Massimiliano Gentile

Unraveling the disease pathogenesis behind lethal hydrolethalus syndrome revealed multiple changes in molecular and cellular level (2009)

Honkala, Heli, Lahtela, Jenni, Fox, Heli, Gentile, Massimiliano, Pakkasjärvi, Niklas, Salonen, Riitta, ...

Abstract Background Hydrolethalus syndrome (HLS) is a severe fetal malformation syndrome characterized by multiple developmental anomalies, including central nervous system (CNS) malformation such as...

Brain gene expression profiles of Cln1and Cln5deficient mice unravels common molecular pathways underlying neuronal degeneration in NCL diseases (2008)

Von Schantz, Carina, Saharinen, Juha, Kopra, Outi, Cooper, Jonathan D, Gentile, Massimiliano, Hovatta, Iiris, ...

Abstract Background The neuronal ceroid lipofuscinoses (NCL) are a group of children's inherited neurodegenerative disorders, characterized by blindness, early dementia and pronounced cortical...

Cross-species analyses implicate Lipin 1 involvement in human glucose metabolism (2006)

Suviolahti, Elina, Reue, Karen, Cantor, Rita M., Phan, Jack, Gentile, Massimiliano, Naukkarinen, Jussi, ...

Recent studies in the mouse have demonstrated that variations in lipin expression levels in adipose tissue have marked effects on adipose tissue mass and insulin sensitivity. In the mouse, lipin...

USF1 and dyslipidemias: converging evidence for a functional intronic variant (2005)

Naukkarinen, Jussi, Gentile, Massimiliano, Soro-Paavonen, Aino, Saarela, Janna, Koistinen, Heikki A., Pajukanta, Päivi, ...

Upstream transcription factor 1 (USF1), the first gene associated with familial combined hyperlipidemia (FCHL), regulates numerous genes of glucose and lipid metabolism. Phenotypic overlap between...

USF1 and Dyslipidemias: converging evidence for a functional intronic variant (2005)

Naukkarinen, Jussi, Gentile, Massimiliano, Soro-Paavonen, Aino, Saarela, Janna, Koistinen, Heikki A, Pajukanta, Päivi, ...

Upstream transcription factor 1 (USF1), the first gene associated with familial combined hyperlipidemia (FCHL), regulates numerous genes of glucose and lipid metabolism. Phenotypic overlap between...

Cell cycle arrest and apoptosis provoked by UV radiation-induced DNA damage are transcriptionally highly divergent responses (2003)

Gentile, Massimiliano, Latonen, Leena, Laiho, Marikki

DNA damage caused by UV radiation initiates cellular recovery mechanisms, which involve activation of DNA damage response pathways, cell cycle arrest and apoptosis. To assess cellular transcriptional...

Cell cycle arrest and apoptosis provoked by UV radiation-induced DNA damage are transcriptionally highly divergent responses

Gentile, Massimiliano, Latonen, Leena, Laiho, Marikki

DNA damage caused by UV radiation initiates cellular recovery mechanisms, which involve activation of DNA damage response pathways, cell cycle arrest and apoptosis. To assess cellular transcriptional...

Cell cycle arrest and apoptosis provoked by UV radiation-induced DNA damage are transcriptionally highly divergent responses

Gentile, Massimiliano, Latonen, Leena, Laiho, Marikki

DNA damage caused by UV radiation initiates cellular recovery mechanisms, which involve activation of DNA damage response pathways, cell cycle arrest and apoptosis. To assess cellular transcriptional...