Matthias Wolf

Automated Calculation of Retinal Arteriovenous Ratio for Detection and Monitoring of Cerebrovascular Disease Based on Assessment of Morphological Changes of Retinal Vascular System (2009)

Radim Chrbstek, Matthias Wolf, Klaus Donath, Heinrich Niemann, Georg Michelsont

In the frame of the ARIC study it could be shown that the retinal vessel system gives important information about retinal, ophthalmic, and cerebrovascular diseases by manually labeling the vessels....

Synchronous visual analysis and editing of RNA sequence and secondary structure alignments using 4SALE (2008)

Seibel, Philipp N, Müller, Tobias, Dandekar, Thomas, Wolf, Matthias

Abstract Background The function of a noncoding RNA sequence is mainly determined by its secondary structure and therefore a family of noncoding RNA sequences is much more conserved on the structural...

ITS2 data corroborate a monophyletic chlorophycean DO-group (Sphaeropleales) (2008)

Keller, Alexander, Schleicher, Tina, Förster, Frank, Ruderisch, Benjamin, Dandekar, Thomas, Müller, Tobias, ...

Abstract Background Within Chlorophyceae the ITS2 secondary structure shows an unbranched helix I, except for the ' Hydrodictyon ' and the ' Scenedesmus ' clade having a ramified first helix. The...

The ITS2 Database II: homology modelling RNA structure for molecular systematics (2008)

Selig, Christian, Wolf, Matthias, Müller, Tobias, Dandekar, Thomas, Schultz, Jörg

An increasing number of phylogenetic analyses are based on the internal transcribed spacer 2 (ITS2). They mainly use the fast evolving sequence for low-level analyses. When considering the highly...

ProfDistS: (profile-) distance based phylogeny on sequence--structure alignments (2008)

Wolf, Matthias, Ruderisch, Benjamin, Dandekar, Thomas, Schultz, Jörg, Müller, Tobias

Motivation: The Profile Neighbor Joining (PNJ) algorithm as implemented in the software ProfDist is computationally efficient in reconstructing very large trees. Besides the huge amount of sequence...

1 (2007)

Matthias Wolf, Klaus Donath, Georg Michelson

Abstract Retinal images give unique diagnostic information not only about eye disease but about other organs as well [1]. To give the physicians a tool for objective quantitative assessment of the...

Distinguishing species (2007)

Müller, Tobias, Philippi, Nicole, Dandekar, Thomas, Schultz, Jörg, Wolf, Matthias

Given two organisms, how can one distinguish whether they belong to the same species or not? This might be straightforward for two divergent organisms, but can be extremely difficult and laborious...

4SALE – A tool for synchronous RNA sequence and secondary structure alignment and editing (2006)

Seibel, Philipp N, Müller, Tobias, Dandekar, Thomas, Schultz, Jörg, Wolf, Matthias

Abstract Background In sequence analysis the multiple alignment builds the fundament of all proceeding analyses. Errors in an alignment could strongly influence all succeeding analyses and therefore...

The internal transcribed spacer 2 database--a web server for (not only) low level phylogenetic analyses (2006)

Schultz, Jörg, Müller, Tobias, Achtziger, Marco, Seibel, Philipp N., Dandekar, Thomas, Wolf, Matthias

The internal transcribed spacer 2 (ITS2) is a phylogenetic marker which has been of broad use in generic and infrageneric level classifications, as its sequence evolves comparably fast. Only...

A common core of secondary structure of the internal transcribed spacer 2 (ITS2) throughout the Eukaryota (2005)

SCHULTZ, JÖRG, MAISEL, STEFANIE, GERLACH, DANIEL, MÜLLER, TOBIAS, WOLF, MATTHIAS

The ongoing characterization of novel species creates the need for a molecular marker which can be used for species- and, simultaneously, for mega-systematics. Recently, the use of the internal...

Homology modeling revealed more than 20,000 rRNA internal transcribed spacer 2 (ITS2) secondary structures (2005)

WOLF, MATTHIAS, ACHTZIGER, MARCO, SCHULTZ, JÖRG, DANDEKAR, THOMAS, MÜLLER, TOBIAS

Structural genomics meets phylogenetics and vice versa: Knowing rRNA secondary structures is a prerequisite for constructing rRNA alignments for inferring phylogenies, and inferring phylogenies is a...

ProfDist: a tool for the construction of large phylogenetic trees based on profile distances (2005)

Friedrich, Joachim, Dandekar, Thomas, Wolf, Matthias, Müller, Tobias

Summary: ProfDist is a user-friendly software package using the profile-neighbor-joining method (PNJ) in inferring phylogenies based on profile distances on DNA or RNA sequences. It is a tool for...

ProfDist: a tool for the construction of large phylogenetic trees based on profile distances (2005)

Friedrich, Joachim, Dandekar, Thomas, Wolf, Matthias, Müller, Tobias

Summary: ProfDist is a user-friendly software package using the profile-neighbor-joining method (PNJ) in inferring phylogenies based on profile distances on DNA or RNA sequences. It is a tool for...

Accurate and robust phylogeny estimation based on profile distances: a study of the Chlorophyceae (Chlorophyta) (2004)

Müller, Tobias, Rahmann, Sven, Dandekar, Thomas, Wolf, Matthias

Abstract Background In phylogenetic analysis we face the problem that several subclade topologies are known or easily inferred and well supported by bootstrap analysis, but basal branching patterns...

BMC Evolutionary Biology BioMed Central Methodology article Accurate and robust phylogeny estimation based on profile distances: a study of the Chlorophyceae (Chlorophyta) (2004)

Tobias Müller, Sven Rahmann, Thomas D, Matthias Wolf, Thomas Dandekar, Matthias Wolf

Background: In phylogenetic analysis we face the problem that several subclade topologies are known or easily inferred and well supported by bootstrap analysis, but basal branching patterns cannot be...

Automatic Measurement of Cusps in 2 1/2 D Dental Images (1996)

D Dental Images, Matthias Wolf, Dietrich Paulus, Heinrich Niemann

Automatic reconstruction of occlusal surfaces of teeth is an application which might become more and more urgent due to the toxicity of amalgam. Modern dental chairside equipment is currently...

Automatische Normierung und Vermessung von 2½D-Aufnahmen des ersten oberen Molars (1996)

Matthias Wolf, Dietrich Paulus, Heinrich Niemann

Aufgrund der aktuellen Diskussion um die Toxizität von Amalgam und der weit verbreiteten Verunsicherung und Ablehnung ist absehbar, daß Amalgam als Füllungswerkstoff in nächster Zukunft nicht...

A common core of secondary structure of the internal transcribed spacer 2 (ITS2) throughout the Eukaryota

SCHULTZ, JÖRG, MAISEL, STEFANIE, GERLACH, DANIEL, MÜLLER, TOBIAS, WOLF, MATTHIAS

The ongoing characterization of novel species creates the need for a molecular marker which can be used for species- and, simultaneously, for mega-systematics. Recently, the use of the internal...

Homology modeling revealed more than 20,000 rRNA internal transcribed spacer 2 (ITS2) secondary structures

WOLF, MATTHIAS, ACHTZIGER, MARCO, SCHULTZ, JÖRG, DANDEKAR, THOMAS, MÜLLER, TOBIAS

Structural genomics meets phylogenetics and vice versa: Knowing rRNA secondary structures is a prerequisite for constructing rRNA alignments for inferring phylogenies, and inferring phylogenies is a...

The internal transcribed spacer 2 database—a web server for (not only) low level phylogenetic analyses

Schultz, Jörg, Müller, Tobias, Achtziger, Marco, Seibel, Philipp N., Dandekar, Thomas, Wolf, Matthias

The internal transcribed spacer 2 (ITS2) is a phylogenetic marker which has been of broad use in generic and infrageneric level classifications, as its sequence evolves comparably fast. Only...

A common core of secondary structure of the internal transcribed spacer 2 (ITS2) throughout the Eukaryota

SCHULTZ, JÖRG, MAISEL, STEFANIE, GERLACH, DANIEL, MÜLLER, TOBIAS, WOLF, MATTHIAS

The ongoing characterization of novel species creates the need for a molecular marker which can be used for species- and, simultaneously, for mega-systematics. Recently, the use of the internal...

Homology modeling revealed more than 20,000 rRNA internal transcribed spacer 2 (ITS2) secondary structures

WOLF, MATTHIAS, ACHTZIGER, MARCO, SCHULTZ, JÖRG, DANDEKAR, THOMAS, MÜLLER, TOBIAS

Structural genomics meets phylogenetics and vice versa: Knowing rRNA secondary structures is a prerequisite for constructing rRNA alignments for inferring phylogenies, and inferring phylogenies is a...

The internal transcribed spacer 2 database—a web server for (not only) low level phylogenetic analyses

Schultz, Jörg, Müller, Tobias, Achtziger, Marco, Seibel, Philipp N., Dandekar, Thomas, Wolf, Matthias

The internal transcribed spacer 2 (ITS2) is a phylogenetic marker which has been of broad use in generic and infrageneric level classifications, as its sequence evolves comparably fast. Only...

The ITS2 Database II: homology modelling RNA structure for molecular systematics

Selig, Christian, Wolf, Matthias, Müller, Tobias, Dandekar, Thomas, Schultz, Jörg

An increasing number of phylogenetic analyses are based on the internal transcribed spacer 2 (ITS2). They mainly use the fast evolving sequence for low-level analyses. When considering the highly...

Distinguishing species

Müller, Tobias, Philippi, Nicole, Dandekar, Thomas, Schultz, Jörg, Wolf, Matthias

Given two organisms, how can one distinguish whether they belong to the same species or not? This might be straightforward for two divergent organisms, but can be extremely difficult and laborious...