Nicoli, Stefania, Giacca, Mauro, Fiorentini, Simona, Caruso, Arnaldo, ...
The HIV-1 transactivating factor Tat accumulates on the surface of endothelium by interacting with heparan sulfate proteoglycans (HSPGs). Tat also interacts with B-lymphoid Namalwa cells but only...
Unsung Hero Robert C. Gallo (2009)
Abbadessa, Giovanni, Accolla, Roberto, Aiuti, Fernando, Albini, Adriana, Aldovini, Anna, Alfano, Massimo, ...
Awarding the Nobel prize in physiology or medicine to Francoise Barré-Sinoussi and Luc Montagnier for the discovery of HIV-1, the causative agent of AIDS, is timely given the harm that the virus...
Pertussis toxin B-oligomer inhibits HIV infection and replication in hu-PBL-SCID mice (2005)
Lapenta, Caterina, Spada, Massimo, Santini, Stefano M., Racca, Sara, Dorigatti, Fernanda, Poli, Guido, ...
Bordetella pertussis toxin B-oligomer (PTX-B) has been shown to inhibit HIV infection and replication in vitro. The potential anti-viral effect of PTX-B was tested here in an in vivo surrogate model...
Pertussis toxin B-oligomer inhibits HIV infection and replication in hu-PBL-SCID mice (2005)
Lapenta, Caterina, Spada, Massimo, Santini, Stefano M., Racca, Sara, Dorigatti, Fernanda, Poli, Guido, ...
Bordetella pertussis toxin B-oligomer (PTX-B) has been shown to inhibit HIV infection and replication in vitro. The potential anti-viral effect of PTX-B was tested here in an in vivo surrogate model...
Role of cyclophilin A in the uptake of HIV-1 by macrophages and T lymphocytes
Sherry, Barbara, Zybarth, Gabriele, Alfano, Massimo, Dubrovsky, Larisa, Mitchell, Robert, Rich, Daniel, ...
Cyclophilins are a family of proteins that bind cyclosporin A (CsA) and possess peptidyl-prolyl cis-trans isomerase activity. In addition, they are secreted by activated cells and act in a...
Schmidtmayerova, Helena, Alfano, Massimo, Nuovo, Gerard, Bukrinsky, Michael
The human immunodeficiency virus type 1 (HIV-1) laboratory strains adapted to T-cell lines, as well as most syncytium-inducing primary isolates, replicate poorly in macrophages, which, beside CD4+ T...
Alfano, Massimo, Pushkarsky, Tatiana, Poli, Guido, Bukrinsky, Michael
We have recently demonstrated that the binding subunit (B-oligomer) of pertussis toxin (PTX-B) deactivates CCR5 and inhibits entry of R5 human immunodeficiency virus type 1 (HIV-1) strains in...
Urokinase–urokinase receptor interaction mediates an inhibitory signal for HIV-1 replication
Alfano, Massimo, Sidenius, Nicolai, Panzeri, Barbara, Blasi, Francesco, Poli, Guido
Elevated levels of soluble urokinase-type plasminogen activator (uPA) receptor, CD87/u-PAR, predict survival in individuals infected with HIV-1. Here, we report that pro-uPA (or uPA) inhibits HIV-1...
Role of cyclophilin A in the uptake of HIV-1 by macrophages and T lymphocytes
Sherry, Barbara, Zybarth, Gabriele, Alfano, Massimo, Dubrovsky, Larisa, Mitchell, Robert, Rich, Daniel, ...
Cyclophilins are a family of proteins that bind cyclosporin A (CsA) and possess peptidyl-prolyl cis-trans isomerase activity. In addition, they are secreted by activated cells and act in a...
Schmidtmayerova, Helena, Alfano, Massimo, Nuovo, Gerard, Bukrinsky, Michael
The human immunodeficiency virus type 1 (HIV-1) laboratory strains adapted to T-cell lines, as well as most syncytium-inducing primary isolates, replicate poorly in macrophages, which, beside CD4+ T...
Alfano, Massimo, Pushkarsky, Tatiana, Poli, Guido, Bukrinsky, Michael
We have recently demonstrated that the binding subunit (B-oligomer) of pertussis toxin (PTX-B) deactivates CCR5 and inhibits entry of R5 human immunodeficiency virus type 1 (HIV-1) strains in...
Urokinase–urokinase receptor interaction mediates an inhibitory signal for HIV-1 replication
Alfano, Massimo, Sidenius, Nicolai, Panzeri, Barbara, Blasi, Francesco, Poli, Guido
Elevated levels of soluble urokinase-type plasminogen activator (uPA) receptor, CD87/u-PAR, predict survival in individuals infected with HIV-1. Here, we report that pro-uPA (or uPA) inhibits HIV-1...
Alfano, Massimo, Schmidtmayerova, Helena, Amella, Carol-Ann, Pushkarsky, Tatiana, Bukrinsky, Michael
Infection of target cells by HIV-1 requires initial binding interactions between the viral envelope glycoprotein gp120, the cell surface protein CD4, and one of the members of the seven-transmembrane...
Fichorova, Raina N., Richardson-Harman, Nicola, Alfano, Massimo, Belec, Laurent, Carbonneil, Cedric, Chen, Silvia, ...
The increase of proinflammatory cytokines in vaginal secretions may serve as a surrogate marker of unwanted inflammatory reaction to microbicide products topically applied for the prevention of...