masayuki
Programmed cell death, or apoptosis, is an essential event in animal development. Spatiotemporal analysis of caspase activation in vivo could provide new insights into programmed cell death occurring...
Caspase-11 Mediates Oligodendrocyte Cell Death and Pathogenesis of Autoimmune-Mediated Demyelination
Hisahara, Shin, Yuan, Junying, Momoi, Takashi, Okano, Hideyuki, Miura, Masayuki
Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are inflammatory diseases of the central nervous system (CNS) characterized by localized areas of...
Takemoto, Kiwamu, Nagai, Takeharu, Miyawaki, Atsushi, Miura, Masayuki
Indicator molecules for caspase-3 activation have been reported that use fluorescence resonance energy transfer (FRET) between an enhanced cyan fluorescent protein (the donor) and enhanced yellow...
Ribeiro, Paulo S., Kuranaga, Erina, Tenev, Tencho, Leulier, François, Miura, Masayuki, Meier, Pascal
In addition to their well-known function in apoptosis, caspases are also important in several nonapoptotic processes. How caspase activity is restrained and shut down under such nonapoptotic...
Involvement of ER stress in retinal cell death
Shimazawa, Masamitsu, Inokuchi, Yuta, Ito, Yasushi, Murata, Hiroshi, Aihara, Makoto, Miura, Masayuki, ...
Kohyama-Koganeya, Ayako, Kim, Yeon-Jeong, Miura, Masayuki, Hirabayashi, Yoshio
Glucose, one of the most important nutrients for animals, acts as a regulatory signal that controls the secretion of hormones, such as insulin, by endocrine tissues. However, how organisms respond to...
Genetic Evidence Linking Age-Dependent Attenuation of the 26S Proteasome with the Aging Process ▿ †
Tonoki, Ayako, Kuranaga, Erina, Tomioka, Takeyasu, Hamazaki, Jun, Murata, Shigeo, Tanaka, Keiji, ...
The intracellular accumulation of unfolded or misfolded proteins is believed to contribute to aging and age-related neurodegenerative diseases. However, the links between age-dependent proteotoxicity...