Matthias T. Dittmar

Human TRIM5α mediated restriction of different HIV-1 subtypes and Lv2 sensitive and insensitive HIV-2 variants (2006)

Kaumanns, Patrick, Hagmann, Isabel, Dittmar, Matthias T

Abstract In order to characterize the antiviral activity of human TRIM5α in more detail human derived indicator cell lines over expressing wild type human TRIM5α were generated and challenged with...

Loss of N-linked glycans in the V3-loop region of gp120 is correlated to an enhanced infectivity of HIV-1 (2001)

Polzer, Svenja, Dittmar, Matthias T., Schmitz, Herbert, Meyer, Bernd, Müller, Harm, Kräusslich, Hans-Georg, ...

We describe mutants of human immunodeficiency virus type-1 (HIV-1) strain NL4-3, which are lacking the thirteenth, fifteenth, or seventeenth sites for N-linked glycosylation (g13, g15, g17) of the...

A Broad Range of Chemokine Receptors Are Used by Primary Isolates of Human Immunodeficiency Virus Type 2 as Coreceptors with CD4

McKnight, Áine, Dittmar, Matthias T., Moniz-Periera, José, Ariyoshi, Koya, Reeves, Jacqueline D., Hibbitts, Sam, ...

Like human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV), HIV-2 requires a coreceptor in addition to CD4 for entry into cells. HIV and SIV coreceptor molecules belong...

The U3 Promoter and the nef Gene of Simian Immunodeficiency Virus (SIV) smmPBj1.9 Do Not Confer Acute Pathogenicity upon SIVagm

Wagener, Stefan, Dittmar, Matthias T., Beer, Brigitte, König, Renate, Plesker, Roland, Norley, Stephen, ...

Two chimeric proviruses comprising the U3 promoter and the nef gene of simian immunodeficiency virus (SIV) smmPBj1.9 in addition to other genomic regions of SIVagm3mc from African green monkeys...

Membrane-Anchored Peptide Inhibits Human Immunodeficiency Virus Entry

Hildinger, Markus, Dittmar, Matthias T., Schult-Dietrich, Patricia, Fehse, Boris, Schnierle, Barbara S., Thaler, Sonja, ...

Peptides derived from the heptad repeats of human immunodeficiency virus (HIV) gp41 envelope glycoprotein, such as T20, can efficiently inhibit HIV type 1 (HIV-1) entry. In this study, replication of...

Lv2, a Novel Postentry Restriction, Is Mediated by both Capsid and Envelope

Schmitz, Christian, Marchant, David, Neil, Stuart J. D., Aubin, Keith, Reuter, Sandra, Dittmar, Matthias T., ...

The characterization of restrictions to lentivirus replication in cells identifies critical steps in the viral life cycle and potential therapeutic targets. We previously reported that a human...

Nef Proteins from Simian Immunodeficiency Virus-Infected Chimpanzees Interact with p21-Activated Kinase 2 and Modulate Cell Surface Expression of Various Human Receptors

Kirchhoff, Frank, Schindler, Michael, Bailer, Nicola, Renkema, G. Herma, Saksela, Kalle, Knoop, Volker, ...

The accessory Nef protein allows human immunodeficiency virus type 1 (HIV-1) to persist at high levels and to cause AIDS in infected humans. The function of HIV-1 group M subtype B nef alleles has...

Construction and Characterization of a Fluorescently Labeled Infectious Human Immunodeficiency Virus Type 1 Derivative

Müller, Barbara, Daecke, Jessica, Fackler, Oliver T., Dittmar, Matthias T., Zentgraf, Hanswalter, Kräusslich, Hans-Georg

The introduction of a label which can be detected in living cells opens new possibilities for the direct analysis of dynamic processes in virus replication, such as the transport and assembly of...

Involvement of Clathrin-Mediated Endocytosis in Human Immunodeficiency Virus Type 1 Entry

Daecke, Jessica, Fackler, Oliver T., Dittmar, Matthias T., Kräusslich, Hans-Georg

Productive entry of human immunodeficiency virus (HIV) is believed to occur by direct fusion at the plasma membrane. Endocytic uptake of HIV particles has been observed in several studies but is...

Determinants of Human Immunodeficiency Virus Type 1 Resistance to Membrane-Anchored gp41-Derived Peptides

Lohrengel, Sabine, Hermann, Felix, Hagmann, Isabel, Oberwinkler, Heike, Scrivano, Laura, Hoffmann, Caroline, ...

The expression of a membrane-anchored gp41-derived peptide (M87) has been shown to confer protection from infection through human immunodeficiency virus type 1 (HIV-1) (Hildinger et al., J. Virol....

Human TRIM5α mediated restriction of different HIV-1 subtypes and Lv2 sensitive and insensitive HIV-2 variants

Kaumanns, Patrick, Hagmann, Isabel, Dittmar, Matthias T

In order to characterize the antiviral activity of human TRIM5α in more detail human derived indicator cell lines over expressing wild type human TRIM5α were generated and challenged with HIV-1 and...

A Broad Range of Chemokine Receptors Are Used by Primary Isolates of Human Immunodeficiency Virus Type 2 as Coreceptors with CD4

McKnight, Áine, Dittmar, Matthias T., Moniz-Periera, José, Ariyoshi, Koya, Reeves, Jacqueline D., Hibbitts, Sam, ...

Like human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV), HIV-2 requires a coreceptor in addition to CD4 for entry into cells. HIV and SIV coreceptor molecules belong...

The U3 Promoter and the nef Gene of Simian Immunodeficiency Virus (SIV) smmPBj1.9 Do Not Confer Acute Pathogenicity upon SIVagm

Wagener, Stefan, Dittmar, Matthias T., Beer, Brigitte, König, Renate, Plesker, Roland, Norley, Stephen, ...

Two chimeric proviruses comprising the U3 promoter and the nef gene of simian immunodeficiency virus (SIV) smmPBj1.9 in addition to other genomic regions of SIVagm3mc from African green monkeys...

Membrane-Anchored Peptide Inhibits Human Immunodeficiency Virus Entry

Hildinger, Markus, Dittmar, Matthias T., Schult-Dietrich, Patricia, Fehse, Boris, Schnierle, Barbara S., Thaler, Sonja, ...

Peptides derived from the heptad repeats of human immunodeficiency virus (HIV) gp41 envelope glycoprotein, such as T20, can efficiently inhibit HIV type 1 (HIV-1) entry. In this study, replication of...

Lv2, a Novel Postentry Restriction, Is Mediated by both Capsid and Envelope

Schmitz, Christian, Marchant, David, Neil, Stuart J. D., Aubin, Keith, Reuter, Sandra, Dittmar, Matthias T., ...

The characterization of restrictions to lentivirus replication in cells identifies critical steps in the viral life cycle and potential therapeutic targets. We previously reported that a human...

Nef Proteins from Simian Immunodeficiency Virus-Infected Chimpanzees Interact with p21-Activated Kinase 2 and Modulate Cell Surface Expression of Various Human Receptors

Kirchhoff, Frank, Schindler, Michael, Bailer, Nicola, Renkema, G. Herma, Saksela, Kalle, Knoop, Volker, ...

The accessory Nef protein allows human immunodeficiency virus type 1 (HIV-1) to persist at high levels and to cause AIDS in infected humans. The function of HIV-1 group M subtype B nef alleles has...

Construction and Characterization of a Fluorescently Labeled Infectious Human Immunodeficiency Virus Type 1 Derivative

Müller, Barbara, Daecke, Jessica, Fackler, Oliver T., Dittmar, Matthias T., Zentgraf, Hanswalter, Kräusslich, Hans-Georg

The introduction of a label which can be detected in living cells opens new possibilities for the direct analysis of dynamic processes in virus replication, such as the transport and assembly of...

Involvement of Clathrin-Mediated Endocytosis in Human Immunodeficiency Virus Type 1 Entry

Daecke, Jessica, Fackler, Oliver T., Dittmar, Matthias T., Kräusslich, Hans-Georg

Productive entry of human immunodeficiency virus (HIV) is believed to occur by direct fusion at the plasma membrane. Endocytic uptake of HIV particles has been observed in several studies but is...

Determinants of Human Immunodeficiency Virus Type 1 Resistance to Membrane-Anchored gp41-Derived Peptides

Lohrengel, Sabine, Hermann, Felix, Hagmann, Isabel, Oberwinkler, Heike, Scrivano, Laura, Hoffmann, Caroline, ...

The expression of a membrane-anchored gp41-derived peptide (M87) has been shown to confer protection from infection through human immunodeficiency virus type 1 (HIV-1) (Hildinger et al., J. Virol....

Human TRIM5α mediated restriction of different HIV-1 subtypes and Lv2 sensitive and insensitive HIV-2 variants

Kaumanns, Patrick, Hagmann, Isabel, Dittmar, Matthias T

In order to characterize the antiviral activity of human TRIM5α in more detail human derived indicator cell lines over expressing wild type human TRIM5α were generated and challenged with HIV-1 and...