Mef Nilbert

Experiences from treatment-predictive KRAStesting; high mutation frequency in rectal cancers from females and concurrent mutations in the same tumor (2009)

Jönsson, Mats, Ekstrand, Anna, Edekling, Thomas, Eberhard, Jakob, Grabau, Dorthe, Borg, David, ...

Abstract Background KRAS mutations represent key alterations in colorectal cancer development and lead to constitutive EGFR signaling. Since EGFR inhibition represents a therapeutic strategy in...

A Parametric Model for Analyzing Anticipation in Genetically Predisposed Families (2009)

Larsen, Klaus, Petersen, Janne, Bernstein, Inge, Nilbert, Mef

Anticipation, i.e. a decreasing age-at-onset in subsequent generations has been observed in a number of genetically triggered diseases. The impact of anticipation is generally studied in affected...

A Parametric Model for Analyzing Anticipation in Genetically Predisposed Families (2009)

Larsen, Klaus, Petersen, Janne, Bernstein, Inge, Nilbert, Mef

Anticipation, i.e. a decreasing age-at-onset in subsequent generations has been observed in a number of genetically triggered diseases. The impact of anticipation is generally studied in affected...

A Parametric Model for Analyzing Anticipation in Genetically Predisposed Families (2009)

Larsen, Klaus, Petersen, Janne, Bernstein, Inge, Nilbert, Mef

Anticipation, i.e. a decreasing age-at-onset in subsequent generations has been observed in a number of genetically triggered diseases. The impact of anticipation is generally studied in affected...

A Parametric Model for Analyzing Anticipation in Genetically Predisposed Families (2009)

Larsen, Klaus, Petersen, Janne, Bernstein, Inge, Nilbert, Mef

Anticipation, i.e. a decreasing age-at-onset in subsequent generations has been observed in a number of genetically triggered diseases. The impact of anticipation is generally studied in affected...

Knowledge about hereditary nonpolyposis colorectal cancer; mutation carriers and physicians at equal levels (2009)

Domanska, Katarina, Carlsson, Christina, Bendahl, Pär-Ola, Nilbert, Mef

Abstract Background Identification and adequate management of individuals at risk for hereditary nonpolyposis colorectal cancer (HNPCC) is crucial since surveillance programmes reduce morbidity and...

Genetic Profiling Differentiates Second Primary Tumors from Metastases in Adult Metachronous Soft Tissue Sarcoma (2009)

Josefin Fernebro, Ana Carneiro, Anders Rydholm, Henryk A. Domanski, Anna Karlsson, Åke Borg, ...

Purpose. Patients with soft tissue sarcomas (STS) are at increased risk of second primary malignancies, including a second STS, but distinction between metastases and a second primary STS is...

Broad phenotypic spectrum in familial adenomatous polyposis; from early onset and severe phenotypes to late onset of attenuated polyposis with the first manifestation at age 72 (2008)

Nilbert, Mef, Kristoffersson, Ulf, Ericsson, Mats, Johannsson, Oskar, Rambech, Eva, Mangell, Peter

Abstract Background Familial adenomatous polyposis (FAP) is typically characterized by multiple colonic polyps and frequent extracolonic features. Whereas the number of colonic polyps has been linked...

Prognostic Impact of Array-based Genomic Profiles in Esophageal Squamous Cell Cancer (2008)

Carneiro, Ana, Isinger, Anna, Karlsson, Anna, Johansson, Jan, Jönsson, Göran, Bendahl, Pär-Ola, ...

Abstract Background Esophageal squamous cell carcinoma (ESCC) is a genetically complex tumor type and a major cause of cancer related mortality. Although distinct genetic alterations have been linked...

Genetic Profiling Differentiates Second Primary Tumors from Metastases in Adult Metachronous Soft Tissue Sarcoma (2008)

Josefin Fernebro, Ana Carneiro, Anders Rydholm, Henryk A. Domanski, Anna Karlsson, Åke Borg, ...

Purpose. Patients with soft tissue sarcomas (STS) are at increased risk of second primary malignancies, including a second STS, but distinction between metastases and a second primary STS is...

Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: hypoxia-induced transcription profile signifies metastatic potential (2007)

Francis, Princy, Namløs, Heidi, Müller, Christoph, Edén, Patrik, Fernebro, Josefin, Berner, Jeanne-Marie, ...

Abstract Background Soft tissue sarcoma (STS) diagnosis is challenging because of a multitude of histopathological subtypes, different genetic characteristics, and frequent intratumoral pleomorphism....

Captured voices in cancer: experiences from networking between individuals with experiential and professional knowledge (2007)

Carlsson, Christina, Segesten, Kerstin, Nilbert, Mef, Nilsson, Kerstin

Abstract Background Patients needs and experiences attract increasing attention within health care. In order to generate knowledge about the voices that emerge from collaborative experiences between...

Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: hypoxia-induced transcription profile signifies metastatic potential (2007)

Francis, Princy, Namløs, Heidi Maria, Christoph Müller, Christoph, Edén, Patrik, Fernebro, Josefin, Berner, Jeanne-Marie, ...

Background Soft tissue sarcoma (STS) diagnosis is challenging because of a multitude of histopathological subtypes, different genetic characteristics, and frequent intratumoral pleomorphism....

Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer) Diagnostics (2007)

Lagerstedt Robinson, Kristina, Liu, Tao, Vandrovcova, Jana, Halvarsson, Britta, Clendenning, Mark, Frebourg, Thierry, ...

Background Preventive programs for individuals who have high lifetime risks of colorectal cancer may reduce disease morbidity and mortality. Thus, it is important to identify the factors that are...

CHEK21100delC in patients with metachronous cancers of the breast and the colorectum (2006)

Isinger, Anna, Bhat, Misha, Borg, Ake, Nilbert, Mef

Abstract Background Development of multiple primary tumors is a hallmark of hereditary cancer. At least 1/10 of breast cancers and colorectal cancers occur because of heredity and recently the cell...

Focus on the Tumour Periphery in MRI Evaluation of Soft Tissue Sarcoma: Infiltrative Growth Signifies Poor Prognosis (2006)

Josefin Fernebro, Marie Wiklund, Kjell Jonsson, Pär-Ola Bendahl, Anders Rydholm, Mef Nilbert, ...

Purpose. Infiltrative microscopical peripheral growth of soft tissue sarcomas (STS) has been shown to be of prognostic importance and preoperative risk stratification could individualize neoadjuvant...

Supporter or obstructer; experiences from contact person activities among Swedish women with breast cancer (2005)

Carlsson, Christina, Nilbert, Mef, Nilsson, Kerstin

Abstract Background Swedish patient associations for breast cancer patients (PABCPs) offer patients with breast cancer unlimited meetings with a breast cancer survivor, a contact person (CP). We...

Immunohistochemical Loss of the DNA Mismatch Repair Proteins MSH2 and MSH6 in Malignant Fibrous Histiocytomas (2004)

Kajsa Ericson, Jacob Engellau, Annette Persson, Annika Lindblom, Henryk Domanski, Måns Åkerman, ...

Purpose: Soft tissue sarcomas (STS) account for less than 1% of all malignancies and constitute a heterogeneous tumor entity in which malignant fibrous histiocytomas (MFH) represent one-third and are...

Predominance of CIN versus MSI in the development of rectal cancer at young age (2002)

Fernebro, Eva, Halvarsson, Britta, Baldetorp, Bo, Nilbert, Mef

Abstract Background Development of proximal and distal colorectal cancers involve partly different mechanisms associated with the microsatellite instability (MSI) and the chromosomal instability...

Cytogenetic aberrations and heterogeneity of mutations in repeat-containing genes in a colon carcinoma from a patient with hereditary nonpolyposis colorectal cancer. (2002)

Planck, Maria, Halvarsson, Britta, Pålsson, Eva, Hallén, Magnus, Ekelund, Mats, Pålsson, Birger, ...

The majority of tumors from patients affected by hereditary nonpolyposis colorectal cancer (HNPCC) exhibit a mutator phenotype characterized by widespread microsatellite instability (MSI) and somatic...

Evaluation of the tissue microarray technique for immunohistochemical analysis in rectal cancer. (2002)

Fernebro, Eva, Dictor, Michael, Bendahl, Pär-Ola, Fernö, Mårten, Nilbert, Mef

BACKGROUND: Immunohistochemical staining for tumor-associated proteins is widely used for the identification of novel prognostic markers. Recently, a tissue-conserving, high-throughput technique,...

Dissecting karyotypic patterns in colorectal tumors: two distinct but overlapping pathways in the adenoma-carcinoma transition. (2002)

Höglund, Mattias, Gisselsson, David, Hansen, Gunnar B, Säll, Torbjörn, Mitelman, Felix, Nilbert, Mef

More than 500 colorectal tumors with clonal chromosomal abnormalities have been reported. Although the pattern of aberrations is nonrandom, no specific primary or secondary karyotypic abnormality has...

Predominance of CIN versus MSI in the development of rectal cancer at young age. (2002)

Fernebro, Eva, Halvarsson, Britta, Baldetorp, Bo, Nilbert, Mef

BACKGROUND: Development of proximal and distal colorectal cancers involve partly different mechanisms associated with the microsatellite instability (MSI) and the chromosomal instability (CIN)...

Viktigt att upptäcka ärftliga fall av kolorektal- och endometriecancer. Mutationer hos »HNPCC-individer» kan orsaka flera tumörsjukdomar [Essential to discover hereditary colorectal and endometrial cancer. ] (2002)

Nilbert, Mef, Grönberg, Henrik, Lindblom, Annika

Hereditary Nonpolyposis Colorectal Cancer (HNPCC) is one of our most common hereditary cancer syndromes and confers an increased risk for several tumor types, with the greatest lifetime risks being...

Focus on the Tumour Periphery in MRI Evaluation of Soft Tissue Sarcoma: Infiltrative Growth Signifies Poor Prognosis

Fernebro, Josefin, Wiklund, Marie, Jonsson, Kjell, Bendahl, Pär-Ola, Rydholm, Anders, Nilbert, Mef, ...

Purpose. Infiltrative microscopical peripheral growth of soft tissue sarcomas (STS) has been shown to be of prognostic importance and preoperative risk stratification could individualize neoadjuvant...

Immunohistochemical Loss of the DNA Mismatch Repair Proteins MSH2 and MSH6 in Malignant Fibrous Histiocytomas

Ericson, Kajsa, Engellau, Jacob, Persson, Annette, Lindblom, Annika, Domanski, Henryk, Åkerman, Måns, ...

Purpose: Soft tissue sarcomas (STS) account for less than 1% of all malignancies and constitute a heterogeneous tumor entity in which malignant fibrous histiocytomas (MFH) represent one-third and are...

Genetic Profiling Differentiates Second Primary Tumors from Metastases in Adult Metachronous Soft Tissue Sarcoma

Fernebro, Josefin, Carneiro, Ana, Rydholm, Anders, Domanski, Henryk A., Karlsson, Anna, Borg, Åke, ...

Purpose. Patients with soft tissue sarcomas (STS) are at increased risk of second primary malignancies, including a second STS, but distinction between metastases and a second primary STS is...

A Parametric Model for Analyzing Anticipation in Genetically Predisposed Families

Klaus Larsen, Janne Petersen, Inge Bernstein, Mef Nilbert

Anticipation, i.e. a decreasing age-at-onset in subsequent generations has been observed in a number of genetically triggered diseases. The impact of anticipation is generally studied in affected...