Masha Fridkis-Hareli

Immunogenetic mechanisms for the coexistence of organ-specific and systemic autoimmune diseases (2008)

Fridkis-Hareli, Masha

Abstract Background Organ-specific autoimmune diseases affect particular targets in the body, whereas systemic diseases engage multiple organs. Both types of autoimmune diseases may coexist in the...

New approaches to eliciting protective immunity through T cell repertoire manipulation: the concept of thymic vaccination (2004)

Fridkis-Hareli, Masha, Reinherz, Ellis L

Abstract Conventional vaccines afford protection against infectious diseases by expanding existing pathogen-specific peripheral lymphocytes, both CD8 cytotoxic effector (CTL) and CD4 helper T cells....

Peptide variants of viral CTL epitopes mediate positive selection and emigration of Ag-specific thymocytes in vivo (2004)

Fridkis-Hareli, Masha, Reche, Pedro A, Reinherz, Ellis L

During development, thymocytes carrying TCRs mediating low-affinity interactions with MHC-bound self-peptides are positively selected for export into the mature peripheral T lymphocyte pool. Thus,...

Synthetic amino acid copolymers that bind to HLA-DR proteins and inhibit type II collagen-reactive T cell clones

Fridkis-Hareli, Masha, Rosloniec, Edward F., Fugger, Lars, Strominger, Jack L.

Copolymer 1 [poly(Y,E,A,K)] is a random synthetic amino acid copolymer of l-tyrosine, l-glutamic acid, l-alanine, and l-lysine that is effective both in suppression of experimental allergic...

Novel synthetic amino acid copolymers that inhibit autoantigen-specific T cell responses and suppress experimental autoimmune encephalomyelitis

Fridkis-Hareli, Masha, Santambrogio, Laura, Stern, Joel N.H., Fugger, Lars, Brosnan, Celia, Strominger, Jack L.

Copolymer 1 (Cop 1, Copaxone [Teva Marion Partners, Kansas City, Missouri, USA]), a random amino acid copolymer of tyrosine (Y), glutamic acid (E), alanine (A), and lysine (K), reduces the frequency...

Amelioration of proteolipid protein 139–151-induced encephalomyelitis in SJL mice by modified amino acid copolymers and their mechanisms

Stern, Joel N. H., Illés, Zsolt, Reddy, Jayagopala, Keskin, Derin B., Sheu, Eric, Fridkis-Hareli, Masha, ...

Copolymer 1 [Cop1, glatiramer acetate, Copaxone, poly(Y,E,A,K)n] is widely used in the treatment of relapsing/remitting multiple sclerosis in which it reduces the frequency of relapses by ≈30%. In...

New approaches to eliciting protective immunity through T cell repertoire manipulation: the concept of thymic vaccination

Fridkis-Hareli, Masha, Reinherz, Ellis L

Conventional vaccines afford protection against infectious diseases by expanding existing pathogen-specific peripheral lymphocytes, both CD8 cytotoxic effector (CTL) and CD4 helper T cells. The...

Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomyelitis

Stern, Joel N. H., Illés, Zsolt, Reddy, Jayagopala, Keskin, Derin B., Fridkis-Hareli, Masha, Kuchroo, Vijay K., ...

Myelin basic protein (MBP) is a major candidate autoantigen in multiple sclerosis (MS). Its immunodominant epitope, MBP 85–99, forms a complex with human leukocyte antigen (HLA)-DR2 with which...

Synthetic amino acid copolymers that bind to HLA-DR proteins and inhibit type II collagen-reactive T cell clones

Fridkis-Hareli, Masha, Rosloniec, Edward F., Fugger, Lars, Strominger, Jack L.

Copolymer 1 [poly(Y,E,A,K)] is a random synthetic amino acid copolymer of l-tyrosine, l-glutamic acid, l-alanine, and l-lysine that is effective both in suppression of experimental allergic...

Novel synthetic amino acid copolymers that inhibit autoantigen-specific T cell responses and suppress experimental autoimmune encephalomyelitis

Fridkis-Hareli, Masha, Santambrogio, Laura, Stern, Joel N.H., Fugger, Lars, Brosnan, Celia, Strominger, Jack L.

Copolymer 1 (Cop 1, Copaxone [Teva Marion Partners, Kansas City, Missouri, USA]), a random amino acid copolymer of tyrosine (Y), glutamic acid (E), alanine (A), and lysine (K), reduces the frequency...

Amelioration of proteolipid protein 139–151-induced encephalomyelitis in SJL mice by modified amino acid copolymers and their mechanisms

Stern, Joel N. H., Illés, Zsolt, Reddy, Jayagopala, Keskin, Derin B., Sheu, Eric, Fridkis-Hareli, Masha, ...

Copolymer 1 [Cop1, glatiramer acetate, Copaxone, poly(Y,E,A,K)n] is widely used in the treatment of relapsing/remitting multiple sclerosis in which it reduces the frequency of relapses by ≈30%. In...

New approaches to eliciting protective immunity through T cell repertoire manipulation: the concept of thymic vaccination

Fridkis-Hareli, Masha, Reinherz, Ellis L

Conventional vaccines afford protection against infectious diseases by expanding existing pathogen-specific peripheral lymphocytes, both CD8 cytotoxic effector (CTL) and CD4 helper T cells. The...

Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomyelitis

Stern, Joel N. H., Illés, Zsolt, Reddy, Jayagopala, Keskin, Derin B., Fridkis-Hareli, Masha, Kuchroo, Vijay K., ...

Myelin basic protein (MBP) is a major candidate autoantigen in multiple sclerosis (MS). Its immunodominant epitope, MBP 85–99, forms a complex with human leukocyte antigen (HLA)-DR2 with which...

Immunogenetic mechanisms for the coexistence of organ-specific and systemic autoimmune diseases

Fridkis-Hareli, Masha