Small silencing RNAs: an expanding universe (2009)
Ghildiyal, Megha, Zamore, Phillip D.
Since the discovery in 1993 of the first small silencing RNA, a dizzying number of small RNA classes have been identified, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and...
Endogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells (2008)
Ghildiyal, Megha, Seitz, Herve, Horwich, Michael D., Li, Chengjian, Du, Tingting, Lee, Soohyun, ...
Small interfering RNAs (siRNAs) direct RNA interference (RNAi) in eukaryotes. In flies, somatic cells produce siRNAs from exogenous double-stranded RNA (dsRNA) as a defense against viral infection....
Seitz, Herve, Ghildiyal, Megha, Zamore, Phillip D.
MicroRNAs (miRNAs) are short regulatory RNAs that direct repression of their mRNA targets. The miRNA "seed"-nucleotides 2-7-establishes target specificity by mediating target binding....
Brady, Michael J., Campellone, Kenneth Geno, Ghildiyal, Megha, Leong, John M.
The Tir proteins of enterohaemorrhagic and enteropathogenic Escherichia coli (EHEC and EPEC respectively) are each translocated into the host plasma membrane where they promote F-actin pedestals in...