Candida albicans Colonization and ASCA in Familial Crohn's Disease (2009)
Sendid, Boualem, Francois, Nadine, Branche, Julien, ...
OBJECTIVES: Anti-Saccharomyces cerevisiae antibodies (ASCAs) are present in 50-60% of patients with Crohn's disease (CD) and in 20-25% of their healthy relatives (HRs). The yeast, Candida albicans,...
Colombel, Jean-Frederic, Standaert-Vitse, Annie, Collot, Mayeul, Halfvarson, Jonas, ...
OBJECTIVES: Anti-S. cerevisiae mannan antibodies (ASCA) are human antibodies associated with Crohn's disease (CD) reacting with Saccharomyces cerevisiae (S. cerevisiae) mannan polymer. As mannan is a...
Nod-Like Receptors: Cytosolic Watchdogs for Immunity against Pathogens (2007)
Jean-Claude Sirard, Cécile Vignal, Rodrigue Dessein, Mathias Chamaillard
In mammals, tissue-specific sets of pattern-recognition molecules, including Nod-like receptors (NLR), enable concomitant and sequential detection of microbial-associated molecular patterns from both...
Nod-like receptors: cytosolic watchdogs for immunity against pathogens. (2007)
Sirard, Jean-Claude, Vignal, Cécile, Dessein, Rodrigue, Chamaillard, Mathias
In mammals, tissue-specific sets of pattern-recognition molecules, including Nod-like receptors (NLR), enable concomitant and sequential detection of microbial-associated molecular patterns from both...
Nod-like receptors: cytosolic watchdogs for immunity against pathogens. (2007)
Sirard, Jean-Claude, Vignal, Cécile, Dessein, Rodrigue, Chamaillard, Mathias
In mammals, tissue-specific sets of pattern-recognition molecules, including Nod-like receptors (NLR), enable concomitant and sequential detection of microbial-associated molecular patterns from both...
Nod-like receptors: cytosolic watchdogs for immunity against pathogens. (2007)
Sirard, Jean-Claude, Vignal, Cécile, Dessein, Rodrigue, Chamaillard, Mathias
In mammals, tissue-specific sets of pattern-recognition molecules, including Nod-like receptors (NLR), enable concomitant and sequential detection of microbial-associated molecular patterns from both...
Thuru, Xavier, Gelot, Agathe, Barnich, Nicolas, Neut, Christel, Dubuquoy, Laurent, ...
Abdominal pain is common in the general population and, in patients with irritable bowel syndrome, is attributed to visceral hypersensitivity. We found that oral administration of specific...
Gene–environment interaction modulated by allelic heterogeneity in inflammatory diseases
Chamaillard, Mathias, Philpott, Dana, Girardin, Stephen E., Zouali, Habib, Lesage, Suzanne, Chareyre, Fabrice, ...
CARD15 is a major susceptibility gene for a frequent multifactorial chronic inflammatory bowel disorder, Crohn disease (CD). By using NF-κB activation assays, the cytosolic CARD15 was shown to...
Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition
Tanabe, Tsuyoshi, Chamaillard, Mathias, Ogura, Yasunori, Zhu, Li, Qiu, Su, Masumoto, Junya, ...
Multiple genetic variants of CARD15/NOD2 have been associated with susceptibility to Crohn's disease and Blau syndrome. NOD2 recognizes muramyl dipeptide (MDP) derived from bacterial peptidoglycan...
Gene–environment interaction modulated by allelic heterogeneity in inflammatory diseases
Chamaillard, Mathias, Philpott, Dana, Girardin, Stephen E., Zouali, Habib, Lesage, Suzanne, Chareyre, Fabrice, ...
CARD15 is a major susceptibility gene for a frequent multifactorial chronic inflammatory bowel disorder, Crohn disease (CD). By using NF-κB activation assays, the cytosolic CARD15 was shown to...
Lesage, Suzanne, Zouali, Habib, Cézard, Jean-Pierre, Colombel, Jean-Frédéric, Belaiche, Jacques, Almer, Sven, ...
CARD15/NOD2 encodes a protein involved in bacterial recognition by monocytes. Mutations in CARD15 have recently been found in patients with Crohn disease (CD), a chronic inflammatory condition of the...
Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition
Tanabe, Tsuyoshi, Chamaillard, Mathias, Ogura, Yasunori, Zhu, Li, Qiu, Su, Masumoto, Junya, ...
Multiple genetic variants of CARD15/NOD2 have been associated with susceptibility to Crohn's disease and Blau syndrome. NOD2 recognizes muramyl dipeptide (MDP) derived from bacterial peptidoglycan...
Nod-Like Receptors: Cytosolic Watchdogs for Immunity against Pathogens
Sirard, Jean-Claude, Vignal, Cécile, Dessein, Rodrigue, Chamaillard, Mathias
In mammals, tissue-specific sets of pattern-recognition molecules, including Nod-like receptors (NLR), enable concomitant and sequential detection of microbial-associated molecular patterns from both...
Koslowski, Maureen J., Kübler, Irmgard, Chamaillard, Mathias, Schaeffeler, Elke, Reinisch, Walter, Wang, Guoxing, ...
Reduced expression of Paneth cell antimicrobial α-defensins, human defensin (HD)-5 and -6, characterizes Crohn's disease (CD) of the ileum. TCF-4 (also named TCF7L2), a Wnt signalling pathway...