Mattias Höglund

Association between polymorphisms in RMI1, TOP3A, and BLMand risk of cancer, a case-control study (2009)

Broberg, Karin, Huynh, Elizabeth, Engström, Karin, Björk, Jonas, Albin, Maria, Ingvar, Christian, ...

Abstract Background Mutations altering BLM function are associated with highly elevated cancer susceptibility (Bloom syndrome). Thus, genetic variants of BLM and proteins that form complexes with...

Advances in Brief Power Law Distribution of Chromosome Aberrations in Cancer 1 (2008)

Attila Frigyesi, David Gisselsson, Felix Mitelman, Mattias Höglund

Cancer cells are characterized by having aberrant chromosomes. The number of aberrations and the specific chromosomes affected are correlated with tumor progression. We show that for breast,...

Normalization of Illumina Infinium whole-genome SNP data improves copy number estimates and allelic intensity ratios (2008)

Staaf, Johan, Vallon-Christersson, Johan, Lindgren, David, Juliusson, Gunnar, Rosenquist, Richard, Höglund, Mattias, ...

Abstract Background Illumina Infinium whole genome genotyping (WGG) arrays are increasingly being applied in cancer genomics to study gene copy number alterations and allele-specific aberrations such...

Segmentation-based detection of allelic imbalance and loss-of-heterozygosity in cancer cells using whole genome SNP arrays (2008)

Staaf, Johan, Lindgren, David, Vallon-Christersson, Johan, Isaksson, Anders, Göransson, Hanna, Juliusson, Gunnar, ...

Abstract We present a strategy for detection of loss-of-heterozygosity and allelic imbalance in cancer cells from whole genome single nucleotide polymorphism genotyping data. Using a dilution series...

Recurrent and multiple bladder tumors show conserved expression profiles (2008)

Lindgren, David, Gudjonsson, Sigurdur, Jee, Kowan, Liedberg, Fredrik, Aits, Sonja, Andersson, Anna, ...

Abstract Background Urothelial carcinomas originate from the epithelial cells of the inner lining of the bladder and may appear as single or as multiple synchronous tumors. Patients with urothelial...

Tiling resolution array CGH and high density expression profiling of urothelial carcinomas delineate genomic amplicons and candidate target genes specific for advanced tumors (2008)

Heidenblad, Markus, Lindgren, David, Jonson, Tord, Liedberg, Fredrik, Veerla, Srinivas, Chebil, Gunilla, ...

Abstract Background Urothelial carcinoma (UC) is characterized by nonrandom chromosomal aberrations, varying from one or a few changes in early-stage and low-grade tumors, to highly rearranged...

Non-Negative Matrix Factorization for the Analysis of Complex Gene Expression Data: Identification of Clinically Relevant Tumor Subtypes (2008)

Attila Frigyesi, Mattias Höglund

Non-negative matrix factorization (NMF) is a relatively new approach to analyze gene expression data that models data by additive combinations of non-negative basis vectors (metagenes). The...

Non-Negative Matrix Factorization for the Analysis of Complex Gene Expression Data: Identification of Clinically Relevant Tumor Subtypes (2008)

Attila Frigyesi, Mattias Höglund

Non-negative matrix factorization (NMF) is a relatively new approach to analyze gene expression data that models data by additive combinations of non-negative basis vectors (metagenes). The...

Analysis of promoter regions of co-expressed genes identified by microarray analysis (2006)

Veerla, Srinivas, Höglund, Mattias

Abstract Background The use of global gene expression profiling to identify sets of genes with similar expression patterns is rapidly becoming a widespread approach for understanding biological...

Independent component analysis reveals new and biologically significant structures in micro array data (2006)

Frigyesi, Attila, Veerla, Srinivas, Lindgren, David, Höglund, Mattias

Abstract Background An alternative to standard approaches to uncover biologically meaningful structures in micro array data is to treat the data as a blind source separation (BSS) problem. BSS...

Connecting mitotic instability and chromosome aberrations in cancer-can telomeres bridge the gap? (2005)

Gisselsson, David, Höglund, Mattias

Abstract is not available

Statistical behavior of complex cancer karyotypes. (2005)

Höglund, Mattias, Frigyesi, Attila, Säll, Torbjörn, Gisselsson, David, Mitelman, Felix

Abstract is not available

Microarray analyses reveal strong influence of DNA copy number alterations on the transcriptional patterns in pancreatic cancer: implications for the interpretation of genomic amplifications. (2005)

Heidenblad, Markus, Lindgren, David, Veltman, Joris A, Jonson, Tord, Mahlamäki, Eija H, Gorunova, Ludmila, ...

Abstract is not available

Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer. (2005)

Broberg, Karin, Björk, Jonas, Paulsson, Karin, Höglund, Mattias, Albin, Maria

Abstract is not available

Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity. (2005)

Stewénius, Ylva, Gorunova, Ludmila, Jonson, Tord, Larsson, Nina, Höglund, Mattias, Mandahl, Nils, ...

Abstract is not available

Ewing tumours and synovial sarcomas have critical features of karyotype evolution in common with epithelial tumours. (2005)

Höglund, Mattias, Gisselsson, David, Mandahl, Nils, Mitelman, Felix

Abstract is not available

Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer (2005)

Broberg, Karin, Björk, Jonas, Paulsson, Karin, Höglund, Mattias, Albin, Maria

Lack of functional telomeres can cause chromosomal aberrations. This type of genetic instability may promote tumorigenesis. We have investigated the association between mean telomere length in buccal...

Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer (2005)

Broberg, Karin, Björk, Jonas, Paulsson, Karin, Höglund, Mattias, Albin, Maria

Lack of functional telomeres can cause chromosomal aberrations. This type of genetic instability may promote tumorigenesis. We have investigated the association between mean telomere length in buccal...

Dissecting karyotypic patterns in malignant melanomas: Temporal clustering of losses and gains in melanoma karyotypic evolution. (2004)

Höglund, Mattias, Gisselsson, David, Hansen, Gunnar B, White, Valerie A, Säll, Torbjörn, Mitelman, Felix, ...

Abstract is not available

The Breakpoint Region of the Most Common Isochromosome, i(17q), in Human Neoplasia Is Characterized by a Complex Genomic Architecture with Large, Palindromic, Low-Copy Repeats. (2004)

Barbouti, Aikaterini, Stankiewicz, Pawel, Nusbaum, Chad, Cuomo, Christina, Cook, April, Höglund, Mattias, ...

Abstract is not available

Identification of cytogenetic subgroups and karyotypic pathways of clonal evolution in follicular lymphomas. (2004)

Höglund, Mattias, Sehn, Laurie, Connors, Joseph M, Gascoyne, Randy D, Siebert, Reiner, Säll, Torbjörn, ...

Abstract is not available

Wilms tumors develop through two distinct karyotypic pathways. (2004)

Höglund, Mattias, Gisselsson, David, Hansen, Gunnar B, Mitelman, Felix

Abstract is not available

Statistical analyses of karyotypic complexity in head and neck squamous cell carcinoma. (2004)

Höglund, Mattias, Jin, Charlotte, Gisselsson, David, Hansen, Gunnar B, Mitelman, Felix, Mertens, Fredrik

Abstract is not available

A model for karyotypic evolution in testicular germ cell tumors. (2004)

Frigyesi, Attila, Gisselsson, David, Hansen, Gunnar B, Soller, Maria, Mitelman, Felix, Höglund, Mattias

Abstract is not available

Genome-wide array-based comparative genomic hybridization reveals multiple amplification targets and novel homozygous deletions in pancreatic carcinoma cell lines. (2004)

Heidenblad, Markus, Jonson, Tord, Gorunova, Ludmila, Veltman, Joris A, Van Kessel, Ad Geurts, ...

Abstract is not available

Dissecting karyotypic patterns in renal cell carcinoma: an analysis of the accumulated cytogenetic data. (2004)

Höglund, Mattias, Gisselsson, David, Soller, Maria, Hansen, Gunnar B, Elfving, Peter, Mitelman, Felix

Abstract is not available

High frequencies of chromosomal aberrations in multiple myeloma and monoclonal gammopathy of undetermined significance in direct chromosome preparation. (2004)

Nilsson, Therese, Lenhoff, Stig, Rylander, Lars, Höglund, Mattias, Turesson, Ingemar, Mitelman, Felix, ...

Abstract is not available

MDS/AML-associated cytogenetic abnormalities in multiple myeloma and monoclonal gammopathy of undetermined significance: Evidence for frequent de novo occurrence and multipotent stem cell involvement of del(20q). (2004)

Nilsson, Therese, Nilsson, Lars, Lenhoff, Stig, Rylander, Lars, Astrand-Grundström, Ingbritt, Strömbeck, Bodil, ...

Abstract is not available

Statistical dissection of cytogenetic patterns in lung cancer reveals multiple modes of karyotypic evolution independent of histological classification. (2004)

Höglund, Mattias, Gisselsson, David, Hansen, Gunnar B, Mitelman, Felix

Abstract is not available

Approximate geodesic distances reveal biologically relevant structures in microarray data (2004)

Nilsson, Jens, Fioretos, Thoas, Höglund, Mattias, Fontes, Magnus

Motivation: Genome-wide gene expression measurements, as currently determined by the microarray technology, can be mathematically represented as points in a high-dimensional gene expression space....

Approximate geodesic distances reveal biologically relevant structures in microarray data (2004)

Nilsson, Jens, Fioretos, Thoas, Höglund, Mattias, Fontes, Magnus

Motivation: Genome-wide gene expression measurements, as currently determined by the microarray technology, can be represented mathematically as points in a high-dimensional gene expression space....

Approximate geodesic distances reveal biologically relevant structures in microarray data (2004)

Nilsson, Jens, Fioretos, Thoas, Höglund, Mattias, Fontes, Magnus

Motivation: Genome-wide gene expression measurements, as currently determined by the microarray technology, can be mathematically represented as points in a high-dimensional gene expression space....

Clustering of deletions on chromosome 13 in benign and low-malignant lipomatous tumors (2003)

Pedeutour, Florence, Domanski, Henryk A, Höglund, Mattias, Bauer, Henrik C F, ...

Deletions and structural rearrangements of the long arm of chromosome 13 are frequently observed in benign and low-malignant lipomatous tumors, but nothing is known about their molecular genetic...

Clustering of deletions on chromosome 13 in benign and low-malignant lipomatous tumors. (2003)

Dahlén, Anna, Debiec-Rychter, Maria, Pedeutour, Florence, Domanski, Henryk A, Höglund, Mattias, Bauer, Henrik C F, ...

Abstract is not available

A Novel Gene, MSI2, Encoding a Putative RNA-binding Protein Is Recurrently Rearranged at Disease Progression of Chronic Myeloid Leukemia and Forms a Fusion Gene with HOXA9 as a Result of the Cryptic t(7;17)(p15;q23). (2003)

Barmpouti, Aikaterini, Höglund, Mattias, Johansson, Bertil, Lassen, Carin, Nilsson, Per-Gunnar, Hagemeijer, Anne, ...

Abstract is not available

A pooled analysis of karyotypic patterns, breakpoints and imbalances in 783 cytogenetically abnormal multiple myelomas reveals frequently involved chromosome segments as well as significant age- and sex-related differences. (2003)

Nilsson, Thérèse, Höglund, Mattias, Lenhoff, Stig, Rylander, Lars, Turesson, Ingemar, Westin, Jan, ...

The cytogenetic features (ploidy, complexity, breakpoints, imbalances) were ascertained in 783 abnormal multiple myeloma (MM) cases to identify frequently involved chromosomal regions as well as a...

Pancreatic carcinoma cell lines with SMAD4 inactivation show distinct expression responses to TGFB1. (2003)

Jonson, Tord, Heidenblad, Markus, Håkansson, Petra, Gorunova, Ludmila, Johansson, Bertil, Fioretos, Thoas, ...

Abstract is not available

Clinical and genetic studies of ETV6/ABL1-positive chronic myeloid leukaemia in blast crisis treated with imatinib mesylate. (2003)

Barbouti, Aikaterini, Ahlgren, Tomas, Johansson, Bertil, Höglund, Mattias, Lassen, Carin, Turesson, Ingemar, ...

Most chronic myeloid leukaemia (CML) patients are genetically characterized by the t(9;22)(q34;q11), generating the BCR/ABL1 fusion gene. However, a few CML patients with rearrangements of 9q34 and...

Ovarian Carcinoma Develops through Multiple Modes of Chromosomal Evolution. (2003)

Höglund, Mattias, Gisselsson, David, Hansen, Gunnar B, Säll, Torbjörn, Mitelman, Felix

Abstract is not available

Power law distribution of chromosome aberrations in cancer. (2003)

Frigyesi, Attila, Gisselsson, David, Mitelman, Felix, Höglund, Mattias

Abstract is not available

Differentially amplified chromosome 12 sequences in low- and high-grade osteosarcoma (2002)

Pålsson, Eva, Höglund, Mattias, Domanski, Henryk, Mertens, Fredrik, Pandis, Nikos, ...

Most osteosarcomas are highly aggressive malignancies characterized by a complex pattern of chromosome abnormalities. However, a subgroup of low-grade, parosteal tumors exhibits a relatively simple...

Differentially amplified chromosome 12 sequences in low- and high-grade osteosarcoma. (2002)

Gisselsson, David, Pålsson, Eva, Höglund, Mattias, Domanski, Henryk, Mertens, Fredrik, Pandis, Nikos, ...

Most osteosarcomas are highly aggressive malignancies characterized by a complex pattern of chromosome abnormalities. However, a subgroup of low-grade, parosteal tumors exhibits a relatively simple...

Cyclin D1 amplification in chromosomal band 11q13 is associated with overrepresentation of 3q21-q29 in head and neck carcinomas. (2002)

Jin, Yuesheng, Jin, Charlotte, Wennerberg, Johan, Höglund, Mattias, Mertens, Fredrik

Eight cytogenetically characterized head and neck squamous cell carcinomas (HNSCCs) with CCND1 amplification in the form of a homogeneously staining region (hsr) in 11q13 were studied by COBRA FISH...

Multivariate analysis of chromosomal imbalances in breast cancer delineates cytogenetic pathways and reveals complex relationships among imbalances. (2002)

Höglund, Mattias, Gisselsson, David, Hansen, Gunnar B, Säll, Torbjörn, Mitelman, Felix

More than 550 breast adenocarcinomas with clonal chromosomal abnormalities have been reported. Although the aberration pattern is clearly nonrandom, no specific primary or secondary karyotypic...

Detailed genomic mapping and expression analyses of 12p amplifications in pancreatic carcinomas reveal a 3.5-Mb target region for amplification. (2002)

Heidenblad, Markus, Jonson, Tord, Mahlamäki, Eija H, Gorunova, Ludmila, Karhu, Ritva, Johansson, Bertil, ...

Previous cytogenetic and comparative genomic hybridization (CGH) analyses have shown that the gain of chromosome arm 12p is frequent in pancreatic carcinomas. We investigated 15 pancreatic carcinoma...

Coping with complexity. multivariate analysis of tumor karyotypes. (2002)

Höglund, Mattias, Gisselsson, David, Säll, Torbjörn, Mitelman, Felix

Human cancers are characterized by chromosomal aberrations, and an increasing number of specific balanced rearrangements have been found among malignant hematologic disorders. Most solid tumors,...

Multicolor COBRA-FISH analysis of chronic myeloid leukemia reveals novel cryptic balanced translocations during disease progression. (2002)

Barbouti, Aikaterini, Johansson, Bertil, Höglund, Mattias, Mauritzson, Nils, Strömbeck, Bodil, Nilsson, Per-Gunnar, ...

During the initial indolent chronic phase of chronic myeloid leukemia (CML), the t(9;22)(q34;q11), resulting in the Philadelphia chromosome (Ph), is usually the sole cytogenetic anomaly, but as the...

Dissecting karyotypic patterns in colorectal tumors: two distinct but overlapping pathways in the adenoma-carcinoma transition. (2002)

Höglund, Mattias, Gisselsson, David, Hansen, Gunnar B, Säll, Torbjörn, Mitelman, Felix, Nilbert, Mef

More than 500 colorectal tumors with clonal chromosomal abnormalities have been reported. Although the pattern of aberrations is nonrandom, no specific primary or secondary karyotypic abnormality has...

Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity

Gisselsson, David, Pettersson, Louise, Höglund, Mattias, Heidenblad, Markus, Gorunova, Ludmila, Wiegant, Joop, ...

It has long been known that rearrangements of chromosomes through breakage-fusion-bridge (BFB) cycles may cause variability of phenotypic and genetic traits within a cell population. Because...

Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors

Gisselsson, David, Jonson, Tord, Petersén, Åsa, Strömbeck, Bodil, Dal Cin, Paola, Höglund, Mattias, ...

Although mechanisms for chromosomal instability in tumors have been described in animal and in vitro models, little is known about these processes in man. To explore cytogenetic evolution in human...

Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity

Stewénius, Ylva, Gorunova, Ludmila, Jonson, Tord, Larsson, Nina, Höglund, Mattias, Mandahl, Nils, ...

Telomere dysfunction has been associated with chromosomal instability in colorectal carcinoma, but the consequences of telomere-dependent instability for chromosome integrity and clonal evolution...

Molecular signatures in childhood acute leukemia and their correlations to expression patterns in normal hematopoietic subpopulations

Andersson, Anna, Olofsson, Tor, Lindgren, David, Nilsson, Björn, Ritz, Cecilia, Edén, Patrik, ...

Global expression profiles of a consecutive series of 121 childhood acute leukemias (87 B lineage acute lymphoblastic leukemias, 11 T cell acute lymphoblastic leukemias, and 23 acute myeloid...

Independent component analysis reveals new and biologically significant structures in micro array data

Frigyesi, Attila, Veerla, Srinivas, Lindgren, David, Höglund, Mattias

Analysis of promoter regions of co-expressed genes identified by microarray analysis

Veerla, Srinivas, Höglund, Mattias

Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity

Gisselsson, David, Pettersson, Louise, Höglund, Mattias, Heidenblad, Markus, Gorunova, Ludmila, Wiegant, Joop, ...

It has long been known that rearrangements of chromosomes through breakage-fusion-bridge (BFB) cycles may cause variability of phenotypic and genetic traits within a cell population. Because...

Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors

Gisselsson, David, Jonson, Tord, Petersén, Åsa, Strömbeck, Bodil, Dal Cin, Paola, Höglund, Mattias, ...

Although mechanisms for chromosomal instability in tumors have been described in animal and in vitro models, little is known about these processes in man. To explore cytogenetic evolution in human...

Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity

Stewénius, Ylva, Gorunova, Ludmila, Jonson, Tord, Larsson, Nina, Höglund, Mattias, Mandahl, Nils, ...

Telomere dysfunction has been associated with chromosomal instability in colorectal carcinoma, but the consequences of telomere-dependent instability for chromosome integrity and clonal evolution...

The Breakpoint Region of the Most Common Isochromosome, i(17q), in Human Neoplasia Is Characterized by a Complex Genomic Architecture with Large, Palindromic, Low-Copy Repeats

Barbouti, Aikaterini, Stankiewicz, Pawel, Nusbaum, Chad, Cuomo, Christina, Cook, April, Höglund, Mattias, ...

Although a great deal of information has accumulated regarding the mechanisms underlying constitutional DNA rearrangements associated with inherited disorders, virtually nothing is known about the...

Molecular signatures in childhood acute leukemia and their correlations to expression patterns in normal hematopoietic subpopulations

Andersson, Anna, Olofsson, Tor, Lindgren, David, Nilsson, Björn, Ritz, Cecilia, Edén, Patrik, ...

Global expression profiles of a consecutive series of 121 childhood acute leukemias (87 B lineage acute lymphoblastic leukemias, 11 T cell acute lymphoblastic leukemias, and 23 acute myeloid...

Independent component analysis reveals new and biologically significant structures in micro array data

Frigyesi, Attila, Veerla, Srinivas, Lindgren, David, Höglund, Mattias

Analysis of promoter regions of co-expressed genes identified by microarray analysis

Veerla, Srinivas, Höglund, Mattias

Hibernomas are Characterized by Homozygous Deletions in the Multiple Endocrine Neoplasia Type I Region : Metaphase Fluorescence in Situ Hybridization Reveals Complex Rearrangements Not Detected by Conventional Cytogenetics

Gisselsson, David, Höglund, Mattias, Mertens, Fredrik, Dal Cin, Paola, Mandahl, Nils

Hibernomas are benign tumors of brown fat, frequently characterized by aberrations of chromosome band 11q13. In this study, the chromosome 11 changes in five hibernomas were analyzed in detail by...

Abnormal Nuclear Shape in Solid Tumors Reflects Mitotic Instability

Gisselsson, David, Björk, Jonas, Höglund, Mattias, Mertens, Fredrik, Dal Cin, Paola, Åkerman, Måns, ...

Abnormalities in nuclear morphology are frequently observed in malignant tissues but the mechanisms behind these phenomena are still poorly understood. In this study, the relation between abnormal...

Distinct evolutionary mechanisms for genomic imbalances in high-risk and low-risk neuroblastomas

Gisselsson, David, Lundberg, Gisela, Øra, Ingrid, Höglund, Mattias

Tiling resolution array CGH and high density expression profiling of urothelial carcinomas delineate genomic amplicons and candidate target genes specific for advanced tumors

Heidenblad, Markus, Lindgren, David, Jonson, Tord, Liedberg, Fredrik, Veerla, Srinivas, Chebil, Gunilla, ...

Recurrent and multiple bladder tumors show conserved expression profiles

Lindgren, David, Gudjonsson, Sigurdur, Jee, Kowan Ja, Liedberg, Fredrik, Aits, Sonja, Andersson, Anna, ...

Normalization of Illumina Infinium whole-genome SNP data improves copy number estimates and allelic intensity ratios

Staaf, Johan, Vallon-Christersson, Johan, Lindgren, David, Juliusson, Gunnar, Rosenquist, Richard, Höglund, Mattias, ...

Segmentation-based detection of allelic imbalance and loss-of-heterozygosity in cancer cells using whole genome SNP arrays

Staaf, Johan, Lindgren, David, Vallon-Christersson, Johan, Isaksson, Anders, Göransson, Hanna, Juliusson, Gunnar, ...

A strategy is presented for detection of loss-of-heterozygosity and allelic imbalance in cancer cells from whole genome SNP genotyping data.

Non-Negative Matrix Factorization for the Analysis of Complex Gene Expression Data: Identification of Clinically Relevant Tumor Subtypes

Frigyesi, Attila, Höglund, Mattias

Non-negative matrix factorization (NMF) is a relatively new approach to analyze gene expression data that models data by additive combinations of non-negative basis vectors (metagenes). The...

Association between polymorphisms in RMI1, TOP3A, and BLM and risk of cancer, a case-control study

Broberg, Karin, Huynh, Elizabeth, Engström, Karin Schläwicke, Björk, Jonas, Albin, Maria, Ingvar, Christian, ...

A global structural EM algorithmfor a model of cancer progression

Tofigh, Ali, Sjölund, Erik, Höglund, Mattias, Lagergren, Jens

Cancer has complex patterns of progression that include converging as well as divergingprogressional pathways. Vogelstein’s path model of colon cancer was clearlya pioneering contribution to cancer...