Melanie Rug

Trafficking and assembly of the cytoadherence complex in Plasmodium falciparum-infected human erythrocytes

Wickham, Mark E., Rug, Melanie, Ralph, Stuart A., Klonis, Nectarios, McFadden, Geoffrey I., Tilley, Leann, ...

After invading human erythrocytes, the malarial parasite Plasmodium falciparum, initiates a remarkable process of secreting proteins into the surrounding erythrocyte cytoplasm and plasma membrane....

Correct Promoter Control Is Needed for Trafficking of the Ring-Infected Erythrocyte Surface Antigen to the Host Cytosol in Transfected Malaria Parasites

Rug, Melanie, Wickham, Mark E., Foley, Michael, Cowman, Alan F., Tilley, Leann

Following invasion of human erythrocytes, the malaria parasite, Plasmodium falciparum, exports proteins beyond the confines of its own plasma membrane to modify the properties of the host red cell...

Genesis of and Trafficking to the Maurer's Clefts of Plasmodium falciparum-Infected Erythrocytes†

Spycher, Cornelia, Rug, Melanie, Klonis, Nectarios, Ferguson, David J. P., Cowman, Alan F., Beck, Hans-Peter, ...

Malaria parasites export proteins beyond their own plasma membrane to locations in the red blood cells in which they reside. Maurer's clefts are parasite-derived structures within the host cell...

Trafficking and assembly of the cytoadherence complex in Plasmodium falciparum-infected human erythrocytes

Wickham, Mark E., Rug, Melanie, Ralph, Stuart A., Klonis, Nectarios, McFadden, Geoffrey I., Tilley, Leann, ...

After invading human erythrocytes, the malarial parasite Plasmodium falciparum, initiates a remarkable process of secreting proteins into the surrounding erythrocyte cytoplasm and plasma membrane....

Correct Promoter Control Is Needed for Trafficking of the Ring-Infected Erythrocyte Surface Antigen to the Host Cytosol in Transfected Malaria Parasites

Rug, Melanie, Wickham, Mark E., Foley, Michael, Cowman, Alan F., Tilley, Leann

Following invasion of human erythrocytes, the malaria parasite, Plasmodium falciparum, exports proteins beyond the confines of its own plasma membrane to modify the properties of the host red cell...

Genesis of and Trafficking to the Maurer's Clefts of Plasmodium falciparum-Infected Erythrocytes†

Spycher, Cornelia, Rug, Melanie, Klonis, Nectarios, Ferguson, David J. P., Cowman, Alan F., Beck, Hans-Peter, ...

Malaria parasites export proteins beyond their own plasma membrane to locations in the red blood cells in which they reside. Maurer's clefts are parasite-derived structures within the host cell...

Trafficking of the major virulence factor to the surface of transfected P falciparum–infected erythrocytes

Knuepfer, Ellen, Rug, Melanie, Klonis, Nectarios, Tilley, Leann, Cowman, Alan F.

After invading human red blood cells (RBCs) the malaria parasite Plasmodium falciparum remodels the host cell by trafficking proteins to the RBC compartment. The virulence protein P falciparum...

The role of KAHRP domains in knob formation and cytoadherence of P falciparum-infected human erythrocytes

Rug, Melanie, Prescott, Stuart W., Fernandez, Kate M., Cooke, Brian M., Cowman, Alan F.

Surface protrusions of Plasmodium falciparum-infected erythrocytes, called knobs, display focal aggregates of P falciparum erythrocyte membrane protein 1 (PfEMP1), the adhesion ligand binding...

Skeleton-binding protein 1 functions at the parasitophorous vacuole membrane to traffic PfEMP1 to the Plasmodium falciparum–infected erythrocyte surface

Maier, Alexander G., Rug, Melanie, O'Neill, Matthew T., Beeson, James G., Marti, Matthias, Reeder, John, ...

A key feature of Plasmodium falciparum, the parasite causing the most severe form of malaria in humans, is its ability to export parasite molecules onto the surface of the erythrocyte. The major...

Signal-mediated export of proteins from the malaria parasite to the host erythrocyte

Marti, Matthias, Baum, Jake, Rug, Melanie, Tilley, Leann, Cowman, Alan F.

Intracellular parasites from the genus Plasmodium reside and multiply in a variety of cells during their development. After invasion of human erythrocytes, asexual stages from the most virulent...

Exported Proteins Required for Virulence and Rigidity of Plasmodium falciparum-Infected Human Erythrocytes

Maier, Alexander G., Rug, Melanie, O'Neill, Matthew T., Brown, Monica, Chakravorty, Srabasti, Szestak, Tadge, ...

A major part of virulence for Plasmodium falciparum malaria infection, the most lethal parasitic disease of humans, results from increased rigidity and adhesiveness of infected host red cells. These...

Crystal Structure of Malaria Parasite Nucleosome Assembly Protein: DISTINCT MODES OF PROTEIN LOCALIZATION AND HISTONE RECOGNITION*S⃞

Gill, Jasmita, Yogavel, Manickam, Kumar, Anuj, Belrhali, Hassan, Jain, S. K., Rug, Melanie, ...

Nucleosome assembly proteins (NAPs) are histone chaperones that are essential for the transfer and incorporation of histones into nucleosomes. NAPs participate in assembly and disassembly of...

Analysis of structure and function of the giant protein Pf332 in Plasmodium falciparum

Hodder, Anthony N, Maier, Alexander G, Rug, Melanie, Brown, Monica, Hommel, Mirja, Pantic, Ivan, ...

Virulence of Plasmodium falciparum, the most lethal parasitic disease in humans, results in part from adhesiveness and increased rigidity of infected erythrocytes. Pf332 is trafficked to the...