Matthias Griese

Surfactant proteins SP-B and SP-C and their precursors in bronchoalveolar lavages from children with acute and chronic inflammatory airway disease (2008)

Tafel, Oliver, Latzin, Philipp, Paul, Karl, Winter, Tobias, Woischnik, Markus, Griese, Matthias

Abstract Background The surfactant proteins B (SP-B) and C (SP-C) are important for the stability and function of the alveolar surfactant film. Their involvement and down-regulation in inflammatory...

Aberrant processing forms of lung surfactant proteins SP–B and SP–C revealed by high-resolution mass spectrometry (2008)

Galetskiy, Dmitry, Woischnik, Markus, Ripper, Jan, Griese, Matthias, Przybylski, Michael

The mutation (g.1286T>C) of the pulmonary surfactant-associated protein C gene (SFTPC) leads to the I73T substitution in the precursor protein (pro-SP-C) and results in interstitial lung disease with...

Deleted in Malignant Brain Tumors 1 (DMBT1) is present in hyaline membranes and modulates surface tension of surfactant (2007)

Müller, Hanna, End, Caroline, Renner, Marcus, Helmke, Burkhard M, Gassler, Nikolaus, Weiss, Christel, ...

Abstract Background Deleted in Malignant Brain Tumors 1 (DMBT1) is a secreted scavenger receptor cysteine-rich protein that binds various bacteria and is thought to participate in innate pulmonary...

Lung alveolar proteomics of bronchoalveolar lavage from a pulmonary alveolar proteinosis patient using high-resolution FTICR mass spectrometry (2007)

Bai, Yu, Galetskiy, Dmitry, Damoc, Eugen, Ripper, Jan, Woischnik, Markus, Griese, Matthias, ...

High-resolution Fourier transform ion cyclotron resonance (FTICR) mass spectrometry was developed and applied to the proteome analysis of bronchoalveolar lavage fluid (BALF) from a patient with...

DNAH5 Mutations are a Common Cause of Primary Ciliary Dyskinesia with Outer Dynein Arm Defects (2006)

Hornef, Nada, Olbrich, Heike, Horvath, Judit, Zariwala, Maimoona A., Fliegauf, Manfred, Loges, Niki Tomas, ...

Rationale: Primary ciliary dyskinesia (PCD) is characterized by recurrent airway infections and randomization of left–right body asymmetry. To date, autosomal recessive mutations have only been...

DNAH5 Mutations are a Common Cause of Primary Ciliary Dyskinesia with Outer Dynein Arm Defects (2006)

Hornef, Nada, Olbrich, Heike, Horvath, Judit, Zariwala, Maimoona A., Fliegauf, Manfred, Loges, Niki Tomas, ...

Rationale: Primary ciliary dyskinesia (PCD) is characterized by recurrent airway infections and randomization of left–right body asymmetry. To date, autosomal recessive mutations have only been...

Therapeutic lung lavages in children and adults (2005)

Paschen, Christian, Reiter, Karl, Stanzel, Franz, Teschler, Helmut, Griese, Matthias

Abstract Background Pulmonary alveolar proteinosis (PAP) is a rare disease, characterized by excessive intra-alveolar accumulation of surfactant lipids and proteins. Therapeutic whole lung lavages...

Sequential analysis of surfactant, lung function and inflammation in cystic fibrosis patients (2005)

Griese, Matthias, Essl, Robert, Schmidt, Reinhold, Ballmann, Manfred, Paul, Karl, Rietschel, Ernst, ...

Abstract Background In a cross-sectional analysis of cystic fibrosis (CF) patients with mild lung disease, reduced surfactant activity was correlated to increased neutrophilic airway inflammation,...

A role for MCP-1/CCR2 in interstitial lung disease in children (2005)

Hartl, Dominik, Griese, Matthias, Nicolai, Thomas, Zissel, Gernot, Prell, Christine, Reinhardt, Dietrich, ...

Abstract Background Interstitial lung diseases (ILD) are chronic inflammatory disorders leading to pulmonary fibrosis. Monocyte chemotactic protein 1 (MCP-1) promotes collagen synthesis and deletion...

Expression profiles of hydrophobic surfactant proteins in children with diffuse chronic lung disease (2005)

Griese, Matthias, Schumacher, Silja, Tredano, Mohammed, Steinecker, Manuela, Braun, Annika, Guttentag, Susan, ...

Abstract Background Abnormalities of the intracellular metabolism of the hydrophobic surfactant proteins SP-B and SP-C and their precursors may be causally linked to chronic childhood diffuse lung...

Interstitial lung disease in children – genetic background and associated phenotypes (2005)

Hartl, Dominik, Griese, Matthias

Abstract Interstitial lung disease in children represents a group of rare chronic respiratory disorders. There is growing evidence that mutations in the surfactant protein C gene play a role in the...

Interstitial lung disease in children – genetic background and associated phenotypes

Hartl, Dominik, Griese, Matthias

Interstitial lung disease in children represents a group of rare chronic respiratory disorders. There is growing evidence that mutations in the surfactant protein C gene play a role in the...

Interstitial lung disease in children – genetic background and associated phenotypes

Hartl, Dominik, Griese, Matthias

Interstitial lung disease in children represents a group of rare chronic respiratory disorders. There is growing evidence that mutations in the surfactant protein C gene play a role in the...

DNAH5 Mutations Are a Common Cause of Primary Ciliary Dyskinesia with Outer Dynein Arm Defects

Hornef, Nada, Olbrich, Heike, Horvath, Judit, Zariwala, Maimoona A., Fliegauf, Manfred, Loges, Niki Tomas, ...

Rationale: Primary ciliary dyskinesia (PCD) is characterized by recurrent airway infections and randomization of left–right body asymmetry. To date, autosomal recessive mutations have only been...