Maureen A. Sartor

LRpath: a logistic regression approach for identifying enriched biological groups in gene expression data (2009)

Sartor, Maureen A., Leikauf, George D., Medvedovic, Mario

Motivation: The elucidation of biological pathways enriched with differentially expressed genes has become an integral part of the analysis and interpretation of microarray data. Several statistical...

Microarray analysis of cytoplasmic versus whole cell RNA reveals a considerable number of missed and false positive mRNAs (2009)

Trask, Heidi W., Sartor, Maureen A., Gui, Jiang, Heath, Catherine V., Renuka, Janhavi, ...

With no known exceptions, every published microarray study to determine differential mRNA levels in eukaryotes used RNA extracted from whole cells. It is assumed that the use of whole cell RNA in...

Nonredundant Functions of {alpha}{beta} and {gamma}{delta} T Cells in Acrolein-Induced Pulmonary Pathology (2008)

Borchers, Michael T., Wesselkamper, Scott C., Eppert, Bryan L., Motz, Gregory T., Sartor, Maureen A., Tomlinson, Craig R., ...

Acrolein exposure represents a significant human health hazard. Repeated acrolein exposure causes the accumulation of monocytes/macrophages and lymphocytes, mucous cell metaplasia, and epithelial...

TESTING FOR DIFFERENTIALLY EXPRESSED GENES AND KEY BIOLOGICAL CATEGORIES IN DNA MICROARRAY ANALYSIS (2007)

SARTOR, MAUREEN A

DNA microarrays are a revolutionary technology able to measure the expression levels of thousands of genes simultaneously, providing a snapshot in time of a tissue or cell culture’s transcriptome....

Intensity-based hierarchical Bayes method improves testing for differentially expressed genes in microarray experiments (2006)

Sartor, Maureen A, Tomlinson, Craig R, Wesselkamper, Scott C, Sivaganesan, Siva, Leikauf, George D, Medvedovic, Mario

Abstract Background The small sample sizes often used for microarray experiments result in poor estimates of variance if each gene is considered independently. Yet accurately estimating variability...

A new method to remove hybridization bias for interspecies comparison of global gene expression profiles uncovers an association between mRNA sequence divergence and differential gene expression in Xenopus (2006)

Sartor, Maureen A., Zorn, Aaron M., Schwanekamp, Jennifer A., Halbleib, Danielle, Karyala, Saikumar, Howell, Michael L., ...

The recent sequencing of a large number of Xenopus tropicalis expressed sequences has allowed development of a high-throughput approach to study Xenopus global RNA gene expression. We examined the...

Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status (2005)

Kann, Simone, Estes, Cameron, Reichard, John F., Huang, Ming-ya, Sartor, Maureen A., Schwemberger, Sandy, ...

Arsenic, first among the top environmentally hazardous substances, is associated with skin, lung, liver, kidney, prostate and bladder cancer. Arsenic is also a cardiovascular and a central nervous...

Butylhydroquinone Protects Cells Genetically Deficient in Glutathione Biosynthesis from Arsenite-Induced Apoptosis Without Significantly Changing Their Prooxidant Status (2005)

Kann, Simone, Estes, Cameron, Reichard, John F., Huang, Ming-ya, Sartor, Maureen A., Schwemberger, Sandy, ...

Arsenic, first among the top environmentally hazardous substances, is associated with skin, lung, liver, kidney, prostate, and bladder cancer. Arsenic is also a cardiovascular and a central nervous...

A new method to remove hybridization bias for interspecies comparison of global gene expression profiles uncovers an association between mRNA sequence divergence and differential gene expression in Xenopus

Sartor, Maureen A., Zorn, Aaron M., Schwanekamp, Jennifer A., Halbleib, Danielle, Karyala, Saikumar, Howell, Michael L., ...

The recent sequencing of a large number of Xenopus tropicalis expressed sequences has allowed development of a high-throughput approach to study Xenopus global RNA gene expression. We examined the...

A new method to remove hybridization bias for interspecies comparison of global gene expression profiles uncovers an association between mRNA sequence divergence and differential gene expression in Xenopus

Sartor, Maureen A., Zorn, Aaron M., Schwanekamp, Jennifer A., Halbleib, Danielle, Karyala, Saikumar, Howell, Michael L., ...

The recent sequencing of a large number of Xenopus tropicalis expressed sequences has allowed development of a high-throughput approach to study Xenopus global RNA gene expression. We examined the...

Intensity-based hierarchical Bayes method improves testing for differentially expressed genes in microarray experiments

Sartor, Maureen A, Tomlinson, Craig R, Wesselkamper, Scott C, Sivaganesan, Siva, Leikauf, George D, Medvedovic, Mario

Unique Bisphenol A Transcriptome in Prostate Cancer: Novel Effects on ERβ Expression That Correspond to Androgen Receptor Mutation Status

Hess-Wilson, Janet K., Webb, Siobhan L., Daly, Hannah K., Leung, Yuet-Kin, Boldison, Joanne, Comstock, Clay E.S., ...

Ligand-Independent Regulation of Transforming Growth Factor β1 Expression and Cell Cycle Progression by the Aryl Hydrocarbon Receptor▿ †

Chang, Xiaoqing, Fan, Yunxia, Karyala, Saikumar, Schwemberger, Sandy, Tomlinson, Craig R., Sartor, Maureen A., ...

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the toxic effects of its xenobiotic ligands and acts as an environmental checkpoint during the cell cycle....

Gene Expression Profiling Identifies Lobe-Specific and Common Disruptions of Multiple Gene Networks in Testosterone-Supported, 17β-Estradiol- or Diethylstilbestrol-Induced Prostate Dysplasia in Noble Rats12

Tam, Neville N C, Szeto, Carol Ying-Ying, Sartor, Maureen A, Medvedovic, Mario, Ho, Shuk-Mei

The xenoestrogen diethylstilbestrol (DES) is commonly believed to mimic the action of the natural estrogen 17β-estradiol (E2). To determine if these two estrogens exert similar actions in prostate...

TESTING FOR DIFFERENTIALLY EXPRESSED GENES AND KEY BIOLOGICAL CATEGORIES IN DNA MICROARRAY ANALYSIS

SARTOR, MAUREEN A

DNA microarrays are a revolutionary technology able to measure the expression levels of thousands of genes simultaneously, providing a snapshot in time of a tissue or cell culture’s transcriptome....

Transcriptome Analyses in Normal Prostate Epithelial Cells Exposed to Low-Dose Cadmium: Oncogenic and Immunomodulations Involving the Action of Tumor Necrosis Factor

Bakshi, Shlomo, Zhang, Xiang, Godoy-Tundidor, Sonia, Cheng, Robert Yuk Sing, Sartor, Maureen A., Medvedovic, Mario, ...

Genomic Profile of Matrix and Vasculature Remodeling in TGF-α–Induced Pulmonary Fibrosis

Hardie, William D., Korfhagen, Thomas R., Sartor, Maureen A., Prestridge, Adrienne, Medvedovic, Mario, Le Cras, Timothy D., ...

Expression of transforming growth factor α (TGF-α) in the respiratory epithelium of transgenic mice caused pulmonary fibrosis, cachexia, pulmonary hypertension, and altered lung function. To...

The Role of Metallothionein in the Pathogenesis of Acute Lung Injury

Wesselkamper, Scott C., McDowell, Susan A., Medvedovic, Mario, Dalton, Timothy P., Deshmukh, Hitesh S., Sartor, Maureen A., ...

Often fatal, acute lung injury has a complicated etiology. Previous studies from our laboratory in mice have demonstrated that survival during acute lung injury is a complex trait governed by...

Genomewide Analysis of Aryl Hydrocarbon Receptor Binding Targets Reveals an Extensive Array of Gene Clusters that Control Morphogenetic and Developmental Programs

Sartor, Maureen A., Schnekenburger, Michael, Marlowe, Jennifer L., Reichard, John F., Wang, Ying, Fan, Yunxia, ...

Gene Expression Changes during the Development of Acute Lung Injury Role of Transforming Growth Factor β

Wesselkamper, Scott C., Case, Lisa M., Henning, Lisa N., Borchers, Michael T., Tichelaar, Jay W., Mason, John M., ...

Rationale: Acute lung injury can occur from multiple causes, resulting in high mortality. The pathophysiology of nickel-induced acute lung injury in mice is remarkably complex, and the molecular...

BACH1 Is a Specific Repressor of HMOX1 That Is Inactivated by Arsenite*S⃞

Reichard, John F., Sartor, Maureen A., Puga, Alvaro

Intracellular heme is a redox active molecule that can be detrimental to cells at high concentrations or under oxidizing conditions. To prevent accumulation, the inducible enzyme heme oxygenase-1...

Nonredundant Functions of αβ and γδ T Cells in Acrolein-Induced Pulmonary Pathology

Borchers, Michael T., Wesselkamper, Scott C., Eppert, Bryan L., Motz, Gregory T., Sartor, Maureen A., Tomlinson, Craig R., ...

Acrolein exposure represents a significant human health hazard. Repeated acrolein exposure causes the accumulation of monocytes/macrophages and lymphocytes, mucous cell metaplasia, and epithelial...