Campellone, Kenneth Geno, Cheng, Hui-Chun, Robbins, Douglas, Siripala, Anosha D., McGhie, Emma J., Hayward, Richard D., ...
Enterohemorrhagic Escherichia coli (EHEC) generate F-actin-rich adhesion pedestals by delivering effector proteins into mammalian cells. These effectors include the translocated receptor Tir, along...
Campellone, Kenneth Geno, Webb, Neil J., Znameroski, Elizabeth A., Welch, Matthew D.
The Arp2/3 complex is an actin nucleator that plays a critical role in many cellular processes. Its activities are regulated by nucleation-promoting factors (NPFs) that function primarily during...
Motility Determinants in WASP Family ProteinsD⃞
Yarar, Defne, D'Alessio, Joseph A., Jeng, Robert L., Welch, Matthew D.
In response to upstream signals, proteins in the Wiskott-Aldrich Syndrome protein (WASP) family regulate actin nucleation via the Arp2/3 complex. Despite intensive study of the function of WASP...
Bodin, Stéphane, Welch, Matthew D.
Exposure of neutrophils to chemoattractant induces cell polarization and migration. These behaviors require the asymmetric activation of distinct signaling pathways and cytoskeletal elements in the...
Motility Determinants in WASP Family ProteinsD⃞
Yarar, Defne, D'Alessio, Joseph A., Jeng, Robert L., Welch, Matthew D.
In response to upstream signals, proteins in the Wiskott-Aldrich Syndrome protein (WASP) family regulate actin nucleation via the Arp2/3 complex. Despite intensive study of the function of WASP...
Bodin, Stéphane, Welch, Matthew D.
Exposure of neutrophils to chemoattractant induces cell polarization and migration. These behaviors require the asymmetric activation of distinct signaling pathways and cytoskeletal elements in the...
Mycobacterium marinum Escapes from Phagosomes and Is Propelled by Actin-based Motility
Stamm, Luisa M., Morisaki, J. Hiroshi, Gao, Lian-Yong, Jeng, Robert L., McDonald, Kent L., Roth, Robyn, ...
Mycobacteria are responsible for a number of human and animal diseases and are classical intracellular pathogens, living inside macrophages rather than as free-living organisms during infection....
Welch, Matthew D., DePace, Angela H., Verma, Suzie, Iwamatsu, Akihiro, Mitchison, Timothy J.
The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells. The human complex consists of seven subunits which include the actin related proteins Arp2 and Arp3,...
Skoble, Justin, Auerbuch, Victoria, Goley, Erin D., Welch, Matthew D., Portnoy, Daniel A.
The Listeria monocytogenes ActA protein mediates actin-based motility by recruiting and stimulating the Arp2/3 complex. In vitro, the actin monomer-binding region of ActA is critical for stimulating...
Formation of filopodia-like bundles in vitro from a dendritic network
Vignjevic, Danijela, Yarar, Defne, Welch, Matthew D., Peloquin, John, Svitkina, Tatyana, Borisy, Gary G.
We report the development and characterization of an in vitro system for the formation of filopodia-like bundles. Beads coated with actin-related protein 2/3 (Arp2/3)–activating proteins can induce...
Skoble, Justin, Portnoy, Daniel A., Welch, Matthew D.
The Listeria monocytogenes ActA protein induces actin-based motility by enhancing the actin nucleating activity of the host Arp2/3 complex. Using systematic truncation analysis, we identified a...
Visualization and Molecular Analysis of Actin Assembly in Living Cells
Schafer, Dorothy A., Welch, Matthew D., Machesky, Laura M., Bridgman, Paul C., Meyer, Shelley M., Cooper, John A.
Actin filament assembly is critical for eukaryotic cell motility. Arp2/3 complex and capping protein (CP) regulate actin assembly in vitro. To understand how these proteins regulate the dynamics of...
Campellone, Kenneth G., Cheng, Hui-Chun, Robbins, Douglas, Siripala, Anosha D., McGhie, Emma J., Hayward, Richard D., ...
Enterohemorrhagic Escherichia coli (EHEC) generate F-actin–rich adhesion pedestals by delivering effector proteins into mammalian cells. These effectors include the translocated receptor Tir, along...