Melanie Babcock

Hominoid lineage specific amplification of low-copy repeats on 22q11.2 (LCR22s) associated with velo-cardio-facial/digeorge syndrome (2007)

Babcock, Melanie, Yatsenko, Svetlana, Hopkins, Janet, Brenton, Matthew, Cao, Qing, De Jong, Pieter, ...

Segmental duplications or low-copy repeats (LCRs) constitute ∼5% of the sequenced portion of the human genome and are associated with many human congenital anomaly disorders. The low-copy repeats...

AT-rich repeats associated with chromosome 22q11.2 rearrangement disorders shape human genome architecture on Yq12 (2007)

Babcock, Melanie, Yatsenko, Svetlana, Stankiewicz, Pawel, Lupski, James R., Morrow, Bernice E.

Low copy repeats (LCRs; segmental duplications) constitute ∼5% of the sequenced human genome. Nonallelic homologous recombination events between LCRs during meiosis can lead to chromosomal...

Frequent translocations occur between low copy repeats on chromosome 22q11.2 (LCR22s) and telomeric bands of partner chromosomes (2003)

Spiteri, Elizabeth, Babcock, Melanie, Kashork, Catherine D., Wakui, Keiko, Gogineni, Swarna, Lewis, Debbie A., ...

The chromosome 22q11.2 region is susceptible to rearrangements, mediated by low copy repeats (LCR22s). Deletions and duplications are mediated by homologous recombination events between LCR22s. The...

Shuffling of Genes Within Low-Copy Repeats on 22q11 (LCR22) by Alu-Mediated Recombination Events During Evolution (2003)

Babcock, Melanie, Pavlicek, Adam, Spiteri, Elizabeth, Kashork, Catherine D., Ioshikhes, Ilya, Shaffer, Lisa G., ...

Low-copy repeats, or segmental duplications, are highly dynamic regions in the genome. The low-copy repeats on chromosome 22q11.2 (LCR22) are a complex mosaic of genes and pseudogenes formed by...

Shuffling of Genes Within Low-Copy Repeats on 22q11 (LCR22) by Alu-Mediated Recombination Events During Evolution

Babcock, Melanie, Pavlicek, Adam, Spiteri, Elizabeth, Kashork, Catherine D., Ioshikhes, Ilya, Shaffer, Lisa G., ...

Low-copy repeats, or segmental duplications, are highly dynamic regions in the genome. The low-copy repeats on chromosome 22q11.2 (LCR22) are a complex mosaic of genes and pseudogenes formed by...

Shuffling of Genes Within Low-Copy Repeats on 22q11 (LCR22) by Alu-Mediated Recombination Events During Evolution

Babcock, Melanie, Pavlicek, Adam, Spiteri, Elizabeth, Kashork, Catherine D., Ioshikhes, Ilya, Shaffer, Lisa G., ...

Low-copy repeats, or segmental duplications, are highly dynamic regions in the genome. The low-copy repeats on chromosome 22q11.2 (LCR22) are a complex mosaic of genes and pseudogenes formed by...

Microduplication and Triplication of 22q11.2: A Highly Variable Syndrome

Yobb, Twila M., Somerville, Martin J., Willatt, Lionel, Firth, Helen V., Harrison, Karen, MacKenzie, Jennifer, ...

22q11.2 microduplications of a 3-Mb region surrounded by low-copy repeats should be, theoretically, as frequent as the deletions of this region; however, few microduplications have been reported. We...

AT-rich repeats associated with chromosome 22q11.2 rearrangement disorders shape human genome architecture on Yq12

Babcock, Melanie, Yatsenko, Svetlana, Stankiewicz, Pawel, Lupski, James R., Morrow, Bernice E.

Low copy repeats (LCRs; segmental duplications) constitute ∼5% of the sequenced human genome. Nonallelic homologous recombination events between LCRs during meiosis can lead to chromosomal...