Megumi Yamashita

Hair loss and defective T- and B-cell function in mice lacking ORAI1 (2008)

Gwack, Yousang, Srikanth, Sonal, Oh-Hora, Masatsugu, Hogan, Patrick G., Lamperti, Edward D., Yamashita, Megumi, ...

ORAI1 is a pore subunit of the store-operated Ca(2+) release-activated Ca(2+) (CRAC) channel. To examine the physiological consequences of ORAI1 deficiency, we generated mice with targeted disruption...

Disturbed Cell Arrangement, Increased Cell Membrane Permeability and Apoptotic Cell Death Occur in Adenomyotic Uterine Tissues in Mice (1997)

Megumi Yamashita, Takao Mori

The relationship of the development of uterine adenomyosis with the changes in the cell arrangement and cell membrane permeability, and incidence of DNA fragmentation was examined in mice. In uterine...

Orai1 Mutations Alter Ion Permeation and Ca2+-dependent Fast Inactivation of CRAC Channels: Evidence for Coupling of Permeation and Gating

Yamashita, Megumi, Navarro-Borelly, Laura, McNally, Beth A., Prakriya, Murali

Ca2+ entry through store-operated Ca2+ release-activated Ca2+ (CRAC) channels is an essential trigger for lymphocyte activation and proliferation. The recent identification of Orai1 as a key CRAC...

Hair Loss and Defective T- and B-Cell Function in Mice Lacking ORAI1▿ †

Gwack, Yousang, Srikanth, Sonal, Oh-hora, Masatsugu, Hogan, Patrick G., Lamperti, Edward D., Yamashita, Megumi, ...

ORAI1 is a pore subunit of the store-operated Ca2+ release-activated Ca2+ (CRAC) channel. To examine the physiological consequences of ORAI1 deficiency, we generated mice with targeted disruption of...

STIM1–Orai1 interactions and Orai1 conformational changes revealed by live-cell FRET microscopy

Navarro-Borelly, Laura, Somasundaram, Agila, Yamashita, Megumi, Ren, Dongjun, Miller, Richard J, Prakriya, Murali

Ca2+ entry through store-operated Ca2+ release-activated Ca2+ (CRAC) channels initiates key functions such as gene expression and exocytosis of inflammatory mediators. Activation of CRAC channels by...