Masayuki Ozawa

Identification of the Ca2+-Binding Domains in Reticulocalbin, an Endoplasmic Reticulum Resident Ca2+-Binding Protein with Multiple EF-Hand Motifs (1997)

Tachikui, Hiroshi, Navet, Apala Farhat, Ozawa, Masayuki

Reticulocalbin (RCN) is a member of the EF-hand Ca2+-binding protein family and is a luminal protein of the endoplasmic reticulum (ER) with a molecular weight of 44,000 [Ozawa, M. and Muramatsu, T....

Molecular Cloning and Expression of a Mouse {alpha}-1,3 Fucosyltransferase Gene That Shows Homology with the Human{alpha}-1,3 Fucosyltransferase IV Gene (1996)

Ozawa, Masayuki, Muramatsu, Takashi

The polymerase chain reaction was used to amplify and clone a fragment of a novel fucosyltransferase cDNA from mouse embryonal carcinoma F9 cells. Southern blot analysis of mouse genomic DNA with the...

Structure of the Mouse Basigin Gene, a Unique Member of the Immunoglobulin Superfamily (1995)

Miyauchi, Teruo, Jimma, Fumie, Igakura, Tadahiko, Yu, Su, Ozawa, Masayuki, Muramatsu, Takashi

Basigin is a membrane glycoprotein belonging to the immunoglobulin superfamily. The mouse basigin gene was isolated from a genomic DNA library of the BALB/c mouse, and the structure of the gene and...

Cloning of an Alternative Form of Plakoglobin ({gamma}-Catenin) Lacking the Fourth Armadillo Repeat (1995)

Ozawa, Masayuki, Nuruki, Kensuke, Toyoyama, Hironobu, Ohi, Yoshitada

Plakoglobin is a member of a protein family with a repeating amino acid motif called the armadillo repeat, and is a cytoplasmic protein found in both adherens junctions and desmosomes. Little is...

Lewis X Structure Increases Cell Substratum Adhesion in L Cells (1995)

Sudou, Akiharu, Ozawa, Masayuki, Muramatsu, Takashi

cDNAs of α-1,3-fucosyltransferase as well as α-1,3/4-fucosyltransferase were placed under the control of a β-actin promoter and cytomegalovirus enhancer and were introduced into L cells. The...

Structure of the Gene Encoding Mouse Reticulocalbin, a Novel Endoplasmic Reticulum-Resident Ca2+-Binding Protein with Multiple EF-Hand Motifs (1995)

Ozawa, Masayuki

Reticulocalbin, an endoplasmic reticulum (ER)-resident Ca2+-binding protein, is a member of the EF-hand Ca2+-binding protein superfamily [Ozawa, M. and Muramatsu, T. (1993) J. Biol. Chem. 268,...

Midkine (MK) Expression in Extraembryonic Tissues, Amniotic Fluid, and Cerebrospinal Fluid during Mouse Embryogenesis (1995)

Obama, Hiroya, Tsutsui, Jun-ichiro, Ozawa, Masayuki, Yoshida, Hiroki, Yoshida, Yoshihiro, Osame, Mitsuhiro, ...

Midkinr (MK) and pleiotrophin (PTN) constitute a new family of heparin-binding growth factors. Extraembryonic membranes and the placenta of the mouse expressed MK mRNA at 11.5 days gestation. While...

The Fourth Armadillo Repeat of Plakoglobin ({gamma}-Catenin) Is Required for Its High Affinity Binding to the Cytoplasmic Domains of E-Cadherin and Desmosomal Cadherin Dsg2, and the Tumor Suppressor APC Protein (1995)

Ozawa, Masayuki, Terada, Hirokazu, Pedraza, Claudio

Plakoglobin is a member of a protein family with a repeated amino acid motif, the armadillo repeat, and is a cytoplasmic protein found in both adherens junctions and desmosomes. Plakoglobin has been...

Cloning of a Human Homologue of Mouse Reticulocalbin Reveals Conservation of Structural Domains in the Novel Endoplasmic Reticulum Resident Ca2+-Binding Protein with Multiple EF-Hand Motifs (1995)

Ozawa, Masayuki

Recently, we described the isolation of a mouse cDNA clone encoding a novel Ca2+-binding protein, tentatively designated as reticulocalbin [Ozawa, M. and Muramatsu, T. (1993) J. Biol. Chem. 268,...

Identification of Nucleolin as a Binding Protein for Midkine (MK) and Heparin-Binding Growth Associated Molecule (HB-GAM) (1994)

Take, Mitsuhiko, Tsutsui, Jun-ichiro, Obama, Hiroya, Ozawa, Masayuki, Nakayama, Tatsuo, Maruyama, Ikurou, ...

Midkine (MK) is a heparin-binding growth/differentiation factor with a molecular weight of 13 kDa, and is structurally unrelated to fibroblast growth factors (FGF). We studied MK-binding proteins in...

Transgenic mouse lines with ectopic expression of {alpha}-1, 3-galactosyltransferase: production and characteristics (1993)

Ikematsu, Shinya, Kaname, Tadashi, Ozawa, Masayuki, Yonezawa, Suguru, Sato, Eiichi, Uehara, Fumiyuki, ...

The cDNA of murine α-1,3-galactosyltransferase was placed under the control of the β-actin promoter and cytomegalo-virus enhancer, then introduced into male pronuclei of fertilized mouse eggs. The...

Mouse Heparin Binding Protein-44 (HBP-44) Associates with Brushin, a High-Molecular-Weight Glycoprotein Antigen Common to the Kidney and Teratocarcinomas (1993)

Nakamoto, Masaru, Ozawa, Masayuki, Jacinto, Sonia D., Furukawa, Tatsuhiko, Natori, Yasuhiro, Shirahama, Hiroshi, ...

Heparin binding protein-44 (HBP-44) is a heparin binding protein of 44 kDa, found by cDNA cloning using antibodies against teratocarcinoma glycoproteins [Furukawa, T. et al. (1990) J. Biochem. 108,...

A New Family of Heparin Binding Growth/Differentiation Factors: Differential Expression of the Midkine (MK) and HB-GAM Genes during Mouse Development (1992)

Nakamoto, Masaru, Matsubara, Shyuichiro, Miyauchi, Teruo, Obama, Hiroya, Ozawa, Masayuki, Muramatsu, Takashi

MK (midkine) and HB-GAM (heparin-binding growth-associated molecule) constitute a new family of heparin-binding growth differentiation factors. The modes of expression of MK and HB-GAM during mouse...

Basigin, a New, Broadly Distributed Member of the Immunoglobulin Superfamily, Has Strong Homology with Both the Immunoglobulin V Domain and the {beta}-Chain of Major Histocompatibility Complex Class II Antigen (1990)

Miyauchi, Teruo, Kanekura, Takuro, Yamaoka, Akihiro, Ozawa, Masayuki, Miyazawa, Sanzo, Muramatasu, Takashi

Lotus tetragonolobus agglutinin (LTA) binds preferentially to early embryonic cells in the mouse. The affinity-purified antibody raised against LTA receptors from embryonal carcinoma cells were used...

A Heparin Binding Protein Whose Expression Increases during Differentiation of Embryonal Carcinoma Cells to Parietal Endoderm Cells: cDNA Cloning and Sequence Analysis (1990)

Furukawa, Tatsuhiko, Ozawa, Masayuki, Huang, Ruo-Pan, Muramatsu, Takashi

A cDNA clone isolated from a λgtll expression library of teratocarcinoma OTTBO5O specifies for a glycoprotein with a molecular weight of about 44,000. The new glycoprotein was termed heparin binding...

Molecular Properties of ECMA 2 and ECMA 3 Antigens Defined by Monoclonal Antibodies against Embryonal Carcinoma Cells (1985)

OZAWA, Masayuki, MURAMATSU, Takashi, KEMLER, Rolf

ECMA 2 and ECMA 3 antigens defined by two monoclonal antibodies are preferentially expressed in early embryonic cells of the mouse. The antigens were isolated from F9 embryonal carcinoma cells by...

The Glycoprotein-Bound Large Carbohydrates from Embryonal Carcinoma Cells Carry Receptors for Several Lectins Recognizing N-Acetylgalactosamine and Galactose (1985)

OZAWA, Masayuki, MURAMATSU, Takashi

When various lectins were mixed with radioactively labeled embryoglycan (poly-lactosamine-type glycoprotein-bound carbohydrates from early embryonic cells) isolated from F9 embryonal carcinoma cells...

Basement Membrane Glycoprotein Laminin Is an Agglutinin (1983)

OZAWA, Masayuki, SATO, Masahiro, MURAMATSU, Takashi

Laminin was purified to homogeneity from the extracellular matrix and soluble fraction of teratocarcinoma OTT6050 and also partially purified from the ascitic fluid of the mice carrying the...

Receptors for Dolichos biflorus Agglutinin on Embryonal Carcinoma Cells (1981)

MURAMATSU, Takashi, MURAMATSU, Hisako, OZAWA, Masayuki

Dolichos biflorus agglutinin (DBA), a lectin specific for N-acetylgalactosamine residues, agglutinated F9 embryonal carcinoma cells. FITC-labeled DBA intensively stained F9 cells, and embryonal...

The Presence and Cleavage of Interpeptide Disulfide: Bonds in Viral Glycoproteins (1979)

OZAWA, Masayuki, ASANO, Akira, OKADA, Yoshio

The presence and nature of interpeptide disulfide bonds in HANA (Aemagglutinin and neura-minidase) glycoprotein and F (fusion) glycoprotein of HVJ (Sendai virus) are described. In the case of HANA,...

Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex

Baki, Lia, Marambaud, Philippe, Efthimiopoulos, Spiros, Georgakopoulos, Anastasios, Wen, Paul, Cui, Wen, ...

Here we show that presenilin-1 (PS1), a protein involved in Alzheimer's disease, binds directly to epithelial cadherin (E-cadherin). This binding is mediated by the large cytoplasmic loop of PS1 and...

Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex

Baki, Lia, Marambaud, Philippe, Efthimiopoulos, Spiros, Georgakopoulos, Anastasios, Wen, Paul, Cui, Wen, ...

Here we show that presenilin-1 (PS1), a protein involved in Alzheimer's disease, binds directly to epithelial cadherin (E-cadherin). This binding is mediated by the large cytoplasmic loop of PS1 and...

The Membrane-proximal Region of the E-Cadherin Cytoplasmic Domain Prevents Dimerization and Negatively Regulates Adhesion Activity

Ozawa, Masayuki, Kemler, Rolf

Cadherins are transmembrane glycoproteins involved in Ca2+-dependent cell–cell adhesion. Deletion of the COOH-terminal residues of the E-cadherin cytoplasmic domain has been shown to abolish its...

CD151 regulates epithelial cell–cell adhesion through PKC- and Cdc42-dependent actin cytoskeletal reorganization

Shigeta, Masaki, Sanzen, Noriko, Ozawa, Masayuki, Gu, Jianguo, Hasegawa, Hitoshi, Sekiguchi, Kiyotoshi

CD151, a member of the tetraspanin family proteins, tightly associates with integrin α3β1 and localizes at basolateral surfaces of epithelial cells. We found that overexpression of CD151 in A431...

Expression of α-catenin in α-catenin–deficient cells increases resistance to sphingosine-induced apoptosis

Matsubara, Shyuichiro, Ozawa, Masayuki

α-Catenin, an intracellular protein, associates with the COOH-terminal region of cadherin cell adhesion molecules through interactions with either β-catenin or γ-catenin (plakoglobin). The full...