Matthew T. G. Holden

Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei (2004)

Holden, Matthew T. G., Titball, Richard W., Peacock, Sharon J., Cerdeno-Tarraga, Ana M., Atkins, Timothy, Crossman, Lisa C., ...

Yes

Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei (2004)

Holden, Matthew T. G., Titball, Richard W., Peacock, Sharon J., Cerdeno-Tarraga, Ana M., Atkins, Timothy, Crossman, Lisa C., ...

Yes

Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei (2004)

Holden, Matthew T. G., Titball, Richard W., Peacock, Sharon J., Cerdeno-Tarraga, Ana M., Atkins, Timothy, Crossman, Lisa C., ...

Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica (2003)

Parkhill,Julian, Sebaihia,Mohammed, Preston,Andrew, Murphy,Lee D., Thomson,Nicholas, Harris,David E., ...

Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica are closely related Gram-negative -proteobacteria that colonize the respiratory tracts of mammals. B. pertussis is a...

Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica (2003)

Parkhill, Julian, Sebaihia, Mohammed, Preston, Andrew, Murphy, Lee D., Thomson, Nicholas, Harris, David E., ...

LuxS: its role in central metabolism and the in vitro synthesis of 4-hydroxy-5-methyl-3(2H)-furanone. (2002)

Winzer, Klaus, Hardie, Kim R., Burgess, Nicola, Doherty, Neil, Kirke, David, Holden, Matthew T. G., ...

Many bacteria produce extracellular molecules which function in cell-to-cell communication. One of these molecules, autoinducer 2 (AI-2), was first described as an extracellular signal produced by...

The Global Posttranscriptional Regulator RsmA Modulates Production of Virulence Determinants and N-Acylhomoserine Lactones in Pseudomonas aeruginosa

Pessi, Gabriella, Williams, Faye, Hindle, Zoë, Heurlier, Karin, Holden, Matthew T. G., Cámara, Miguel, ...

Posttranscriptional control is known to contribute to the regulation of secondary metabolism and virulence determinants in certain gram-negative bacteria. Here we report the isolation of a...

The Global Posttranscriptional Regulator RsmA Modulates Production of Virulence Determinants and N-Acylhomoserine Lactones in Pseudomonas aeruginosa

Pessi, Gabriella, Williams, Faye, Hindle, Zoë, Heurlier, Karine, Holden, Matthew T. G., Cámara, Miguel, ...

Complete genomes of two clinical Staphylococcus aureus strains: Evidence for the rapid evolution of virulence and drug resistance

Holden, Matthew T. G., Feil, Edward J., Lindsay, Jodi A., Peacock, Sharon J., Day, Nicholas P. J., Enright, Mark C., ...

Staphylococcus aureus is an important nosocomial and community-acquired pathogen. Its genetic plasticity has facilitated the evolution of many virulent and drug-resistant strains, presenting a major...

Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei

Holden, Matthew T. G., Titball, Richard W., Peacock, Sharon J., Cerdeño-Tárraga, Ana M., Atkins, Timothy, Crossman, Lisa C., ...

Burkholderia pseudomallei is a recognized biothreat agent and the causative agent of melioidosis. This Gram-negative bacterium exists as a soil saprophyte in melioidosis-endemic areas of the world...

The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation

Thomson, Nicholas R., Yeats, Corin, Bell, Kenneth, Holden, Matthew T.G., Bentley, Stephen D., Livingstone, Morag, ...

The obligate intracellular bacterial pathogen Chlamydophila abortus strain S26/3 (formerly the abortion subtype of Chlamydia psittaci) is an important cause of late gestation abortions in ruminants...

Design, Validation, and Application of a Seven-Strain Staphylococcus aureus PCR Product Microarray for Comparative Genomics†

Witney, Adam A., Marsden, Gemma L., Holden, Matthew T. G., Stabler, Richard A., Husain, Sarah E., Vass, J. Keith, ...

Bacterial comparative genomics has been revolutionized by microarrays, but the power of any microarray is dependent on the number and diversity of gene reporters it contains. Staphylococcus aureus is...

Functional Analysis of luxS in Staphylococcus aureus Reveals a Role in Metabolism but Not Quorum Sensing

Doherty, Neil, Holden, Matthew T. G., Qazi, Saara N., Williams, Paul, Winzer, Klaus

The function of AI-2 in many bacteria and the physiological role of LuxS, the enzyme responsible for its production, remain matters of debate. Here, we show that in Staphylococcus aureus the luxS...

Nonrandom Distribution of Burkholderia pseudomallei Clones in Relation to Geographical Location and Virulence

Vesaratchavest, Mongkol, Tumapa, Sarinna, Day, Nicholas P. J., Wuthiekanun, Vanaporn, Chierakul, Wirongrong, Holden, Matthew T. G., ...

Burkholderia pseudomallei is a soil-dwelling saprophyte and the causative agent of melioidosis, a life-threatening human infection. Most cases are reported from northeast Thailand and northern...

The Global Posttranscriptional Regulator RsmA Modulates Production of Virulence Determinants and N-Acylhomoserine Lactones in Pseudomonas aeruginosa

Pessi, Gabriella, Williams, Faye, Hindle, Zoë, Heurlier, Karin, Holden, Matthew T. G., Cámara, Miguel, ...

Posttranscriptional control is known to contribute to the regulation of secondary metabolism and virulence determinants in certain gram-negative bacteria. Here we report the isolation of a...

The Global Posttranscriptional Regulator RsmA Modulates Production of Virulence Determinants and N-Acylhomoserine Lactones in Pseudomonas aeruginosa

Pessi, Gabriella, Williams, Faye, Hindle, Zoë, Heurlier, Karine, Holden, Matthew T. G., Cámara, Miguel, ...

Complete genomes of two clinical Staphylococcus aureus strains: Evidence for the rapid evolution of virulence and drug resistance

Holden, Matthew T. G., Feil, Edward J., Lindsay, Jodi A., Peacock, Sharon J., Day, Nicholas P. J., Enright, Mark C., ...

Staphylococcus aureus is an important nosocomial and community-acquired pathogen. Its genetic plasticity has facilitated the evolution of many virulent and drug-resistant strains, presenting a major...

Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei

Holden, Matthew T. G., Titball, Richard W., Peacock, Sharon J., Cerdeño-Tárraga, Ana M., Atkins, Timothy, Crossman, Lisa C., ...

Burkholderia pseudomallei is a recognized biothreat agent and the causative agent of melioidosis. This Gram-negative bacterium exists as a soil saprophyte in melioidosis-endemic areas of the world...

The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation

Thomson, Nicholas R., Yeats, Corin, Bell, Kenneth, Holden, Matthew T.G., Bentley, Stephen D., Livingstone, Morag, ...

The obligate intracellular bacterial pathogen Chlamydophila abortus strain S26/3 (formerly the abortion subtype of Chlamydia psittaci) is an important cause of late gestation abortions in ruminants...

Design, Validation, and Application of a Seven-Strain Staphylococcus aureus PCR Product Microarray for Comparative Genomics†

Witney, Adam A., Marsden, Gemma L., Holden, Matthew T. G., Stabler, Richard A., Husain, Sarah E., Vass, J. Keith, ...

Bacterial comparative genomics has been revolutionized by microarrays, but the power of any microarray is dependent on the number and diversity of gene reporters it contains. Staphylococcus aureus is...

Functional Analysis of luxS in Staphylococcus aureus Reveals a Role in Metabolism but Not Quorum Sensing

Doherty, Neil, Holden, Matthew T. G., Qazi, Saara N., Williams, Paul, Winzer, Klaus

The function of AI-2 in many bacteria and the physiological role of LuxS, the enzyme responsible for its production, remain matters of debate. Here, we show that in Staphylococcus aureus the luxS...

Nonrandom Distribution of Burkholderia pseudomallei Clones in Relation to Geographical Location and Virulence

Vesaratchavest, Mongkol, Tumapa, Sarinna, Day, Nicholas P. J., Wuthiekanun, Vanaporn, Chierakul, Wirongrong, Holden, Matthew T. G., ...

Burkholderia pseudomallei is a soil-dwelling saprophyte and the causative agent of melioidosis, a life-threatening human infection. Most cases are reported from northeast Thailand and northern...

The Complete Genome Sequence and Comparative Genome Analysis of the High Pathogenicity Yersinia enterocolitica Strain 8081

Thomson, Nicholas R, Howard, Sarah, Wren, Brendan W, Holden, Matthew T. G, Crossman, Lisa, Challis, Gregory L, ...

The human enteropathogen, Yersinia enterocolitica, is a significant link in the range of Yersinia pathologies extending from mild gastroenteritis to bubonic plague. Comparison at the genomic level is...

Complete Genome of Acute Rheumatic Fever-Associated Serotype M5 Streptococcus pyogenes Strain Manfredo▿

Holden, Matthew T. G., Scott, Annabel, Cherevach, Inna, Chillingworth, Tracey, Churcher, Carol, Cronin, Ann, ...

Comparisons of the 1.84-Mb genome of serotype M5 Streptococcus pyogenes strain Manfredo with previously sequenced genomes emphasized the role of prophages in diversification of S. pyogenes and the...

Genome sequence of a proteolytic (Group I) Clostridium botulinum strain Hall A and comparative analysis of the clostridial genomes

Sebaihia, Mohammed, Peck, Michael W., Minton, Nigel P., Thomson, Nicholas R., Holden, Matthew T.G., Mitchell, Wilfrid J., ...

Clostridium botulinum is a heterogeneous Gram-positive species that comprises four genetically and physiologically distinct groups of bacteria that share the ability to produce botulinum neurotoxin,...

Chlamydia trachomatis: Genome sequence analysis of lymphogranuloma venereum isolates

Thomson, Nicholas R., Holden, Matthew T.G., Carder, Caroline, Lennard, Nicola, Lockey, Sarah J., Marsh, Pete, ...

Chlamydia trachomatis is the most common cause of sexually transmitted infections in the UK, a statistic that is also reflected globally. There are three biovariants of C. trachomatis: trachoma...